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The William Harvey Research Institute - Barts and The London

Professor Sussan Nourshargh

Sussan

Head, Centre for Microvascular Research

Centre: Microvascular Research

Email: s.nourshargh@qmul.ac.uk
Telephone: +44(0) 20 7882 8240 

Website: https://www.centre-for-microvascular-research.com/nourshargh-lab
Twitter: @NoursharghLab

Profile

ORCID iD: https://orcid.org/0000-0001-5677-1806

Sussan Nourshargh is a pharmacologist who studied at University College London (BSc) and King’s College London (PhD) and became Professor of Immunopharmacology at Imperial College London in 2006. In 2007 she joined Queen Mary University of London where she established the Centre for Microvascular Research within the William Harvey Research Institute. 

Awards

  • The Gabor Kaley Prize in Microcirculation Research from the American Societies of Physiology and Microcirculation (2016)
  • The Astra Zeneca Prize for Women in Pharmacology from the British Pharmacology Society (2014)
  • Quintiles Prize for outstanding contribution to Immunopharmacology from the British Pharmacology Society (2001)

Fellowships

  • Wellcome Trust Investigator Award (2020)
  • Wellcome Trust Senior Investigator Award (2012)
  • Fellow of the Academy of Medical Sciences (2012)
  • Fellow of the Society of Biology (2010)
  • Fellow of the British Pharmacological Society (2005)
  • Wellcome Trust University Award (1996)
  • Wellcome Trust Career Development Fellowship (1990) 

Memberships

  • British Heart Foundation Board of Trustees and Advisory Council (2015 - 2021)
  • Wellcome Trust’s Biomedical Resources & Multi-User Equipment Committee (2015-2018)
  • Academy of Medical Sciences Springboard Panel (2015-2017)
  • Chair and Member of the Academy of Medical Sciences Committee (SC3) for selection of new Fellows (2012-2017)
  • Royal Society’s Newton Advanced Fellowship Panel (2014-2016)
  • British Heart Foundation Fellowship Committee (2011-2014)
  • Wellcome Trust’s Peer Review College (2012-2016)
  • Treasurer of the UK Adhesion Society (2007-2016)
  • Editor, European Journal of Immunology (2013-2020)
  • Editor, British Journal of Pharmacology (2010-2013) 

Research

Group members

Post-doctoral Researchers: Natalia Reglero, Loïc Rolas, Clare Latta.
PhD students: Monja Stein, Josh Martin.
Support staff: Laura Vasquez Martinez (Research Assistant), Matthew Golding (Lab Manager), Joana Mateu (PA & Centre Administrator).

Summary 

The principal objective of our research is to investigate the mode, dynamics and mechanisms of leukocyte transmigration, the final stage in the leukocyte adhesion cascade, that describes the movement of leukocytes from the vascular lumen into inflamed and/or injured tissues. To achieve this goal, we employ a multi-disciplinary approach to investigate the associated molecular and cellular pathways involved in neutrophil-vessel wall interactions. A key approach is the application of confocal intravital microscopy that enables rigorous and direct means of investigating the interactions of leukocytes with different components of microvessel walls (endothelial cells, pericytes and the vascular basement membrane) in real-time in vivo. We employ models for analysis of both physiologically relevant as well as pathological inflammatory models and a key component of our work is a research programme that investigates how pathological inflammatory insults impact the dynamics of neutrophil-vessel wall interactions and the implications of disrupted modes of neutrophil transmigration (e.g. neutrophil reverse transendothelial cell migration) on inflammatory disease development and dissemination. Collectively through the application of molecular and cellular assays, and advanced imaging platforms, our work aims to unravel previously unexplored cellular and molecular physiological concepts and identify disease-specific phenomena in immunity, inflammation and vascular biology. 

Our work is largely funded by the Wellcome Trust (Investigator Award), the MRC.
 

Key Publications

For a full list of publications click here 

Collaborators

  • Professor Vicky Sanz-Moreno, Barts Cancer Institute, Queen Mary University of London
  • Dr Tim Lammermann, Max Planck Institute of Immunobiology & Epigenetics, Freiburg, Germany 
  • Dr Lucy Collinson, Crick Institute, London
  • Professor Mauro Perretti, Biochemical Pharmacology, William Harvey Research Institute, Queen Mary University of London.
  • Professor Dietmar Vestweber, Max Planck Institute, Munster, Germany.
  • Professor Uli von Andrian, Harvard Medical School, Boston, USA.
  • Professor Karim Brohi, Trauma Centre, Queen Mary University of London.
  • Professor Antal Rot, Centre for Microvascular Research, William Harvey Research Institute, Queen Mary University of London.
  • Professor Carlos Lopez Otin, University of Oviedo, Spain.
  • Professor Axel Roers, Director Institute of Immunology, Technical University of Dresden.
  • Dr Sharon Tooze, Crick Institute, London.
  • Dr Ezra Aksoy, Centre for Biochemical Pharmacology, William Harvey Research Institute, Queen Mary University of London.

News

  • Awarded a Wellcome Trust Investigator Award (2020).
  • Awarded an MRC Programme Grant in collaboration with Prof Paul Martin and Dr Helen Weaver from University of Bristol (2020). 
  • The paper by Owen-Woods et al., J Clin Invest, 2020, receives multiple F1000 recommendations, is covered by a J Clin Invest commentary (https://www.jci.org/articles/view/136259) and selected as an EVBO Publication highlight (https://evboweb.files.wordpress.com/2020/10/evbo-publication-highlight-oct-2020.pdf).  
  • Team members Natalia Reglero-Real and Lorena Perez receive best poster prize at the International Cell Migration Zoo Meeting (Rotterdam, Holland, May 2019). 
  • BHF Accelerator Award (Director Prof Federica Marelli-Berg & Deputy Director Prof Sussan Nourshargh), £1,000,000 for 5 years starting in April 2019.
  • The paper by Girbl et al., Immunity, 2018, receives the prestigious Servier Award in Microcirculation. This award is given every two years by the European Society for Microcirculation and European Vascular Biology Society to an outstanding publication on microcirculation/vascular biology in basic or clinical research (http://esm-evbo2019.org/registration/travel-awards/).
  • Awarded a Royal Society Newton Advanced Fellowship Grant (2018) in collaboration with Dr Michael Schnoor, Department of Molecular Biomedicine, CINESTAV, Mexico-City, Mexico.