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Professor Costantino Pitzalis

Costantino

Versus Arthritis Professor of Rheumatology, Deputy Director of the William Harvey Research Institute, and Head of Centre for Experimental Medicine and Rheumatology

Centre: Experimental Medicine and Rheumatology

Email: m.tesone@qmul.ac.uk
Telephone: +44(0) 20 7882 2926 (PA: Marianna Tesone)
Twitter: @EMR_QMUL

Profile

ORCID iD: 0000-0003-1326-5051

Costantino Pitzalis is Versus Arthritis Professor of Rheumatology at the William Harvey Research Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London.

He is Deputy Director of the William Harvey Research Institute and Head of the Centre for Experimental Medicine and Rheumatology (EULAR Centre of Excellence in Rheumatology 2023-28), leading a multidisciplinary research team of Clinicians, Scientists, Biostatisticians, Bioinformaticians, Clinical Trial Managers and administrative support staff who strive to deliver best care to patients with Rheumatic Diseases.

Costantino also leads the Musculoskeletal Theme of the NIHR Barts Biomedical Research Centre 2022-27 which provides the opportunity to tackle health inequalities and deliver pioneering, innovative healthcare to people of east London and beyond.

His research interests focus on the cellular and molecular mechanisms of inflammation and autoimmunity in chronic rheumatic conditions, particularly rheumatoid arthritis (RA). He has published over 300 highly cited peer-reviewed papers in the field of inflammation, immunity, and arthritis.

He was the Chief Investigator of the first 2 stratified, biopsy-driven, multicentre, randomised clinical trials in rheumatoid arthritis (RA) which were funded by the NIHR and MRC/VA (R4RA and STRAP). These RCTs are the first worldwide biopsy-driven trials that span the disease course from early to late RA and are synchronised for drug exposure. 

His clinical interests encompass general rheumatology with a focus on immune/inflammatory rheumatic diseases, including rheumatoid and psoriatic arthritis as well as other autoimmune rheumatic conditions (CTDs & Sjogren’s Syndrome) and osteoarthritis.

Research

Group members
https://www.qmul.ac.uk/whri/emr/our-team/

The Centre for Experimental Medicine and Rheumatology’s mission is to better understand disease pathogenesis in order to develop novel therapeutics and maximise therapeutic utility of existing therapies. The ultimate goal is to find a cure for rheumatoid and osteoarthritis.

To achieve this goal the Centre focuses on a strong basic science programme in the field of immunology & inflammation linked to a clinical translational programme in the following 4 research areas:

  1. Breach of Tolerance & Autoimmunity
    Investigating development of T/B cell autoimmunity in secondary- vs tertiary-lymphoid-structures and in early vs established RA (Bombardieri / Pitzalis); b) Role of FDCs and RASF in auto-antigen retention and breach of B cell tolerance (ElShikh / Pitzalis) and c) analysis of the antigenic specificities of lesional T and B cells (Bombardieri / Pitzalis).

  2. Development and resolution of inflammation & Mechanisms of Tissue Damage and Repair
    Mechanisms of T and B cell recruitment and retention using in vivo models (eg. RA/SCID/)(Bombardieri/Pitzalis); b) Resolution-of-inflammation through endogenous anti-inflammatory pathway. This area is investigated/developed through a long-standing collaboration with Prof Perretti and c) Mechanisms of Tissue Damage and Repair with particular emphasis on cartilage homeostasis. This research area is particular competence of Professor Dell’Accio.

  3. Developing new therapies through understanding of pathogenesis
    The Centre is actively involved in the development of novel therapeutics both through its own drug development programme (e.g. developing single chain (sc)Fv antibodies, identified by phage display technology, to specifically target joint tissues) and, in collaboration with industry, via the progression of the pharma pipeline. The Centre has been awarded an ARUK Experimental Arthritis Treatment Centres and is part of the National Institute for Health Research Translational Research Partnership.

  4. Patients stratification to understand pathogenesis of disease evolution and response to therapy
    The Centre builds on an existing large biomarker discovery and clinical trial programme to identify specific synovial tissue-driven bio-variables and blood correlates of clinical evolution and response to therapy. These include MRC/PEAC, MRC/ABPI and NIHR-EME initiatives. In addition, the ability of targeted biologics (TNF/IL6R/B-cell blockade) to modulate the panoply of RA-associated immune abnormalities will be utilised to better understand and dissect the complex immunological networks in the disease tissue in patients with RA.

More info: https://www.qmul.ac.uk/whri/emr/research-themes/

Publications

  • Hanlon MM, Smith CM, Canavan M et al. (2024). Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset. nameOfConference


  • Thomas BL, Montero‐Melendez T, Oggero S et al. (2024). Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis. nameOfConference


  • Zack SR, Alzoubi O, Satoeya N et al. (2024). Another Notch in the Belt of Rheumatoid Arthritis. nameOfConference


  • Ruscitti P, Allanore Y, Baldini C et al. (2024). Tailoring the treatment of inflammatory rheumatic diseases by a better stratification and characterization of the clinical patient heterogeneity. Findings from a systematic literature review and experts' consensus. nameOfConference


  • Rolas L, Stein M, Barkaway A et al. (2024). Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues. nameOfConference


  • Çubuk C, Lau R, Cutillas P et al. (2024). Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes. nameOfConference


  • Dunlap G, Wagner A, Meednu N et al. (publicationYear). Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium. nameOfConference


  • Stadler M, Rivellese F, Plant D et al. (2024). AB0757 TREATMENT RESPONSE CRITERIA FOR THE TWO-COMPONENT DISEASE ACTIVITY SCORE. Scientific Abstracts


    QMRO: qmroHref
  • Pontarini E, Sciacca E, Cavallaro G et al. (2024). AB0809 USER-FRIENDLY TOOL FOR EXPLORING RNA-SEQUENCE AND BIOMARKER DISCOVERY IN SJOGREN’S DISEASE: ANALYSE THE TWO BIGGEST DATASETS OF BLOOD AND SALIVARY GLAND RNA-SEQUENCING DATA USING R SHINY APPS. Scientific Abstracts


    QMRO: qmroHref
  • Lau R, Cubuk C, Rajeeve V et al. (2024). OP0218 SYNOVIAL PHOSPHOPROTEOME ANALYSIS OF LATE-STAGE RHEUMATOID ARTHRITIS PATIENTS (R4RA TRIAL) IDENTIFIES SIGNALLING PATHWAYS ASSOCIATED WITH PATHOTYPE AND RESPONSE TO RITUXIMAB AND TOCILIZUMAB. Scientific Abstracts


