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The William Harvey Research Institute - Barts and The London

Professor Antal Rot

Antal

Wellcome Trust Investigator and Chair in Inflammation Sciences Versus Arthritis

Centre: Centre for Microvascular Research

Email: a.rot@qmul.ac.uk
Telephone: +44(0) 20 7882 8241

Profile

ORCID iD: https://orcid.org/0000-0002-9730-6166

Antal Rot obtained his M.D. at the Semmelweis University, Budapest, Hungary where subsequently he was formally trained as an Anatomical and Surgical Pathologist. His post-doctoral research training was in the lab of legendary Edward Leonard at the National Cancer Institute, Frederick, USA. Afterwards, Antal joined Sandoz/ Novartis Forschungsinstitut in Vienna, Austria where for 20 years he was the Head of Experimental Pathology. After Institute’s closure, Antal moved to the UK taking up successive professorial appointments at the Universities of Birmingham and York. Since 2017 Antal works at the Centre for Microvascular Research, William Harvey Research Institute and the Centre for Inflammation and Therapeutic Innovation, Barts and the London School of Medicine, Queen Mary University of London. 

Research

Group members

Dr Caroline Anderson (Postdoctoral Research Assistant), Dr Julia Gutjahr (Postdoctoral Research Assistant), Dr. Elin Hub (Research Associate), Stefan Russo, BHF MS/PhD student, Dr Maryna Samus (Postdoctoral Research Assistant).

Summary 

Antal’s research interests are related to the molecular and cellular mechanisms of inflammation and the involvement of chemokines, their classical and atypical receptors in immune response and disease pathogenesis. 

 

Key Publications

from total >100; cited > 12000 times; h-index: 51; Google Scholar)

• Duchene J, Novitzky-Basso I, Thiriot A, Casanova-Acebes M, Bianchini M, Etheridge SL, Hub E, Nitz K, Artinger K, Eller K, Caamaño J, Rülicke T, Moss P, Megens RTA, von Andrian UH, Hidalgo A, Weber C, Rot A. Atypical chemokine receptor 1 on nucleated erythroid cells regulates haematopoiesis Nat Immunol 18:753-761, 2017.
* Reviewed in F1000, IF: 21.5. 
• Ulvmar MH, Braun A, Werth K, Kelay P, Hub E, Eller K, Lucas B, Nakamura K, Chan L, Novitzky-Basso I, Rülicke T, Nibbs RJB, Worbs T, Forster R and Rot A. Atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes Nat Immunol 15:623-30, 2014.
* Reviewed in F1000, IF: 26.2. 
• Bachelerie F, Graham GJ, Locati M, Mantovani A, Murphy PM, Nibbs R, Rot A, Sozzani S and Thelen M. New nomenclature for atypical chemokine receptors. Nat Immunol 5:207-8, 2014; IF: 26.2.
• Pruenster M, Mudde-Boer L, Bombosi P, Zsak M, Dimitrova S, Middleton J, Richmond A, Graham GJ, Segerer S, Nibbs RJ and Rot A. Duffy antigen/receptor for chemokines transports chemokines and supports their pro-migratory activity. Nat Immunol 10:101-8, 2009.
* Reviewed in F1000; IF: 26.9. 
• Rubic T, Lametschwandtner G, Jost S, Hinteregger S, Kund J, Carballido-Perrig N, Schwaerzler C, Junt T, Voshol H, Meingassner J, Mao X, Werner G, Rot A and Carballido J. Triggering the succinate receptor GPR91 on dendritic cells enhances immunity. Nat Immunol 9:1261–69, 2008.
* Reviewed in F1000; IF: 25.1. 
• Förster R, Davalos-Misslitz AC and Rot A. CCR7 and its ligands: balancing immunity and tolerance Nat Rev Immunol 8:362-71, 2008; IF: 30.0. 
• Schneider MA, Meingassner J, Lipp M, Moore H and Rot A. CCR7 is required for the in vivo function of CD4+CD25+ regulatory T cells. J Exp Med 204:735-45, 2007. 
*Reviewed in F1000 IF: 15.6. 
• Dar A, Goichberg P, Shinder V, Kalinkovich A, Kollet O, Netzer N, Margalit R, Zsak M, Nagler A, Hardan I, Resnick I, Rot A and Lapidot T. Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells. Nat Immunol 6:1038-46, 2005; IF: 27.6. 
• Rot A and von Andrian UH. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 22:891- 928, 2004; IF: 52.4.
• Nibbs RJ, Ponath P, Parent D, Qin S, Campbell JD, Henderson A, Kerjaschki D, Graham GJ and Rot A. The -chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors Am J Pathol 158:867-77, 2001; IF: 7.103. 
• Wolff B, Burns A, Middleton J and Rot A. Endothelial cell “memory” of inflammatory stimulation: human venular endothelial cells store IL-8 in Weibel- Palade bodies. J Exp Med 188:1757-62, 1998; IF: 15.882. 
• Middleton J, Neil S, Wintle J, Clark-Lewis I, Moore H, Lam C, Auer M, Hub E and Rot A. Transcytosis and surface presentation of IL-8 by venular endothelial cells. Cell 91:385-95, 1997; IF: 37.3.

Collaborators

External

  • Johan Duchene and Christian Weber, LMU, Munich, Germany
  • Daniel Legler, BIT, Kreuzlingen, Switzerland
  • Marcus Thelen, IRB, Bellinzona, Switzerland
  • Cornelia Halin, ETH, Zürich, Switzerland
  • Reinhold Förster, MHH, Hannover, Germany
  • Wolfgang Kastenmüller, University of Würzburg, Germany

News

June 2017 

How ancestry shapes our immune cells
ZME Science