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The William Harvey Research Institute - Faculty of Medicine and Dentistry

Professor Ken Suzuki

Ken

Professor of Translational Cardiovascular Therapeutics

Centre: Microvascular Research

Email: ken.suzuki@qmul.ac.uk
Telephone: +44(0) 20 7882 8233
Website: https://www.centre-for-microvascular-research.com/suzuki-lab

Profile

ORCID iD: 0000-0002-8970-1553

Ken Suzuki is a clinical academic in the field of cardiac surgery, initially trained at Osaka University, Japan. Following the 10-year clinical training and a PhD awarded for his work on gene therapy for myocardial ischaemia-reperfusion injury, he was recruited to the Harefield Heart Science Centre, National Heart and Lung Institute, Imperial College London (head; Prof Sir Magdi Yacoub) in 1998. In this Centre of excellence, he completed a series of research projects on stem cell therapy and gene therapy for heart diseases, in parallel to his surgical training. Subsequently, Suzuki took up the chair of a new research group within the William Harvey Research Institute in 2007. Here, he continues basic, translational, pre-clinical, and clinical cardiovascular research, which aims to develop innovative therapies for heart failure, with a multi-disciplinary group. Suzuki is a former Japan Society for the Promotion of Science Fellow and UK Medical Research Council Senior Fellow. 

Research

Group members

  • Senior staff: Dr Fiona Lewis-McDougall (Lecturer)
  • Research Fellows: Dr Kazuya Kobayashi; Dr Tomoya Ito; Dr Elena Tsisanova
  • PhD student: Mr Emrah Ozcan 

Summary

Suzuki’s research primarily aims to develop innovative therapies, including stem cell therapy, to treat heart attack and other types of heart diseases. There are currently three major research lines in the group.

1. Adult stem cell therapy for myocardial repair

Human organs have distinct types of stem/progenitor cells, named “adult stem cells” or “tissue-resident stem cells”. When collected, expanded, and transplanted, these cells are able to improve cardiac performance and structure by repairing the damaged myocardium primarily through secretion of reparative factors (“paracrine effects”). Suzuki’s 25-year research indicated that allogeneic mesenchymal stromal cells (MSCs) are a most promising cell type for the purpose of clinical success of this approach. His group has been optimising the most effective source of MSCs. His research has identified the issues associated with the current cell-injection methods, including poor donor cell survival and risks of complications such as arrhythmia occurrence and coronary blockage. To solve these limitations, Suzuki’s team developed the innovative cell-delivery route, namely “epicardial placement”. His group optimised this technique by applying a range of distinct biocompatible materials/tissue engineering methods, including the cell-sheet technique, different types of hydrogels, bioengineered membrane, etc.

Current projects include:

  • Translational studies of biomaterial-aided epicardial placement of MSCs, aiming to initiate the first-in-human clinical trial
  • Pre-clinical characterisation of human amnion-derived MSCs and induced pluripotent stem cell (iPSC)-derived MSCs as a donor for clinical cell therapy
  • Mechanistic investigations with focuses on the “primary” and “secondary” paracrine effects induced by MSC therapy
  • Study of the role of tissue-repairing macrophages in the MSC-derived secondary paracrine effect
  • Elucidation of the role of exosomes in MSC-based therapy
  • Application of exosomes for the treatment of heart failure
  • Further improvement of the epicardial placement methods, including biomaterial-aided intrapericardial injection
  • Development of “designer” MSCs, which are genetically engineered to achieve greater therapeutic benefits

2. Tissue-repairing macrophages for the treatment of heart failure and other diseases

Immunity and inflammation play a vital role in development of and recovery from heart failure. Suzuki’s group has investigated the role of high-mobility group protein 1, toll like receptors as well as tissue-repairing (M2-like) macrophages in heart failure. In addition to elucidating their basic molecular/cellular biological characterisation, we challenge to apply these data for the development of innovative therapies of heart failure and other diseases.

Current projects include:

  • Biological and functional characterisation of cardiac M2-like macrophages in the intact and damaged heart
  • Investigation of the role of M2-like macrophages in non-cardiac diseases, including post-operative adhesions
  • Establishment of the ideal production protocol of M2-like macrophages from different tissues and/or iPSCs
  • Development of new cell transplantation therapy using M2-like macrophages for treating/preventing heart failure
  • Development of new technologies, including long-acting IL-4, for the treatment of cardiac and non-cardiac disease through modulating M2-like macrophages

3. Pluripotent stem cell therapy for myocardial regeneration

iPSCs are more promising to achieve myocardial regeneration (generation of new cardiomyocytes), compared to adult stem cells. However, pluripotent cells remain associated with critical issues to attain clinical success, including mass production of high-quality and homogeneous cardiomyocytes and regulation of their differentiation (i.e. avoidance of tumour formation). In addition, insufficient maturation and inappropriate integration of stem cell-derived cardiomyocytes as well as suboptimal cell-delivery method have to be overcome. With determination to progress this approach toward clinical application, we currently conduct basics/translational research using these cells as follows:

