Professor Ken SuzukiProfessor of Translational Cardiovascular Therapeutics Centre: Microvascular Research Email: ken.suzuki@qmul.ac.ukTelephone: +44(0) 20 7882 8233 Website: https://www.centre-for-microvascular-research.com/suzuki-labProfileResearchPublicationsSponsorsCollaboratorsTeachingDisclosuresProfileORCID iD: 0000-0002-8970-1553 Ken Suzuki is a clinical academic in the field of cardiac surgery, initially trained at Osaka University, Japan. Following the 10-year clinical training and a PhD awarded for his work on gene therapy for myocardial ischaemia-reperfusion injury, he was recruited to the Harefield Heart Science Centre, National Heart and Lung Institute, Imperial College London (head; Prof Sir Magdi Yacoub) in 1998. In this Centre of excellence, he completed a series of research projects on stem cell therapy and gene therapy for heart diseases, in parallel to his surgical training. Subsequently, Suzuki took up the chair of a new research group within the William Harvey Research Institute in 2007. Here, he continues basic, translational, pre-clinical, and clinical cardiovascular research, which aims to develop innovative therapies for heart failure, with a multi-disciplinary group. Suzuki is a former Japan Society for the Promotion of Science Fellow and UK Medical Research Council Senior Fellow. ResearchGroup members Senior staff: Dr Fiona Lewis-McDougall (Lecturer) Research Fellows: Dr Kazuya Kobayashi; Dr Tomoya Ito; Dr Elena Tsisanova PhD student: Mr Emrah Ozcan Summary Suzuki’s research primarily aims to develop innovative therapies, including stem cell therapy, to treat heart attack and other types of heart diseases. There are currently three major research lines in the group. 1. Adult stem cell therapy for myocardial repairHuman organs have distinct types of stem/progenitor cells, named “adult stem cells” or “tissue-resident stem cells”. When collected, expanded, and transplanted, these cells are able to improve cardiac performance and structure by repairing the damaged myocardium primarily through secretion of reparative factors (“paracrine effects”). Suzuki’s 25-year research indicated that allogeneic mesenchymal stromal cells (MSCs) are a most promising cell type for the purpose of clinical success of this approach. His group has been optimising the most effective source of MSCs. His research has identified the issues associated with the current cell-injection methods, including poor donor cell survival and risks of complications such as arrhythmia occurrence and coronary blockage. To solve these limitations, Suzuki’s team developed the innovative cell-delivery route, namely “epicardial placement”. His group optimised this technique by applying a range of distinct biocompatible materials/tissue engineering methods, including the cell-sheet technique, different types of hydrogels, bioengineered membrane, etc. Current projects include: Translational studies of biomaterial-aided epicardial placement of MSCs, aiming to initiate the first-in-human clinical trial Pre-clinical characterisation of human amnion-derived MSCs and induced pluripotent stem cell (iPSC)-derived MSCs as a donor for clinical cell therapy Mechanistic investigations with focuses on the “primary” and “secondary” paracrine effects induced by MSC therapy Study of the role of tissue-repairing macrophages in the MSC-derived secondary paracrine effect Elucidation of the role of exosomes in MSC-based therapy Application of exosomes for the treatment of heart failure Further improvement of the epicardial placement methods, including biomaterial-aided intrapericardial injection Development of “designer” MSCs, which are genetically engineered to achieve greater therapeutic benefits 2. Tissue-repairing macrophages for the treatment of heart failure and other diseasesImmunity and inflammation play a vital role in development of and recovery from heart failure. Suzuki’s group has investigated the role of high-mobility group protein 1, toll like receptors as well as tissue-repairing (M2-like) macrophages in heart failure. In addition to elucidating their basic molecular/cellular biological characterisation, we challenge to apply these data for the development of innovative therapies of heart failure and other diseases.Current projects include: Biological and functional characterisation of cardiac M2-like macrophages in the intact and damaged heart Investigation of the role of M2-like macrophages in non-cardiac diseases, including post-operative adhesions Establishment of the ideal production protocol of M2-like macrophages from different tissues and/or iPSCs Development of new cell transplantation therapy using M2-like macrophages for treating/preventing heart failure Development of new technologies, including long-acting IL-4, for the treatment of cardiac and non-cardiac disease through modulating M2-like macrophages 3. Pluripotent stem cell therapy for myocardial regenerationiPSCs are more promising to achieve myocardial regeneration (generation of new cardiomyocytes), compared to adult stem cells. However, pluripotent cells remain associated with critical issues to attain clinical success, including mass production of high-quality and homogeneous cardiomyocytes and regulation of their differentiation (i.e. avoidance of tumour formation). In addition, insufficient maturation and inappropriate integration of stem cell-derived cardiomyocytes as well as suboptimal cell-delivery method have to be overcome. With determination to progress this approach toward clinical application, we currently conduct basics/translational research using these cells as follows: Development of an advanced method to deliver iPSC-derived cardiomyocytes cells to the heart by applying the epicardial placement technique Investigation to elucidate and amplify intra-cardiac migration and integration of cardiomyocytes derived from iPSCs Investigation of differentiation