In this World View article for the journal Nature Reviews Cancer, Professor Frances Balkwill discusses her dual career in public engagement and research.
Researchers at Queen Mary University of London and Cardiff University have developed a rapid test for the diagnosis of a constellation of rare and debilitating genetic conditions. The new high-resolution technology will be 'step-change' in testing for telomere disorders.
In this research summary of a recent study from Blizard Institute researchers Patrick Kennedy and Upkar Gill, we hear about the potential of liver cancer development in patients with ‘quiescent’ chronic hepatitis B, after the group extensively studied the liver compartment in a cohort of east London patients.
Less than one-third of COVID-19 clinical trials are led by women, which is half the proportion observed in non-COVID-19 trials, according to research led by Queen Mary University of London, University of St Andrews, Brigham and Women's Hospital and Harvard Medical School.
People who have previously had COVID-19 have an enhanced antibody response with a single dose of RNA vaccine, according to a study of 51 UK healthcare workers, around half of whom had a previous laboratory-confirmed SARS-CoV-2 infection.
In a new paper published in Nature Microbiology, researchers from the Blizard Institute and colleagues from the Tropical Gastroenterology & Nutrition group in Zambia have found that constant exposure to microbial pathogens in children leads to stunted growth.
A team of interdisciplinary researchers from Queen Mary University of London’s Barts and The London School of Medicine and Dentistry, and the School of Engineering and Materials Science, are one of three awardees for Phase 1 funding of the NC3Rs CRACK IT Challenge call. The funding will allow the team to develop a way to study tissue regeneration after traumatic injuries using organ-on-a-chip technology.
In a paper published today in Science Immunology, researchers from the Blizard Institute conduct a detailed study of how antibody responses are generated in humans using a technique to measure the genes expressed by individual B cells and in parallel sequence their antibody genes. The findings could have implications for testing vaccine efficacy and understanding our immune systems more generally.
Research published in the journal Immunotherapy Advances by scientists from the Centre for Immunobiology at the Blizard Institute, University College London, University of Edinburgh and Royal Free Hospital in London has shown that vitamin D replacement enhances antigen-specific immunity in the elderly. In this Q&A, Corresponding Author Dr Emma Chambers from the Centre for Immunobiology discusses these recent findings and the wider implications for improving the health-span of the UK’s aging population.
New research involving scientists from Queen Mary University of London has found evidence of protective immunity in people up to four months after mild or asymptomatic Covid-19.
Congratulations to the MSc Emergency and Resuscitation Medicine programme team at the Blizard Institute for receiving the award. Professor Colin Bailey, President and Principal, and Professor Stephanie Marshall, Vice-Principal (Education), presented Queen Mary's Education Excellence Awards and President and Principal's Prizes for 2020/21 at an online ceremony held on Tuesday 8 December 2020.
An inquest has ruled that air pollution was the cause of death of a nine year old girl. The outcome has made legal history as air pollution has never been identified as a cause of death before in the UK.
Researchers from the Blizard Institute will use miniaturised living systems with human cells, known as organ-chips, donated by Emulate, Inc to investigate how Covid-19 affects the lungs.
New study to determine if air pollution increases COVID-19 risk
30 November 2020
A new study has been launched to better understand the link between air pollution and increased risk of developing COVID-19.
Q&A: MeCP2 reactivation for Rett Syndrome therapy
30 November 2020
In a new collaborative study involving the Cerase lab at the Blizard Institute, screening of around 30,000 molecules has shown that inhibitors of Janus Kinases, a class of protein that can modify other proteins in the cell, are potent reactivators of Methyl CpG binding protein 2 (MeCP2). Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the MeCP2 gene. In this Q&A, Dr Andrea Cerase explains why this new discovery could help introduce new therapeutic molecules into the treatment of RTT.
MS clinical trial to focus on people who can’t walk
19 November 2020
The first multiple sclerosis (MS) clinical trial to focus only on people who can’t walk is to start recruiting. The ChariotMS trial, led by researchers at Queen Mary University of London, will test whether cladribine tablets (Mavenclad®), already licensed for highly active relapsing MS, can slow the rate of upper limb disability progression in people with advanced MS.
Londoners are today being urged to join a leading phase three Covid-19 vaccine study, as Barts Health NHS Trust and Queen Mary University of London administer a new trial from the Barts Health Vaccines Trials Centre at Bethnal Green Library.
Dr Helen Rowe from the Centre for Immunobiology explains how Hale Tunbak and Rocio Enriquez-Gasca in her lab have linked LINE-1 elements and the HUSH complex to regulation of the human innate immune system.
Queen Mary University of London is part of a consortium of 13 organisations across nine countries set to receive €9.5m in EU funding for a ground-breaking research project into the treatment of faecal incontinence.
On Friday 23 October, Professor Qasim Aziz, Director of the Wingate Institute (part of the Blizard Institute) and Professor of Neurogastroenterology, was confirmed as President of the European Society of Neurogastroenterology and Motility (ESNM). The official confirmation follows his election to the post on Saturday 15 February 2020.
Researchers from Queen Mary University of London, funded by Barts Charity, have launched a new clinical trial to investigate whether taking vitamin D could protect people from COVID-19.
Channel 4 has featured Dr Madusha Peiris from the Wingate Institute of Neurogastroenterology (part of the Blizard Institute) in their latest episode of "How to beat... Fat" where she helped 10 volunteers develop new weight loss techniques.
Air pollution particles and metals found in the placenta
23 September 2020
Pollution particles, including metals, have been found in the placentas of fifteen women in London, according to research led by Queen Mary University of London.
Wingate professor featured in BBC film about living with IBD
14 September 2020
Professor Qasim Aziz, Director of the Wingate Institute of Neurogastroenterology at the Blizard Institute, features in a new short film produced by the BBC and released online on Saturday 12 September. He discusses the connection between the brain and the gut, and potential new treatments for inflammatory bowel disease.
