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The William Harvey Research Institute - Barts and The London

Dr Neil Dufton

Neil

Lecturer in Inflammatory Sciences

Centre: Microvascular Research

Email: n.dufton@qmul.ac.uk
Website: https://www.centre-for-microvascular-research.com/dufton-lab

Profile

Neil Dufton graduated from the University of Bath with a BSc (Hon) Pharmacology in 2006. He went on to undertake a PhD at the William Harvey Research Institute at Queen Mary University of London (QMUL) with Professors Mauro Perretti and Rod Flower. The project focused on the interaction of the anti-inflammatory protein Annexin 1 with its receptor FPR2/ALX in regulating innate immunology and the resolution of inflammation. 

In 2010 he moved to Canada for two years to work with Professor John Wallace at the Farncombe Family Digestive Health Research Institute, McMaster University investigating the role of hydrogen sulfide gas in regulating inflammation. This was followed by a second post-doctoral position at the National Heart and Lung Institute (NHLI) at Imperial College London between 2012-2019 with Prof. Anna Randi. Neil returned to QMUL in 2019 as a Lecturer in Inflammatory Sciences in the Centre for Microvascular Research.

Neil is a passionate science communicator and has developed a number of public engagement activities. He also produces science/microscopy inspired images which have been selected by national competitions including BHF Reflections in Research and Wellcome Trust Image awards as well as being published in Journal of Hepatology and National Geographic.

Twitter: @neildufton 

Research

The adaptability and plasticity of blood vessels, and particularly the cells that line them, termed endothelial cells (EC) are fundamental to both vascular and tissue development, homeostasis and disease pathogenesis. I focus on visualising pathways that result in disease-associated endothelial phenotypes, such as endothelial-to-mesenchymal transition (EndMT), in models of inflammation and fibrosis.

Key Publications

  • Low shear stress-dependent regulation of thrombosis in the microvasculature orchestrated by the transcription factor ERG. Peghaire C, Dufton N, Lang M, Salles-Crawley II, Ahnström J, Kalna V, Raimondi C, Pericleous C, Inuabasi L, Mason JC, Birdsey GM and Randi AM. Nov. 2019, 10: 5014 Nature Communications.
  • Dynamic regulation of canonical TGFβ signaling by endothelial transcription factor ERG protects from liver fibrogenesis. Dufton N, Peghaire C, Osuna-Almagro L, Raimondi C, Kalna V, Chuahan A, Webb G, Yang Y, Birdsey G, Lalor P, Mason J, Adams D and Randi AM – Oct. 2017, 12;8(1):895. Nature Communications.
  • The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling. Birdsey GM, Shah AV, Dufton N, Reynolds LE, Osuna Almagro L, Yang Y, Aspalter IM, Khan ST, Mason JC, Dejana E, Göttgens B, Hodivala-Dilke K, Gerhardt H, Adams RH, Randi AM. – Jan. 2015, 32(1):82-96. Developmental Cell.
  • Hydrogen sulfide and resolution of acute inflammation: A comparative study utilizing a novel fluorescent probe. Dufton N, Natividad J, Verdu E and Wallace JL – Jul. 2012, 2:499. Scientific Reports.