stage-specific abilities of iPSC-derived cardiac cells (committed cardiomyocytes versus cardiac progenitors) Development of new methods to enhance maturation of iPSC-derived cardiomyocytes Publications Ichihara Y, Kaneko M, Yamahara K et al. (2024). Corrigendum to “Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure” [Biomaterials 154 (2018) 12–23]. nameOfConference DOI: 10.1016/j.biomaterials.2024.122611 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100617 Shintani Y, Drexler HC, Kioka H et al. (2024). Author Correction: Toll‐like receptor 9 protects non‐immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2. nameOfConference DOI: 10.1038/s44319-024-00100-1 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100593 Kobayashi K, Ichihara Y, Sato N et al. (2024). Corrigendum to “On-site fabrication of bi-layered adhesive mesenchymal stromal cell dressings for the treatment of heart failure” [Biomaterials 209 (2019) 41–53]. nameOfConference DOI: 10.1016/j.biomaterials.2024.122499 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100614 Ichihara Y, Kaneko M, Yamahara K et al. (2024). Corrigendum to “Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure” [Biomaterials 154 (2018) 12–23]. nameOfConference DOI: 10.1016/j.biomaterials.2024.122500 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100616 Shintani Y, Fukushima S, Varela-Carver A et al. (2024). Corrigendum to “Donor cell-type specific paracrine effects of cell transplantation for post-infarction heart failure” [J Mol Cell Cardiol 47 (2009) 288–295]. nameOfConference DOI: 10.1016/j.yjmcc.2024.01.001 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100612 Fields L, Ito T, Kobayashi K et al. (2024). Epicardial placement of human MSC-loaded fibrin sealant films for heart failure: Preclinical efficacy and mechanistic data. nameOfConference DOI: 10.1016/j.ymthe.2023.12.016 QMRO: qmroHref Ishida H, Saba R, Kokkinopoulos I et al. (2023). GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. nameOfConference DOI: 10.1016/j.celrep.2023.113383 QMRO: qmroHref Shiraishi M, Suzuki K, Yamaguchi A (2023). Effect of mechanical tension on fibroblast transcriptome profile and regulatory mechanisms of myocardial collagen turnover. nameOfConference DOI: 10.1096/fj.202201899r QMRO: qmroHref Koga-Ikuta A, Fukushima S, Ishibashi-Ueda H et al. (2022). Immunocompetent cells in durable ventricular assist device-implanted non-ischaemic dilated cardiomyopathy. nameOfConference DOI: 10.1007/s11748-022-01773-y QMRO: qmroHref Shiraishi M, Yamaguchi A, Suzuki K (2022). Nrg1/ErbB signaling‐mediated regulation of fibrosis after myocardial infarction. nameOfConference DOI: 10.1096/fj.202101428rr QMRO: qmroHref Suzuki K, Ito T, Lewis F (publicationYear). Epicardial Placement of Fibrin Sealant Film-incorporating Human Mesenchymal Stromal Cells for the Treatment of Heart Failure: Towards Clinical Translation and Mechanistic Implication. nameOfConference DOI: 10.1016/j.ymthe.2021.04.018 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/71498 Ito T, Shintani Y, Fields L et al. (publicationYear). Cell barrier function of resident peritoneal macrophages in post-operative adhesions. nameOfConference DOI: 10.1038/s41467-021-22536-y QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/71369 Suzuki K, Gautrot J (publicationYear). Engineered Cell-Degradable Poly(2-alkyl-2-oxazoline) Hydrogels Improve Epicardial Placement of Mesenchymal Stromal Cells by Stimulating Paracrine Signaling for Cardiac Repair. nameOfConference DOI: 10.1016/j.biomaterials.2020.120356 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/67461 You Y, Kobayashi K, Colak B et al. (2020). Engineered cell-degradable poly(2-alkyl-2-oxazoline) hydrogel for epicardial placement of mesenchymal stem cells for myocardial repair. nameOfConference DOI: 10.1016/j.biomaterials.2020.120356 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67321 Ishida H, Miyagawa S, Ozono K et al. (2020). A Neurotrophic Factor Receptor GFRA2, a Specific Surface Antigen for Cardiac Progenitor Cells, Regulates the Process of Myocardial Compaction. nameOfConference DOI: 10.1007/978-981-15-1185-1_56 QMRO: qmroHref Podaru MN, Fields L, Kainuma S et al. (2019). 2419Reparative macrophage transplantation for myocardial repair: a refinement of bone marrow mononuclear cell-based therapy. ESC DOI: 10.1093/eurheartj/ehz748.0167 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67360 Podaru MN, Fields L, Kainuma S et al. (2019). Reparative macrophage transplantation for myocardial repair: a refinement of bone marrow mononuclear cell-based therapy. European Society of Cardiology DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66259 Kobayashi K, Ichihara Y, Sato N et al. (2019). Self-adhesive bi-layered dressing incorporating amnion-derived mesenchymal stromal cells for the treatment of heart failure: a pre-clinical proof of concept study. European Society of Cardiology DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67345 Saba R, Kitajima K, Rainbow L et al. (2019). Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice.. nameOfConference DOI: 10.1038/s41598-019-48321-y QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64947 Podaru M-N, Fields L, Kainuma S et al. (2019). Abstract 718: Reparative Macrophage Transplantation for Myocardial Repair: A Refinement of Bone Marrow Mononuclear Cell-Based Therapy. AHA DOI: 10.1161/res.125.suppl_1.718 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66641 Podaru M-N, Fields L, Kainuma S et al. (2019). Reparative Macrophage Transplantation for Myocardial Repair: A Refinement of Bone Marrow Mononuclear Cell-Based Therapy. American Heart Association DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68760 Suzuki K, Podaru M, Fields L et al. (publicationYear). Reparative Macrophage Transplantation for Myocardial Repair: A Refinement of Bone Marrow Mononuclear Cell-Based Therapy. nameOfConference DOI: 10.1007/s00395-019-0742-1 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/58979 Kobayashi K, Ichihara Y, Sato N et al. (2019). On-site fabrication of Bi-layered adhesive mesenchymal stromal cell-dressings for the treatment of heart failure. nameOfConference DOI: 10.1016/j.biomaterials.2019.04.014 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/57098 Hussain MA, Colicchia M, Veerapen J et al. (2019). Circulatory support and stem cell therapy in the management of advanced heart failure: a concise review of available evidence.. nameOfConference DOI: 10.2217/rme-2018-0121 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/59918 Fukumitsu M, Suzuki K (2019). Mesenchymal stem/stromal cell therapy for pulmonary arterial hypertension: Comprehensive review of preclinical studies. nameOfConference DOI: 10.1016/j.jjcc.2019.04.006 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/72394 Kobayashi K, Ichihara Y, Sato N et al. (2018). On-Site, Instant Production of Bi-Layered Bio-Dressing Incorporating Mesenchymal Stromal Cells for the Treatment of Heart Failure. AHA DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66815 Kobayashi K, Suzuki K (2018). Mesenchymal Stem/Stromal Cell-Based Therapy for Heart Failure - What Is the Best Source?. nameOfConference DOI: 10.1253/circj.CJ-18-0786 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/55163 Kobayashi K, Ichihara Y, Tano N et al. (publicationYear). Fibrin Glue-aided, Instant Epicardial Placement Enhances the Efficacy of Mesenchymal Stromal Cell-Based Therapy for Heart Failure. nameOfConference DOI: 10.1038/s41598-018-27881-5 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/41023 Sawhney V, Brouilette S, Campbell N et al. (2018). Association of genetic variation in telomere‐related SNP and telomerase with ventricular arrhythmias in ischemic cardiomyopathy. nameOfConference DOI: 10.1111/pace.13284 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/44809 SUZUKI K (2018). Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure. nameOfConference DOI: 10.1016/j.biomaterials.2017.10.050 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/31343 Shintani Y, Ito T, Laura F et al. (2017). Augmentation of alternatively activated macrophages by IL-4 for the treatment of myocardial infarction. European Society of Cardiology DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65259 Shintani Y, Ito T, Laura F et al. (2017). P4372Augmentation of alternatively activated macrophages by IL-4 for the treatment of myocardial infarction. ESC DOI: 10.1093/eurheartj/ehx504.p4372 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66842 SUZUKI K, Shintani Y, ITO T et al. (2017). IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice. nameOfConference DOI: 10.1038/s41598-017-07328-z QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/24888 Ichihara Y, Tano N, Fields L et al. (2016). Epicardial Placement of Instantly Produced Fibrin Glue-Incorporating Mesenchymal Stromal Cells for the Treatment of Heart Failure. American Heart Association DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/58968 Ishida H, Saba R, Kokkinopoulos I et al. (2016). GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway.. nameOfConference DOI: 10.1016/j.celrep.2016.06.050 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/13911 SUZUKI K, Campbell N, Mathur A (2016). Cell Size Critically Determines Initial Retention of Bone Marrow Mononuclear Cells in the Heart after Intracoronary Injection: Evidence from A Rat Model. nameOfConference DOI: 10.1371/journal.pone.0158232 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/13418 Shiraishi M, Shintani Y, Shintani Y et al. (2016). Alternatively activated macrophages determine repair of the infarcted adult murine heart. nameOfConference DOI: 10.1172/JCI85782 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/12779 Tano N, Kaneko M, Ichihara Y et al. (2016). Allogeneic Mesenchymal Stromal Cells Transplanted Onto the Heart Surface Achieve Therapeutic Myocardial Repair Despite Immunologic Responses in Rats. nameOfConference DOI: 10.1161/jaha.115.002815 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/12778 Sawhney V, Campbell NG, Brouilette SW et al. (2016). Telomere shortening and telomerase activity in ischaemic cardiomyopathy patients – Potential markers of ventricular arrhythmia. nameOfConference DOI: 10.1016/j.ijcard.2016.01.066 QMRO: qmroHref Kokkinopoulos I, Ishida H, Saba R et al. (2016). Cardiomyocyte differentiation from mouse embryonic stem cells using a simple and defined protocol. nameOfConference DOI: 10.1002/dvdy.24366 QMRO: qmroHref Kokkinopoulos I, Ishida H, Saba R et al. (publicationYear). Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo. nameOfConference DOI: 10.1371/journal.pone.0140831 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/13417 Sawhney V, Brouilette S, Campbell N et al. (2015). 69 Association of TERC Related Genetic Variation and Telomerase Activity with Ventricular Arrhythmias in Ischaemic Cardiomtyopathy. nameOfConference DOI: 10.1136/heartjnl-2015-308066.69 QMRO: qmroHref Sawhney VS, Brouilette SWB, Campbell NGC et al. (2014). 23Association of TERC related genetic variation and telomerase activity with ventricular arrhythmias in ischaemic cardiomyopathy. nameOfConference DOI: 10.1093/europace/euu238.5 QMRO: qmroHref Tano N, Narita T, Kaneko M et al. (2014). Epicardial placement of mesenchymal stromal cell-sheets for the treatment of ischemic cardiomyopathy; in vivo proof-of-concept study.. nameOfConference DOI: 10.1038/mt.2014.110 QMRO: qmroHref Narita T, Suzuki K (2015). Bone marrow-derived mesenchymal stem cells for the treatment of heart failure. nameOfConference DOI: 10.1007/s10741-014-9435-x QMRO: qmroHref Shintani Y, Drexler HCA, Kioka H et al. (2014). Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2.. nameOfConference DOI: 10.1002/embr.201337945 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/12787 Suzuki K (2014). 5 Cell delivery routes for cardiac stem cell therapy. nameOfConference DOI: 10.1533/9780857096708.2.99 QMRO: qmroHref Suzuki K (2014). Cell delivery routes for cardiac stem cell therapy. nameOfConference DOI: 10.1533/9780857096708.2.99 QMRO: qmroHref Ikebe C, Suzuki K (2014). Mesenchymal Stem Cells for Regenerative Therapy: Optimization of Cell Preparation Protocols. nameOfConference DOI: 10.1155/2014/951512 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68763 Shintani Y, Kioka H, Takashima S et al. (2014). Toll-like Receptor 9 Protects Cardiomyocytes from Stress by Modulating Mitochondrial ATP Synthesis through the Inhibition of SERCA2. nameOfConference DOI: 10.1016/j.cardfail.2014.07.103 QMRO: qmroHref Narita T, Shintani Y, Ikebe C et al. (2013). The use of cell-sheet technique eliminates arrhythmogenicity of skeletal myoblast-based therapy to the heart with enhanced therapeutic effects.. nameOfConference DOI: 10.1016/j.ijcard.2012.09.081 QMRO: qmroHref Narita T, Shintani Y, Ikebe C et al. (2013). The use of scaffold-free cell sheet technique to refine mesenchymal stromal cell-based therapy for heart failure.. nameOfConference DOI: 10.1038/mt.2013.9 QMRO: qmroHref Shintani Y, Kapoor A, Kaneko M et al. (2013). TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons.. nameOfConference DOI: 10.1073/pnas.1219243110 QMRO: qmroHref Fukushima S, Sawa Y, Suzuki K (2013). Choice of cell-delivery route for successful cell transplantation therapy for the heart. nameOfConference DOI: 10.2217/fca.12.85 QMRO: qmroHref Xiao Q, Zhang F, Lin L et al. (2013). Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions.. nameOfConference DOI: 10.1161/CIRCRESAHA.112.274019 QMRO: qmroHref Kaneko M, Shintani Y, Narita T et al. (2013). Extracellular high mobility group box 1 plays a role in the effect of bone marrow mononuclear cell transplantation for heart failure.. nameOfConference DOI: 10.1371/journal.pone.0076908 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/33503 Tano N, Kaneko M, Ikebe C et al. (2013). Scaffold Free "Cell Sheets" Composed of Mesenchymal Stromal Cells for the Treatment of Chronic Heart Failure; In Viveo Proof-of-Concept Study. nameOfConference DOI: doi QMRO: qmroHref Tano N, Kaneko M, Ikebe C et al. (2013). The Use of Allogeneic Mesenchymal Stromal Cells to Refine the Emerging "Cell-Sheet" Technique for the Treatment of Heart Failure. nameOfConference DOI: doi QMRO: qmroHref Brouilette S, Kuersten S, Mein C et al. (2012). A simple and novel method for RNA-seq library preparation of single cell cDNA analysis by hyperactive Tn5 transposase.. nameOfConference DOI: 10.1002/dvdy.23850 QMRO: qmroHref Nandra KK, Takahashi K, Collino M et al. (2012). Acute treatment with bone marrow-derived mononuclear cells attenuates the organ injury/dysfunction induced by hemorrhagic shock in the rat.. nameOfConference DOI: 10.1097/SHK.0b013e31824e4c0d QMRO: qmroHref Sawhney VS, Campbell NGC, Brouilette SWB et al. (2012). 056 Leucocyte telomere/telomerase dynamics in patients with implantable cardioverter defibrillator; potential biomarker for ventricular arrhythmias. nameOfConference DOI: 10.1136/heartjnl-2012-301877b.56 QMRO: qmroHref Xiao Q, Zhang F, Lin L et al. (2012). A Functional Role of Matrix Metalloproteinase-8 in Stem/progenitor Cell Migration and Their Recruitment Into Atherosclerotic Lesions. nameOfConference DOI: doi QMRO: qmroHref Kaneko M, Shintani Y, Narita T et al. (2012). Bone Marrow Mononuclear Cell Transplantation Improves Cardiac Function in Ischemic Cardiomyopathy via High Mobility Group Box 1 Released from Dead Donor Cells. nameOfConference DOI: doi QMRO: qmroHref Campbell NG, Suzuki K (2012). Cell Delivery Routes for Stem Cell Therapy to the Heart: Current and Future Approaches. nameOfConference DOI: 10.1007/s12265-012-9378-3 QMRO: qmroHref Kaneko M, Shintani Y, Narita T et al. (2012). High mobility group box 1 released from dead donor cells plays a key role in bone marrow mononuclear cell transplantation for treating heart failure. nameOfConference DOI: doi QMRO: qmroHref Campbell NG, Kaneko M, Shintani Y et al. (2012). SIZE-DEPENDENT RETENTION OF STEM CELLS FOLLOWING INTRACORONARY INJECTION. nameOfConference DOI: 10.1136/heartjnl-2012-301877b.119 QMRO: qmroHref Felkin LE, Narita T, Germack R et al. (2011). Calcineurin Splicing Variant Calcineurin A beta 1 Improves Cardiac Function After Myocardial Infarction Without Inducing Hypertrophy. nameOfConference DOI: 10.1161/CIRCULATIONAHA.110.012211 QMRO: qmroHref Fukushima S, Campbell NG, Coppen SR et al. (2011). Quantitative assessment of initial retention of bone marrow mononuclear cells injected into the coronary arteries. nameOfConference DOI: 10.1016/j.healun.2010.09.002 QMRO: qmroHref Suzuki K, Kita T, Yamada H (2011). Wavelength tunable laser diodes with Si-wire waveguide ring resonator wavelength filters. Silicon Photonics VI DOI: 10.1117/12.874662 QMRO: qmroHref Shintani Y, Kapoor A, Drexler H et al. (2011). A Novel Toll-Like Receptor 9 Signaling in Cardiomyocytes. nameOfConference DOI: doi QMRO: qmroHref Kapoor A, Shintani Y, Collino M et al. (2011). BENEFICIAL ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-BETA/DELTA IN SEPTIC SHOCK. nameOfConference DOI: doi QMRO: qmroHref Nandra K, Takahashi K, Collino M et al. (2011). BONE-MARROW DERIVED MONONUCLEAR CELLS PROTECT AGAINST MULTIPLE ORGAN FAILURE IN HEMORRHAGIC SHOCK THROUGH AN AKT DEPENDANT PATHWAY. nameOfConference DOI: doi QMRO: qmroHref Narita T, Shintani Y, Ikebe C et al. (2011). Enhancing the "Paracrine Effects" of Mesenchymal Stem Cells to Recover Damaged Myocardium by the Use of Cell-Sheets. nameOfConference DOI: doi QMRO: qmroHref Kapoor A, Shintani Y, Collino M et al. (2010). Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock.. nameOfConference DOI: 10.1164/rccm.201002-0240OC QMRO: qmroHref Narita T, Shintani Y, Takahashi K et al. (2010). The Use of “Cell Sheet” Technique Enhances the Therapeutic Effects of Skeletal Myoblast Transplantation with Elimination of Arrhythmogenicity. American Heart Association DOI: doi QMRO: qmroHref Lovell MJ, Yasin M, Lee KL et al. (2010). Bone marrow mononuclear cells reduce myocardial reperfusion injury by activating the PI3K/Akt survival pathway.. nameOfConference DOI: 10.1016/j.atherosclerosis.2010.07.045 QMRO: qmroHref Kratsios P, Huth M, Temmerman L et al. (2010). Antioxidant Amelioration of Dilated Cardiomyopathy Caused by Conditional Deletion of NEMO/IKK gamma in Cardiomyocytes. nameOfConference DOI: 10.1161/CIRCRESAHA.109.202200 QMRO: qmroHref Shintani Y, Fukushima S, Varela-Carver A et al. (2009). Donor cell-type specific paracrine effects of cell transplantation for post-infarction heart failure. nameOfConference DOI: 10.1016/j.yjmcc.2009.05.009 QMRO: qmroHref Lee J, Stagg MA, Fukushima S et al. (2009). Adult progenitor cell transplantation influences contractile performance and calcium handling of recipient cardiomyocytes. nameOfConference DOI: 10.1152/ajpheart.00931.2008 QMRO: qmroHref Chen Z-C, Suzuki K, Miura S et al. (2009). Microstructural features and deformation-induced lattice defects in hot-extruded Bi2Te3 thermoelectric compound. nameOfConference DOI: 10.1016/j.msea.2008.09.030 QMRO: qmroHref Kagisaki K, Masai T, Kadoba K et al. (1997). Biocompatibility of Heparin‐Coated Circuits in Pediatric Cardiopulmonary Bypass. nameOfConference DOI: 10.1111/j.1525-1594.1997.tb03753.x QMRO: qmroHref Yasin M, Shintani Y, Collino M et al. (2008). Abstract 1741: Bone Marrow Mononuclear Cell Therapy upon Reperfusion Reduces Myocardial Infarct Size by Activating the PI3K/Akt Survival Pathway. nameOfConference DOI: 10.1161/circ.118.suppl_18.s_380-b QMRO: qmroHref Yasin M, Shintani Y, Collino M et al. (2008). Bone Marrow Mononuclear Cell Therapy upon Reperfusion Reduces Myocardial Infarct Size by Activating the PI3K/Akt Survival Pathway. nameOfConference DOI: doi QMRO: qmroHref Shintani Y, Fukushima S, Varela-Carver A et al. (2008). Different Paracrine Mediators and Response of the Host Myocardium by Coll Therapy: Direct Comparison between Skeletal Myoblasts and Bone Marrow Mononuclear Cells. nameOfConference DOI: doi QMRO: qmroHref Coppen SR, Fukushima S, Shintani Y et al. (2008). A factor underlying late-phase arrhythmogenicity after cell therapy to the heart - Global downregulation of connexin43 in the host myocardium after skeletal myoblast transplantation. nameOfConference DOI: 10.1161/CIRCULATIONAHA.107.779629 QMRO: qmroHref Takahashi K, Fukushima S, Yamahara K et al. (2008). Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart. nameOfConference DOI: 10.1161/CIRCULATIONAHA.107.757443 QMRO: qmroHref Fukushima S, Coppen SR, Lee J et al. (2008). Choice of Cell-Delivery Route for Skeletal Myoblast Transplantation for Treating Post-Infarction Chronic Heart Failure in Rat. nameOfConference DOI: 10.1371/journal.pone.0003071 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68762 Yamahara K, Fukushima S, Coppen SR et al. (2008). Heterogeneic nature of adult cardiac side population cells. nameOfConference DOI: 10.1016/j.bbrc.2008.04.021 QMRO: qmroHref Lara-Pezzi E, Winn N, Paul A et al. (2007). A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration. nameOfConference DOI: 10.1083/jcb.200704179 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68761 Suzuki K, Fukushima S, Varela-Carver A et al. (2007). Response to letter regarding article, "Direct Intramyocardial but Not Intracoronary Injection of Bone Marrow Cells Induces Ventricular Arrhythmias in a Rat Chronic Ischemic Heart Failure Model". nameOfConference DOI: 10.1161/CIRCULATIONAHA.107.725937 QMRO: qmroHref Takahashi K, Fukushima S, Yamahara K et al. (2007). Controlled inflammation induced by injection of High Mobility Group Box 1 recovers post-infarction chronic failing heart. nameOfConference DOI: doi QMRO: qmroHref Coppen SR, Fukushima S, Varela-Carver A et al. (2007). Downregulation of myocardial connexin43 and arrythmogenesis after injection of skeletal myoblasts but not bone marrow cells into the failing heart. nameOfConference DOI: doi QMRO: qmroHref Santini MP, Tsao L, Monassier L et al. (2007). Enhancing repair of the mammalian heart. nameOfConference DOI: 10.1161/CIRCRESAHA.107.148791 QMRO: qmroHref Fukushima S, Varela-Carver A, Coppen SR et al. (2007). Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model. nameOfConference DOI: 10.1161/CIRCULATIONAHA.106.662577 QMRO: qmroHref Smolenski RT, Forni M, Maccherini M et al. (2007). Reduction of hyperacute rejection and protection of metabolism and function in hearts of human decay accelerating factor (hDAF)-expressing pigs. nameOfConference DOI: 10.1016/j.cardiores.2006.10.027 QMRO: qmroHref Coppen SR, Fukushima S, Varela-Carver A et al. (2006). Factors contributing to ventricular arrhythmias after skeletal myoblast transplantation. nameOfConference DOI: doi QMRO: qmroHref Yamahara K, Fukushima S, Varela-Carver A et al. (2006). High-mobility group box 1 protein (HMGB1) released by cell transplantation plays an important role in the therapeutic effects for treating chronic ischemic heart failure. nameOfConference DOI: doi QMRO: qmroHref Fukushima S, Varela-Carver A, Coppen SR et al. (2006). Regardless of cell-delivery route, skeletal myoblast transplantation into chronic heart failure induces transient therapeutic effects with persistent arrhythmogenesis. nameOfConference DOI: doi QMRO: qmroHref Fukushima S, Yamahara K, Smolenski RT et al. (2006). The pattern, quantity and possible mechanism of migration of bone marrow cells into the myocardium after intracoronary injection. nameOfConference DOI: doi QMRO: qmroHref Varela-Carver A, Fukushima S, Coppen SR et al. (2006). Transplantation of bone