Dr Mathieu-Benoit VoisinSenior Lecturer in Immunology Centre: Microvascular Research Email: m.b.voisin@qmul.ac.ukTelephone: +44(0) 20 7882 3909ProfileResearchKey PublicationsSponsorsCollaboratorsNewsProfileORCID iD: 0000-0003-3001-0894 Mathieu-Benoit Voisin graduated in 2000 from the University of Bordeaux II (France) in Biological Sciences with a specialisation in Immunology. He obtained his PhD from the University of Tours (France) in 2003 and conducted post-doctoral research at Imperial College London. In 2007, he relocated with Prof Nourshargh to the William Harvey Research Institute to investigate the mechanisms of leukocyte diapedesis through blood vessels, developing new imaging techniques to visualise the responses. His work lead him to receive the Werner Risau New Investigator Award in Vascular Biology in 2010. In 2012 he was the recipient of the prestigious Versus Arthritis Career Development Fellowship to establish his own independent research programme studying neutrophil migration and functions in the lymphatic & lymphoid system. Since 2017, Dr Voisin is a Principal Investigator and Senior Lecturer in Immunology at the Centre for Microvascular Research. ResearchGroup members Researcher/Staff: Dr Jonathon Alexis Coates; Ms Julia Dielesen (PhD Student) Summary Neutrophils are key effectors of the innate immune response but can also contribute to the development of many acute inflammatory diseases. There is also evidence for neutrophil involvement in the regulation of the adaptive immunity and the pathogenesis of numerous chronic inflammatory conditions such as rheumatoid arthritis. The precise role of neutrophils in this autoimmune disorder is unclear and the focus of my research is to elucidate the mechanisms of neutrophil migration into lymphatic vessels and lymph nodes following antigen-induced arthritis and their role in the regulation of the acquired immunity. The main hypothesis is that neutrophil entry into lymphatic vessels plays an important role in the initiation of autoimmune diseases by changes in their phenotypes and their entry to the lymphatic vascular system. The project thus aims to characterize the mechanisms of neutrophil/lymphatic vessel interactions in vivo as analyzed by intravital confocal microscopy and the implications of this response to the development of arthritis. Collectively, the project will address a previously unexplored aspect of leukocyte biology and chronic disorders thus making a significant and novel contribution to the field of inflammation. Publications Rolas L, Stein M, Barkaway A et al. (2024). Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues. nameOfConference DOI: 10.1038/s44319-024-00182-x QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/98188 Caxaria S, Bharde S, Fuller AM et al. (2023). Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia. nameOfConference DOI: 10.1073/pnas.2211631120 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/86231 Joulia R, Guerrero-Fonseca IM, Girbl T et al. (publicationYear). Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A. nameOfConference DOI: 10.1038/s41467-022-34695-7 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/82420 Iqbal AJ, Krautter F, Blacksell IA et al. (2022). Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner. nameOfConference DOI: 10.1096/fj.202100832r QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/76220 Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A et al. (2021). Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. nameOfConference DOI: 10.1016/j.immuni.2021.07.012 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/74480 Barkaway A, Rolas L, Joulia R et al. (2021). Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. nameOfConference DOI: 10.1016/j.immuni.2021.04.025 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/72327 Topping LM, Thomas BL, Rhys HI et al. (2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. nameOfConference DOI: 10.3389/fimmu.2020.00010 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/63161 Owen-Woods C, Joulia R, Barkaway A et al. (2020). Local microvascular leakage promotes trafficking of activated neutrophils to remote organs. nameOfConference DOI: 10.1172/JCI133661 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/62838 Arokiasamy S, King R, Boulaghrasse H et al. (2019). Heparanase-dependent Remodelling of Initial Lymphatic Glycocalyx 1 Regulates Tissue-fluid Drainage during Acute Inflammation in vivo. nameOfConference DOI: 10.3389/fimmu.2019.02316 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/60002 VOISIN M, leoni G, WOODFIN A et al. (2019). Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury. nameOfConference DOI: 10.1002/path.5234 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/54857 View Profile Publication Page Sponsors British Heart Foundation William Harvey Research Foundation Versus Arthritis (Formerly Arthritis Research UK) CollaboratorsInternal Prof S. Nourshargh (WHRI) Prof C. Pitzalis (WHRI) Prof M. Perretti (WHRI) Dr P Longhi (WHRI) Prof A Nissim (WHRI) Prof F Marelli-Berg (WHRI) Dr M. Capasso (BCI) Dr Esther Castellano Sanchez (BCI) External Prof Q. Sattentau (Oxford) Prof R Chambers (UCL) Prof J Greenwood (UCL) Prof J. Gutierrez (Costa Rica) Prof Ed Rainger (University of Birmingham) News Dr. Mathieu-Benoit Voisin awarded Arthritis Research UK Fellowship (January 2012). Dr. Mathieu-Benoit Voisin awarded Young Investigator Award (Best oral presentation) at the international meeting of “Neutrophil in Immunity”, Quebec, Canada (June 2012). Back to top