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Blizard Institute - Faculty of Medicine and Dentistry

Dr Laura Green, MBBS, FRCP, FRCPath, MD(Res)

Laura

Senior Clinical Lecturer in Transfusion Research and Innovation; Consultant in Haemostasis and Transfusion Medicine

Centre: Centre for Neuroscience, Surgery and Trauma

Email: laura.green@qmul.ac.uk
Telephone: +44 7720275360
Twitter: @LGreenBartsNHS

Profile

Dr Green entered the specialist training in Haematology at Kings College Hospital in 2004 and went on to undertake research in Haemostasis and Thrombosis at University College London, leading to the degree of MD(Res). In 2011 she was appointed a Consultant in Haemostasis and Transfusion Medicine, with joint appointments at NHS Blood and Transplant (NHSBT) and Barts Health Trust and in 2018 she was appointed a Senior Clinical Lecturer in Transfusion Research and Innovation at Queen Mary University of London. In 2020 she became a Principal Investigator at NHSBT.

Research

Research Interests:

Dr Green has led in several national studies/trials to improve transfusion management of patients. Examples include:

Ongoing

  • SWIFT trial (2022 – 2025) that will evaluate Whole Blood transfusion versus standard of care in pre-hospital settings. This is a collaboration between NHSBT, several Air Ambulance Services and Ministry of Defence.
  • Implementing Bedside Electronic Transfusion Checks at Barts Health Trust (2022 – 2025).
  • Opening a satellite transfusion laboratory at the Royal London Hospital (2022 – 2025).

Completed

  • Red cell and Plasma study (2018 – 2020) that evaluated the red cell and plasma components in pre-hospital setting. This was a collaboration between NHSBT, London’s Air Ambulance Charity and Barts Charity.
  • ACROBAT cluster pilot trial (2017 – 2020) that evaluated the early administration of cryoprecipitate in obstetric bleeding.
  • PROPHESY-1 pilot trial (2017 – 2019) that evaluated fresh frozen plasma versus prothrombin complex concentrates in cardiac surgery.
  • ORANGE study (2013 – 2016) that evaluated clinical outcomes of patients who develop major bleeding on oral anticoagulants in the UK (co-led with Dr P. MacCallum).
  • UK-Obstetric Surveillance System study (2013 – 2014) that evaluated clinical outcomes of women who developed postpartum haemorrhage in the UK and who received massive transfusion.

Publications

Key Publications

Cardigan R, Latham T, Weaver A, Yazer M, Green L (2022). Estimating the risks of prehospital transfusion of D-positive whole blood to trauma patients who are bleeding in England. Vox Sang 10.1111/vox.13249

Green L, Daru J, Gonzalez Carreras FJ, Lanz D, Pardo MDC, Perez T, Philip S, Tanqueray T et al. (2022). Early cryoprecipitate transfusion versus standard care in severe postpartum haemorrhage: a pilot cluster-randomised trial. Anaesthesia, 77 (2), 175-184.

Green L, Roberts N, Cooper J, Agarwal S, Brunskill SJ, Chang I, Gill R, Johnston A et al. (2021). Prothrombin complex concentrate vs. fresh frozen plasma in adult patients undergoing heart surgery – a pilot randomised controlled trial (PROPHESY trial). Anaesthesia vol. 76, (7) 892 - 901.

Green L, Tan J, Morris JK, Alikhan R, Curry N, Everington T, Mclean R, Saja K, Stanworth S, Tait C, MacCallum P. A three-year prospective study of the presentation and clinical outcomes of major bleeding episodes associated with oral anticoagulant use in the UK (ORANGE study). Haematologica. 2018 Apr;103(4):738-745

Green L, Knight M, Seeney FM, Hopkinson C, Collins PW, Collis RE, Simpson NAB, Weeks A et al. (2016). The epidemiology and outcomes of women with postpartum haemorrhage requiring massive transfusion with eight or more units of red cells: A national cross‐sectional study. BJOG: vol. 123, (13) 2164 – 2170.

All Publications

Supervision

Dr Green is supervising several PhD/MD students - a common research theme of their research is better understanding of current transfusion management of bleeding and their coagulation abnormali-ties, with a view to testing targeted interventions through future trials.

Ongoing students

  • Dr H. Tucker. PhD (2019 – 2024) – first supervisor
  • Ms J. McCullagh. PhD (2018 - 2022) – first supervisor
  • Dr A. Rossetto. PhD (2020 – 2022) – second supervisor

Completed

  • Dr R. Kohli. MD (completed December 2021) - second supervisor
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