    QMRO: qmroHref
  • Wang S, Nair N, Cubuk C et al. (2024). OP0224 INTEGRATION OF DNA METHYLATION INTO MULTI-OMIC ANALYSIS OF SYNOVIAL BIOPSIES FROM THE STRAP RANDOMIZED CLINICAL TRIAL IDENTIFIES PREDICTORS OF RESPONSE TO ANTI-TNF THERAPY IN RHEUMATOID ARTHRITIS. Scientific Abstracts


    QMRO: qmroHref
  • Surace A, Overend L, Sciacca E et al. (2024). OP0242 SYNOVIAL TISSUE AND BLOOD DEEP B/T CELL PHENOTYPING EXPLAINS RESPONSE MECHANISMS TO RITUXIMAB IN RHEUMATOID ARTHRITIS IN R4RA. Scientific Abstracts


    QMRO: qmroHref
  • Pontarini E, Rizzo MT, Liefers SC et al. (2024). POS0265 ESTABLISHING CONSISTENCY IN THE DIGITAL IMAGING ANALYSIS OF HISTOLOGICAL PARAMETERS IN SJOGREN’S DISEASE. Scientific Abstracts


    QMRO: qmroHref
  • Iaquinta FS, Sciacca E, Abatecola F et al. (2024). POS0351 A POST-HOC ANALYSIS OF THE BIOPSY-DRIVEN, MULTICENTRE, RANDOMISED R4RA CLINICAL TRIAL REVEALS AN INNATE IMMUNE SIGNATURE IN MULTI-DRUG RESISTANT RHEUMATOID ARTHRITIS PATIENTS WITH A LYMPHO-MYELOID PATHOTYPE. Scientific Abstracts


    QMRO: qmroHref
  • Colafrancesco S, Simoncelli E, Pontarini E et al. (2024). POS0997 INFLAMMATION IN SJӦGREN DISEASE INDUCES SALIVARY GLAND EPITHELIAL CELLS (SGECS) METABOLIC REPROGRAMMING: FOCUS ON GLYCOLYSIS AND ITS REGULATION OF EPITHELIAL CELL ACTIVATION. Scientific Abstracts


    QMRO: qmroHref
  • Weinand K, Sakaue S, Nathan A et al. (publicationYear). The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis. nameOfConference


  • Corsiero E, Caliste M, Jagemann L et al. (2024). Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response. nameOfConference


  • Perera J, Delrosso CA, Nerviani A et al. (publicationYear). Clinical Phenotypes, Serological Biomarkers, and Synovial Features Defining Seropositive and Seronegative Rheumatoid Arthritis: A Literature Review. nameOfConference


  • Bai Z, Bartelo N, Aslam M et al. (2024). Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis. nameOfConference


  • Sakaue S, Weinand K, Isaac S et al. (2024). Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles. nameOfConference


  • Nerviani A, Boutet M-A, Ghirardi GM et al. (publicationYear). Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis. nameOfConference


  • Pontarini E, Sciacca E, Chowdhury F et al. (2024). Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell–Targeted Therapy in the Trial of Anti–B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS). nameOfConference


  • Weisenfeld D, Zhang F, Donlin L et al. (2024). Associations Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Types and States. nameOfConference


  • Meyer A, Zack SR, Nijim W et al. (2024). Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis. nameOfConference


    QMRO: qmroHref
  • Pitzalis C (2024). Advances in Targeted Therapies (ATT) What's cooking in the academic's kitchen? 3TR (IMI). nameOfConference


    QMRO: qmroHref
  • Boutet M-A, Nerviani A, Fossati-Jimack L et al. (2024). Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features. nameOfConference


  • Goldmann K, Spiliopoulou A, Iakovliev A et al. (2024). Expression quantitative trait loci analysis in rheumatoid arthritis identifies tissue specific variants associated with severity and outcome. nameOfConference


  • Iaquinta FS, Rivellese F, Pitzalis C (2023). Synovial biopsies for molecular definition of rheumatoid arthritis and treatment response phenotyping: where can we improve?. nameOfConference


  • Zhang F, Jonsson AH, Nathan A et al. (2023). Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes. nameOfConference


  • Rivellese F, Nerviani A, Giorli G et al. (2023). Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials. nameOfConference


  • MacBrayne A, Curzon P, Soyel H et al. (publicationYear). Attitudes to technology supported rheumatoid arthritis care: investigating patient and clinician perceived opportunities and barriers. nameOfConference


  • Zack SR, Meyer A, Zanotti B et al. (2024). Notch ligands are biomarkers of anti-TNF response in RA patients. nameOfConference


    QMRO: qmroHref
  • Wang SS, Lewis MJ, Pitzalis C (publicationYear). DNA Methylation Signatures of Response to Conventional Synthetic and Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis. nameOfConference


  • Kugler M, Dellinger M, Kartnig F et al. (2023). Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis. nameOfConference


  • Vigorito E, Barton A, Pitzalis C et al. (2023). BBmix: a Bayesian beta-binomial mixture model for accurate genotyping from RNA-sequencing. nameOfConference


  • Khmelevskaya A, Houtman M, Buerki K et al. (2023). AB0062 ABUNDANCE AND ACTIVATION OF MEMORY B-CELLS CHARACTERIZE SYNOVITIS IN RHEUMATOID ARTHRITIS PATIENTS WITH EARLY TREATMENT RESPONSE. nameOfConference


  • Ghirardi GM, Nerviani A, Fossati-Jimack L et al. (2023). AB0067 MODE OF ACTION AND TARGET INVESTIGATION OF THE NEW ANTI-RHEUMATIC DRUG RABEXIMOD.. nameOfConference


    QMRO: qmroHref
  • Rivellese F, Currado D, Giorli G et al. (2023). AB0340 MULTI-DRUG RESISTANT RA IS ASSOCIATED WITH HIGHER BASELINE DISEASE ACTIVITY, MULTI-MORBIDITY, AND LOWER QUALITY OF LIFE: ANALYSES FROM THE R4RA BIOPSY-DRIVEN CLINICAL TRIAL. nameOfConference


  • Pontarini E, Lucchesi D, Goldmann K et al. (2023). POS0292 TRANSCRIPTOMIC PROFILING OF SJOGREN’S SALIVARY GLANDS IDENTIFIES FOLLICULAR AND EXTRA-FOLLICULAR GENE SIGNATURES ASSOCIATED WITH RHEUMATOID FACTOR SEROPOSITIVITY. nameOfConference


    QMRO: qmroHref
  • Ruscitti P, Currado D, Rivellese F et al. (2023). POS1020 A DIMINISHED EXPRESSION OF THE UBIQUITIN-PROTEASOME SYSTEM IN PATIENTS WITH RHEUMATOID ARTHRITIS AND DIABETES IS LINKED TO IL-1 PATHWAY HYPER-ACTIVITY. nameOfConference


  • Curzon P, Macbrayne A, Humby F et al. (2023). Attitudes to Technology supported Rheumatoid Arthritis care Questionnaire study: Barriers to People with RA & their clinicians using Technology in the care pathway. British Society for Rheumatology Annual COnference 2023