marrow cells, but not skeletal myoblasts, normalizes the downregulation of myocardial Akt in chronic heart failure. nameOfConference DOI: doi QMRO: qmroHref Yamahara K, Coppen S, Varela-Carver A et al. (2006). Characterization of cardiac side population cell and its potential for cardiac regeneration. nameOfConference DOI: doi QMRO: qmroHref Suzuki K, Fukushima S, Coppen S et al. (2006). Enhanced efficiency of superoxide dismutase-induced cardioprotection by retrograde intracoronary administration prior to reperfusion. nameOfConference DOI: doi QMRO: qmroHref Lee J, Fukushima S, Stagg MA et al. (2006). Paracrine effects of cell transplantation on recipient cardiomyocytes in a rat model of heart failure. nameOfConference DOI: doi QMRO: qmroHref Suzuki K, Fukushima S, Varela-Carver A et al. (2006). Retrograde intracoronary infusion as a route for cell transplantation for treating post-infarction chronic heart failure. nameOfConference DOI: doi QMRO: qmroHref Fukushima S, Coppen SR, Varela-Carver A et al. (2006). A novel strategy for myocardial protection by combined antibody therapy inhibiting both P-selectin and intercellular adhesion molecule-1 via retrograde intracoronary route. nameOfConference DOI: 10.1161/CIRCULATIONAHA.105.000794 QMRO: qmroHref Suzuki K, Fukushima S, Coppen SR et al. (2006). A novel strategy for myocardial protection by combined antibody therapy inhibiting both P-selectin and intercellular adhesion molecule-1 via retrograde intracoronary route. nameOfConference DOI: 10.1016/j.yjmcc.2006.03.163 QMRO: qmroHref Yamahara K, Coppen SR, Varela-Carver A et al. (2006). Characterization of cardiac side population cells. nameOfConference DOI: 10.1016/j.yjmcc.2006.03.215 QMRO: qmroHref Suzuki K, Fukushima S, Varela-Carver A et al. (2006). Ventricular arrhythmias induced by bone marrow cell transplantation into post-infarction chronic heart failure. nameOfConference DOI: 10.1016/j.yjmcc.2006.03.183 QMRO: qmroHref Yacoub M, Suzuki K, Rosenthal N (2006). The future of regenerative therapy in patients with chronic heart failure. nameOfConference DOI: 10.1038/ncpcardio0401 QMRO: qmroHref Fukushima S, Coppen SR, Varela-Carver A et al. (2006). Enhanced efficiency of superoxide dismutase-induced cardioprotection by retrograde intracoronary administration. nameOfConference DOI: 10.1016/j.cardiores.2005.10.008 QMRO: qmroHref Lee J, Fukushima S, Stagg MA et al. (2006). Paracrine effects of transplanted bone marrow cells and skeletal myoblasts on recipient cardiomyocyte function in a rat model of heart failure. nameOfConference DOI: 10.1016/j.healun.2005.11.324 QMRO: qmroHref Stagg MA, Coppen SR, Suzuki K et al. (2006). Evaluation of frequency, type, and function of gap junctions between skeletal myoblasts overexpressing connexin43 and cardiomyocytes: relevance to cell transplantation. nameOfConference DOI: 10.1096/fj.05-5088fje QMRO: qmroHref Fukushima S, Coppen SR, Varela-Carver A et al. (2005). A novel strategy for myocardial protection by combined antibody therapy inhibiting both P-selectin and intercellular adhesion molecule-1 via retrograde intracoronary route. nameOfConference DOI: doi QMRO: qmroHref Fukushima S, Brindley G, Yamahara K et al. (2005). Direct intramyocardial injection, but not intracoronary infusion of bone marrow mononuclear cells induces ventricular arrhythmias in chronic ischemic heart failure. nameOfConference DOI: doi QMRO: qmroHref Yuen AHY, Boscoe M, Lango R et al. (2005). Prevention of adriamycin induced heart failure by an increase in endogenous adenosine production. nameOfConference DOI: 10.1081/NCN-200059705 QMRO: qmroHref Coppen SR, Varela-Carver A, Stagg MA et al. (2004). An investigation of gap junction formation between skeletal myoblasts and adult cardiac myocytes using myoblasts overexpressing Connexin43. nameOfConference DOI: doi QMRO: qmroHref Stagg MA, Coppen SR, Lee A et al. (2004). Connexin43 overexpression increases gap junctional conductance between skeletal myoblasts and adult rat ventricular myocytes in coculture. nameOfConference DOI: doi QMRO: qmroHref Suzuki K, Murtuza B, Beauchamp JR et al. (2004). Role of interleukin-1 beta in acute inflammation and graft death after cell transplantation to the heart. nameOfConference DOI: 10.1161/01.CIR.0000138388.55416.06 QMRO: qmroHref Suzuki K, Murtuza B, Fukushima S et al. (2004). Targeted cell delivery into infarcted rat hearts by retrograde intracoronary infusion: Distribution, dynamics, and influence on cardiac function. nameOfConference DOI: 10.1161/01.CIR.0000138191.11580.e3 QMRO: qmroHref Yacoub MH, Yuen AHY, Kalsi KAK et al. (2004). C34T AMP deaminase 1 gene mutation protects cardiac function in donors. nameOfConference DOI: 10.1097/01.TP.0000122413.46512.05 QMRO: qmroHref Suzuki K, Murtuza B, Beauchamp JR et al. (2004). Dynamics and mediators of acute graft attrition after myoblast transplantation to the heart. nameOfConference DOI: 10.1096/fj.03-1308fje QMRO: qmroHref Suzuki K, Murtuza B, Brand NJ et al. (2004). Enhanced effect of myocardial gene transfection by VP22-mediated intercellular protein transport. nameOfConference DOI: 10.1016/j.yjmcc.2004.01.007 QMRO: qmroHref Murtuza B, Suzuki K, Bou-Gharios G et al. (2004). Transplantation of skeletal myoblasts secreting an IL-1 inhibitor modulates adverse remodeling in infarcted murine myocardium. nameOfConference DOI: 10.1073/pnas.0306205101 QMRO: qmroHref Suzuki K, Murtuza B, Smolenski RT et al. (2004). Selective cell dissemination into the heart by retrograde intracoronary infusion in the rat. nameOfConference DOI: 10.1097/01.TP.0000114482.21064.8F QMRO: qmroHref Suzuki K (2004). Heat Shock Protein 70 and Myocardial Protection against Ischemia-Reperfusion Injury. nameOfConference DOI: doi QMRO: qmroHref Kurpisz M, Suzuki K, Smoleński RT et al. (2003). Cell transplantation for the treatment of heart disease.. nameOfConference DOI: doi QMRO: qmroHref Suzuki