Pregnant women seen in hospital with COVID-19 are less likely to show symptoms, and seem to be at increased risk of needing admission to an intensive care unit than non-pregnant women of similar age, according to a study involving researchers from the Blizard Institute and Institute of Population Health Sciences at Queen Mary University of London.
In a new paper published in Alimentary Pharmacology and Therapeutics, researchers from the Wingate Institute of Neurogastroenterology at the Blizard Institute have demonstrated that transcutaneous vagal nerve stimulation (t‐VNS) prevents the development of and/or reverses established visceral hypersensitivity in a previously validated model of acid‐induced oesophageal pain.
New study into air pollution exposure in African children
27 August 2020
Researchers from Queen Mary University of London have received funding from the National Institute for Health Research (NIHR) to conduct research into air pollution exposure affecting children in Africa.
Childhood and adolescent obesity is projected to contribute up to 14 per cent of overall risk of Multiple Sclerosis (MS) in 2035, according to research led by Queen Mary University of London.
Educators at Centre of the Cell shown to boost learning
24 August 2020
New research led by North Carolina State University and the University of Exeter has shown that youth educators at informal science learning sites such as Centre of the Cell play an important role in promoting engagement with STEM learning for young people outside of formal education.
In a UK-first, Queen Mary University of London is leading a clinical trial of a new rapid COVID-19 testing system that delivers results in under an hour. Working with the East London Health and Care Partnership, up to 2,000 staff and residents in 50 care homes are being recruited to see how effective rapid daily COVID-19 testing is at reducing rates of infection, hospitalisation and deaths.
A new report from the Academy of Medical Sciences released on Tuesday 14 July warns that the UK must prepare now for a potential new wave of coronavirus infections this winter, which could be even more deadly than the first.
A gene has been discovered that can naturally suppress the signs of Alzheimer’s Disease in human brain cells, in research led by Queen Mary University of London. The scientists have also developed a new rapid drug-screening system for treatments that could potentially delay or prevent the disease.
A new paper by a researchers from the Brain Tumour Research Centre of Excellence, part of the Centre for Genomics and Child Health at the Blizard Institute, published in The EMBO Journal, finds that reactions in the microglia triggered by Glioblastoma multiforme hinders effective T‐cell infiltration, proliferation and immune reactivity, thereby contributing to tumour immune evasion and promoting tumour growth.
Various studies are currently looking at ways to rejuvenate old cells using young donor cells or certain drugs, however many of these approaches are toxic or may have unwanted side effects such as cancer. In this study published in the journal Cell Metabolism, researchers from the Epigenetics and Cellular Senescence Group at the Blizard Institute have demonstrated a much safer potential avenue using 'extracellular vesicles' released by young donor cells. In this Q&A, Dr Ana O’Loghlen describes the finding and the potential for future therapeutic use.
Researchers from Queen Mary University of London, University of Cambridge, and Barts Health NHS Trust have identified new avenues for possible treatment of the genetic skin disorder harlequin ichthyosis using a 3D cell model in a new paper published in The Journal of Clinical Investigation. In this Q&A, Professor Edel O’Toole from the Blizard Institute’s Centre for Cell Biology and Cutaneous Research explains how they identified new inflammatory therapeutic targets and the wider implications of the results.
A new paper by Dr Ana O’Loghlen and Juan Antonio Fafián-Labora from the Epigenetics and Cellular Senescence Group at the Blizard Institute, published in the journal Trends in Cell Biology, provides a review of different means of intercellular communication including soluble factors in the context of senescence, ageing and age-related diseases. In this Q&A, Dr O’Loghlen discusses the importance and wider implications of this review.
Barts Charity has donated £2.9 million to establish a new centre of excellence for academic trauma and orthopaedic surgery at Queen Mary University of London and Barts Health NHS Trust.
A new study led by Queen Mary University of London has demonstrated the effectiveness of using a novel light technology to monitor the presence of anti-drug antibodies in the treatment of multiple sclerosis (MS), which can lead to drug resistance and treatment failure. The researchers say that they have also applied the technology to COVID-19 for potential use in antibody testing to determine whether someone has previously been infected with the virus.
We're incredibily proud of all our staff and students who are working or volunteering on the front line or behind the scenes in response to the COVID-19 pandemic. Many of our postgraduate students have taken time from their studies and are currently working within the NHS, Public Health Wales and the ambulance service. Here we are highlighting the work of some of our students on the MSc Biomedical Science (Medical Microbiology) and MSc Clinical Science (Infection Science) programmes.
Blizard Institute Professor of Surgery and Barts Health NHS Trust Consultant Surgeon, Professor Charles Knowles, has written and recorded a ballad in memory of all NHS staff and other key workers who have lost their lives in the fight against the coronavirus pandemic.
Research involving Queen Mary University of London suggests that currently the public should not fear contracting COVID-19 from hospital staff, who appear to be at low risk of infection by patients.
The Queen Mary University of London community, including researchers, clinicians and support staff, have stepped in to assist the NHS with urgent requirements of personal protective equipment (PPE) to combat the outbreak of COVID-19.
On Thursday 5 March, Queen Mary hosted a successful precision medicine leadership event at St Bartholomew’s Great Hall on our West Smithfield campus. The event, run in partnership with One Nucleus and Cerba Research, explored new developments in the field of precision medicine as well as opportunities for academic and industrial collaboration.
PhD student Harriet Allan from the Blizard Institute's Centre for Immunobiology attended Parliament to present her research to politicians and scientific experts as part of the STEM for BRITAIN event.
The first clinical samples of COVID-19 have been received by the Blizard Institute.
Professor of Paediatrics appointed as NIHR Senior Investigator
28 February 2020
The Blizard Institute's Professor Grigg has been appointed as a Senior Investigator for 2020 by the National Institute for Health Research (NIHR) – the nation's largest funder of health and care research.
