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The William Harvey Research Institute - Barts and The London

Dr Zudin Puthucheary

Zudin

Senior Clinical Lecturer in Intensive Care Medicine

Email: z.puthucheary@qmul.ac.uk
Telephone: +44(0) 20 3594 0319

Profile

ORCID iD: https://orcid.org/0000-0003-4267-1892

Zudin graduated from Nottingham University in 1997 and moved to London post MRCP in 2000. Following a 3-year stint in Sydney, he started his Respiratory training in Bristol, before completing his critical care training in London. His research interests are in muscle wasting, critical care nutrition and functional outcome research, which began when he was a  National Institute for Health Research Fellow in Respiratory and Critical Care at University College London. Zudin was a Respiratory and Intensive Care Consultant at National University Hospital Singapore from 2013-2015, and he continues to collaborate actively in Singapore.

His work on acute muscle wasting has won awards from the European Society of Intensive Care Medicine, European Society of Anesthesia, the British Thoracic Society, The Intensive Care Society, The American Society of Enteral and Parenteral Nutrition and Zudin was named a Global Rising Star by the Australia and New Zealand Intensive Care Society.

Zudin has been a member of the E-Learning committee of  European Society of Intensive Care since 2015.

Research

Critical Care and Perioperative Medicine Group


Group members

Dr Angela McNelly, MA (Cantab), PhD, MSc

 

Angela gained a degree in Natural Sciences from the University of Cambridge, and her PhD in Cellular Chemotherapy from the University of London. She undertook a post-doctoral project studying T-cell function in Multiple Sclerosis in the UCL Departments of Immunology and Neurochemistry, and after spending time abroad working in medical publishing, Angela returned to UCL in 2010 gaining a distinction in the Clinical and Public Health Nutrition Masters course.  

She coordinates a multicentre randomised controlled trial investigating the effect of intermittent versus continuous nasogastric feeding on muscle wasting in early critical illness. This was funded by the NIHR Biomedical Research Centre at UCL/UCLH, and a New Investigator award from the Intensive Care Society. Together with Dr Zudin Puthucheary she has been awarded NIHR Research for Patient Benefit funding for a new clinical trial commencing in 2019, to investigate a potential role for ketones as an alternative source of energy during critical illness.

 

Summary 

Our research is focussed on both primary and secondary prevention of acquired functional disability following critical illness. We are primarily focussed on physical disability- loss of muscle mass and the resultant decrease in physical activity, and attempts to modify this using nutritional and exercise interventions. In addition, we seek to understand the patient population in terms of pre-existing multi-morbidity and frailty as important predisposing factors to disability, and as limiters to functional recovery.

Key Publications

  1. Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, Hopkinson N, Padhke R, Dew T, Sidhu PS, Velloso C, Seymour J, Agley CC, Selby A, Limb M , Edwards L,Smith K, Rowlerson A, Rennie MJ, Moxham J, and Harridge SDR, Hart N, Montgomery HE. “Acute skeletal muscle wasting in critical illness” JAMA (2013). 310(15): p. 1591-600.
  2. Puthucheary ZA, McNelly AS, Rawal J, Connolly B, Sidhu PS Rowlerson A, Moxham J, and Harridge SD, Hart N, Montgomery HE “Rectus Femoris Cross-sectional Area and Muscle Layer Thickness: Comparative Markers of Muscle Wasting and Weakness” AJRCCM Jan 01 2017, Vol 195 pp136-137.
  3. Zudin Puthucheary and Linda Denehey. “Exercise Interventions in Critical Illness survivors-understanding inclusion and stratification criteria” ARJCCM June 15, 2015, Vol. 191, No. 12 : pp. 1464-1467.
  4. Zudin A Puthucheary; Ronan Astin; Mark M McPhail; Saeed S; Pasha Y; Bear DE; Constantin D; Velloso C; Manning S; Calvert L; Mervyn Singer; Rachel L Batterham; Gomez-Romero M; Holmes E; Steiner M; Atherton PJ; Paul Greenhaff; Lindsay Edwards; Smith K; and Stephen D Harridge; Nicholas Hart; Hugh E Montgomery.” The metabolic phenotype of skeletal muscle in early critical illness” Thorax 2018 ;73:926-935.
  5. Puthucheary, ZA, Phadke R,Rawal J, McPhail MJW, Sidhu PS, Rowlerson A, Moxham J, Harridge S, Hart N, Montgomery HE. “Qualitative ultrasound in acute critical illness muscle wasting” Critical Care Medicine (2015) 43(8); 1603-1611.
  6. Angela S McNelly, Jai Rawal, Dinesh Shrikrishna, Nicholas S Hopkinson, John Moxham, Stephen D Harridge, Nicholas Hart, Hugh E Montgomery, and Zudin A Puthucheary. “An Exploratory Study of Long-term Outcome Measures in Critical Illness Survivors: Construct Validity of Physical Activity, Frailty and Health-Related Quality of Life Measures“ Critical Care Medicine. 2016; 44(6):e362-369. 10.1097/CCM.0000000000001645.
  7. Puthucheary ZA, Sun Y, Zeng K, Vu LH, Zhang ZW, Lim RZL, Chew NSY, Cove ME. “Sepsis reduces bone strength before morphologic changes are identifiable”. Crit Care Med 2017; 45: e1254-e1261 doi: 10.1097/CCM.0000000000002732.

Collaborators

Internal:

Julie Sanders, John Prowle, Gareth Ackland

External:

International:

  • Profs Linda Denehey and Sue Berney (University of Melbourne)
  • Prof Marianne Chapman and Dr Lee-Anne Chapple (University of Adelaide)
  • Prof Winston Chow and Dr Matthew Cove (National University of Singapore)
  • Prof Stephen Olde Damick (University of Maastricht)
  • Sepsis and Critical Illness Research Centre (University of Florida)
  • Dr Louise Thwaites (Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh, Vietnam) 

National:

  • Medical Research Council/Arthritis Research UK Centre of excellence for musculoskeletal ageing research (University of Nottingham)
  • Centre of Human and Aerospace Physiological Sciences (Kings College London)
  • Centre for Human Health and Performance (University College London)