Dr Zudin Puthucheary

Profile

ORCID iD: 0000-0003-4267-1892

Zudin graduated from Nottingham University in 1997 and moved to London post MRCP in 2000. Following a 3-year stint in Sydney, he started his Respiratory training in Bristol, before completing his critical care training in London. His research interests are in muscle wasting, critical care nutrition and functional outcome research, which began when he was a  National Institute for Health Research Fellow in Respiratory and Critical Care at University College London. Zudin was a Respiratory and Intensive Care Consultant at National University Hospital Singapore from 2013-2015, and he continues to collaborate actively in Singapore.

His work on acute muscle wasting has won awards from the European Society of Intensive Care Medicine, European Society of Anesthesia, the British Thoracic Society, The Intensive Care Society, The American Society of Enteral and Parenteral Nutrition and Zudin was named a Global Rising Star by the Australia and New Zealand Intensive Care Society.

Zudin has been a member of the E-Learning committee of  European Society of Intensive Care since 2015.

Research

Critical Care and Perioperative Medicine Group

Group members

Dr Angela McNelly, MA (Cantab), PhD, MSc

Angela gained a degree in Natural Sciences from the University of Cambridge, and her PhD in Cellular Chemotherapy from the University of London. She undertook a post-doctoral project studying T-cell function in Multiple Sclerosis in the UCL Departments of Immunology and Neurochemistry, and after spending time abroad working in medical publishing, Angela returned to UCL in 2010 gaining a distinction in the Clinical and Public Health Nutrition Masters course.  

She coordinates a multicentre randomised controlled trial investigating the effect of intermittent versus continuous nasogastric feeding on muscle wasting in early critical illness. This was funded by the NIHR Biomedical Research Centre at UCL/UCLH, and a New Investigator award from the Intensive Care Society. Together with Dr Zudin Puthucheary she has been awarded NIHR Research for Patient Benefit funding for a new clinical trial commencing in 2019, to investigate a potential role for ketones as an alternative source of energy during critical illness.

Summary 

Our research is focussed on both primary and secondary prevention of acquired functional disability following critical illness. We are primarily focussed on physical disability- loss of muscle mass and the resultant decrease in physical activity, and attempts to modify this using nutritional and exercise interventions. In addition, we seek to understand the patient population in terms of pre-existing multi-morbidity and frailty as important predisposing factors to disability, and as limiters to functional recovery.

Key Publications

1. Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, Hopkinson N, Padhke R, Dew T, Sidhu PS, Velloso C, Seymour J, Agley CC, Selby A, Limb M , Edwards L,Smith K, Rowlerson  A, Rennie MJ, Moxham J, and Harridge SDR,  Hart N, Montgomery HE. “Acute skeletal muscle wasting in critical illness” JAMA (2013). 310(15): p. 1591-600.
2. Sunil Patel, Thomas Francis, Raghini Rajaram, Rhodri Handslip, Sharon Mumby, Danielle E Bear, Rahul Padhke, Nicholas Hart, Hugh Montgomery, Masao Takata, Stephen D.R Harridge, Brijesh V Patel, Zudin Puthucheary. "Programmed myofibre necrosis in critical illness acquired muscle wasting" JCSM 2023
3. Zudin A Puthucheary; Ronan Astin; Mark M McPhail; Saeed S; Pasha Y; Bear DE; Constantin D; Velloso C; Manning S; Calvert L; Mervyn Singer;  Rachel L Batterham; Gomez-Romero M; Holmes E; Steiner M; Atherton PJ; Paul Greenhaff; Lindsay Edwards;  Smith K; and Stephen D Harridge; Nicholas Hart; Hugh E Montgomery. ”The metabolic phenotype of skeletal muscle in early critical illness” Thorax 2018 ;73:926-935.
4. Angela S. McNelly, Danielle E. Bear, Bronwen A. Connolly, Gill Arbane, Laura Allum, Azhar Tarbhai, Jackie A. Cooper, Philip A. Hopkins, Matthew P. Wise, David Brealey, Kieron Rooney, Jason Cupitt, Bryan Carr, Kiran Koelfat, Steven Olde Damink, Philip J. Atherton, Nicholas Hart, Hugh E. Montgomery and Zudin A. Puthucheary “Effect of intermittent or continuous feed on muscle wasting in critical illness: a randomised trial” Chest 2020;158(1):183-94.
5. Brijesh V. Patel, Shlomi Haar, Rhodri Handslip, Chaiyawan Auepanwiriyakul, Teresa Mei‑Ling Lee,Sunil Patel, J. Alex Harston, Feargus Hosking‑Jervis, Donna Kelly, Barnaby Sanderson, Barbara Borgatta, Kate Tatham, Ingeborg Welters, Luigi Camporota, Anthony C. Gordon, Matthieu Komorowski, David Antcliffe, John R. Prowle, Zudin Puthucheary Aldo A. Faisal, on behalf of the United Kingdom COVID-ICU National Service Evaluation “Natural history, trajectory, and management of mechanically ventilated COVID‑19 patients in the United Kingdom” Intensive Care Medicine 2021.
6. Davies TW, van Gassel RJJ, van de Poll M, Gunst, J, Casaer MP, Christopher KB, Preiser JC, Hill A, Gundogan K, Reintam-Blaser A, Rousseau A.-F. Hodgson C, Needham DM, Castro M, Schaller S, McClelland T Pilkington JJ, Sevin CM, Wischmeyer PE^, Lee ZY, Govil D²⁴, Li A, Chapple L, Denehy L, Montejo-González JC, Taylor B, Bear DE, Pearse R, McNelly A, Prowle J, Puthucheary ZA. Core Outcome Measures for Clinical Effectiveness Trials of Nutritional and Metabolic Interventions in Critical Illness: An International Modified Delphi Consensus Study Evaluation (CONCISE) Crit Care (2022) 26:240 https://doi.org/10.1186/s13054-022-04113-x.

Collaborators

Internal

• Prof Julie Sanders
• Dr John Prowle
• Prof Gareth Ackland

External

International:

• Profs Linda Denehey and Sue Berney (University of Melbourne)
• Prof Marianne Chapman and Dr Lee-Anne Chapple (University of Adelaide)
• Prof Winston Chow and Dr Matthew Cove (National University of Singapore)
• Prof Stephen Olde Damick (University of Maastricht)
• Sepsis and Critical Illness Research Centre (University of Florida)
• Dr Louise Thwaites (Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh, Vietnam) 

National:

• Medical Research Council/Arthritis Research UK Centre of excellence for musculoskeletal ageing research (University of Nottingham)
• Centre of Human and Aerospace Physiological Sciences (Kings College London)
• Centre for Human Health and Performance (University College London)

Disclosures

• GlaxoSmithKline - Specialist Advisory Board for muscle wasting in critical illness
• Fresunius Kabi - Specialist Advisory Board for functional recovery post-critical illness
• Lyric Pharmaceuticals - Consultant
• Faraday Pharmaceuticals - Consultant
• Nestle - Specialist Advisory Board for muscle wasting in critical illness
• Nutricia - Specialist Advisory Board for mitochondrial dysfunction in critical illness
• Bioage - Consultant