  • Development of an advanced method to deliver iPSC-derived cardiomyocytes cells to the heart by applying the epicardial placement technique
  • Investigation to elucidate and amplify intra-cardiac migration and integration of cardiomyocytes derived from iPSCs
  • Investigation of differentiation stage-specific abilities of iPSC-derived cardiac cells (committed cardiomyocytes versus cardiac progenitors)
  • Development of new methods to enhance maturation of iPSC-derived cardiomyocytes

Publications

  • Ichihara Y, Kaneko M, Yamahara K et al. (2024). Corrigendum to “Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure” [Biomaterials 154 (2018) 12–23]. nameOfConference


  • Shintani Y, Drexler HC, Kioka H et al. (2024). Author Correction: Toll‐like receptor 9 protects non‐immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2. nameOfConference


  • Kobayashi K, Ichihara Y, Sato N et al. (2024). Corrigendum to “On-site fabrication of bi-layered adhesive mesenchymal stromal cell dressings for the treatment of heart failure” [Biomaterials 209 (2019) 41–53]. nameOfConference


  • Ichihara Y, Kaneko M, Yamahara K et al. (2024). Corrigendum to “Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure” [Biomaterials 154 (2018) 12–23]. nameOfConference


  • Shintani Y, Fukushima S, Varela-Carver A et al. (2024). Corrigendum to “Donor cell-type specific paracrine effects of cell transplantation for post-infarction heart failure” [J Mol Cell Cardiol 47 (2009) 288–295]. nameOfConference


  • Fields L, Ito T, Kobayashi K et al. (2024). Epicardial placement of human MSC-loaded fibrin sealant films for heart failure: Preclinical efficacy and mechanistic data. nameOfConference


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  • Ishida H, Saba R, Kokkinopoulos I et al. (2023). GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. nameOfConference


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  • Shiraishi M, Suzuki K, Yamaguchi A (2023). Effect of mechanical tension on fibroblast transcriptome profile and regulatory mechanisms of myocardial collagen turnover. nameOfConference


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  • Koga-Ikuta A, Fukushima S, Ishibashi-Ueda H et al. (2022). Immunocompetent cells in durable ventricular assist device-implanted non-ischaemic dilated cardiomyopathy. nameOfConference


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  • Shiraishi M, Yamaguchi A, Suzuki K (2022). Nrg1/ErbB signaling‐mediated regulation of fibrosis after myocardial infarction. nameOfConference


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  • Suzuki K, Ito T, Lewis F (publicationYear). Epicardial Placement of Fibrin Sealant Film-incorporating Human Mesenchymal Stromal Cells for the Treatment of Heart Failure: Towards Clinical Translation and Mechanistic Implication. nameOfConference


  • Ito T, Shintani Y, Fields L et al. (publicationYear). Cell barrier function of resident peritoneal macrophages in post-operative adhesions. nameOfConference


  • Suzuki K, Gautrot J (publicationYear). Engineered Cell-Degradable Poly(2-alkyl-2-oxazoline) Hydrogels Improve Epicardial Placement of Mesenchymal Stromal Cells by Stimulating Paracrine Signaling for Cardiac Repair. nameOfConference


  • You Y, Kobayashi K, Colak B et al. (2020). Engineered cell-degradable poly(2-alkyl-2-oxazoline) hydrogel for epicardial placement of mesenchymal stem cells for myocardial repair. nameOfConference


  • Ishida H, Miyagawa S, Ozono K et al. (2020). A Neurotrophic Factor Receptor GFRA2, a Specific Surface Antigen for Cardiac Progenitor Cells, Regulates the Process of Myocardial Compaction. nameOfConference


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  • Podaru MN, Fields L, Kainuma S et al. (2019). 2419Reparative macrophage transplantation for myocardial repair: a refinement of bone marrow mononuclear cell-based therapy. ESC


  • Podaru MN, Fields L, Kainuma S et al. (2019). Reparative macrophage transplantation for myocardial repair: a refinement of bone marrow mononuclear cell-based therapy. European Society of Cardiology

    DOI: doi

  • Kobayashi K, Ichihara Y, Sato N et al. (2019). Self-adhesive bi-layered dressing incorporating amnion-derived mesenchymal stromal cells for the treatment of heart failure: a pre-clinical proof of concept study. European Society of Cardiology

    DOI: doi

  • Saba R, Kitajima K, Rainbow L et al. (2019). Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice.. nameOfConference


  • Podaru M-N, Fields L, Kainuma S et al. (2019). Abstract 718: Reparative Macrophage Transplantation for Myocardial Repair: A Refinement of Bone Marrow Mononuclear Cell-Based Therapy. AHA


  • Podaru M-N, Fields L, Kainuma S et al. (2019). Reparative Macrophage Transplantation for Myocardial Repair: A Refinement of Bone Marrow Mononuclear Cell-Based Therapy. American Heart Association

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  • Suzuki K, Podaru M, Fields L et al. (publicationYear). Reparative Macrophage Transplantation for Myocardial Repair: A Refinement of Bone Marrow Mononuclear Cell-Based Therapy. nameOfConference