New light technology helps identify anti-drug antibodies
18 February 2020
Researchers from Queen Mary University of London, including the Blizard Institute, have successfully demonstrated the use of a novel light emitting technology in identifying anti-drug antibodies that can reduce effectiveness of monoclonal antibody therapies.
Neuron Pod named one of the 10 best buildings of 2019
12 February 2020
On Saturday 8 February, Neuron Pod, the state-of-the-art, purpose-built learning and community space at Centre of the Cell, was named by The Times as one of the 10 best buildings in 2019.
Researchers led by Professor John Pasi from the Blizard Institute have demonstrated the efficacy and long-term safety of adeno-associated virus (AAV)-mediated gene therapy to treat Haemophilia A over three years. In this Q&A, Professor Pasi discusses why this study is important, and the wider implications for the research.
Dr Yung-Yao Lin from the Centre for Genomics and Child Health at the Blizard Institute has been awarded funding to offer a PhD studentship in ‘3D bio-printing human pluripotent stem cell-derived skeletal muscle constructs for disease modelling and drug discovery’ by the National Centre for the Replacement Refinement and Reduction of Animals in Research (NC3Rs)
Congratulations to Dr Benita Morrissey of the Centre for Genomics and Child Health at the Blizard Institute for winning the President and Principal’s Prize at the Education Excellence Awards yesterday evening.
Centre of the Cell reaches milestone of 200,000 participants
29 November 2019
Centre of the Cell, Queen Mary University of London’s informal biomedical science learning centre, has recorded 200,000 participants in its activities.
Dr Mariana Pinto da Costa, a Queen Mary University of London Doctoral Research Fellow, has received a Fellowship from the World Association of Social Psychiatry.
Academics from Queen Mary University of London have been awarded £5.5 million to deliver an innovative ‘Health Data in Practice' PhD Programme, with the first intake of students planned for October 2020.
Centre of the Cell has received a commendation for ‘a high standard of design’ for Neuron Pod, the new state-of-the-art, purpose-built learning and community space.
Professor Karim Brohi, Centre for Trauma Sciences (C4TS) lead and Consultant Trauma and Vascular Surgeon at Barts Health NHS Trust, has for the second year in a row been named in the Evening Standard's Progress 1000 list which recognises the most influential people in the capital.
Medical care of injured soldiers could improve with new Artificial Intelligence (AI) tools designed for the battlefield and the hospital following a grant from the US Department of Defense for research at Queen Mary University of London.
Researchers at the Blizard Institute have demonstrated for the first time the feasibility of models using patient-derived stem cells in assessing future drug candidates in the treatment of dystroglycanopathies (a group of congenital muscular dystrophies). In this Q&A, Dr Yung-Yao Lin from the Centre for Genomics and Child Health explains the implications of this proof of concept study in identifying drug therapies in the treatment of dystroglycanopathies, and for the study of other neurological diseases.
The European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) launched new guidelines for the management of dyslipidaemias at the ESC meeting 1–4 September 2019 with the guidelines concurrently published in the European Heart Journal. Professor Borislava Mihaylova, Chair in Health Economics at the Centre for Primary Care and Public Health at the Blizard Institute, is a member of the guidelines Taskforce.
Universities Minister Chris Skidmore toured Queen Mary University of London’s Whitechapel campus as part of a funding announcement that will help universities stimulate growth in their local economies and provide vital support for innovative new companies.
Before going public with his HIV diagnosis, Gareth Thomas spoke to Professor Chloe Orkin, British HIV Association (BHIVA) Chair and Clinical Professor of HIV Medicine at the Blizard Institute, who helped him to tackle the stigmas, myths and misunderstandings surrounding the condition. Their conversation features in the BBC documentary, "HIV and Me," broadcast on Wednesday 18 September.
Rett syndrome is a rare and devastating neurological disorder. It is a genetic disease caused by a mutation on the X chromosome, and affects almost only girls. Andrea Cerase from the Centre for Genomics and Child Health discusses his research into rare disease differences between sexes, and the implications for treating epigenetics-based disorders.
A team of researchers from the Blizard Institute’s Centre for Trauma Sciences (C4TS) and Centre for Immunobiology have recently had research published in the journal PNAS which found that histones, small proteins released by the injured tissues of trauma patients, punch holes in platelets causing them to swell into balloon structures. The surface of these platelet balloons support blood clot formation, and microparticles released from balloons then stick to white blood cells and may alter the response of the immune system.
In this Q&A, Dr Scarlett Gillespie from C4TS explains the significance of the results and implications for further research.
Queen Mary hosts first international tuberculosis symposium
21 August 2019
This summer, the Blizard Institute at Queen Mary University of London, in collaboration with the World Health Organization (WHO) Collaborating Centre in Tradate, Italy, held Queen Mary’s first international tuberculosis (TB) symposium.
A simple Mediterranean-style diet in pregnancy does not reduce the overall risk of adverse maternal and offspring complications, but has the potential to reduce weight gain in pregnancy and the risk of gestational diabetes, according to a clinical trial led by Queen Mary University of London and the University of Warwick.
Paul Vulliamy, Clinical Research Fellow in the Centre for Neuroscience, Surgery and Trauma, came out on top for his image of 'White Blood Cells in Colour'. He received an iPad Air and Apple pencil for his win.
On Tuesday 9 July, Charles Perrin CBE and his wife Gill visited the Blizard Institute to view his 2018 donation on display outside the Perrin Lecture Theatre at Queen Mary’s Whitechapel campus.
With every week that a pregnancy continues past term (37 weeks), the risk of stillbirth increases, according to an analysis of more than 15 million pregnancies led by Queen Mary University of London.
The causes of persistent high levels of anaemia among Peruvian children will be investigated by a new study led by Queen Mary University of London and the Instituto Nacional de Salud del Niño (INSN), in collaboration with Universidad Nacional Intercultural de la Amazonia (UNIA) and Universidad Nacional San Christobal de Huamanga in Peru.
