Dr James Whiteford Reader in Extracellular Matrix Biology, Director of Graduate StudiesCentre: Microvascular ResearchEmail: j.whiteford@qmul.ac.uk Telephone: +44(0) 20 7882 3909Website: https://www.centre-for-microvascular-research.com/whiteford-labTwitter: @LabWhitefordProfileResearchKey PublicationsSponsorsCollaboratorsNewsTeachingProfileJames Whiteford graduated in Applied Biology from King’s College London in 1994 and obtained his PhD from King’s College London in 1998. Following post-doctoral research at Imperial College London and Copenhagen University (Denmark) he joined the Centre for Microvascular Research and was awarded an Arthritis Research UK career development fellowship in 2009. He obtained his Lectureship at the William Harvey Research Institute in 2014, and obtained his Senior Lectureship in 2016. Memberships and Awards Chairman London Matrix Biology Group BSMB Organising Committee Member Editor British Journal of Pharmacology Editor Pharmacology Research and Perspectives Editor Frontiers in Immunology ResearchSummary Our teams’ research focuses on angiogenesis, which is the process by which new blood vessels are formed from existing ones. Angiogenesis is a critical process in numerous diseases including cancer, diseases of the eye and inflammatory disorders such as Rheumatoid Arthritis. For some years we have been studying the role of the syndecan family of cell surface receptors in new blood vessel formation and inflammation with the aim of discovering therapeutic innovations which can modify this process to improve disease outcomes. We are currently developing a novel therapy for Wet-Age Related macular Degeneration and are also investigating the potential of our reagents as therapies for both arthritis and cancer. Group members Dr Faheem Shaik, Dr Samantha Arokiasamy, Miss Michaela Balderstone and Miss Nikayla Patel. Publications Arokiasamy S, Balderstone MJM, Shaik F et al. (2024). QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular ageārelated macular degeneration. nameOfConference DOI: 10.1111/bph.17362 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100742 mohamed M, WHITEFORD J, fan S (2024). WCN24-1216 CHARACTERISATION AND MODULATION OF GUT MICROBIOTA IN A MULTIETHNIC DIALYSIS COHORT USING THE BARTS DIABETIC KIDNEY CENTRE BIOBANK: A FEASIBILITY AND PILOT STUDY. nameOfConference DOI: 10.1016/j.ekir.2024.02.1234 QMRO: qmroHref Moss BJ, McKenna N, Ochsner S et al. (2023). Regulation of Senescence and Mitochondrial Function by CD148 in Idiopathic Pulmonary Fibrosis Alveolar Epithelial Cells. A107. AGING AND LUNG DISEASES COMING TO AGE DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2665 QMRO: qmroHref Mauro D, Manou-Stathopoulou S, Rivellese F et al. (2023). UBE2L3 regulates TLR7-induced B cell autoreactivity in Systemic Lupus Erythematosus. nameOfConference DOI: 10.1016/j.jaut.2023.103023 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/85700 Weeraman D, Jones DA, Hussain M et al. (2023). Proangiogenic Growth Factor Therapy for the Treatment of Refractory Angina: A Meta-analysis. nameOfConference DOI: 10.1016/j.jscai.2022.100527 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/88688 Joulia R, Guerrero-Fonseca IM, Girbl T et al. (publicationYear). Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A. nameOfConference DOI: 10.1038/s41467-022-34695-7 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/82420 Whiteford J, Arokiasamy S, Thompson CL et al. (2022). Novel application of live imaging to determine the functional cell biology of endothelial-to-mesenchymal transition (EndMT) within a liver-on-a-chip platform. nameOfConference DOI: 10.1007/s44164-022-00034-9 QMRO: qmroHref Whiteford J, Arokiasamy S, Thompson C et al. (2022). FRI198 Investigating the function of Endothelial-To-Mesenchymal transition during liver fibrogenesis using a Liver-On-A-Chip platform. nameOfConference DOI: 10.1016/s0168-8278(22)01308-3 QMRO: qmroHref Moss BJ, Ebrahimpour A, Coarfa C et al. (2022). CD148 Loss-of-Function Promotes Cellular Senescence and the Development of Experimental Fibrosis. C29. SENESCENCE, SENOLYTICS, AND AGING IN LUNG BIOLOGY DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3895 QMRO: qmroHref Thorup A-S, Wilson J, Strachan D et al. (2022). BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS, IN PART BY MODULATING YAP SIGNALLING. nameOfConference DOI: 10.1016/j.joca.2022.02.201 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/95161 View Profile Publication Page Sponsors Arthritis Research UK Barts Charity Queen Mary Innovation Fight for Sight Collaborators Dr Tero Järvinen (University of Tampere, Finland) Prof James Bainbridge (UCL, UK) NewsNovember 2015 Male and female mice respond differently to inflammation (EurekAlert) Teaching Module Lead on BMD211 Pharmacology and IT BSc Degree Programme BMD175 ‘Research Skills for Pharmacologists’ Back to top