  • Kobayashi K, Ichihara Y, Sato N et al. (2019). On-site fabrication of Bi-layered adhesive mesenchymal stromal cell-dressings for the treatment of heart failure. nameOfConference


  • Hussain MA, Colicchia M, Veerapen J et al. (2019). Circulatory support and stem cell therapy in the management of advanced heart failure: a concise review of available evidence.. nameOfConference


  • Fukumitsu M, Suzuki K (2019). Mesenchymal stem/stromal cell therapy for pulmonary arterial hypertension: Comprehensive review of preclinical studies. nameOfConference


  • Kobayashi K, Ichihara Y, Sato N et al. (2018). On-Site, Instant Production of Bi-Layered Bio-Dressing Incorporating Mesenchymal Stromal Cells for the Treatment of Heart Failure. AHA

    DOI: doi

  • Kobayashi K, Suzuki K (2018). Mesenchymal Stem/Stromal Cell-Based Therapy for Heart Failure - What Is the Best Source?. nameOfConference


  • Kobayashi K, Ichihara Y, Tano N et al. (publicationYear). Fibrin Glue-aided, Instant Epicardial Placement Enhances the Efficacy of Mesenchymal Stromal Cell-Based Therapy for Heart Failure. nameOfConference


  • Sawhney V, Brouilette S, Campbell N et al. (2018). Association of genetic variation in telomere‐related SNP and telomerase with ventricular arrhythmias in ischemic cardiomyopathy. nameOfConference


  • SUZUKI K (2018). Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure. nameOfConference


  • Shintani Y, Ito T, Laura F et al. (2017). Augmentation of alternatively activated macrophages by IL-4 for the treatment of myocardial infarction. European Society of Cardiology

    DOI: doi

  • Shintani Y, Ito T, Laura F et al. (2017). P4372Augmentation of alternatively activated macrophages by IL-4 for the treatment of myocardial infarction. ESC


  • SUZUKI K, Shintani Y, ITO T et al. (2017). IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice. nameOfConference


  • Ichihara Y, Tano N, Fields L et al. (2016). Epicardial Placement of Instantly Produced Fibrin Glue-Incorporating Mesenchymal Stromal Cells for the Treatment of Heart Failure. American Heart Association

    DOI: doi

  • Ishida H, Saba R, Kokkinopoulos I et al. (2016). GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway.. nameOfConference


  • SUZUKI K, Campbell N, Mathur A (2016). Cell Size Critically Determines Initial Retention of Bone Marrow Mononuclear Cells in the Heart after Intracoronary Injection: Evidence from A Rat Model. nameOfConference


  • Shiraishi M, Shintani Y, Shintani Y et al. (2016). Alternatively activated macrophages determine repair of the infarcted adult murine heart. nameOfConference


  • Tano N, Kaneko M, Ichihara Y et al. (2016). Allogeneic Mesenchymal Stromal Cells Transplanted Onto the Heart Surface Achieve Therapeutic Myocardial Repair Despite Immunologic Responses in Rats. nameOfConference


  • Sawhney V, Campbell NG, Brouilette SW et al. (2016). Telomere shortening and telomerase activity in ischaemic cardiomyopathy patients – Potential markers of ventricular arrhythmia. nameOfConference


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  • Kokkinopoulos I, Ishida H, Saba R et al. (2016). Cardiomyocyte differentiation from mouse embryonic stem cells using a simple and defined protocol. nameOfConference


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  • Kokkinopoulos I, Ishida H, Saba R et al. (publicationYear). Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo. nameOfConference


  • Sawhney V, Brouilette S, Campbell N et al. (2015). 69 Association of TERC Related Genetic Variation and Telomerase Activity with Ventricular Arrhythmias in Ischaemic Cardiomtyopathy. nameOfConference


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  • Sawhney VS, Brouilette SWB, Campbell NGC et al. (2014). 23Association of TERC related genetic variation and telomerase activity with ventricular arrhythmias in ischaemic cardiomyopathy. nameOfConference


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  • Tano N, Narita T, Kaneko M et al. (2014). Epicardial placement of mesenchymal stromal cell-sheets for the treatment of ischemic cardiomyopathy; in vivo proof-of-concept study.. nameOfConference


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  • Narita T, Suzuki K (2015). Bone marrow-derived mesenchymal stem cells for the treatment of heart failure. nameOfConference


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  • Shintani Y, Drexler HCA, Kioka H et al. (2014). Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2.. nameOfConference


  • Suzuki K (2014). 5 Cell delivery routes for cardiac stem cell therapy. nameOfConference


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  • Suzuki K (2014). Cell delivery routes for cardiac stem cell therapy. nameOfConference


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  • Ikebe C, Suzuki K (2014). Mesenchymal Stem Cells for Regenerative Therapy: Optimization of Cell Preparation Protocols. nameOfConference


  • Shintani Y, Kioka H, Takashima S et al. (2014). Toll-like Receptor 9 Protects Cardiomyocytes from Stress by Modulating Mitochondrial ATP Synthesis through the Inhibition of SERCA2. nameOfConference


