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The William Harvey Research Institute - Faculty of Medicine and Dentistry

Professor Rupert Pearse


NIHR Professor of Intensive Care Medicine

Centre: Translational Medicine and Therapeutics

Telephone: +44(0) 20 3594 0351
Twitter: @rupert_pearse


ORCID iD: 0000-0002-4373-5934

Rupert Pearse graduated in 1996 from St George’s Hospital Medical School, London, UK. He also completed much of his clinical training in the south-west Thames region. His clinical duties are based on the busy Adult Critical Care Unit at the Royal London Hospital where he oversees the care of patients with critical illnesses of various causes. In 2006, Rupert was appointed Senior Lecturer in Intensive Care Medicine at Queen Mary University of London and was promoted to Professor in 2014. He is an active member of several national and international societies for anaesthesia and intensive care medicine. He leads the Critical Care and Perioperative Medicine Research Group. Rupert’s main research interest is in improving patient outcomes following major surgery, and has led numerous large multi-centre randomised trials, epidemiological studies and mixed-methods research projects in his field.


Group members
Critical Care and Perioperative Medicine Research Group


My research is focused on improving the care pathway for patients before, during and after major surgery. This includes the study of risk factors for poor health, interventions during surgery which may improve patient outcomes, through to better ways to make decisions about surgical treatments together with patients. Increasingly, my work involves the care of patients who need surgical treatments in low and middle-income countries as well as high-income countries.

Key Publications

Full list of publications

  • Peden C, Stephens T, Martin G, Kahan B, Thomson A, Rivett K, Wells D, Richardson G, Kerry S, Bion J, Pearse RM, on behalf of the Enhanced Peri-Operative Care for High-risk patients (EPOCH) trial group. Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery: A stepped-wedge cluster randomised trial. Lancet 2019; 393: 2213-2221. PMID: 31030986
  • Bishop D, Dyer R, Maswime S, …, Pearse RM, Biccard B, on behalf of the ASOS investigators. Maternal and neonatal outcomes after caesarean delivery in the African Surgical Outcomes Study: a 7-day prospective observational cohort study. Lancet Global Health 7: e513-e522. PMID: 30879511
  • Biccard BM, Madiba TE, Kluyts HL, …., Pearse RM; African Surgical Outcomes Study (ASOS) investigators. Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study. Lancet. 2018; 391:1589-1598. PMID: 29306587
  • Wijeysundera DN, Pearse RM, Shulman MA, Abbott TEF, Torres E, Ambosta A, Croal BL, Granton JT, Thorpe KE, Grocott MPW, Farrington C, Myles PS, Cuthbertson BH, on behalf of the METS study investigators. Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study. Lancet. 2018; 391: 2631-40. PMID: 30070222
  • Kahan BC, Koulenti D, Arvaniti K, Beavis V, Campbell D, Chan M, Moreno R, Pearse RM; International Surgical Outcomes Study (ISOS) group. Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries. Intensive Care Med. 2017; 43: 971-979. PMID: 28439646. 
  • Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MP, Ahern A, Griggs K, Scott R, Hinds C, Rowan K; OPTIMISE Study Group. Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA. 2014; 311: 2181-90. PMID: 24842135
  • Pearse RM, Moreno R, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent J-L, Hoeft A, Rhodes A. Mortality after surgery in Europe: a seven day cohort study. Lancet 2012; 380: 1059-65. PMID: 22998715
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