A new study involving researchers from the Blizard Institute found that short-term pedometer interventions produce significant health benefits several years later.
The Blizard Institute’s Dr Ana O’Loghlen and team* has had research published today in the journal Cell Reports, which shows that senescent (damaged and/or old) cells send messages in the form of packed ‘bags’ to other nearby cells to indicate that they are not well.
In this Q&A, Dr O’Loghlen explains the relevance of this research in ageing and age-related diseases, and discusses how this could be the reason why ageing can spread so quickly between different tissues in the body.
On Thursday 13 June, Queen Mary welcomed a delegation of civil servants from South Korea’s Gyeongsangbuk-do provincial government to learn about Tuberculosis (TB) elimination policy in London. The meeting was hosted at the Blizard Institute in conjunction with the Queen Mary Global Policy Institute.
Professor Chloe Orkin has been appointed as the new Vice-President of the UK’s leading organisation for women doctors.
The most severe pandemic in recent history, killing some 50 million people worldwide, the Spanish Influenza, may have emerged up to two years earlier than previously believed, according to a new study by Queen Mary University of London researchers.
Professor Deborah Swinglehurst from the Centre for Primary Care and Public Health at the Blizard Institute, Barts and The London School of Medicine and Dentistry, has received the John Fry Award for promoting the discipline of general practice through research and publishing.
A new project to improve asthma in African children has been officially launched at an event in Durban, South Africa.
Many patients with potentially deadly liver cirrhosis and liver cancer are being diagnosed at late advanced stages of disease, according to a study led by Queen Mary University of London and the University of Glasgow.
A new risk calculator for pregnant women with epilepsy, developed by researchers from Queen Mary University of London, has been found to accurately predict the risk of seizures during pregnancy and up to six weeks after delivery, and could save the lives of mothers and babies.
In order to train the next generation of tuberculosis (TB) specialists, Queen Mary University of London has announced the launch of the world’s first postgraduate certificate to focus exclusively on TB, which will be delivered across the world through online distance learning from September 2019.
Professor Dame Parveen Kumar DBE from the Centre for Immunobiology at the Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, has received the BMJ Award for Outstanding Contribution to Health.
Dr Ruairi Robertson, Postdoctoral Research Fellow in the Centre for Genomics and Child Heath at the Blizard Institute, has been recognised by the British Nutrition Foundation (BNF) for his work on how different nutrients affect the gut microbiota in early life and the subsequent effects on child health and disease, particularly child growth.
The Blizard Institute's Dr Claire Bourke and Dr Andrew Prendergast and colleagues had research published this week in the journal Science Translational Medicine, which shows for the first time that otrimoxazole treatment suppresses inflammation among people living with HIV.
In this Q&A, Dr Bourke explains the significance of the research and the implications that this might have in the treatment of other health conditions that are made worse by ongoing inflammation.
Caesarean sections are disproportionately threatening the lives of women and babies in low and middle-income countries (LMIC), according to a study led by Queen Mary University of London.
‘Neuron Pod’ - a striking 23-metre long and 10-metre high free-standing structure – has opened its doors as an informal science learning centre at Queen Mary University of London’s Whitechapel campus.
There is a significant association between the rise of populism across Europe and the level of mistrust around vaccines, according to a study by Queen Mary University of London.
Treat vitamin D deficiency to prevent deadly lung attacks
15 January 2019
Vitamin D supplements have been found to reduce the risk of potentially fatal lung attacks in some chronic obstructive pulmonary disease (COPD) patients, according to a study led by Queen Mary University of London.
£1.5 million from Barts Charity has been awarded to brain tumour researchers at Queen Mary University of London to extend their successful lab-based research into clinical trials with patients.
Research team’s award-winning work in the fight against TB
12 December 2018
A tuberculosis screening and treatment programme involving researchers from Queen Mary University of London has won a ‘Community or Primary Care Services Redesign’ award at the 2018 Health Service Journal (HSJ) awards.
Cultural shift needed to keep trust in use of patient data
28 November 2018
A radical culture change in the NHS, and across the health data and medical technology community, is needed to make sure that the NHS can deliver benefits from patient data, and to retain public trust, says a new report authored by Queen Mary University of London academics.
Smoking found to reduce risk of developing Parkinson’s disease
21 November 2018
People who smoke, or are passively exposed to cigarette smoke, are less likely to develop Parkinson’s disease, according to a study led by Queen Mary University of London of more than 220,000 people.
Children exposed to diesel-dominated air pollution in London are showing poor lung capacity, putting them at risk of lifelong breathing disorders, according to a study led by Queen Mary University of London, King’s College London and the University of Edinburgh.
Dr Richard Hooper, Reader in Medical Statistics at the Blizard Institute, Queen Mary University of London has been awarded a senior fellowship from The Healthcare Improvement Studies (THIS) Institute.
Research funded by the British Heart Foundation (BHF) at Queen Mary University of London will explore how regions of our DNA that were previously thought to have no purpose could contribute to causing heart disease.
Researchers from Queen Mary University of London are calling for a police and community focus during the hours after school, after their research found that young people are most likely to be stabbed after school finishes for the day.
Levels of gender inequality across the world are associated with disproportionate death rates among girls under five years old, according to a study led by Queen Mary University of London.
Losing control of gene activity in Alzheimer’s disease
25 October 2018
New research into the mechanisms controlling gene activity in the brain could hold the key to understanding Alzheimer’s disease.
Trauma surgeon named as one of London’s most influential people
11 October 2018
Professor Karim Brohi, Head of Trauma Sciences at Queen Mary University of London and Consultant Trauma and Vascular Surgeon at Barts Health NHS Trust, has been named in the Evening Standard's Progress 1000 list, recognising the most influential people in the capital.
Academics from Queen Mary University of London helped raise the profile of tuberculosis (TB) and the need for increased funding at the UN General Assembly in New York, which was attended by global Heads of State and government ministers.