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  • Narita T, Shintani Y, Ikebe C et al. (2013). The use of cell-sheet technique eliminates arrhythmogenicity of skeletal myoblast-based therapy to the heart with enhanced therapeutic effects.. nameOfConference


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  • Narita T, Shintani Y, Ikebe C et al. (2013). The use of scaffold-free cell sheet technique to refine mesenchymal stromal cell-based therapy for heart failure.. nameOfConference


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  • Shintani Y, Kapoor A, Kaneko M et al. (2013). TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons.. nameOfConference


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  • Fukushima S, Sawa Y, Suzuki K (2013). Choice of cell-delivery route for successful cell transplantation therapy for the heart. nameOfConference


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  • Xiao Q, Zhang F, Lin L et al. (2013). Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions.. nameOfConference


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  • Kaneko M, Shintani Y, Narita T et al. (2013). Extracellular high mobility group box 1 plays a role in the effect of bone marrow mononuclear cell transplantation for heart failure.. nameOfConference


  • Tano N, Kaneko M, Ikebe C et al. (2013). Scaffold Free "Cell Sheets" Composed of Mesenchymal Stromal Cells for the Treatment of Chronic Heart Failure; In Viveo Proof-of-Concept Study. nameOfConference

    DOI: doi

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  • Tano N, Kaneko M, Ikebe C et al. (2013). The Use of Allogeneic Mesenchymal Stromal Cells to Refine the Emerging "Cell-Sheet" Technique for the Treatment of Heart Failure. nameOfConference

    DOI: doi

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  • Brouilette S, Kuersten S, Mein C et al. (2012). A simple and novel method for RNA-seq library preparation of single cell cDNA analysis by hyperactive Tn5 transposase.. nameOfConference


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  • Nandra KK, Takahashi K, Collino M et al. (2012). Acute treatment with bone marrow-derived mononuclear cells attenuates the organ injury/dysfunction induced by hemorrhagic shock in the rat.. nameOfConference


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  • Sawhney VS, Campbell NGC, Brouilette SWB et al. (2012). 056 Leucocyte telomere/telomerase dynamics in patients with implantable cardioverter defibrillator; potential biomarker for ventricular arrhythmias. nameOfConference


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  • Xiao Q, Zhang F, Lin L et al. (2012). A Functional Role of Matrix Metalloproteinase-8 in Stem/progenitor Cell Migration and Their Recruitment Into Atherosclerotic Lesions. nameOfConference

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  • Kaneko M, Shintani Y, Narita T et al. (2012). Bone Marrow Mononuclear Cell Transplantation Improves Cardiac Function in Ischemic Cardiomyopathy via High Mobility Group Box 1 Released from Dead Donor Cells. nameOfConference

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  • Campbell NG, Suzuki K (2012). Cell Delivery Routes for Stem Cell Therapy to the Heart: Current and Future Approaches. nameOfConference


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  • Kaneko M, Shintani Y, Narita T et al. (2012). High mobility group box 1 released from dead donor cells plays a key role in bone marrow mononuclear cell transplantation for treating heart failure. nameOfConference

    DOI: doi

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  • Campbell NG, Kaneko M, Shintani Y et al. (2012). SIZE-DEPENDENT RETENTION OF STEM CELLS FOLLOWING INTRACORONARY INJECTION. nameOfConference


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  • Felkin LE, Narita T, Germack R et al. (2011). Calcineurin Splicing Variant Calcineurin A beta 1 Improves Cardiac Function After Myocardial Infarction Without Inducing Hypertrophy. nameOfConference


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  • Fukushima S, Campbell NG, Coppen SR et al. (2011). Quantitative assessment of initial retention of bone marrow mononuclear cells injected into the coronary arteries. nameOfConference


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  • Suzuki K, Kita T, Yamada H (2011). Wavelength tunable laser diodes with Si-wire waveguide ring resonator wavelength filters. Silicon Photonics VI


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  • Shintani Y, Kapoor A, Drexler H et al. (2011). A Novel Toll-Like Receptor 9 Signaling in Cardiomyocytes. nameOfConference

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  • Kapoor A, Shintani Y, Collino M et al. (2011). BENEFICIAL ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-BETA/DELTA IN SEPTIC SHOCK. nameOfConference

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  • Nandra K, Takahashi K, Collino M et al. (2011). BONE-MARROW DERIVED MONONUCLEAR CELLS PROTECT AGAINST MULTIPLE ORGAN FAILURE IN HEMORRHAGIC SHOCK THROUGH AN AKT DEPENDANT PATHWAY. nameOfConference

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  • Narita T, Shintani Y, Ikebe C et al. (2011). Enhancing the "Paracrine Effects" of Mesenchymal Stem Cells to Recover Damaged Myocardium by the Use of Cell-Sheets. nameOfConference

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  • Kapoor A, Shintani Y, Collino M et al. (2010). Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock.. nameOfConference


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  • Narita T, Shintani Y, Takahashi K et al. (2010). The Use of “Cell Sheet” Technique Enhances the Therapeutic Effects of Skeletal Myoblast Transplantation with Elimination of Arrhythmogenicity. American Heart Association

