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The William Harvey Research Institute - Barts and The London

Dr Suzanne Eldridge

Lecturer of Musculoskeletal Regenerative Medicine

Centre: Experimental Medicine and Rheumatology

Email: s.e.eldridge@qmul.ac.uk

Profile

Dr Eldridge is a molecular biologist with a background in engineering whose main research interest is in the regeneration of musculoskeletal tissues. During her PhD she discovered the role of Agrin in cartilage homeostasis. Her predominant aim is to develop new therapeutic technologies which will either prevent cartilage breakdown or enhance cartilage repair, for use in disease and following cartilage trauma.

Research

Group members

Aida Barawi (PhD student), Beatriz Fernandez Fernandez (Technician)

Key Publications

  • Eldridge S*., Pengas, I*., Assiotis, A., McNicholas, M., Mendes, J. E. and Laver, L. (2018). MMP-3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomy. Journal of Experimental Orthopaedics, 5(1), 21. doi:10.1186/s40634-018-0132-x
  • Nalesso, G., Thomas, B. L., Sherwood, J. C., Yu, J., Addimanda, O., Eldridge, S. E., Thorup, A.-S., Dale, L., Schett, G., Zwerina, J., Eltawil, N., Pitzalis, C. and Dell’Accio, F. (2017). WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis. Annals of the Rheumatic Diseases, annrheumdis-2015-208577.
  • Eldridge, S., Nalesso, G., Ismail, H., Vicente-Greco, K., Kabouridis, P., Ramachandran, M., Niemeier, A., Herz, J., Pitzalis, C., Perretti, M. and Dell’Accio, F. (2016). Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. Annals of the Rheumatic Diseases, 75(6), 1228–35.
  • Sherwood, J. C., Bertrand, J., Eldridge, S. E. and Dell’Accio, F. (2014). Cellular and molecular mechanisms of cartilage damage and repair. Drug Discovery Today, 19(8), 1172–7.