Q&A: Colon function decreases as we age
27 September 2018
Dr John Broad, Professor Gareth Sanger and Professor Charles Knowles and colleagues, from the Blizard Institute published the results of their study on colon function last week.
The researchers found that the ability of nerves to cause muscle contractions in the colon decreases with age.
In this Q&A, Dr Broad explains the significance of the research and its implications for treating constipation.
The Barts Charity Trauma Appeal, which was launched today, aims to raise £1 million to support vital research at The Royal London Hospital, in conjunction with Queen Mary University of London’s Centre for Trauma Sciences.
First evidence that soot from polluted air may be reaching placenta
16 September 2018
Evidence of tiny particles of carbon, typically created by burning fossil fuels, has been found in placentas for the first time, in early research involving a small number of people, presented today by researchers from Queen Mary University of London.
Study links widely-used drug azathioprine to skin cancers
10 September 2018
A drug used to treat inflammatory bowel disease and arthritis, and prevent organ rejection in transplant patients, has been identified as an important contributor to skin cancer development, in research by Queen Mary University of London, University of Dundee and the Wellcome Sanger Institute.
A leading higher education professional association, Advance HE, has awarded Dr Vicky Jolliffe from Queen Mary University of London a 2018 National Teaching Fellow award.
A clinical trial has begun which will use stem cell transplants to grow a new immune system for people with untreatable Crohn’s disease – a painful and chronic intestinal disease which affects at least 115,000 people in the UK.
Ruairi Robertson is a Sir Henry Wellcome Postdoctoral Research Fellow based at the Blizard Institute, Queen Mary University of London. In the second part of his blog covering a recent trip to Zimbabwe, he reports from a symposium bringing together experts from all over the world and from different fields, who are hoping to find a solution to widespread child malnutrition.
A new study led by Queen Mary University of London and Curtin University, Australia found that Cannabinoid improves survival rates of mice with pancreatic cancer.
Ruairi Robertson is a Sir Henry Wellcome Postdoctoral Research Fellow based at the Blizard Institute, Queen Mary University of London. In this two-part blog, he describes his recent trip to Zimbabwe where he and his team are carrying out research into severe acute malnutrition.
Former players will be recruited through the Professional Footballers’ Association for a study examining the link between heading the ball or concussions and long-term brain function.
15 million adults in England have a long-term condition (LTC) and can access online peer support. Online health communities can influence health, use of healthcare resources, and improve illness self-management. The way people connect online and in particular how highly active users (called superusers) shape the online communities play a fundamental role in information diffusion, according a study published today in the journal JMIR.
Dr Hemanth Tummala and colleagues from the Blizard Institute had research published this week in the journal PNAS, which finds a new role for a gene in DNA repair.
Primarily funded by the Medical Research Council and Bloodwise charity, the researchers studied children with inherited bone marrow failure (IBMF) to find mutations that might be causing their disease.
In this Q&A, Dr Tummala explains the significance of the research and how it might lead to new treatments for cancer.
A new clinical trial testing a disease-modifying drug for multiple sclerosis (MS) will be the first in the world to recognise the importance of wheelchair users retaining the use of their hands.
The team from Queen Mary University of London, Barts Health NHS Trust and pharmaceutical company Roche, hope that the study will make lasting changes in a field that has previously only looked at a patient’s walking ability when assessing the potential of MS drugs.
Over 3,000 primary school children in polluted areas of London and Luton will have their lung health monitored over a four-year period in a new international study led by Queen Mary University of London, launched today by the Mayor of London Sadiq Khan at Netley Primary School.
Researchers from Queen Mary University of London have developed new cell-based technologies which could improve understanding of the muscle-wasting disease Duchenne muscular dystrophy (DMD) and test potential drugs for the disease.
Researchers at Queen Mary University of London have developed a school programme to reduce high levels of poorly managed asthma in young people.
Queen Mary University of London has appointed four research fellows to its new Rutherford Academy of Population Genomics and Health Data Science, funded by the Medical Research Council and UK Research and Investment’s Rutherford Fund.
Barts Charity and Action Duchenne have combined forces to support research into new stem cell therapies for Duchenne Muscular Dystrophy. With a combined award of £276,000 (£250,000 from Barts Charity and £26,000 from Action Duchenne) they will be supporting the research of Dr Yung-Yao Lin, lecturer at the Barts and The London School of Medicine and Dentistry, Queen Mary University of London.
Queen Mary University of London has received funding from the National Institute of Health Research (NIHR) to advise researchers on how to develop high quality research proposals.
Neuron Pod coming to Whitechapel
16 April 2018
Construction has started on Centre of the Cell’s new ‘Neuron Pod’ - a striking 10-metre high free-standing structure in the mews area of the Blizard Institute at Whitechapel.
A new health promotion tool has been launched to inform people about latent tuberculosis (TB) and engage migrant communities with local NHS testing and treatment.
Over a half of stroke patients require a degree of help with taking medicine and a sizeable minority say they do not receive as much assistance as they need, according a study by researchers at Queen Mary University of London and University of Cambridge.
Pregnant women with anaemia are twice as likely to die during or shortly after pregnancy compared to those without the condition, according to a major international study led by Queen Mary University of London of over 300,000 women across 29 countries.
Our curly hair was clue to hidden heart killer
19 March 2018
One woman tells CHRISTIE NORRIS how she finally discovered that she carries the deadly gene which has plagued her relatives for generations
The Blizard institute is very pleased to be able to celebrate the inaugural lecture of Professor James Lindsay which took place on Tuesday 13th March 2018 and addressed "Exploring the ‘ologies’ of Crohn’s disease: microbiology, immunology and stem-cell biology"
Academic receives honour from the Queen
27 February 2018
Health ministers and politicians visit brain tumour research labs
26 February 2018
UK health ministers shared the news of an upcoming funding boost to brain tumour research, during a visit to laboratories at Queen Mary University of London this week.
