Neuroscience student wins best poster presentation on analysis of brain tissue in severe traumatic brain injury
Congratulations to third-year BSc Neuroscience student, Chloe Kam, who was awarded best poster presentation at the 3rd International Electronic Conference on Biomolecules (IECBM) 2024.
The research, titled 'Multilayer immunohistochemical analysis of brain tissue in severe traumatic brain injury', was completed as part of the primary research project during the second year of the BSc Neuroscience programme under the supervision of Dr Ping Yip, Senior Lecturer in Neuroscience at Queen Mary University of London, with contribution from the Department of Neurosurgery at the Royal London Hospital in Whitechapel, London.
Severe traumatic brain injury (TBI) is a complex condition, and understanding the cellular changes it causes is essential for predicting outcomes and improving treatment strategies. One effective method for studying these changes is through brain tissue biopsies taken shortly after the injury, a safe procedure for patients. By analysing the cellular markers in the tissue, researchers can gain valuable insights into the complex biological processes at play, which could lead to more targeted and effective therapies.
This is the first study to conduct a cheap multilayer immunohistochemistry technique on brain biopsy from patients with severe TBI. The researchers applied 12 different immunostaining markers to brain tissue biopsies from two patients – one who recovered and one who passed away. The markers targeted various cell types, including neurons, oligodendrocytes, astrocytes, microglia, and vasculature. By combining the images of these stains, the researchers were able to observe complex cellular interactions and compare marker expression levels between the two patients, providing insights into how these differences may relate to their functional outcomes.
Find out more
Kam, C.L.; Guner, C.; Hasan, S.; Uff, C.E.; Yip, P.K. Multilayer immunohistochemical analysis of brain tissue in severe traumatic brain injury, in Proceedings of the 3rd International Electronic Conference on Biomolecules, 23–25 April 2024, MDPI: Basel, Switzerland. https://sciforum.net/paper/view/17234