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The William Harvey Research Institute - Faculty of Medicine and Dentistry


John R

Clinical Reader in Critical Care Nephrology

Centre: Critical Care and Perioperative Medicine Research Group

Telephone: +44(0) 20 3594 0322


ORCID iD: 0000-0002-5002-2721

Dr Prowle is Clinical reader in Critical Care Nephrology in the Critical Care and Perioperative Medicine Research Group at William Harvey Research Institute, Queen Mary University of London and is an Honorary Consultant Physician in Intensive Care Medicine and Renal Medicine at the Royal London Hospital, Barts Health NHS Trust. 

Dr Prowle graduated with distinction in medicine from the University of Cambridge in 1999 and undertook Doctoral Research under the supervision of Prof Rinaldo Bellomo (the most published and highly cited researcher in the history of Australian Medicine) in Melbourne, Australia leading to the award of his MD research doctorate in 2012.

His research interests include the pathogenesis, diagnosis and outcomes of Acute Kidney Injury, Renal replacement Therapy in the ICU the Epidemiology of Critical Illness and its recovery and the impact of multi-morbidity of high risk surgical and ICU outcomes. Since 2009 he has co-authored over 160 peer-reviewed publications and 30 book chapters.  

He is a active senior contributor to national and international collaborations in critical care nephrology including the Acute Disease Quality Initiative (ADQI), Kidney Disease Improving Global Outcomes AKI Group and the UK Kidney research Consortium Clinical Studies Group in AKI (as co-chair).


Critical Care and Perioperative Medicine Research Group

Dr Prowle’s academic interests include the Pathogenesis, Diagnosis and Treatment and Outcomes of Acute Kidney Injury, Continuous Renal Replacement Therapies in the ICU, Fluid Therapy and Medical Complications of Major Surgery.