Rising accident and emergency attendance rates are driven by patients’ long term health conditions, and are not related to lack of GP provision, according to a study by Queen Mary University of London of more than 800,000 patients in east London.
Theatre project boosts peer support for young people with asthma
11 September 2017
An innovative theatre project and a game app have been presented by Queen Mary University of London (QMUL) researchers at the British Science Festival as new ways to help teenagers with asthma.
The rapper Professor Green is helping to raise funds for trauma research at Queen Mary University of London (QMUL) in a major appeal led by Barts Charity.
Pregnant women who have a healthy diet and regular moderate exercise are less likely to have a caesarean section, gain excessive weight, or develop diabetes in pregnancy, according to a study led by Queen Mary University of London (QMUL) using data from over 12,000 women.
The Blizard Institute’s science education centre, Centre of the Cell, reached a milestone of 150,000 participants in June 2017.
High maternal sugar intake during pregnancy may increase the risk of allergy and allergic asthma in the offspring, according to an early study led by Queen Mary University of London (QMUL) involving almost 9,000 mother-child pairs
The Blizard institute is very pleased to be able to celebrate the inaugural lecture of Professor Nick Croft which took place on Wednesday 28 June and addressed ‘Children, Digestive Diseases and the Grand National’.
Congratulations to Professor Parveen Kumar who was named in the Queen's annual Birthday Honours' list; been conferred the prestigious Dames Commander of the Order of the British Empire (DBE) for services to medicine and medical education.
Congratulations to Professor Denise Sheer who will be collaborating in a ground-breaking £5 million investment for research into Paediatric Low Grade Brain Tumours
The Blizard institute is very pleased to be able to celebrate the inaugural lecture of Professor Tom Vulliamy which took place on Friday the 15 June 2017. The lecture was title ‘Searching for genes – a long unwinding road’.
Through a Freedom of Information request to the European Medicines Agency, researchers from Queen Mary University of London (QMUL) have gained access to data from drug trials, revealing new information about a key drug for multiple sclerosis (MS).
The research, published in BMJ Open, analysed posts written by teenagers and their parents from Asthma UK’s online forum between 2006 and 2016. It found that the social stigma of asthma can play a role in teenagers choosing not to use their inhalers.
Queen Mary University of London (QMUL) will establish a new Centre for Preventive Neurology, thanks to £1.5m of funding from Barts Charity.
Queen Mary University of London (QMUL) has received £2m from Barts Charity to launch the Barts Research Centre for Women's Health, with the aim of tackling problems that affect mothers and their unborn and newborn children
Some common assumptions about the nature of multiple sclerosis (MS) are being challenged in two new studies led by Queen Mary University of London (QMUL) that analyse the brains and spinal cords of patients.
Study makes Anti-ageing breakthrough
6 April 2017
A new tool developed by researchers from Queen Mary University of London (QMUL) could save mothers’ and babies’ lives by predicting whether women with early onset pre-eclampsia are safe to prolong their pregnancy.
QMUL professor selected as NIHR senior investigator
30 March 2017
Congratulations to Professor Sandra Eldridge from the Centre for Primary Care and Public Health, who has been selected as a National Institute for Health Research (NIHR) senior investigator.
The Health Foundation, an independent charity, has today announced funding in the region of £40 million over a period of 10 years for the University of Cambridge to establish and run a new improvement research institute, the first of its kind in Europe.
Londoners were warned of 'very high' pollution levels earlier this year AFP/Getty Images
The snake skin woman: Extraordinary people
29 March 2017
Congratulations to Dr Rosalind Hannen and Professor Kenny Linton who have been successful in securing an award from MedCity’s new ‘Collaborate to Innovate’ scheme. The £2m ‘Collaborate to Innovate programme, led by King’s College London and part-funded by ERDF and HEFCE, is connecting 16 life sciences SMEs with leading academics to address a specific challenge related to their product or service.
New protein discovered in ageing and cancer
9 March 2017
A protein has been found to have a previously unknown role in the ageing of cells, according to an early study by Queen Mary University of London (QMUL). The researchers hope that the findings could one day lead to new treatments for ageing and early cancer.
Blizard students publish in Journal of Physiology
24 February 2017
Congratulations to Blizard students for publishing a paper in the Journal of Physiology.
Blizard Club - Paper of the Year 2016
23 February 2017
More than 280 doctors, nurses and other health professionals have signed a letter to Theresa May calling for national action to dramatically cut the number of diesel cars, vans, taxis and light trucks to protect a generation of young children.
Queen Mary University of London (QMUL) and NHS Blood & Transplant have been awarded £2.4m from the National Institute for Health Research and Barts Charity to carry out a large multi-centre clinical trial to evaluate a new treatment in major traumatic haemorrhage
Engagement and Enterprise Awards 2017
8 February 2017
David Kelsell, winner of the CHANEL-CERIES Research Award 2016
30 January 2017
Congratulations to Prof David Kelsell, winner of the CHANEL-CERIES Research Award 2016 for his work on skin molecular mechanisms and to the Kelsell Research Group for their recent publication in Nature Communications.
QMUL and BH announce major new initiative in the Life Sciences
25 January 2017
Queen Mary University of London (QMUL) and Barts Health NHS Trust (BH) announce plans for a major new centre for Life Sciences in Whitechapel, home to the Royal London Hospital and a campus of QMUL’s Barts and The London School of Medicine and Dentistry.
Barts Innovations in Healthcare Awards - Winners
19 January 2017
Congratulations to the winners of the Barts Innovations in Healthcare Awards November 2016!
Scar Academy 2016
19 January 2017
Queen Mary University of London in collaboration with Oscare, Belgium organised a two day multidisciplinary conference called: ‘Scar Academy 2016’ last month in London
£1m awarded for global health research
19 January 2017
Researchers from Queen Mary University of London (QMUL) have been awarded grants totalling £1m for medical research projects in low and middle income countries (LMICs)
Giant ‘nerve cell’ to be built in London’s East End
25 November 2016
Planning permission has been granted for the construction of a new science education space in Whitechapel, East London at Centre of the Cell, Queen Mary University of London (QMUL).
