Dr Carles Gaston-MassuetReader in Developmental Genetics and EndocrinologyCentre: EndocrinologyEmail: c.gaston-massuet@qmul.ac.ukTelephone: +44(0) 20 7882 2115ProfileResearchKey PublicationsSponsorsCollaboratorsProfile ORCID iD: 0000-0002-6793-3118 I graduated in Medical Sciences from Barcelona University with exchange programme at King’s College London University. I undertook my PhD studies in Developmental Molecular Biology in Professor Andrew Copp’s laboratory at University College London Institute of Child Health. My thesis work involved analyses of congenital birth defects of the central nervous system. I then joined the group Dr Martinez-Barbera to study congenital abnormalities of hypothalamic-pituitary axis development. In 2009, I was awarded a Research Fellowship from the National Institute of Health Research to specialise in the genetics of rare endocrine diseases in children, from paediatric tumours called adamantinomatous cranyoparhyngioma to the identification of genes that cause congenital forms of hypothalamic-pituitary dysfunction. In February 2013, I was awarded an Early Career Fellowship through an open base competition to start my own independent research group at the Centre for Endocrinology within the William Harvey Research Institute at Queen Mary University London and Saint Bartholomew's Hospital. Since 2013 I have obtained external funding from several grant funding bodies and Research Councils, among others: Action Medical Research for Sick Children; Barts and The London Strategic Body, Barts Cancer Institute, Children with Cancer Research UK, Medical Research Council, The Rose-Tree Foundation, Marie-Curie WHRI-Co-Fund, the Society of Endocrinology, British Society for Neuroendocrinology, Joan Adams Fellowships. I was awarded the Fellow of Higher Education Academy of the UK (Distinction) from the Institute of Learning University of London and, promoted to my current position as Group Leader & Senior Lecturer in Genetics and Endocrinology. ResearchGroup members Developmental Genetics and Tumorigenesis Group Ms Valeria Scagliotti, Research Assistant (PhD Student); Ms Angelica Gualtieri (Research Assistant); Dr Nikolina Kyprianou (BTLC Clinical Fellowship); Dr Rachael Tan (MRC-PhD Studentship); Mr James Gervace Nicholson (MRC-PhD Studentship) Co-supervising with Professor Marta KorbonitsDr Antonia Solomou, PhD (MRC-funded Postdoctoral Researcher); Dr Alejandro Ibáñez-Costa, PhD (Marie-Curie Co-fund Postdoctoral Researcher); Ms Maria Lillina Vignola (Research Assistant) Summary The hypothalamic-pituitary (HP-axis) is critical for life as it regulates body homeostasis through the secretion of hormones that control vital biological functions such as metabolism, fertility, reproduction, stress response, lactation, growth and electrolyte balance among others. Aberrant pituitary function often results from abnormal development of the hypothalamic-pituitary axis, leading to congenital hypopituitarism, characterised by absent or low-level secretion of one or more hormones. The molecular mechanisms that dictate the congruent development of the HP-axis, and how these mechanisms interact to create a master regulator of body homeostasis is poorly understood. Moreover, our understanding of how this adult organ adapts its plasticity to meet endocrine challenges such as pregnancy and obesity remains in its infancy. Within my group, we have identified genes that are important for the development and homeostasis of this endocrine master regulator. We have, for example, discovered that the Wnt/beta-catenin pathway is critical for maintaining the progenitor pituitary pool and that mutations within genes on this pathway lead to severe endocrine diseases such as paediatric pituitary tumours and congenital hypopituitarism. Our research has also shown that crosstalk between Wnt/beta-catenin and Eph-EphrinB signaling mediates the cellular differentiation of hormone-producing cells and adult organ homeostasis. By identifying key molecular regulators, we have discovered genes that play a critical role in diseases such as infertility, growth restriction and pituitary tumours in humans. Unravelling how these molecules orchestrate the congruent development and maintenance of endocrine cells under hypothalamic inputs will allow us to understand the etiologies of complex congenital hypothalamic-pituitary conditions. Specific projects 1) Using a transgenic approach, we have generated a murine model that demonstrates that over-activation of Wnt signaling causes Adamantinomatous craniopharyngioma (ACP). This pituitary tumor, which mainly occurs in children, is often invasive and hence affects the hypothalamus and optic nerve, leading to severe endocrine dysfunction and high morbidity. We are using this model to pharmacologically identify novel therapeutics for treating ACP tumors. 