K, Murtuza B, Brand N et al. (2003). Inhibition of interleukin-1 beta improves graft survival and proliferation following cell transplantation to the heart. nameOfConference DOI: doi QMRO: qmroHref Suzuki K, Murtuza B, Smolenski RT (2003). Targeted delivery of skeletal myoblasts into infarcted hearts by retrograde intracoronary infusion: Distribution, survival, proliferation and influence on cardiac function. nameOfConference DOI: doi QMRO: qmroHref Sim EKW, Haider HK, Law PK (2003). Single fiber skeletal muscle transplantation or purified myoblast engraftment?. nameOfConference DOI: 10.1067/mtc.2003.288 QMRO: qmroHref Murtuza B, Suzuki K, Yacoub MH (2003). Single fiber skeletal muscle transplantation or purified myoblast engraftment? Reply. nameOfConference DOI: 10.1067/mtc.2003.289 QMRO: qmroHref Suzuki K, Murtuza B, Sammut IA et al. (2002). Heat shock protein 72 enhances manganese superoxide dismutase activity during myocardial ischemia-reperfusion injury, associated with myocardial protection and apoptosis reduction. nameOfConference DOI: 10.1161/01.cir.0000032880.55215.92 QMRO: qmroHref Suzuki K, Murtuza B, Suzuki N et al. (2002). Human cytomegalovirus immediate-early protein IE2-86, but not IE1-72, causes graft coronary arteriopathy in the transplanted rat heart. nameOfConference DOI: 10.1161/01.cir.0000032881.55218.db QMRO: qmroHref Suzuki K, Murtuza B, Smolenski RT et al. (2002). Development of an in vivo ischemia-reperfusion model in heterotopically transplanted rat hearts. nameOfConference DOI: 10.1097/00007890-200205150-00007 QMRO: qmroHref Suzuki K, Murtuza B, Heslop L et al. (2002). Single fibers of skeletal muscle as a novel graft for cell transplantation to the heart. nameOfConference DOI: 10.1067/mtc.2002.121507 QMRO: qmroHref Suzuki K, Latif N, Sammut IA et al. (2001). Heat shock protein 70-induced cardioprotection involves preservation of manganese superoxide dismutase activity, associated with mitochondrial protection and apoptosis reduction. nameOfConference DOI: doi QMRO: qmroHref Suzuki K, Khan M, Murtuza B et al. (2001). Human cytomegalovirus immediate-early protein IE2, but not IE1, causes graft coronary arteriopathy in the transplanted rat heart. nameOfConference DOI: doi QMRO: qmroHref Suzuki K, Brand NJ, Allen S et al. (2001). Overexpression of connexin 43 in skeletal myoblasts: Relevance to cell transplantation to the heart. nameOfConference DOI: 10.1067/mtc.2001.116210 QMRO: qmroHref Suzuki K, Murtuza B, Smolenski RT et al. (2001). Cell transplantation for the treatment of acute myocardial infarction using vascular endothelial growth factor-expressing skeletal myoblasts. nameOfConference DOI: 10.1161/hc37t1.094524 QMRO: qmroHref Jayakumar J, Suzuki K, Sammut IA et al. (2001). Heat shock protein 70 gene transfection protects mitochondrial and ventricular function against ischemia-reperfusion injury. nameOfConference DOI: 10.1161/hc37t1.094932 QMRO: qmroHref Suzuki K, Murtuza B, Suzuki N et al. (2001). Intracoronary infusion of skeletal myoblasts improves cardiac function in doxorubicin-induced heart failure. nameOfConference DOI: 10.1161/hc37t1.094929 QMRO: qmroHref Suzuki K, Murtuza B, Smolenski RT et al. (2001). Overexpression of interleukin-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptosis. nameOfConference DOI: 10.1161/hc37t1.094871 QMRO: qmroHref Smolenski RT, Raisky O, Slominska EM et al. (2001). Protection from reperfusion injury after cardiac transplantation by inhibition of adenosine metabolism and nucleotide precursor supply. nameOfConference DOI: 10.1161/hc37t1.094712 QMRO: qmroHref Abunasra HJ, Smolenski RT, Morrison K et al. (2001). Efficacy of adenoviral gene transfer with manganese superoxide dismutase and endothelial nitric oxide synthase in reducing ischemia and reperfusion injury. nameOfConference DOI: 10.1016/s1010-7940(01)00704-7 QMRO: qmroHref Smolenski RT, Raisky O, Zych M et al. (2001). Enhanced endogenous adenosine protects from reperfusion injury after heart transplantation. nameOfConference DOI: 10.1016/s0041-1345(00)02271-5 QMRO: qmroHref Watanabe Y, Yi Y, Kondo T et al. (2001). Steam Oxidation of Ferritic Heat-resistant Steels for Ultra Supercritical Boilers. nameOfConference DOI: 10.3323/jcorr1991.50.50 QMRO: qmroHref Suzuki K, Brand NJ, Smolenski RT et al. (2000). Development of a Novel Method for Cell Transplantation Through the Coronary Artery. nameOfConference DOI: 10.1161/01.cir.102.suppl_3.iii-359 QMRO: qmroHref Jayakumar J, Suzuki K, Khan M et al. (2000). Gene Therapy for Myocardial Protection. nameOfConference DOI: 10.1161/01.cir.102.suppl_3.iii-302 QMRO: qmroHref Suzuki K, Smolenski RT, Jayakumar J et al. (2000). Heat Shock Treatment Enhances Graft Cell Survival in Skeletal Myoblast Transplantation to the Heart. nameOfConference DOI: 10.1161/01.cir.102.suppl_3.iii-216 QMRO: qmroHref Suzuki K, Murtuza B, Jayakumar J et al. (2000). Feasibility of single fiber of skeletal muscle as a novel graft for cell transplantation to the heart. nameOfConference DOI: doi QMRO: qmroHref Jayakumar J, Suzuki K, Sammut IA et al. (2000). Hsp70 gene therapy protects both mitochondrial and ventricular function after ischemia-reperfusion injury. nameOfConference DOI: doi QMRO: qmroHref Suzuki K, Murtuza B, Abunasra H et al. (2000). Infra-coronary infusion of skeletal myoblasts improves cardiac function of doxorubicin-induced heart failure. nameOfConference DOI: doi QMRO: qmroHref Suzuki K, Murtuza B, Sammut IA et al. (2000). Overexpression of IL-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptotis. nameOfConference DOI: doi QMRO: qmroHref Suzuki K, Murtuza B, Sammut IA et al. (2000). Refinement of cell transplantation to the heart by using VEGF-overexpressing skeletal myoblasts. nameOfConference DOI: doi QMRO: qmroHref Suzuki K, Sawa Y, Kagisaki K et al. (2000). Reduction in myocardial apoptosis associated with overexpression of heat shock protein 