  • Curzon P, Macbrayne A, Soyel H et al. (2023). Attitudes to Technology supported Rheumatoid Arthritis care, questionnaire study: Opportunities for technology to improve RA care. British Society for Rheumatology Annual Conference, 2023


  • Curzon P, Macbrayne A, Soyel H et al. (2023). Attitudes to Technology supported Rheumatoid Arthritis care: Opportunities & Barriers for technology in RA -Key themes from Qualitative arm of Mixed-Methods Study. British SOciety for Rheumatology Annual COnference, 2023


  • Sciacca E, Alaimo S, Silluzio G et al. (2023). DEGGs: an R package with shiny app for the identification of differentially expressed gene–gene interactions in high-throughput sequencing data. nameOfConference


  • Lewis MJ, Spiliopoulou A, Goldmann K et al. (2023). nestedcv: an R package for fast implementation of nested cross-validation with embedded feature selection designed for transcriptomics and high-dimensional data. nameOfConference


  • Mauro D, Manou-Stathopoulou S, Rivellese F et al. (2023). UBE2L3 regulates TLR7-induced B cell autoreactivity in Systemic Lupus Erythematosus. nameOfConference


  • Meyer A, Sienes RE, Nijim W et al. (2023). Syntenin-1-mediated arthritogenicity is advanced by reprogramming RA metabolic macrophages and Th1 cells. nameOfConference


  • Aly NAR, Rizk S, Enein AA et al. (publicationYear). The role of lymphoid tissue SPARC in the pathogenesis and response to treatment of multiple myeloma. nameOfConference


  • Lewis MJ, Pitzalis C (2023). Progress continues in prediction of the response to treatment of RA. nameOfConference


  • Caxaria S, Kouvatsos N, Eldridge SE et al. (2022). Disease modification and symptom relief in osteoarthritis using a mutated GCP-2/CXCL6 chemokine. nameOfConference


  • Shikh MEME, Sayed RE, Aly NAR et al. (publicationYear). Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis. nameOfConference


  • Rivellese F, Pitzalis C (2021). Introduction to the special issue: Cellular and molecular diversity in rheumatic autoimmune diseases. nameOfConference


  • Flak MB, Colas RA, Muñoz-Atienza E et al. (2022). Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis. nameOfConference


  • Wang J, Conlon D, Rivellese F et al. (2022). Synovial Inflammatory Pathways Characterize Anti‐TNF–Responsive Rheumatoid Arthritis Patients. nameOfConference


  • Humby F, Durez P, Buch MH et al. (publicationYear). Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients:the R4-RA RCT. nameOfConference


  • Carlotti E, Murray-Brown W, Blighe K et al. (2022). High-throughput sequencing of IgH gene in minor salivary glands from Sjögren's syndrome patients reveals dynamic B cell recirculation between ectopic lymphoid structures.. nameOfConference


  • Sciacca E, Surace AEA, Alaimo S et al. (2022). Network analysis of synovial RNA sequencing identifies gene-gene interactions predictive of response in rheumatoid arthritis. nameOfConference


  • Cooles FAH, Tarn J, Lendrem DW et al. (2022). Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming. nameOfConference


  • Banda NK, Deane KD, Bemis EA et al. (2022). Analysis of Complement Gene Expression, Clinical Associations, and Biodistribution of Complement Proteins in the Synovium of Early Rheumatoid Arthritis Patients Reveals Unique Pathophysiologic Features.. nameOfConference


  • Papandrikopoulou A, Burmester GR, Fang F et al. (2022). AB0379 DOSE-DEPENDENT SUPPRESSION OF T CELL-DEPENDENT ANTIBODY RESPONSE IN HEALTHY VOLUNTEERS BY KPL-404, AN ANTI-CD40 MONOCLONAL ANTIBODY, SUPPORTS CHRONIC DOSING STUDY IN PATIENTS WITH RHEUMATOID ARTHRITIS. nameOfConference


    QMRO: qmroHref
  • Surace A, Sciacca E, Goldmann K et al. (2022). OP0077 SYNOVIAL RNA-SEQ ANALYSIS OF THE R4RA TRIAL IDENTIFIES SIGNATURES OF TREATMENT RESISTANCE AND REFRACTORY STATE IN RHEUMATOID ARTHRITIS. nameOfConference


  • Rivellese F, Cubuk C, Surace A et al. (2022). OP0085 CELL LINEAGE-SPECIFIC TRANSCRIPT DECONVOLUTION OF SYNOVIAL BIOPSIES FROM THE R4RA TRIAL IDENTIFIES CELL POPULATIONS ASSOCIATED WITH RESPONSE TO RITUXIMAB AND TOCILIZUMAB. nameOfConference


  • Goldmann K, Vigorito E, Wallace C et al. (2022). OP0109 EXPRESSION QUANTITATIVE TRAIT LOCI IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS. nameOfConference


    QMRO: qmroHref
  • Prediletto E, Cubuk C, Pontarini E et al. (2022). POS0138 RHEUMATOID SYNOVIAL FIBROBLASTS DISPLAY IMPRINTED MEMORY OF THEIR SYNOVIAL ENDOTYPE WHICH CAN BE PLASTICALLY MODULATED BY B-CELLS CROSSTALK. nameOfConference


  • Pontarini E, Chowdhury F, Sciacca E et al. (2022). POS0145 CLINICAL RESPONSE TO RITUXIMAB IS ASSOCIATED WITH PREVENTION OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EPITHELIAL RESTORATION AS REVEALED BY MOLECULAR PATHOLOGY: RESULTS FROM THE TRACTISS TRIAL IN PRIMARY SJOGREN’S SYNDROME. nameOfConference


  • Corsiero E, Caliste M, Jagemann L et al. (2022). POS0399 CHARACTERIZATION OF HSP60, A STROMAL-DERIVED AUTOANTIGEN, RECOGNIZED BY RA SYNOVIAL RECOMBINANT MONOCLONAL ANTIBODIES. nameOfConference


  • Elshikh M, El Sayed R, Aly N et al. (2022). POS0431 PDGF-BB, TNF-α, AND LT-β REGULATE FOLLICULAR DENDRITIC CELL DEVELOPMENT IN THE RHEUMATOID SYNOVIUM. nameOfConference


    QMRO: qmroHref
  • Caliste M, Prediletto E, Corsiero E et al. (2022). POS0439 STROMAL B-CELL CROSSTALK PROMOTES THE ESTABLISHMENT OF SYNOVIAL B CELL NICHES THROUGH THE SELECTION, ACTIVATION OF NATURALLY OCCURRING EBV+ B CELLS. nameOfConference