2) From a genetic screen we have identified that the Eph:EphrinBs pathway contributes to both hypothalamic-pituitary development and Wnt-mediated tumorigenesis (Fig). Using tissue-specific transgenic modification, we are establishing the requirement for Eph:EphrinBs in hypothalamic-pituitary (HP) development and assessing its role in oncogenic HP tumorigenesis. Embryonic development of the hypothalamus and the pituitary gland: A) Detection of Efnb2 GFP+ve cells during embryogenesis. B) Efnb2 GFP+ve cells mark anterior pituitary gland and the ventral diencephalon (prospective hypothalamus). C) EfnB2 GFP+ve cells partially localises with pituitary stem cell marker Sox2 (red). D) Abnormal development of anterior pituitary gland during development leading to a pituitary tumour (AP, anterior pituitary; PP posterior pituitary gland).Publications Rolas L, Stein M, Barkaway A et al. (2024). Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues. nameOfConference DOI: 10.1038/s44319-024-00182-x QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/98188 Garcia-Rendueles AR, Chenlo M, Oroz-Gonjar F et al. (2023). Correction: RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas. nameOfConference DOI: 10.1038/s41388-023-02862-9 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92760 Scagliotti V, Vignola ML, Willis T et al. (publicationYear). Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland. nameOfConference DOI: 10.7554/elife.84092 QMRO: qmroHref Escuin S, Rose Raza-Knight S, Savery D et al. (2023). Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse.. nameOfConference DOI: 10.1242/dmm.049858 QMRO: qmroHref Rai A, Yelamanchi SD, Radotra BD et al. (publicationYear). Phosphorylation of β-catenin at Serine552 correlates with invasion and recurrence of non-functioning pituitary neuroendocrine tumours. nameOfConference DOI: 10.1186/s40478-022-01441-5 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/81441 Glaser J, Iranzo J, Borensztein M et al. (publicationYear). The imprinted Zdbf2 gene finely tunes control of feeding and growth in neonates. nameOfConference DOI: 10.7554/elife.65641 QMRO: qmroHref Rai A, Yelamanchi SD, Radotra BD et al. (2021). Hyper-phosphorylation of [beta]-catenin at Serine552 correlates with invasion and predicts recurrence of Non-Functioning Pituitary Tumours (NFPTs). BES2021 DOI: 10.1530/endoabs.77.oc1.2 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/76097 Garcia-Rendueles AR, Chenlo M, Oroz-Gonjar F et al. (2021). RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas. nameOfConference DOI: 10.1038/s41388-021-02009-8 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74628 Thomas B, Eldridge S, Nosrati B et al. (2021). WNT3A-loaded exosomes enable cartilage repair. nameOfConference DOI: 10.1002/jev2.12088 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/68377 Kaygusuz SB, Ates EA, Vignola ML et al. (2021). Dysgenesis and Dysfunction of the Pancreas and Pituitary Due to FOXA2 Gene Defects. nameOfConference DOI: 10.1210/clinem/dgab352 QMRO: qmroHref View Profile Publication Page Sponsors Barts Charity Medical Research Council Society for Endocrinology Children with Cancer UK Rosetrees Trust BSPED Action Medical Research for Children Faculty of Medicine and Dentistry, Queen Mary University of London Collaborators External Postgraduate Institute of Medical Research, Chandigarh India: Professor Pinaki Duta, Professor Anil Bansali, Professor KKM. Chandigarh, Centre for Endocrinology and Neurosurgery University of California Los Angeles: Professor Harvey R. Herschman, Cox2 Cycloxygenases and pharmacology. University of Toulouse: Dr Nicolas Zenac, Centre for Lipiodmics. University of Milan: Dr Valentina Massa and Professor Bulfatamante. University of Barcelona Hospital Clinic and San Clinic and San Joan de Deu: Professor Teresa Ribalta University Autonoma of Barcelona, Hospital San Pau: Professor Susann Webb and Dr Eugenia Resmini. Universidad Autónoma de Madrid, University Hospital Niño Jesús: Professor Jesus Argente, MD, PhD head of Department of Pediatric and Pediatric Endocrinology. Imperial College London, Professor of Pharmacology Jane Mitchell Internal Centre for Endocrinology (WHRI) Professor Marta Korbonits (pituitary andenomas) Dr Leo Guasti (Wnt in adrenal gland zonation), Professor in Inflammation Professor Mauro Perretti, Professor in Translational Medicine Professor Francesco Del Accio, Professor in Pharmacology Blizard Institute Professor Tim Warner Barts Cancer Institute: Centre for Cancer and Inflammation Professor Fran Balkwill Centre for Tumour Biology: Dr Trevor Graham Centre for Epigenetic and Cancer: Dr Gabriela Fritz Head of the Mouse Cyro-Preservation FMD Transgenic Unit: Co-supervised by Angelica Guiltier Back to top