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  • Lovell MJ, Yasin M, Lee KL et al. (2010). Bone marrow mononuclear cells reduce myocardial reperfusion injury by activating the PI3K/Akt survival pathway.. nameOfConference


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  • Kratsios P, Huth M, Temmerman L et al. (2010). Antioxidant Amelioration of Dilated Cardiomyopathy Caused by Conditional Deletion of NEMO/IKK gamma in Cardiomyocytes. nameOfConference


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  • Shintani Y, Fukushima S, Varela-Carver A et al. (2009). Donor cell-type specific paracrine effects of cell transplantation for post-infarction heart failure. nameOfConference


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  • Lee J, Stagg MA, Fukushima S et al. (2009). Adult progenitor cell transplantation influences contractile performance and calcium handling of recipient cardiomyocytes. nameOfConference


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  • Chen Z-C, Suzuki K, Miura S et al. (2009). Microstructural features and deformation-induced lattice defects in hot-extruded Bi2Te3 thermoelectric compound. nameOfConference


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  • Kagisaki K, Masai T, Kadoba K et al. (1997). Biocompatibility of Heparin‐Coated Circuits in Pediatric Cardiopulmonary Bypass. nameOfConference


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  • Yasin M, Shintani Y, Collino M et al. (2008). Abstract 1741: Bone Marrow Mononuclear Cell Therapy upon Reperfusion Reduces Myocardial Infarct Size by Activating the PI3K/Akt Survival Pathway. nameOfConference


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  • Yasin M, Shintani Y, Collino M et al. (2008). Bone Marrow Mononuclear Cell Therapy upon Reperfusion Reduces Myocardial Infarct Size by Activating the PI3K/Akt Survival Pathway. nameOfConference

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  • Shintani Y, Fukushima S, Varela-Carver A et al. (2008). Different Paracrine Mediators and Response of the Host Myocardium by Coll Therapy: Direct Comparison between Skeletal Myoblasts and Bone Marrow Mononuclear Cells. nameOfConference

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  • Coppen SR, Fukushima S, Shintani Y et al. (2008). A factor underlying late-phase arrhythmogenicity after cell therapy to the heart - Global downregulation of connexin43 in the host myocardium after skeletal myoblast transplantation. nameOfConference


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  • Takahashi K, Fukushima S, Yamahara K et al. (2008). Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart. nameOfConference


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  • Fukushima S, Coppen SR, Lee J et al. (2008). Choice of Cell-Delivery Route for Skeletal Myoblast Transplantation for Treating Post-Infarction Chronic Heart Failure in Rat. nameOfConference


  • Yamahara K, Fukushima S, Coppen SR et al. (2008). Heterogeneic nature of adult cardiac side population cells. nameOfConference


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  • Lara-Pezzi E, Winn N, Paul A et al. (2007). A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration. nameOfConference


  • Suzuki K, Fukushima S, Varela-Carver A et al. (2007). Response to letter regarding article, "Direct Intramyocardial but Not Intracoronary Injection of Bone Marrow Cells Induces Ventricular Arrhythmias in a Rat Chronic Ischemic Heart Failure Model". nameOfConference


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  • Takahashi K, Fukushima S, Yamahara K et al. (2007). Controlled inflammation induced by injection of High Mobility Group Box 1 recovers post-infarction chronic failing heart. nameOfConference

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  • Coppen SR, Fukushima S, Varela-Carver A et al. (2007). Downregulation of myocardial connexin43 and arrythmogenesis after injection of skeletal myoblasts but not bone marrow cells into the failing heart. nameOfConference

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  • Santini MP, Tsao L, Monassier L et al. (2007). Enhancing repair of the mammalian heart. nameOfConference


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  • Fukushima S, Varela-Carver A, Coppen SR et al. (2007). Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model. nameOfConference


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  • Smolenski RT, Forni M, Maccherini M et al. (2007). Reduction of hyperacute rejection and protection of metabolism and function in hearts of human decay accelerating factor (hDAF)-expressing pigs. nameOfConference


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  • Coppen SR, Fukushima S, Varela-Carver A et al. (2006). Factors contributing to ventricular arrhythmias after skeletal myoblast transplantation. nameOfConference

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  • Yamahara K, Fukushima S, Varela-Carver A et al. (2006). High-mobility group box 1 protein (HMGB1) released by cell transplantation plays an important role in the therapeutic effects for treating chronic ischemic heart failure. nameOfConference

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  • Fukushima S, Varela-Carver A, Coppen SR et al. (2006). Regardless of cell-delivery route, skeletal myoblast transplantation into chronic heart failure induces transient therapeutic effects with persistent arrhythmogenesis. nameOfConference

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  • Fukushima S, Yamahara K, Smolenski RT et al. (2006). The pattern, quantity and possible mechanism of migration of bone marrow cells into the myocardium after intracoronary injection. nameOfConference

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  • Varela-Carver A, Fukushima S, Coppen SR et al. (2006). Transplantation of bone marrow cells, but not skeletal myoblasts, normalizes the downregulation of myocardial Akt in chronic heart failure. nameOfConference