  • Nerviani A, Boutet MA, Ghirardi GM et al. (2022). POS0441 IN-DEPTH ANALYSIS OF Axl AND MerTK EXPRESSION PATTERNS AND REGULATION BY BIOLOGIC TREATMENTS IN RHEUMATOID ARTHRITIS. nameOfConference


  • Rivellese F, Surace AEA, Goldmann K et al. (2022). Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial. nameOfConference


  • Isaacs JD, Brockbank S, Pedersen AW et al. (publicationYear). RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients. nameOfConference


  • Banda NK, Deane KD, Seifert J et al. (2022). A Snap Shot of Complement Gene Expression and Presence of Complement Proteins in Synovial Biopsies from Early Rheumatoid Arthritis Patients. nameOfConference


    QMRO: qmroHref
  • Meednu N, Rangel-Moreno J, Zhang F et al. (2022). Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression. nameOfConference


  • Pistorius K, Ly L, Souza PR et al. (2022). MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis. nameOfConference


  • Thorup A-S, Wilson J, Strachan D et al. (2022). BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS, IN PART BY MODULATING YAP SIGNALLING. nameOfConference


  • Carlucci PM, Li J, Fava A et al. (2022). High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership. nameOfConference


  • Najm A, Costantino F, Alivernini S et al. (2022). EULAR points to consider for minimal reporting requirements in synovial tissue research in rheumatology. nameOfConference


  • Micheroli R, Elhai M, Edalat S et al. (2022). Role of synovial fibroblast subsets across synovial pathotypes in rheumatoid arthritis: a deconvolution analysis. nameOfConference


  • Iakovliev A, Ling SF, Colombo M et al. (2022). Association of Genetic Loci for Human Plasma Proteins with Response to Treatment in People with Rheumatoid Arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Rivellese F, Pitzalis C (2022). Cellular and molecular diversity in Rheumatoid Arthritis. nameOfConference


  • Banda N, Deane K, Seifert J et al. (2022). Complement gene expression and biodistribution of complement proteins in the synovium from early rheumatoid arthritis patients. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pupim L, Burmester G, Fang F et al. (2022). Dose-dependent Suppression of T Cell-Dependent Antibody Response in Healthy Volunteers by KPL-404, an Anti-CD40 Monoclonal Antibody, Supports Phase 2 Study in Patients with Rheumatoid Arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pistorius K, Souza PR, Gomez EA et al. (2022). MCTR3 reprogramming arthritic monocytes to exert pro-resolving and tissue-protective functions in inflammatory arthritis. nameOfConference

    DOI: doi

  • Rivellese F, Pontarini E, Cubuk C et al. (2022). Module Signatures of Synovial Single-cell States Identify Disease Phenotypes in Early Treatment-naive Rheumatoid Arthritis. nameOfConference

    DOI: doi

  • Pontarini E, Chowdhury F, Sciacca E et al. (2022). RITUXIMAB PREVENTS WORSENING OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EXCRETORY FUNCTION IN PRIMARY SJOGREN'S SYNDROME: RESULTS FROM THE TRACTISS TRIAL. nameOfConference

    DOI: doi

  • Prediletto E, Cubuk C, Pontarini E et al. (2022). Rheumatoid Synovial Fibroblasts Display Imprinted Memory of Their Synovial Endotype Which Can Be Plastically Modulated by B-cells Crosstalk. nameOfConference

    DOI: doi

  • Dunlap G, Wagner A, Meednu N et al. (2022). Single-Cell Characterization of the TCR Repertoire Across Tissue and Blood in Rheumatoid Arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Wagner A, Meednu N, Dunlap G et al. (2022). Single-cell Profiling of B Cell Repertoire and Gene Expression in the RA Synovium Reveals Tissue Specific Clonal Expansion. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pitzalis C, Hands R, Venuturupalli S et al. (2022). Tc99m Tilmanocept Imaging Can Differentiate the Fibroid Pathotype of Rheumatoid Arthritis from Non-Fibroid Pathotypes in Patients. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Dejaco C, Machado PM, Carubbi F et al. (2022). EULAR points to consider for the use of imaging to guide interventional procedures in patients with rheumatic and musculoskeletal diseases (RMDs). nameOfConference


    QMRO: qmroHref
  • Iqbal AJ, Krautter F, Blacksell IA et al. (2022). Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner. nameOfConference


  • Barnes M, Brockbank S, Bruce IN et al. (2021). Characterization of disease course and remission in early seropositive rheumatoid arthritis: results from the TACERA longitudinal cohort study. nameOfConference


  • Coleby R, Lucchesi D, Pontarini E et al. (2021). Stepwise changes in the murine salivary gland immune response during virally-induced ectopic lymphoid structure formation.. nameOfConference


  • Pontarini E, Chowdhury F, Sciacca E et al. (2021). OP0136 RITUXIMAB PREVENTS THE PROGRESSION OF B-CELL DRIVEN INFLAMMATORY INFILTRATE IN THE MINOR SALIVARY GLANDS OF PRIMARY SJOGREN’S SYNDROME BY DOWNREGULATING IMMUNOLOGICAL PATHWAYS KEY IN ECTOPIC GERMINAL CENTRE ORGANIZATION: RESULTS FROM THE TRACTISS TRIAL. nameOfConference


  • Pontarini E, Sciacca E, Grigoriadou S et al. (publicationYear). NKp30 Receptor Upregulation in Salivary Glands of Sjögren’s Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment. nameOfConference


  • Deonaraine KK, Carlucci PM, Fava A et al. (2021). Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network. nameOfConference


  • Serrano-Blesa E, Porter A, Lendrem DW et al. (2021). Robust optimization of SWATH-MS workflow for human blood serum proteome analysis using a quality by design approach. nameOfConference


  • Silva‐Gomes R, Mapelli SN, Boutet M et al. (2022). Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions. nameOfConference


  • Boutet M-A, Nerviani A, Lliso-Ribera G et al. (publicationYear). Circulating and Synovial Pentraxin-3 (PTX3) Expression Levels Correlate With Rheumatoid Arthritis Severity and Tissue Infiltration Independently of Conventional Treatments Response. nameOfConference


  • Colombo F, Corsiero E, Lewis MJ et al. (publicationYear). Generation of restriction endonucleases barcode map to trace SARS-CoV-2 origin and evolution. nameOfConference


  • Eldridge S, Barawi A, Wang H et al. (2021). AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO. nameOfConference


  • Rivellese F, Pontarini E, Fossati-Jimack L et al. (2021). OP0011 INTEGRATION OF FLOW AND DIGITAL CYTOMETRY IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS IDENTIFIES DISTINCT IMMUNOPHENOTYPES IN PERIPHERAL BLOOD AND DISEASE TISSUE. nameOfConference


  • Thorup AS, Strachan D, Caxaria S et al. (2021). OP0200 BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS. nameOfConference