Key Publications

For a full list of publications click here

  • Wan YI, Apea VJ, Dhairyawan R, Puthucheary ZA, Pearse RM, Orkin CM, Prowle JR. Ethnic disparities in hospitalisation and hospital-outcomes during the second wave of COVID-19 infection in east London. Sci Rep. 2022 Mar 8;12(1):3721. doi: 10.1038/s41598-022-07532-6. PMID: 35260620; PMCID: PMC8904852.
  • Haines RW, Fowler AJ, Wan YI, Flower L, Heyland DK, Day A, Pearse RM, Prowle JR, Puthucheary Z. Catabolism in Critical Illness: A Reanalysis of the REducing Deaths due to OXidative Stress (REDOXS) Trial. Crit Care Med. 2022 Jul 1;50(7):1072-1082. doi: 10.1097/CCM.0000000000005499. Epub 2022 Feb 28. PMID: 35220340.
  • Fowler AJ, Wan YI, Prowle JR, Chew M, Campbell D, Cuthbertson B, Wijeysundera DN, Pearse R, Abbott T. Long-term mortality following complications after elective surgery: a secondary analysis of pooled data from two prospective cohort studies. Br J Anaesth. 2022 Aug 18:S0007-0912(22)00320-8. doi: 10.1016/j.bja.2022.06.019. Epub ahead of print. PMID: 35989114.
  • Wan YI, Bien Z, Apea VJ, Orkin CM, Dhairyawan R, Kirwan CJ, Pearse RM, Puthucheary ZA, Prowle JR. Acute kidney injury in COVID-19: multicentre prospective analysis of registry data. Clin Kidney J. 2021 Mar 27;14(11):2356-2364. doi: 10.1093/ckj/sfab071. PMID: 34751235; PMCID: PMC8083651.
  • Wan YI, Robbins AJ, Apea VJ, Orkin CM, Pearse RM, Puthucheary ZA, Prowle JR. Ethnicity and acute hospital admissions: Multi-center analysis of routine hospital data. EClinicalMedicine. 2021 Aug 19;39:101077. doi: 10.1016/j.eclinm.2021.101077. PMID: 34611614; PMCID: PMC8478677.
  • Prowle JR, Forni LG, Bell M, Chew MS, Edwards M, Grams ME, Grocott MPW, Liu KD, McIlroy D, Murray PT, Ostermann M, Zarbock A, Bagshaw SM, Bartz R, Bell S, Bihorac A, Gan TJ, Hobson CE, Joannidis M, Koyner JL, Levett DZH, Mehta RL, Miller TE, Mythen MG, Nadim MK, Pearse RM, Rimmele T, Ronco C, Shaw AD, Kellum JA. Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative. Nat Rev Nephrol. 2021 Sep;17(9):605-618. doi: 10.1038/s41581-021-00418-2. Epub 2021 May 11. PMID: 33976395; PMCID: PMC8367817.
  • Patel BV, Haar S, Handslip R, Auepanwiriyakul C, Lee TM, Patel S, Harston JA, Hosking-Jervis F, Kelly D, Sanderson B, Borgatta B, Tatham K, Welters I, Camporota L, Gordon AC, Komorowski M, Antcliffe D, Prowle JR, Puthucheary Z, Faisal AA; United Kingdom COVID-ICU National Service Evaluation. Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom. Intensive Care Med. 2021 May;47(5):549-565. doi: 10.1007/s00134-021-06389-z. Epub 2021 May 11. PMID: 33974106; PMCID: PMC8111053.
  • Apea VJ, Wan YI, Dhairyawan R, Puthucheary ZA, Pearse RM, Orkin CM, Prowle JR. Ethnicity and outcomes in patients hospitalised with COVID-19 infection in East London: an observational cohort study. BMJ Open. 2021 Jan 17;11(1):e042140. doi: 10.1136/bmjopen-2020-042140. PMID: 33455936; PMCID: PMC7813387.
  • Nadim MK, Forni LG, Mehta RL, Connor MJ Jr, Liu KD, Ostermann M, Rimmelé T, Zarbock A, Bell S, Bihorac A, Cantaluppi V, Hoste E, Husain-Syed F, Germain MJ, Goldstein SL, Gupta S, Joannidis M, Kashani K, Koyner JL, Legrand M, Lumlertgul N, Mohan S, Pannu N, Peng Z, Perez-Fernandez XL, Pickkers P, Prowle J, Reis T, Srisawat N, Tolwani A, Vijayan A, Villa G, Yang L, Ronco C, Kellum JA. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nat Rev Nephrol. 2020 Dec;16(12):747-764. doi: 10.1038/s41581-020-00356-5. Epub 2020 Oct 15. Erratum in: Nat Rev Nephrol. 2020 Nov 2;: PMID: 33060844; PMCID: PMC7561246.
  • Ostermann M, Bellomo R, Burdmann EA, Doi K, Endre ZH, Goldstein SL, Kane- Gill SL, Liu KD, Prowle JR, Shaw AD, Srisawat N, Cheung M, Jadoul M, Winkelmayer WC, Kellum JA; Conference Participants. Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference. Kidney Int. 2020 Aug;98(2):294-309. doi: 10.1016/j.kint.2020.04.020. Epub 2020 Apr 26. PMID: 32709292; PMCID: PMC8481001.
  • Wang D, Yin Y, Hu C, Liu X, Zhang X, Zhou S, Jian M, Xu H, Prowle J, Hu B, Li Y, Peng Z. Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China. Crit Care. 2020 Apr 30;24(1):188. doi: 10.1186/s13054-020-02895-6. PMID: 32354360; PMCID: PMC7192564.
  • Hoste E, Bihorac A, Al-Khafaji A, Ortega LM, Ostermann M, Haase M, Zacharowski K, Wunderink R, Heung M, Lissauer M, Self WH, Koyner JL, Honore PM, Prowle JR, Joannidis M, Forni LG, Kampf JP, McPherson P, Kellum JA, Chawla LS; RUBY Investigators. Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study. Intensive Care Med. 2020 May;46(5):943-953. doi: 10.1007/s00134-019-05919-0. Epub 2020 Feb 6. PMID: 32025755; PMCID: PMC7210248.
  • Haines RW, Zolfaghari P, Wan Y, Pearse RM, Puthucheary Z, Prowle JR. Elevated urea-to-creatinine ratio provides a biochemical signature of muscle catabolism and persistent critical illness after major trauma. Intensive Care Med. 2019 Dec;45(12):1718-1731. doi: 10.1007/s00134-019-05760-5. Epub 2019 Sep 17. PMID: 31531715.
  • Chaudery H, MacDonald N, Ahmad T, Chandra S, Tantri A, Sivasakthi V, Mansor M, Matos R, Pearse RM, Prowle JR; International Surgical Outcomes Study (ISOS) Group. Acute Kidney Injury and Risk of Death After Elective Surgery: Prospective Analysis of Data From an International Cohort Study. Anesth Analg. 2018 Nov 9.
  • Haines RW, Lin SP, Hewson R, Kirwan CJ, Torrance HD, O'Dwyer MJ, West A, Brohi K, Pearse RM, Zolfaghari P, Prowle JR. Acute Kidney Injury in Trauma Patients Admitted to Critical Care: Development and Validation of a Diagnostic Prediction Sci Rep. 2018 Feb 26;8(1):3665.
  • Kellum JA, Prowle JR. Paradigms of acute kidney injury in the intensive care setting. Nat Rev Nephrol. 2018 Apr;14(4):217-230.
  • Ravn B, Prowle JR, Mårtensson J, Martling CR, Bell M. Superiority of Serum Cystatin C Over Creatinine in Prediction of Long-Term Prognosis at Discharge From ICU. Crit Care Med. 2017 Sep;45(9):e932-e940.
  • O'Connor ME, Hewson RW, Kirwan CJ, Ackland GL, Pearse RM, Prowle JR. Acute kidney injury and mortality 1 year after major non-cardiac surgery. Br J Surg. 2017 Jun;104(7):868-876.
  • O'Connor ME, Kirwan CJ, Pearse RM, Prowle JR. Incidence and associations of acute kidney injury after major abdominal surgery. Intensive Care Med. 2016 Apr;42(4):521-530. doi: 10.1007/s00134-015-4157-7.
  • Prowle JR, Kam EP, Ahmad T, Smith NC, Protopapa K, Pearse RM. Preoperative renal dysfunction and mortality after non-cardiac surgery. Br J Surg. 2016 Sep;103(10):1316-25
  • Kirwan CJ, Blunden MJ, Dobbie H, James A, Nedungadi A, Prowle JR. Critically ill patients requiring acute renal replacement therapy are at an increased risk of long-term renal dysfunction, but rarely receive specialist nephrology follow-up. Nephron. 2015;129(3):164-70.
  • Prowle JR, Kolic I, Purdell-Lewis J, Taylor R, Pearse RM, Kirwan CJ. Serum creatinine changes associated with critical illness and detection of persistent renal dysfunction after AKI. Clin J Am Soc Nephrol. 2014 Jun 6;9(6):1015-23.
  • Prowle JR, Molan MP, Hornsey E, Bellomo R. Measurement of renal blood flow by phase-contrast magnetic resonance imaging during septic acute kidney injury: a pilot investigation. Crit Care Med. 2012 Jun;40(6):1768-76.
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