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  • Yamahara K, Coppen S, Varela-Carver A et al. (2006). Characterization of cardiac side population cell and its potential for cardiac regeneration. nameOfConference

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  • Suzuki K, Fukushima S, Coppen S et al. (2006). Enhanced efficiency of superoxide dismutase-induced cardioprotection by retrograde intracoronary administration prior to reperfusion. nameOfConference

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  • Lee J, Fukushima S, Stagg MA et al. (2006). Paracrine effects of cell transplantation on recipient cardiomyocytes in a rat model of heart failure. nameOfConference

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  • Suzuki K, Fukushima S, Varela-Carver A et al. (2006). Retrograde intracoronary infusion as a route for cell transplantation for treating post-infarction chronic heart failure. nameOfConference

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  • Fukushima S, Coppen SR, Varela-Carver A et al. (2006). A novel strategy for myocardial protection by combined antibody therapy inhibiting both P-selectin and intercellular adhesion molecule-1 via retrograde intracoronary route. nameOfConference


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  • Suzuki K, Fukushima S, Coppen SR et al. (2006). A novel strategy for myocardial protection by combined antibody therapy inhibiting both P-selectin and intercellular adhesion molecule-1 via retrograde intracoronary route. nameOfConference


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  • Yamahara K, Coppen SR, Varela-Carver A et al. (2006). Characterization of cardiac side population cells. nameOfConference


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  • Suzuki K, Fukushima S, Varela-Carver A et al. (2006). Ventricular arrhythmias induced by bone marrow cell transplantation into post-infarction chronic heart failure. nameOfConference


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  • Yacoub M, Suzuki K, Rosenthal N (2006). The future of regenerative therapy in patients with chronic heart failure. nameOfConference


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  • Fukushima S, Coppen SR, Varela-Carver A et al. (2006). Enhanced efficiency of superoxide dismutase-induced cardioprotection by retrograde intracoronary administration. nameOfConference


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  • Lee J, Fukushima S, Stagg MA et al. (2006). Paracrine effects of transplanted bone marrow cells and skeletal myoblasts on recipient cardiomyocyte function in a rat model of heart failure. nameOfConference


    QMRO: qmroHref
  • Stagg MA, Coppen SR, Suzuki K et al. (2006). Evaluation of frequency, type, and function of gap junctions between skeletal myoblasts overexpressing connexin43 and cardiomyocytes: relevance to cell transplantation. nameOfConference


    QMRO: qmroHref
  • Fukushima S, Coppen SR, Varela-Carver A et al. (2005). A novel strategy for myocardial protection by combined antibody therapy inhibiting both P-selectin and intercellular adhesion molecule-1 via retrograde intracoronary route. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Fukushima S, Brindley G, Yamahara K et al. (2005). Direct intramyocardial injection, but not intracoronary infusion of bone marrow mononuclear cells induces ventricular arrhythmias in chronic ischemic heart failure. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Yuen AHY, Boscoe M, Lango R et al. (2005). Prevention of adriamycin induced heart failure by an increase in endogenous adenosine production. nameOfConference


    QMRO: qmroHref
  • Coppen SR, Varela-Carver A, Stagg MA et al. (2004). An investigation of gap junction formation between skeletal myoblasts and adult cardiac myocytes using myoblasts overexpressing Connexin43. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Stagg MA, Coppen SR, Lee A et al. (2004). Connexin43 overexpression increases gap junctional conductance between skeletal myoblasts and adult rat ventricular myocytes in coculture. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Suzuki K, Murtuza B, Beauchamp JR et al. (2004). Role of interleukin-1 beta in acute inflammation and graft death after cell transplantation to the heart. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Murtuza B, Fukushima S et al. (2004). Targeted cell delivery into infarcted rat hearts by retrograde intracoronary infusion: Distribution, dynamics, and influence on cardiac function. nameOfConference


    QMRO: qmroHref
  • Yacoub MH, Yuen AHY, Kalsi KAK et al. (2004). C34T AMP deaminase 1 gene mutation protects cardiac function in donors. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Murtuza B, Beauchamp JR et al. (2004). Dynamics and mediators of acute graft attrition after myoblast transplantation to the heart. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Murtuza B, Brand NJ et al. (2004). Enhanced effect of myocardial gene transfection by VP22-mediated intercellular protein transport. nameOfConference


    QMRO: qmroHref
  • Murtuza B, Suzuki K, Bou-Gharios G et al. (2004). Transplantation of skeletal myoblasts secreting an IL-1 inhibitor modulates adverse remodeling in infarcted murine myocardium. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Murtuza B, Smolenski RT et al. (2004). Selective cell dissemination into the heart by retrograde intracoronary infusion in the rat. nameOfConference


    QMRO: qmroHref
  • Suzuki K (2004). Heat Shock Protein 70 and Myocardial Protection against Ischemia-Reperfusion Injury. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kurpisz M, Suzuki K, Smoleński RT et al. (2003). Cell transplantation for the treatment of heart disease.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Suzuki K, Murtuza B, Brand N et al. (2003). Inhibition of interleukin-1 beta improves graft survival and proliferation following cell transplantation to the heart. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Suzuki K, Murtuza B, Smolenski RT (2003). Targeted delivery of skeletal myoblasts into infarcted hearts by retrograde intracoronary infusion: Distribution, survival, proliferation and influence on cardiac function. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Sim EKW, Haider HK, Law PK (2003). Single fiber skeletal muscle transplantation or purified myoblast engraftment?. nameOfConference