    QMRO: qmroHref
  • Pagani S, Colombo F, Pitzalis C (2021). POS0206 DESIGN AND CHARACTERISATION OF A THERAPEUTIC BISPECIFIC TANDEM scFv-Fc FUSION PROTEIN WITH ANTI-TNF AND SYNOVIUM-TARGETING SPECIFICITY FOR THE TREATMENT OF RHEUMATOID ARTHRITIS. nameOfConference


    QMRO: qmroHref
  • Thomas B, Eldridge S, Nosrati B et al. (2021). WNT3A-loaded exosomes enable cartilage repair. nameOfConference


  • Meednu N, Rangel-Moreno J, Zhang F et al. (publicationYear). Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression. nameOfConference


  • Fanelli G, Romano M, Nova-Lamperti E et al. (publicationYear). PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype. nameOfConference


  • Serrano-Blesa E, Porter A, Lendrem DW et al. (publicationYear). Robust Optimization of SWATH-MS workflow for human blood serum proteome analysis using a Quality by Design approach. nameOfConference


    QMRO: qmroHref
  • Rivellese F, Manou-Stathopoulou S, Mauro D et al. (2021). Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus. nameOfConference


  • Nalesso G, Thorup A-S, Eldridge SE et al. (publicationYear). Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis. nameOfConference


  • Ferrari M, Onuoha SC, Fossati-Jimack L et al. (2021). Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis. nameOfConference


  • Pitzalis C, Humby F, Rivellese F et al. (2021). Rituximab versus Tocilizumab in anti-TNF inadequate responder patients with Rheumatoid Arthritis (R4RA): a stratified, biopsy-driven, multi-centre, randomised, open label, controlled clinical trial – 16 week outcomes Article (Randomised Controlled Trial). nameOfConference

    DOI: doi

  • Boutet M-A, Courties G, Nerviani A et al. (2021). Novel insights into macrophage diversity in rheumatoid arthritis synovium. nameOfConference


    QMRO: qmroHref
  • Silva-Gomes R, Mapelli SN, Boutet M-A et al. (2021). Expression and regulation of MS4A molecules in myeloid cells. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Boutet MA, Nerviani A, Ribera GL et al. (2021). Pentraxin-3 (PTX3) circulating and synovial expression levels correlate with rheumatoid arthritis severity and tissue infiltration independently of the response to conventional treatments. nameOfConference

    DOI: doi

  • Pontarini E, Chowdhury F, Sciacca E et al. (2021). Rituximab Prevents the Progression of B-cell Driven Inflammatory Infiltrate in the Minor Salivary Glands of Primary Sjogren's Syndrome by Downregulating Immunological Pathways Key in Ectopic Germinal Centre Organization: Results from the TRACTISS Trial. nameOfConference

    DOI: doi

  • Humby F, Durez P, Buch MH et al. (2021). Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial. nameOfConference


  • Meednu N, Wagner A, Dunlap G et al. (2021). Single-cell Profiling of B and T Cell Repertoire and Gene Expression in the RA Synovium Reveals Tissue Specific Clonal Expansion. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Romão VC, Fonseca JE, Pitzalis C (2021). Elderly-onset rheumatoid arthritis is a unique disease subset associated with poor overall outcomes: Response to the letter by Haroon and Ayamer. nameOfConference


    QMRO: qmroHref
  • Giacomelli R, Afeltra A, Bartoloni E et al. (2021). The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus. nameOfConference


  • Fahmi A, MacBrayne A, Kyrimi E et al. (2020). Causal Bayesian Networks for Medical Diagnosis: A Case Study in Rheumatoid Arthritis. 2020 IEEE International Conference on Healthcare Informatics (ICHI)


    QMRO: qmroHref
  • Nerviani A, Boutet M-A, Tan WSG et al. (2020). IL-23 skin and joint profiling in Psoriatic Arthritis: novel perspectives in understanding clinical responses to IL-23 inhibitors. nameOfConference


  • Sciacca E, Surace A, Lewis M et al. (2020). Novel Network Tool Highlights Key Features Associated with Disease Pathotypes and Response to Treatment in Early Rheumatoid Arthritis. ACR Convergence 2020


  • Gomez EA, Colas RA, Souza PR et al. (publicationYear). Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis. nameOfConference


  • Pontarini E, Murray-Brown WJ, Croia C et al. (2020). Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren’s syndrome with ectopic germinal centres and MALT lymphoma. nameOfConference


  • Thorup A-S, Strachan D, Caxaria S et al. (2020). ROR2 blockade as a therapy for osteoarthritis. nameOfConference


  • Pitzalis C, Choy EHS, Buch MH (2020). Transforming clinical trials in rheumatology: towards patient-centric precision medicine. nameOfConference


    QMRO: qmroHref
  • Eldridge SE, Barawi A, Wang H et al. (2020). Agrin induces long term osteochondral regeneration by supporting repair morphogenesis. nameOfConference


  • Cherlin S, Lewis MJ, Plant D et al. (2020). Investigation of genetically regulated gene expression and response to treatment in rheumatoid arthritis highlights an association between IL18RAP expression and treatment response. nameOfConference


  • Lucchesi D, Coleby R, Pontarini E et al. (2020). Impaired Interleukin‐27–Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome. nameOfConference


  • Rivellese F, Rossi FW, Giorli G et al. (2020). Persistence of Mast Cell-Positive Synovitis in Early Rheumatoid Arthritis Following Treatment With Conventional Synthetic Disease Modifying Anti-Rheumatic Drugs. nameOfConference


  • Alivernini S, MacDonald L, Elmesmari A et al. (2020). Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. nameOfConference


  • Svensson MND, Zoccheddu M, Yang S et al. (2020). Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. nameOfConference


    QMRO: qmroHref
  • Bellan M, Quaglia M, Nerviani A et al. (2021). Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis.. nameOfConference


  • Rivellese F, Humby F, Lliso Ribera G et al. (2020). OP0217 INVOLVEMENT OF LARGE JOINTS AT DISEASE PRESENTATION IS ASSOCIATED WITH DIVERSE HISTOPATHOLOGICAL FEATURES AND CLINICAL OUTCOMES IN EARLY RHEUMATOID ARTHRITIS. nameOfConference


  • Nerviani A, Boutet MA, Ghirardi GM et al. (2020). THU0082 MERTK SYNOVIAL EXPRESSION CORRELATES WITH TREATMENT RESPONSE IN RHEUMATOID ARTHRITIS. nameOfConference


    QMRO: qmroHref
  • Rivellese F, Pontarini E, Pitzalis C (2020). Tertiary Lymphoid Organs in Rheumatoid Arthritis.. nameOfConference


  • Romão VC, Humby F, Kelly S et al. (2020). Treatment-resistant synovitis and radiographic progression are increased in elderly-onset rheumatoid arthritis patients: findings from a prospective observational longitudinal early arthritis cohort study. nameOfConference