70. nameOfConference DOI: 10.1007/s003950070039 QMRO: qmroHref Ohata T, Sawa Y, Kadoba K et al. (2000). Role of nitric oxide in a temperature dependent regulation of systemic vascular resistance in cardiopulmonary bypass. nameOfConference DOI: 10.1016/s1010-7940(00)00455-3 QMRO: qmroHref Sakaguchi T, Sawa Y, Kitakaze M et al. (2000). Ecto-5′-nucleotidase plays a role in the cardioprotective effects of heat shock protein 72 in ischemia–reperfusion injury in rat hearts. nameOfConference DOI: 10.1016/s0008-6363(00)00070-5 QMRO: qmroHref Smolenski RT, Raisky O, Kalsi KK et al. (2000). Enhanced endogenous adenosine production and protection of the heart after transplantation. nameOfConference DOI: 10.1007/0-306-46843-3_34 QMRO: qmroHref Ohata T, Sawa Y, Ohtake S et al. (1999). Clinical role of blood heparin level monitoring during open heart surgery. nameOfConference DOI: 10.1007/bf03218071 QMRO: qmroHref Suzuki K, Sawa Y, Ichikawa H et al. (1999). Myocardial protection with endogenous overexpression of manganese superoxide dismutase. nameOfConference DOI: 10.1016/s0003-4975(99)00726-2 QMRO: qmroHref Epelbaum BM, Yoshikawa A, Shimamura K et al. (1999). Microstructure of Al2O3/Y3Al5O12 eutectic fibers grown by μ-PD method. nameOfConference DOI: 10.1016/s0022-0248(98)01052-5 QMRO: qmroHref Sawa Y, Kaneda Y, Bai H-Z et al. (1998). Efficient transfer of oligonucleotides and plasmid DNA into the whole heart through the coronary artery. nameOfConference DOI: 10.1038/sj.gt.3300750 QMRO: qmroHref Suzuki K, Sawa Y, Kaneda Y et al. (1998). Overexpressed Heat Shock Protein 70 Attenuates Hypoxic Injury in Coronary Endothelial Cells. nameOfConference DOI: 10.1006/jmcc.1998.0678 QMRO: qmroHref Suzuki K, Sawa Y, Kaneda Y et al. (1998). [In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat].. nameOfConference DOI: doi QMRO: qmroHref Suzuki K, Sawa Y, Kadoba K et al. (1998). Early Detection of Cardiac Damage With Heart Fatty Acid-Binding Protein After Cardiac Operations. nameOfConference DOI: 10.1016/s0003-4975(97)01260-5 QMRO: qmroHref Sawa Y, Morishita R, Suzuki K et al. (1997). A novel strategy for myocardial protection using in vivo transfection of cis element 'decoy' against NFkappaB binding site: evidence for a role of NFkappaB in ischemia-reperfusion injury.. nameOfConference DOI: doi QMRO: qmroHref Matsuwaka R, Shimazaki Y, Miyamoto Y et al. (1997). Staged Cardiac and Aortic Aneurysm Surgery Using Ventricular Assist Device. nameOfConference DOI: 10.1177/021849239700500210 QMRO: qmroHref Suzuki K, Sawa Y, Kaneda Y et al. (1997). In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat.. nameOfConference DOI: 10.1172/jci119327 QMRO: qmroHref Sawa Y, Kadoba K, Suzuki K et al. (1997). Efficient gene transfer method into the whole heart through the coronary artery with hemagglutinating virus of Japan liposome. nameOfConference DOI: 10.1016/s0022-5223(97)70364-7 QMRO: qmroHref Suzuki K, Sawa Y, Kadoba K et al. (1996). [The earlier detection of myocardial damage in open heart surgery using serum human heart fatty acid-binding protein].. nameOfConference DOI: doi QMRO: qmroHref Sawa Y, Suzuki K, Bai H-Z et al. (1995). Efficiency of in vivo gene transfection into transplanted rat heart by coronary infusion of HVJ liposome.. nameOfConference DOI: 10.1161/01.cir.92.9.479 QMRO: qmroHref Kuki S, Yoshida K, Suzuki K et al. (1994). [An experience of successful valve repair for acquired mitral and tricuspid regurgitation in dextrocardia, situs inversus, bilateral vena cava, and hemiazygos continuation].. nameOfConference DOI: doi QMRO: qmroHref Kuki S, Yoshida K, Suzuki K et al. (1994). Successful surgical management for multiple cerebral mycotic aneurysmsinvolving both carotid and vertebrobasilar systems in active infectiveendocarditis. nameOfConference DOI: 10.1016/1010-7940(94)90024-8 QMRO: qmroHref Kuki S, Yoshida K, Suzuki K et al. (1994). [A successful case of left heart bypass with biocompatible bypass circuit and minimal heparin for severe heart failure after open mitral commissurotomy].. nameOfConference DOI: doi QMRO: qmroHref Kuki S, Yoshida K, Izutani H et al. (1994). Multichannel myocardial temperature probe. nameOfConference DOI: 10.1016/0003-4975(94)90237-2 QMRO: qmroHref Kuki S, Yoshida K, Hirai Y et al. (1994). A new system for warm blood cardioplegia. nameOfConference DOI: doi QMRO: qmroHref Kuki S, Yoshida K, Suzuki K et al. (1994). [A successful case of valve-sparing surgery for tricuspid valve endocarditis].. nameOfConference DOI: doi QMRO: qmroHref Izutani H, Suzuki K, Kuki S et al. (1993). [A case of impending rupture of acute aortic dissection with thrombosed false lumen in early phase].. nameOfConference DOI: doi QMRO: qmroHref Okamura K, Suzuki M, Chihara T et al. (1989). Clinical evaluation of sizofiran combined with irradiation in patients with cervical cancer. nameOfConference DOI: 10.1007/bf02170141 QMRO: qmroHref Sponsors British Heart Foundation Medical Research Council Heart Research UK Barts Charity CollaboratorsInternalFaculty of Medicine and Dentistry Prof Rakesh Uppal Prof Anthony Mathur Prof Mauro Perretti Prof Sussan Nourshargh Dr Tom Nightingale Dr Mathieu-Benoit Voisin Dr Neil Dufton School of Engineering and Materials and Science Prof Julien Gautrot External Dr Satsuki Fukushima and Dr Yasunori Shintani (Japan National Cardiovascular Research Center) Dr Makoto Ikeya and Dr Akitsu Hotta (Kyoto Univ, Japan) Dr Kenichi Yamahara (Hyogo Medical College, Japan) Dr Manabu Shiraishi and Prof Atsushi Yamaguchi (Jichi Univ, Japan) Prof Alvaro Mata (Nottingham Univ, UK) Teaching BHF 4-year MRes/PhD DTP Board member BSc Pharmacology and Innovative Therapeutics (B211) PhD student supervision (primary and secondary) MRes student supervision OSCE regular examiners Disclosures 2017-2023 Prof Suzuki has received consultancy funds from Kaneka Corp. 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