Prof Karim Brohi wins Lifetime Achievement Award for Trauma Research
25 November 2016
Karim Brohi, Professor of Trauma Sciences in the Centre for Neuroscience and Trauma, has received a Lifetime Achievement Award in Resuscitation Science from the American Heart Association.
Dr Neil McCarthy, pictured above (right) with supervisor Dr Andy Stagg, from the Centre for Immunobiology, was awarded the prize for best oral presentation in the ECR session at the UCL Infection, Immunology and Inflammation Symposium.
MS drug may reverse some physical disability
13 October 2016
Alemtuzumab is used in relapsing-remitting MS, the most common form of the disease, in which symptoms alternate between sudden worsening and remission. Because it can cause serious side effects, the drug is generally used in people who have not responded well to other drugs. In this study, however, it was used relatively early in the course of MS.
Collecting injury data could reduce emergency attendances
13 October 2016
Multi-drug-resistant TB cure rates higher than expected
15 September 2016
Cure rates for multi-drug-resistant tuberculosis (MDR-TB) in Europe have been estimated to be twice as high as previously thought, according to a research team in the Centre for Immunobiology here at the Blizard Institute, Queen Mary University of London (QMUL).
Most twins should be delivered at 37 weeks to minimise deaths
7 September 2016
Scientists from the Centre for Primary Care and Public Health have analysed the twin pregnancies of more than 30,000 women to identify the ideal delivery period in an attempt to reduce rates of stillbirth.
Vitamin D protects against severe asthma attacks
6 September 2016
Taking oral vitamin D supplements in addition to standard asthma medication could halve the risk of asthma attacks requiring hospital attendance, according to research led by Queen Mary University of London (QMUL).
Blizard AfterTrauma Nominated for Times Higher Education Award 2016
2 September 2016
AfterTrauma – Nominated for Outstanding Contribution to Innovation and Technology in Times Higher Education Awards 2016
The process by which a mother’s diet during pregnancy can permanently affect her offspring’s attributes, such as weight, could be strongly influenced by genetic variation in an unexpected part of the genome, according to research led by Prof Vardhman Rakyan from the Centre for Genomics and Child Health.
Community-based programme improves depression in chronic pain patients
Queen Mary University of London has been ranked the 34th best university in the UK by The Guardian University Guide 2017.
Blizard Institute Announces its first Paper of the Year Winners
26 February 2016
In February 2015 an initiative was started in the Blizard Institute to recognise outstanding publications by our researchers. Each month, a shortlist is prepared by Prof David Kelsell, Deputy Director for Research, and Prof Graham Hitman, Institute Director, and sent out for all Blizard Institute staff and students to vote on. The winning publication becomes the Blizard Paper of the Month and at the end of the calendar year these are in turn entered into an open vote for Blizard Paper of the Year.
Congratulations are due to Professor Graham Foster and his team in the Centre for Immunobiology for the below publication. Hepatitis C is a global problem and this treatment will go a long way to reducing the global burden of this disease. The impact of this work cannot be underestimated.
Blizard Building Marks 10 Year Anniversary
9 December 2015
The iconic RIBA award winning building was opened by Princess Anne in October 2005, and over the past ten years has seen major advances in the research areas of cell biology, genomics, immunology, neuroscience, trauma, primary care and public health.
Students triumph at Biotechnology Entrepreneurs Scheme
29 October 2015
A team of Queen Mary postgraduate students are through to the final of the annual Biotechnology YES (Young Entrepreneur Scheme) competition.
New study removes cancer doubt for Multiple sclerosis drug
12 October 2015
Researchers from the Blizard Institute at Queen Mary University of London (QMUL) are calling on the medical community to reconsider developing a known drug to treat people with relapsing Multiple sclerosis (MS) after new evidence shows it does not increase the risk of cancer as previously thought.
The Medical Research Council (MRC) has awarded a grant of £3.5m to researchers from the Blizard Institute, Queen Mary University of London (QMUL), and University of Cape Town (UCT) to carry out a trial to determine whether a weekly vitamin D supplement can prevent tuberculosis (TB) in South African primary school children.
QMUL ranked in top 100 universities in the world
1 October 2015
Queen Mary University of London has been ranked in the top 100 universities in the world in the 2015/16 Times Higher Education World University Rankings:
Two Blizard Institute Researchers Awarded Young Investigator Awards by the International Society for Chemotherapy and Cancer
Andy Prendergast from the Centre for Genomics and Child Health has been awarded a five-year Wellcome Trust Senior Clinical Fellowship to continue work he is undertaking in Zimbabwe on malnutrition. His group is exploring interventions to prevent stunting in childhood - an often overlooked form of chronic malnutrition which increases mortality from infections and impairs long-term child development. His current work on the SHINE trial is evalauting the independent and combined effects of improving water/hygiene/sanitation or infant feeding on stunting. In his Senior Fellowship, Andy has been awarded £2M from the Wellcome Trust to undertake a trial to evaluate the impact of the antibiotic cotrimoxazole on birth outcomes and growth in rural Zimbabwe. Antenatal women will be randomized to cotrimoxazole or placebo to see whether antibiotics reduces prematurity and increase birth weight, then infants will be randomized to cotrimoxazole or placebo to evaluate the impact of antibiotics on linear growth by 6 months. Specimens will be collected from mothers and infants to explore the impact of antibiotics on inflammation, immune function, intestinal inflammation and the microbiota, in laboratory work to be undertaken in Zimbabwe and at the Blizard Institute.
Blizard Researcher wins Best Offered Paper Prize
30 June 2015
Professor Sandra Eldridge from the Centre for Primary Care and Public Health has been awarded an Honorary Fellowship of the Royal College of General Practitioners.