    QMRO: qmroHref
  • Nerviani A, Di Cicco M, Mahto A et al. (publicationYear). A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients. nameOfConference


  • Corsiero E, Carlotti E, Jagemann L et al. (2020). H and L Chain Affinity Maturation and/or Fab N-Glycosylation Influence Immunoreactivity toward Neutrophil Extracellular Trap Antigens in Rheumatoid Arthritis Synovial B Cell Clones. nameOfConference


    QMRO: qmroHref
  • Wei K, Korsunsky I, Marshall JL et al. (2020). Notch signalling drives synovial fibroblast identity and arthritis pathology. nameOfConference


    QMRO: qmroHref
  • Humby FC, Lewis M, Durez P et al. (2020). O07 Randomised, open labelled clinical trial to investigate synovial mechanisms determining response: resistance to rituximab versus tocilizumab in RA patients failing TNF inhibitor therapy. nameOfConference


  • Nerviani A, Lliso-Ribera G, Boutet M-A et al. (2020). O20 Histological and molecular features of the diseased synovium in early untreated PsA in comparison with RA. nameOfConference


  • Lucchesi D, Coleby R, Pontarini E et al. (2020). O31 IL-27 regulates the magnitude of ectopic germinal centres in experimental sialadenitis but fails to modulate IL-17 and IFNg production in CD4 T cells from patients with Sjögren's syndrome. nameOfConference


  • MacBrayne ACB, Pott J, Petrovic V et al. (2020). P214 Preliminary results: driving improvements in disease outcomes for rheumatoid arthritis patients using remote disease activity monitoring via smartphone app. nameOfConference


    QMRO: qmroHref
  • Rivellese F, Humby F, Bugatti S et al. (2020). P233 B cell-rich synovitis in early and established rheumatoid arthritis. nameOfConference


    QMRO: qmroHref
  • Sciacca E, Alaimo S, Pulvirenti A et al. (2020). P22 Micro-RNA enriched pathway impact analysis applied to synovial RNA-seq in early rheumatoid arthritis identifies response prediction pathways. British Society for Rheumatology Annual Conference 2020


  • Rivellese F, Humby F, Bugatti S et al. (publicationYear). B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.. nameOfConference


  • Huizinga TW, Holers VM, Anolik J et al. (2020). Disruptive innovation in rheumatology: new networks of global public–private partnerships are needed to take advantage of scientific progress. nameOfConference


    QMRO: qmroHref
  • Pernicova I, Kelly S, Ajodha S et al. (2020). Metformin to reduce metabolic complications and inflammation in patients on systemic glucocorticoid therapy: a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial.. nameOfConference


  • John CR, Watson D, Russ D et al. (2020). M3C: Monte Carlo reference-based consensus clustering. nameOfConference


  • Pagani S, Bellan M, Mauro D et al. (2020). New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis. nameOfConference


  • Muñoz-Atienza E, Flak MB, Sirr J et al. (2020). The P. gingivalis Autocitrullinome Is Not a Target for ACPA in Early Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • Rivellese F, Humby F, Bugatti S et al. (2020). B CELL-RICH SYNOVITIS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS. nameOfConference

    DOI: doi

  • Nerviani A, Lliso-Ribera G, Boutet M-A et al. (2020). HISTOLOGICAL AND MOLECULAR FEATURES OF THE DISEASED SYNOVIUM IN EARLY UNTREATED PSA IN COMPARISON WITH RA. nameOfConference

    DOI: doi

  • Rivellese F, Humby F, Giorli G et al. (2020). Histo-pathological Cellular Markers of Treatment Response to Rituximab and Tocilizumab in Matched Pre- and Post-treatment Synovial Biopsies from the R4RA Randomised Clinical Trial in Rheumatoid Arthritis. nameOfConference

    DOI: doi

  • Lucchesi D, Coleby R, Pontarini E et al. (2020). IL-27 REGULATES THE MAGNITUDE OF ECTOPIC GERMINAL CENTRES IN EXPERIMENTAL SIALADENITIS BUT FAILS TO MODULATE IL-17 AND IFNG PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJOGREN'S SYNDROME. nameOfConference

    DOI: doi

  • Nerviani A, Boutet M-A, Ghirardi GM et al. (2020). MerTK Synovial Expression Correlates with Disease Activity and Treatment Response in Rheumatoid Arthritis Patients. nameOfConference

    DOI: doi

  • MacBrayne ACB, Pott J, Petrovic V et al. (2020). PRELIMINARY RESULTS: DRIVING IMPROVEMENTS IN DISEASE OUTCOMES FOR RHEUMATOID ARTHRITIS PATIENTS USING REMOTE DISEASE ACTIVITY MONITORING VIA SMARTPHONE APP. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Humby FC, Lewis M, Durez P et al. (2020). RANDOMISED, OPEN LABELLED CLINICAL TRIAL TO INVESTIGATE SYNOVIAL MECHANISMS DETERMINING RESPONSE: RESISTANCE TO RITUXIMAB VERSUS TOCILIZUMAB IN RA PATIENTS FAILING TNF INHIBITOR THERAPY. nameOfConference

    DOI: doi

  • Meednu N, Zhang F, Escalera-Rivera K et al. (2020). Role of NR4A Nuclear Receptor Family in RA Synovial Ectopic Lymphoid Neogenesis Revealed by Single Cell Profiling. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pucino V, Certo M, Bulusu V et al. (2019). Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring. nameOfConference


  • Lliso-Ribera G, Humby F, Lewis M et al. (2019). Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC). nameOfConference


  • Tarn JR, Howard-Tripp N, Lendrem DW et al. (2019). Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials. nameOfConference


    QMRO: qmroHref
  • John CR, Watson D, Barnes MR et al. (2020). Spectrum: fast density-aware spectral clustering for single and multi-omic data. nameOfConference


  • Boutet M-A, Nerviani A, Lliso-Ribera G et al. (2019). Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis.. nameOfConference


  • Lewis MJ, Barnes MR, Blighe K et al. (2019). Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes. nameOfConference


  • Romão VC, Polido-Pereira J, Barros R et al. (2019). Efficacy, safety and sample quality of ultrasound-guided synovial needle biopsy in clinical practice and research: a prospective observational study.. nameOfConference


  • Rodríguez-Ubreva J, de la Calle-Fabregat C, Li T et al. (2019). Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis. nameOfConference


  • Humby F, Lewis M, Townsend MJ et al. (2020). Response to: ‘Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients’ by Buch et al. nameOfConference


  • Flak MB, Colas RA, Muñoz-Atienza E et al. (2019). Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis. nameOfConference


  • El Shikh MEM, El Sayed R, Nerviani A et al. (2019). Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis. nameOfConference


  • Mattiola I, Tomay F, De Pizzol M et al. (2019). The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis. nameOfConference


