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The William Harvey Research Institute - Barts and The London

PhD Opportunities

 

  • If you have already secured personal funding, and would like to apply for a PhD at the William Harvey Research Institute, please see the research areas where we are able to offer projects.
  • Currently available PhD projects within the William Harvey Research Institute are also listed below.
  • Once you have identified an area of research or specific PhD project that interests you please contact the listed supervisor to discuss further.
  • If you wish to discuss PhD projects and research opportunities further please contact Professor Paul Chapple (Director of Graduate Studies)
  • Once you have identified a suitable project and supervisor please submit an online application where you should select the relevant William Harvey Research Institute course.

Current PhD projects

Application of traditional clinical and imaging risk assessment tools for ischaemic heart disease in BAME cohorts and development of ethnic specific tools 
Professor Steffen PetersenProfessor Patricia Munroe

Augmentation of cardiac macrophages for the treatment of heart failure
Professor Ken Suzuki

Bioenergetic failure and creatine supplementation in critical illness
Dr Zudin Puthucheary and Dr John Prowle

Deciphering the role of PI3K signalling in dendritic cell antigen presentation  functions and adaptive immunity
Dr Ezra Aksoy

Determining Pharmacogenetic Influences of Response to Antihypertensives and Statins Treatment using Clinical Trials and Large Biobanks
Dr Helen Warren (supervisor) and Professor Patricia Munroe (co-supervisor)

Development of a novel strategy of adult stem cell therapy for heart failure
Professor Ken Suzuki

Development of an innovative approach for ESC/IPSC therapy for heart failure
Professor Ken Suzuki

Development of an innovative extracellular vesicle-based therapy for heart failure
Professor Ken Suzuki

Development of a new strategy for prevention of post-operative adhesion
Professor Ken Suzuki

Evaluating the impact of metabolic regulation on iPSC-cardiomyogenic maturation
Dr Fiona Lewis-McDougall

Exploring the molecular mechanisms of PI3K alpha - RAS signalling in amino acids sensing mTORC1 pathway in intestinal epithelial homeostasis
Dr Ezra Aksoy

Histone tails in vascular diseases
Dr Vahitha Abdul Salam

Identifying novel pathogenic mechanisms by integrating Human DNA methylome variation within Common-Disease associated loci
Dr Christopher Bell

Imaging and clinical predictors of cardiovascular outcomes in valvular heart disease
Professor Steffen Petersen

Imaging, clinical, and genetic predictors of outcomes in cardiomyopathies and heart failure
Professor Steffen Petersen

Impact of cardiac metabolic modulation on post-ischemic functional recovery
Dr Dunja Aksentijevic

Inflammation as a common risk factor for mental and physical illnesses
Dr. L.A. Carvalho, Dr. Christopher Bell, Dr. Helen Warren

Inflammation in kidney disease and depression
Dr. L A Carvalho, Prof. K. Bhui, Prof. Magdi Yaqoob

Inflammation in treatment resistant depression
Dr. L A Carvalho, Prof G. Lewis

Investigating disease mechanisms underlying puberty disorders 
Dr Sasha Howard

Investigating Immune Mechanisms in Cerebral Small Vessel Disease Using Genetics and MR Imaging
Dr Matthew Traylor

Investigating new regulators of cancer immune surveillance
Dr Tyson Sharp

Investigation of novel genetic causes of adrenal insufficiency
Professor Lou Metherell

Investigation of the role of cardiac macrophages in myocardial infarction and heart failure
Professor Ken Suzuki

Investigation of peritoneal macrophages during formation of post-operative adhesion
Professor Ken Suzuki

Investigating the genetic interplay between adult height, adiposity and disease
Dr Eirini Marouli
 

Linking the maternal immune response to pregnancy outcome
Dr Suchita Nadkarni

Machine learning for disease identification and prediction
Dr Eirini Marouli

3D Mapping of Lymphoid Tissue Stromal subsets Using Multiplex Deep Tissue Microscopy: From Homeostasis to Inflammation
Dr Lalit Dubey 

Mapping lung proteome to disease and function
Dr Vahitha Abdul Salam

Mental well-being and cardiovascular health
Professor Steffen Petersen, Professor Patricia Munroe

Mitochondria in platelet-endothelial crosstalk
Dr Vahitha Abdul Salam

Molecular and cellular mechanism of CLIC proteins in vascular dysfunction
Dr Vahitha Abdul Salam

Molecular chaperone dysfunction in neurodegenerative disease
Professor Paul Chapple

Molecular mechanism controlling hypothalamic-pituitary axis
Dr Carles Gaston-Massuet

ML approach to risk stratify patients with stable chest pain using multimodality imaging, clinical, and biochemistry data
Professor Steffen Petersen

Multimodality intravascular and non-invasive imaging for assessment of plaque pathophysiology
Professor Andreas Baumbach

Myocardial Insulin Resistance in Chronic Kidney Failure
Dr Dunja Aksentijevic

Novel regulatory mechanisms for controlling Von Willebrand factor secretion from endothelial cells
Dr Tom Nightingale

Platelet dysfunction in pulmonary hypertension
Dr Vahitha Abdul Salam

Proteomics based druggable target discovery in cardiovascular diseases
Dr Vahitha Abdul Salam

Prospective observational study investigating genomic determinants of outcome from cardiogenic shock (GOlDilOCS)
Dr Alastair Proudfoot, (CI), Professor Charles Hinds (PI), J Knight (PI), T Gerschlick (PI) 

Role of melanocortin receptor accessory proteins in adrenal function and metabolism
Dr Li Chan 

Role of stem cell in hypothalamic-pituitary tumours
Dr Carles Gaston-Massuet

Regulatory science: evaluation and marketing authorisation of medicines
Dr Patricia McGettigan

Study of heart diseases using artificial intelligence (AI) with cardiovascular magnetic resonance (CMR) and electronic health record (HER) data in the Barts BioResource 
Professor Steffen Petersen 

Succinate dehydrogenase mutations in endocrine tumours
Professor Paul Chapple

Tissue morphogenesis in the adult skeleton
Professor Francesco Dell’accio, Dr Anne-Sophie Thorup and Dr Suzanne Eldridge

Trafficking of endothelial tight junction proteins during inflammation and angiogenesis
Dr Tom Nightingale
  

Transcriptomic and Proteomic screening of novel drug targets for vascular fibrosis
Dr Neil Dufton and Dr Vahitha Abdul Salam

Understanding critical and acute care outcomes from large datasets
Dr Zudin Puthucheary and Dr John Prowle

Understanding impacts of diet on cardiovascular health
Professor Steffen Petersen, Professor Patricia Munroe

Understanding the molecular mechanisms of osteoarthritis progression using transgenic models
Dr Suzanne Eldridge and Professor Francesco Dell’accio

Unravelling hypertension-related cardiovascular risk using large scale cohort data and -omics approaches 
Professor Patricia Munroe, Professor Steffen Petersen

Unravelling the links between phagocytosis defects in innate immune cells and inflammatory bowel disease
Dr Ezra Aksoy

Using bioinformatics to understand the complex relationships between thyroid function and disease
Dr Eirini Marouli

Using Genetics to Prioritise Treatments for Cerebral Small Vessel Disease
Dr Matthew Traylor