    QMRO: qmroHref
  • Murtuza B, Suzuki K, Yacoub MH (2003). Single fiber skeletal muscle transplantation or purified myoblast engraftment? Reply. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Murtuza B, Sammut IA et al. (2002). Heat shock protein 72 enhances manganese superoxide dismutase activity during myocardial ischemia-reperfusion injury, associated with myocardial protection and apoptosis reduction. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Murtuza B, Suzuki N et al. (2002). Human cytomegalovirus immediate-early protein IE2-86, but not IE1-72, causes graft coronary arteriopathy in the transplanted rat heart. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Murtuza B, Smolenski RT et al. (2002). Development of an in vivo ischemia-reperfusion model in heterotopically transplanted rat hearts. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Murtuza B, Heslop L et al. (2002). Single fibers of skeletal muscle as a novel graft for cell transplantation to the heart. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Latif N, Sammut IA et al. (2001). Heat shock protein 70-induced cardioprotection involves preservation of manganese superoxide dismutase activity, associated with mitochondrial protection and apoptosis reduction. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Suzuki K, Khan M, Murtuza B et al. (2001). Human cytomegalovirus immediate-early protein IE2, but not IE1, causes graft coronary arteriopathy in the transplanted rat heart. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Suzuki K, Brand NJ, Allen S et al. (2001). Overexpression of connexin 43 in skeletal myoblasts: Relevance to cell transplantation to the heart. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Murtuza B, Smolenski RT et al. (2001). Cell transplantation for the treatment of acute myocardial infarction using vascular endothelial growth factor-expressing skeletal myoblasts. nameOfConference


    QMRO: qmroHref
  • Jayakumar J, Suzuki K, Sammut IA et al. (2001). Heat shock protein 70 gene transfection protects mitochondrial and ventricular function against ischemia-reperfusion injury. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Murtuza B, Suzuki N et al. (2001). Intracoronary infusion of skeletal myoblasts improves cardiac function in doxorubicin-induced heart failure. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Murtuza B, Smolenski RT et al. (2001). Overexpression of interleukin-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptosis. nameOfConference


    QMRO: qmroHref
  • Smolenski RT, Raisky O, Slominska EM et al. (2001). Protection from reperfusion injury after cardiac transplantation by inhibition of adenosine metabolism and nucleotide precursor supply. nameOfConference


    QMRO: qmroHref
  • Abunasra HJ, Smolenski RT, Morrison K et al. (2001). Efficacy of adenoviral gene transfer with manganese superoxide dismutase and endothelial nitric oxide synthase in reducing ischemia and reperfusion injury. nameOfConference


    QMRO: qmroHref
  • Smolenski RT, Raisky O, Zych M et al. (2001). Enhanced endogenous adenosine protects from reperfusion injury after heart transplantation. nameOfConference


    QMRO: qmroHref
  • Watanabe Y, Yi Y, Kondo T et al. (2001). Steam Oxidation of Ferritic Heat-resistant Steels for Ultra Supercritical Boilers. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Brand NJ, Smolenski RT et al. (2000). Development of a Novel Method for Cell Transplantation Through the Coronary Artery. nameOfConference


    QMRO: qmroHref
  • Jayakumar J, Suzuki K, Khan M et al. (2000). Gene Therapy for Myocardial Protection. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Smolenski RT, Jayakumar J et al. (2000). Heat Shock Treatment Enhances Graft Cell Survival in Skeletal Myoblast Transplantation to the Heart. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Murtuza B, Jayakumar J et al. (2000). Feasibility of single fiber of skeletal muscle as a novel graft for cell transplantation to the heart. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Jayakumar J, Suzuki K, Sammut IA et al. (2000). Hsp70 gene therapy protects both mitochondrial and ventricular function after ischemia-reperfusion injury. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Suzuki K, Murtuza B, Abunasra H et al. (2000). Infra-coronary infusion of skeletal myoblasts improves cardiac function of doxorubicin-induced heart failure. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Suzuki K, Murtuza B, Sammut IA et al. (2000). Overexpression of IL-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptotis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Suzuki K, Murtuza B, Sammut IA et al. (2000). Refinement of cell transplantation to the heart by using VEGF-overexpressing skeletal myoblasts. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Suzuki K, Sawa Y, Kagisaki K et al. (2000). Reduction in myocardial apoptosis associated with overexpression of heat shock protein 70. nameOfConference


    QMRO: qmroHref
  • Ohata T, Sawa Y, Kadoba K et al. (2000). Role of nitric oxide in a temperature dependent regulation of systemic vascular resistance in cardiopulmonary bypass. nameOfConference