  • Davies K, Mirza K, Tarn J et al. (2019). Fatigue in primary Sjögren’s syndrome (pSS) is associated with lower levels of proinflammatory cytokines: a validation study. nameOfConference


    QMRO: qmroHref
  • Colombo F, Durigutto P, De Maso L et al. (2019). Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis. nameOfConference


  • Rivellese F, Humby F, Bugatti S et al. (2019). THU0058 B CELL SYNOVITIS AND CLINICAL PHENOTYPES IN RHEUMATOID ARTHRITIS AT DIFFERENT DISEASE STAGES. Annual European Congress of Rheumatology, EULAR 2019


  • Manou-Stathopoulou S, Rivellese F, Mauro D et al. (2019). AB0179 THE TRANSCRIPTION FACTORS IKZF1 AND IKZF3 CONTROL B CELL ACTIVATION AND DIFFERENTIATION IN SYSTEMIC LUPUS ERYTHEMATOSUS. Abstracts Accepted for Publication


  • Nerviani A, Ribera GL, Boutet MA et al. (2019). OP0113 HISTOLOGICAL AND MOLECULAR PORTRAIT OF THE SYNOVIAL TISSUE IN EARLY TREATMENT-NAÏVE PSORIATIC ARTHRITIS IN COMPARISON WITH RHEUMATOID ARTHRITIS. Oral Presentations


    QMRO: qmroHref
  • Ribera GL, Humby F, Nerviani A et al. (2019). OP0120 BASELINE CELLULAR AND MOLECULAR CHARACTERISTICS OF SYNOVIAL TISSUE AND RELATION WITH TNFI RESPONSE. RESULTS FROM THE PATHOBIOLOGY OF THE EARLY ARTHRITIS COHORT (PEAC). Oral Presentations


    QMRO: qmroHref
  • Lucchesi D, Coleby R, Pontarini E et al. (2019). OP0276 DENDRITIC CELL-DERIVED IL-27 REGULATES THE MAGNITUDE OF INDUCIBLE ECTOPIC GERMINAL CENTRES BUT FAILS TO DOWNMODULATE IL-17 PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJÖGREN’S SYNDROME. Oral Presentations


  • Pontarini E, Brown WM, Croia C et al. (2019). OP0279 A UNIQUE IL-21 SIGNATURE CHARACTERIZES LESIONAL AND CIRCULATING T-FOLLICULAR HELPER CELLS IN SJÖGREN’S SYNDROME PATIENTS WITH ECTOPIC GERMINAL CENTRES AND MALT LYMPHOMA. Oral Presentations


  • Purkayastha N, Ismail S, Taylor PC et al. (2019). OP0350 ULTRASOUND POWER DOPPLER SEMI-QUANTITATIVE SCORING, IS IT TIME WE MOVED TO A RED PIXEL DENSITY ALGORITHMIC PROGRAM TO DETERMINE TRUE TREATMENT RESPONSE?. Oral Presentations


    QMRO: qmroHref
  • Mauro D, Rivellese F, Manou-Stathopoulou S et al. (2019). SAT0025 THE EFFECT OF DIMETHYL FUMARATE ON PLASMABLAST DIFFERENTIATION TRANSCRIPTIONAL PROGRAMMES IN SYSTEMIC LUPUS ERYTHEMATOSUS. SATURDAY, 15 JUNE 2019


  • Nerviani A, Humby F, Ribera GL et al. (2019). THU0092 DEFINING A LEARNING CURVE FOR CLINICIANS PERFORMING ULTRASOUND-GUIDED DEFINING A LEARNING CURVE FOR CLINICIANS PERFORMING ULTRASOUND-GUIDED NEEDLE SYNOVIAL BIOPSIES: A RETROSPECTIVE ANALYSIS OF THE EXPERIENCE AT THE EXPERIMENTAL MEDICINE AND RHEUMATOLOGY, QUEEN MARY UNIVERSITY OF LONDON. Poster Presentations


  • Rivellese F, Manou-Stathopoulou S, Mauro D et al. (2019). THU0234 THE TRANSCRIPTION FACTORS IKAROS (IKZF1) AND AIOLOS (IKZF3) ARE EXPRESSED IN THE SALIVARY GLANDS OF SJÖGREN’S SYNDROME PATIENTS WITH LYMPHOID AGGREGATES AND MODULATE B CELL ACTIVATION IN VITRO. Poster Presentations


  • John CR, Watson D, Barnes M et al. (publicationYear). Spectrum: Fast density-aware spectral clustering for single and multi-omic data. nameOfConference


  • Zhang F, Wei K, Slowikowski K et al. (2019). Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. nameOfConference


    QMRO: qmroHref
  • Spiliopoulou A, Colombo M, Plant D et al. (2019). Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39. nameOfConference


    QMRO: qmroHref
  • Rivellese F, Rossi FW, Galdiero MR et al. (publicationYear). Mast Cells in Early Rheumatoid Arthritis. nameOfConference


  • Hackett KL, Davies K, Tarn J et al. (2019). Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome. nameOfConference


  • Manou-Stathopoulou S, Rivellese F, Mauro D et al. (2019). 235 IKZF1 and IKZF3 inhibition impairs B cell differentiation and modulates gene expression in systemic lupus erythematosus. Abstracts


    QMRO: qmroHref
  • Twohig JP, Cardus Figueras A, Andrews R et al. (2019). Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells. nameOfConference


  • HUMBY F (2019). Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients. nameOfConference


  • Boutet M-A, Nerviani A, Pitzalis C (publicationYear). IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential. nameOfConference


  • Boutet M-A, Nerviani A, Lliso-Ribera G et al. (2019). P125 IL-36 axis is an emerging therapeutic target in psoriatic arthritis synovial tissue. Abstracts


    QMRO: qmroHref
  • Hensor EMA, McKeigue P, Ling SF et al. (2019). Validity of a two-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis.. nameOfConference


  • Bottini A, Wu DJ, Ai R et al. (2019). PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes. nameOfConference


  • PITZALIS C, CORSIERO E, DELVECCHIO F et al. (2019). B cells in the formation of Tertiary Lymphoid Organs in autoimmunity, transplantation and tumorigenesis.. nameOfConference


  • Dorris ER, Tazzyman SJ, Moylett J et al. (2019). The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated Resolution of Inflammation. nameOfConference


  • Humby F, Buch MH, Durez P et al. (2019). A Randomised, Open Labelled Clinical Trial to Investigate Synovial Mechanisms Determining Response - Resistance to Rituximab versus Tocilizumab in Rheumatoid Arthritis Patients Failing TNF Inhibitor Therapy. nameOfConference

