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The William Harvey Research Institute - Barts and The London

Professor Patricia Munroe

Patricia

Professor of Molecular Medicine

Centre: Clinical Pharmacology

Email: p.b.munroe@qmul.ac.uk
Telephone: +44(0) 20 7882 3586
Twitter: @munroe_patsy

Profile

ORCID iD: 0000-0002-4176-2947 

Patricia graduated with a B.Sc. in Biochemistry, and M.Sc. in Biotechnology from the National University Ireland, Galway. She then worked at the Wellcome Trust Research Laboratories for six months before commencing a PhD in cardiovascular genetics at St Bartholomew’s Hospital. Patricia was awarded a PhD in Medicine in 1995 and following a post-doctoral fellowship at University College London (NIH funded), she joined the William Harvey Research Institute as a Lecturer in 1998. In 2007 she was appointed Professor of Molecular Medicine.

Prof Munroe’s lab investigates the molecular basis of cardiac arrythmia’s, hypertension and heart failure. Our research includes genomic studies of cardiovascular risk factors as a route for elucidating disease mechanisms, the development of ‘omic biomarkers and clinical models for improved risk prediction, pharmacogenetics and personalised medicine.

She co-leads several international complex genetic disease consortia. Using meta-analysis of genome-wide association studies (GWAS) and large-scale candidate gene studies she has discovered over 1000 genetic loci associated with hypertension.  She has identified hundreds of genetic loci for electrocardiogram markers using the UK Biobank. As a member of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium she co-leads projects leading to the discovery of loci for electrocardiogram markers and gene x environment interactions for cardiovascular risk factors. She is Adjunct Professor at the Department of Physiology and Pharmacology, The University of Toledo, USA.

She was listed as a Highly Cited Researcher by Thomson Reuters in 2015, 2016, 2017 and 2018 (Top 1% in Molecular Biology & Genetics).

 

Research

Group members

Research staff: Dr Chris Bell, Dr Helen Warren, Dr Julia Ramirez, Farah Ahmed, Dr Stefan van Duijvenboden, Dr Elham Essary

PhD students: Kenneth Fung, William Young, Hafiz Naderi, Kaya Olczak Richard Burns, Sandra Machlitt-Northen, Victoria Taylor-Bateman, Aled Jones, Zahra Raisi Estabragh

Summary 

My research group investigates the molecular basis of cardiac arrythmia’s, hypertension and heart failure.

Genetic discovery projects for blood pressure, heart rate, ECG markers, cardiac magnetic resonance imaging markers and cardiometabolic traits. We perform genome-wide association studies (GWAS) and exome analyses to find new loci and detailed bioinformatic analyses to locate likely causative genetic variants and genes.

Functional studies of candidate genes from GWAS using molecular biology techniques and “in vitro” models (via collaboration). 

Risk modelling for cardiovascular disease. We are developing and testing genetic risk scores and clinical models for improved risk prediction for cardiac arrhythmias and heart failure and using Mendelian Randomisation for assessing causal relationships.

  1. Our focus is on blood pressure / anti-hypertensive drugs, lipids / statins). We perform GWAS and work closely with international pharmacogenetics consortia (ICAPS, CHARGE – PGX working group, and Genomic Investigation of Statin Therapy (GIST) consortium).

Key Publications

For a full list of publications click here


*denotes joint first or last author and # denotes the corresponding author.

  • Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B, et al.  Boerwinkle E, Chasman DI, Levy D, Newton-Cheh C, Munroe PB*#, Howson JMM*#. Nat Genet. 2020 Dec;52(12):1314-1332.
  • Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval. Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD*, Munroe PB#*, Tinker A#*. Am J Hum Genet. 2020 Jun 4;106(6):764-778.
  • Genetic Basis and Prognostic Value of Exercise QT Dynamics. van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A*, Munroe PB#*, Lambiase PD#*. Circ Genom Precis Med. 2020 Aug;13(4):e002774. 
  • The Effect of Blood Lipids on the Left Ventricle: A Mendelian Randomization Study. Aung N, Sanghvi MM, Piechnik SK, Neubauer S, Munroe PB*, Petersen SE*. J Am Coll Cardiol. 2020 Nov 24;76(21):2477-2488.
  • Ramírez J, van Duijvenboden S, Aung N, Laguna P, Pueyo E, Tinker A, Lambiase PD, Orini M, Munroe PB#*. Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics. Circ Arrhythm Electrophysiol. 2019 Oct;12(10):e007549.
  • Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Ntalla I*, Weng LC*, Cartwright JH, Hall AW, et al. Lubitz SA*#, Munroe PB*#. Nat Commun. 2020 May 21;11(1):2542.
  • Genome-Wide Analysis of Left Ventricular Image-Derived Phenotypes Identifies Fourteen Loci Associated With Cardiac Morphogenesis and Heart Failure Development. Aung N, Vargas, JD, Yang C, Cabrera CP, Warren HR, FungK, Tzanis E, Barnes MR, Rotter JI, Taylor KD, Manichaikul AW, Lima JAC, Bluemke DA, Piechnik SK, Neubauer, Munroe PB*#, Petersen SE*#. Circulation. 2019 Oct 15;140(16):1318-1330.
  • Johnson T#., Gaunt TR., - 99 co-authors -., Samani NJ., Caulfield MJ., Munroe PB#. ‘Blood Pressure Loci Identified with a Gene-Centric Array’. American Journal of Human Genetics. 2011. Dec 9;89(6):688-700. 
  • Georg B. Ehret*, Patricia B. Munroe*## then 345 co-authors then Bruce M. Psaty*, Gonçalo R Abecasis*, Aravinda Chakravarti*, Paul Elliott*, Cornelia M. van Duijn*, Christopher Newton-Cheh*#, Daniel Levy*##, Mark J. Caulfield*##, Toby Johnson*. Genetic variants from novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011;478 (7367):103-9. Voted top 5 paper in CV research and number 1 in stroke by the American Heart Association.
  • Louise V Wain*, then 246 co-authors- then Patricia B. Munroe*, Bruce Psaty*, Mark J Caulfield*, Dabeeru C Rao*, Martin D Tobin*#, Paul Elliott*#, Cornelia M van Duijn*#. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nature Genetics 2011; 43(10):1005-11.
  • Wellcome Trust Case Control Consortium. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature. 2010; 464 (7289):713-20.
  • Christopher Newton-Cheh*#, then 165 co-authors then Mark Caulfield*#, Patricia B Munroe*#. Eight blood pressure loci identified by genome-wide association study of 34,433 people. Nature Genetics 2009; 41:666-676. Voted American Heart Association Top ten paper in worldwide CV research in 2009.
  • Caulfield MJ*, Patricia B. Munroe* et al. (2008) SLC2A9 is a high-capacity urate transporter in humans. PLoS Med 2008; 5(9): e197.
  • Wallace C., - 19 others -., Munroe PB#. ‘Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia’. American Journal of Human Genetics 2008, 82(1), (2008), 139-49.
  • Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-678. Voted Best Scientific Research Paper in the World in 2007 (by both Nature and Science).

Collaborators

Internal: Prof Andy Tinker, Prof Steffen Petersen, Prof Mike Barnes, Prof Mark Caulfield, Prof Adrian Hobbs, Dr Claudia Cabrera, Prof Amrita Ahluwalia

External: Prof Pier Lambiase (UCL), Prof Andrew Morris (University of Manchester), Prof Alistair Young (Kings College), Dr Chris Newton-Cheh (Harvard University), Dr Borbala Mifsud (University of Qatar), Prof Nona Sotoodehnia (University of Washington, USA), Dr DC Rao (Washington University, USA), Dr Rosanne Jepson (Royal Veterinary College),Prof Shu Ye (Leicester), Professor Nilesh Samani (Leicester University). 

Electrogenomics Group – collaboration with UCL for studies attempting to unravel the electrical and genetic causes of cardiovascular mortality. 

Visit the Electrogenomics Group webpage