    QMRO: qmroHref
  • Sakaguchi T, Sawa Y, Kitakaze M et al. (2000). Ecto-5′-nucleotidase plays a role in the cardioprotective effects of heat shock protein 72 in ischemia–reperfusion injury in rat hearts. nameOfConference


    QMRO: qmroHref
  • Smolenski RT, Raisky O, Kalsi KK et al. (2000). Enhanced endogenous adenosine production and protection of the heart after transplantation. nameOfConference


    QMRO: qmroHref
  • Ohata T, Sawa Y, Ohtake S et al. (1999). Clinical role of blood heparin level monitoring during open heart surgery. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Sawa Y, Ichikawa H et al. (1999). Myocardial protection with endogenous overexpression of manganese superoxide dismutase. nameOfConference


    QMRO: qmroHref
  • Epelbaum BM, Yoshikawa A, Shimamura K et al. (1999). Microstructure of Al2O3/Y3Al5O12 eutectic fibers grown by μ-PD method. nameOfConference


    QMRO: qmroHref
  • Sawa Y, Kaneda Y, Bai H-Z et al. (1998). Efficient transfer of oligonucleotides and plasmid DNA into the whole heart through the coronary artery. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Sawa Y, Kaneda Y et al. (1998). Overexpressed Heat Shock Protein 70 Attenuates Hypoxic Injury in Coronary Endothelial Cells. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Sawa Y, Kaneda Y et al. (1998). [In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat].. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Suzuki K, Sawa Y, Kadoba K et al. (1998). Early Detection of Cardiac Damage With Heart Fatty Acid-Binding Protein After Cardiac Operations. nameOfConference


    QMRO: qmroHref
  • Sawa Y, Morishita R, Suzuki K et al. (1997). A novel strategy for myocardial protection using in vivo transfection of cis element 'decoy' against NFkappaB binding site: evidence for a role of NFkappaB in ischemia-reperfusion injury.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Matsuwaka R, Shimazaki Y, Miyamoto Y et al. (1997). Staged Cardiac and Aortic Aneurysm Surgery Using Ventricular Assist Device. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Sawa Y, Kaneda Y et al. (1997). In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat.. nameOfConference


    QMRO: qmroHref
  • Sawa Y, Kadoba K, Suzuki K et al. (1997). Efficient gene transfer method into the whole heart through the coronary artery with hemagglutinating virus of Japan liposome. nameOfConference


    QMRO: qmroHref
  • Suzuki K, Sawa Y, Kadoba K et al. (1996). [The earlier detection of myocardial damage in open heart surgery using serum human heart fatty acid-binding protein].. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Sawa Y, Suzuki K, Bai H-Z et al. (1995). Efficiency of in vivo gene transfection into transplanted rat heart by coronary infusion of HVJ liposome.. nameOfConference


    QMRO: qmroHref
  • Kuki S, Yoshida K, Suzuki K et al. (1994). [An experience of successful valve repair for acquired mitral and tricuspid regurgitation in dextrocardia, situs inversus, bilateral vena cava, and hemiazygos continuation].. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kuki S, Yoshida K, Suzuki K et al. (1994). Successful surgical management for multiple cerebral mycotic aneurysmsinvolving both carotid and vertebrobasilar systems in active infectiveendocarditis. nameOfConference


    QMRO: qmroHref
  • Kuki S, Yoshida K, Suzuki K et al. (1994). [A successful case of left heart bypass with biocompatible bypass circuit and minimal heparin for severe heart failure after open mitral commissurotomy].. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kuki S, Yoshida K, Izutani H et al. (1994). Multichannel myocardial temperature probe. nameOfConference


    QMRO: qmroHref
  • Kuki S, Yoshida K, Hirai Y et al. (1994). A new system for warm blood cardioplegia. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kuki S, Yoshida K, Suzuki K et al. (1994). [A successful case of valve-sparing surgery for tricuspid valve endocarditis].. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Izutani H, Suzuki K, Kuki S et al. (1993). [A case of impending rupture of acute aortic dissection with thrombosed false lumen in early phase].. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Okamura K, Suzuki M, Chihara T et al. (1989). Clinical evaluation of sizofiran combined with irradiation in patients with cervical cancer. nameOfConference


    QMRO: qmroHref

Collaborators

Internal

Faculty of Medicine and Dentistry

School of Engineering and Materials and Science

External

  • Dr Satsuki Fukushima and Dr Yasunori Shintani (Japan National Cardiovascular Research Center)
  • Dr Makoto Ikeya and Dr Akitsu Hotta (Kyoto Univ, Japan)
  • Dr Kenichi Yamahara (Hyogo Medical College, Japan)
  • Dr Manabu Shiraishi and Prof Atsushi Yamaguchi (Jichi Univ, Japan)
  • Prof Alvaro Mata (Nottingham Univ, UK)

Teaching

  • BHF 4-year MRes/PhD DTP Board member
  • BSc Pharmacology and Innovative Therapeutics (B211)
  • PhD student supervision (primary and secondary)
  • MRes student supervision
  • OSCE regular examiners

Disclosures

  • 2017-2023 Prof Suzuki has received consultancy funds from Kaneka Corp.
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