Dr Protima Amon, Clinical Research Fellow in Paediatric Gastroenterology, won 1st prize in the QMUL Three Minute Thesis (3MT™) competition on Thursday 11th June for her talk entitled: “It’s a bug’s life”. Her PhD work examines the bacteria in children who have inflammation in the intestine.
A simple blood test can predict with 90 to 100 per cent accuracy whether a patient is likely to suffer life-threatening complications after major surgery, according to new research from Blizard Institute, Queen Mary University of London, and published in the journal Annals of Surgery.
The governing body of the British Neuro-Oncology Society has unanimously supported the nomination of Professor Silvia Marino, based within the Centre for Genomics and Child Health here at the Blizard Institute, as the new Vice President of the society. Professor Marino will serve for two years as Vice President from July 2015 before succeeding the incoming President, Mr David Jellinek, in July 2017. The Society’s mission is to promote research and education in Neuro-Oncology and to improve treatment of patients with tumours of the central nervous system.
Blizard Institute's Professor David Kelsell and colleagues including Professor Andy Silver have been awarded a £1.1million Cancer Research UK (CRUK) programme grant to work on squamous oesophageal cancer.
Norman Williams, Professor of Surgery in the Blizard Institute, has been awarded a knighthood in the 2015 New Year’s Honours for services to surgery.
The results of the Research Excellence Framework (REF), published 18th December 2014, confirm Queen Mary University of London (QMUL)’s place in the very top group of research-led universities.
Dr Neha Pathak, an Academic Clinical Fellow from Queen Mary University of London, was last night awarded the ‘Ultimate Game Changer’ prize at the Cosmopolitan Ultimate Women Awards.
The 4th Annual Society of British Neurological Surgeons (SBNS) and Neurology & NeuroSurgery Interest Group (NANSIG) conference took place (22/11/14) at the Royal College of Surgeons (RCS), London. The SBNS comprises some of the most highly respected neurosurgeons and researchers in neuroscience across the UK. In partnership with NANSIG, it hosts the annual B.Braun Undergraduate Research prize, an annual prize for the most outstanding undergraduate research in neuroscience in the U.K. This year the prestigious prize was won by Amy Bowes, a final year medical student at the School of Medicine and Dentistry and research assistant for the Centre for Trauma Science’s (C4TS) Neurotrauma and Neurodegeneration Group.
Professor Allyson Pollock replies to questions on the ebola crisis – originally asked prior to the BBC Politics show on 19 October
William Harvey Day – Tuesday 21st October 2014
A ground-breaking new research partnership with UCL Institute of Neurology (under UCLPartners) and the charity Brain Tumour Research begins today, as the Brain Tumour Research Centre of Excellence launches. The partnership starts a new chapter in long-term, sustainable and continuous research into brain tumours, the biggest cancer killer of children and adults under 40.
A campaign to put patient care at the centre of evidence-based medicine (EBM) is launched by Professor Trish Greenhalgh, Public Health expert at Centre for Primary Care and Public Health, Blizard Institute, Queen Mary University of London, at the BioMed Central’s Health Services Research conference at Kings’ College London.
Asthma affects one in 11 children and young people in the UK. On average, this is two children in every classroom. Scientists from the Blizard Institute are launching a new study to measure the impact asthma has on school children, with the aim of improving school life for those with asthma.
Queen Mary University of London is delighted to announce a ground-breaking new research partnership with UCL Institute of Neurology (under UCLPartners) and the charity Brain Tumour Research. The partnership begins a new chapter in long-term, sustainable and continuous research into brain tumours, the biggest cancer killer of children and adults under 40. Formally presented to MPs at a reception in Speaker’s House today, the research is led by Professor Silvia Marino, a leading brain tumour scientist and neuropathologist based within Queen Mary’s Blizard Institute. Professor Sheer, also from Queen Mary, and Professor Brandner and Dr Rees at UCL Institute of Neurology will be the other key partners in this initiative. The research will focus on glioblastoma multiforme (GBM), the most common and most aggressive type of malignant brain tumour found in humans. The aim of the research is to increase our understanding of the cells within the brain from which GBM originates. The team will look at how this particular type of brain tumour develops from normal cells, and determine which genes and biological functions control its behaviour. By uncovering this essential knowledge, the clinical evaluation of each individual patient can be improved and better and more specific drugs which target the tumour cells can be identified. Silvia Marino, Professor of Neuropathology at Queen Mary University of London, comments: “We know a cure for glioblastoma can and will be found – and this funding boost will hopefully enable significant steps towards a breakthrough. The plan for our centre of excellence is to specialise in adult glioblastoma as we have a wealth of experience in the field, ranging from preclinical experimental models to advanced genomics for direct patient benefit. We also look forward to strengthening collaborative links between us and the UCL Institute of Neurology.” The partnership is part of the charity’s aim for a £20 million investment in brain tumour research over the next five years. Brain Tumour Research aims to establish seven Research Centres of Excellence across the UK, building a ‘critical mass’ of research teams and aiming to bring the UK to the forefront of brain tumour research. With secure long-term funding, researchers will be able to pursue the sustainable and continuous research so desperately needed by the scientists and clinicians working in the heavily underfunded field of brain tumour research. Promising scientists will be trained up through the ranks and as specialist brain tumour expertise and knowledge builds, experienced researchers can then move between Centres to encourage cross-pollination of the very best thinking at the cutting-edge of brain tumour research. Sue Farrington Smith, Chief Executive of Brain Tumour Research, comments: “Today we will be forming a powerful new network of researchers in order to accelerate progress in brain tumour research and make a clinical difference. All partners involved share a vision of a sustainable and secure environment for research into brain tumours in the UK, ultimately creating better futures for all those diagnosed and living with a brain tumour. We are determined to do all we can to change this, and to one day find a cure for this devastating disease.” Queen Mary would also like to thank Barts Charity, for their supporting role in this partnership.