    DOI: doi

  • Corsiero E, Jagemann L, Perretti M et al. (2019). Characterization of calreticulin, a stromal-derived autoantigens, recognized by RA synovial recombinant monoclonal antibodies. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pucino V, Certo M, Bulusu V et al. (2019). Lactate influx into human CD4+T-cells, via SLC5A12, causes STAT3-and fatty acid synthesis-mediated IL17 expression and tissue retention. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Rivellese F, Lliso-Ribera G, Nerviani A et al. (2019). Persistence of B Cell-rich Synovitis Following Conventional Synthetic Disease Modifying Anti-Rheumatic Drug Treatment in Early Rheumatoid Arthritis Is Associated with Radiographic Progression Independently of Clinical Response. nameOfConference

    DOI: doi

  • Prediletto E, Pontarini E, Lucchesi D et al. (2019). Synovial fluid fibroblast-like synoviocytes enhance long-term survival of EBV infected memory B cells in rheumatoid arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Mauro D, Macaluso F, Nerviani A et al. (2019). The Deubiquitinase TRABID Is a Potential Therapeutic Target in Spondyloarthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Mattiola I, Tomay F, De Pizzol M et al. (2019). The macrophage tetraspan MS4A4A enhances Dectin-1-dependent NK cell-mediated resistance to metastasis. nameOfConference

    DOI: doi

  • Cope AP, Barnes MR, Belson A et al. (2018). The RA-MAP Consortium: a working model for academia-industry collaboration.. nameOfConference


  • Just SA, Humby F, Lindegaard H et al. (2018). Patient-reported outcomes and safety in patients undergoing synovial biopsy: comparison of ultrasound-guided needle biopsy, ultrasound-guided portal and forceps and arthroscopic-guided synovial biopsy techniques in five centres across Europe. nameOfConference


    QMRO: qmroHref
  • Consortium R-M (2018). Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data. nameOfConference


  • Cherlin S, Plant D, Taylor JC et al. (2018). Prediction of treatment response in rheumatoid arthritis patients using genome‐wide SNP data. nameOfConference


    QMRO: qmroHref
  • Purkayastha N, Humby F, Rocher-Ros V et al. (2019). Wrist ultrasound - the model method for grey-scale and power Doppler scoring. nameOfConference


  • Cecchinato V, D'Agostino G, Raeli L et al. (2018). Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis.. nameOfConference


    QMRO: qmroHref
  • Massey J, Plant D, Hyrich K et al. (2018). Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis. nameOfConference


    QMRO: qmroHref
  • Corsiero E, Jagemann L, Bombardieri M et al. (2018). Generation of Recombinant Monoclonal Antibodies from Single B Cells Isolated from Synovial Tissue of Rheumatoid Arthritis Patients.. nameOfConference


  • Rivellese F, Mauro D, Nerviani A et al. (2018). Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production. nameOfConference


  • Notarstefano C, Croia C, Pontarini E et al. (2018). A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sjögren's syndrome.. nameOfConference

    DOI: doi

  • PITZALIS C, CORSIERO E, JAGEMANN L et al. (2018). Characterization of a synovial B cell-derived 1 recombinant monoclonal antibody 2 targeting stromal calreticulin in the rheumatoid joints. nameOfConference


  • John C, Watson D, Russ D et al. (2018). M3C: Monte Carlo reference-based consensus clustering. nameOfConference


  • Donlin LT, Rao DA, Wei K et al. (2018). Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue. nameOfConference


    QMRO: qmroHref
  • Nerviani A, Pitzalis C (2018). Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer. nameOfConference


  • Mauro D, Tsang V, Lucey-Clayton I et al. (2018). FRI0271 Dimethyl fumarate inhibits ube2l3 mediated tlr7 signalling and autoreactive b cell development in sle. FRIDAY, 15 JUNE 2018


  • Lliso-Ribera G, Humby F, Nerviani A et al. (2018). OP0040 Synovial cell infiltration in acpa-ve patients displays similar signatures to other seronegative inflammatory arthritis. results from the pathobiology of early arthritis cohort (PEAC). WEDNESDAY, 13 JUNE 2018


    QMRO: qmroHref
  • Just SA, Humby F, Lindegaard H et al. (2018). OP0278-HPR Patient reported outcomes and safety in patients undergoing synovial biopsy: comparison of arthroscopic, ultrasound-guided portal-forceps and ultrasound-guided needle biopsy techniques, in five centres across europe. FRIDAY, 15 JUNE 2018


    QMRO: qmroHref
  • Boutet M-A, Nerviani A, Lliso-Ribera G et al. (2018). SAT0024 Il-36 axis is an emerging therapeutic target in psoriatic arthritis synovial tissue. Saturday, 16 JUNE 2018


    QMRO: qmroHref
  • Ruiz-Romero C, Picchi F, González-Rodríguez L et al. (2018). SAT0074 Identification of a protein panel useful for the prediction of response to methotrexate in rheumatoid arthritis patients. Saturday, 16 JUNE 2018


    QMRO: qmroHref
  • Rivellese F, Nerviani A, Mauro D et al. (2018). SAT0076 Synovial mast cells and responses to synthetic and biologic dmards in early and established rheumatoid arthritis. Saturday, 16 JUNE 2018


  • Ruiz-Romero C, Picchi F, Fernández-Puente P et al. (2018). THU0052 A circulating protein signature correlates with synovial pathotypes in rheumatoid arthritis patients. THURSDAY, 14 JUNE 2018


    QMRO: qmroHref
  • Nerviani A, Mauro D, Pagani S et al. (2018). THU0061 Restricted axl synovial expression and increased cleavage of axl ectodomain correlate with highly inflamed synovitis and more severe rheumatoid arthritis. THURSDAY, 14 JUNE 2018


  • Rivellese F, Congia M, Mauro D et al. (2018). THU0070 The transcription factors ikaros and aiolos are expressed in the synovial membrane of early rheumatoid arthritis patients in association with synovial lymphoid aggregates. THURSDAY, 14 JUNE 2018


  • Purkayastha N, Tan WS, Mahto A et al. (2018). THU0122 Imaging characterisation of remission in rheumatoid arthritis. THURSDAY, 14 JUNE 2018


    QMRO: qmroHref
  • Taylor JC, Bongartz T, Massey J et al. (2018). Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients. nameOfConference


  • Mandelin AM, Homan PJ, Shaffer AM et al. (2018). Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound‐Guided Synovial Biopsies in Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • Cole S, Walsh A, Yin X et al. (2018). Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus. nameOfConference


  • Ribera GL, Humby F, Kelly S et al. (2018). 244 The clinical phenotype of inflammatory arthritis correlates with synovial immune cell infiltration: results from the pathobiology of early arthritis cohort. nameOfConference


    QMRO: qmroHref
  • Massey J, Plant D, Hyrich K et al. (2018). 248 Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis. nameOfConference


    QMRO: qmroHref
  • Ribera GL, Humby F, Kelly S et al. (2018). O09 A lymphoid pathotype at baseline, in early inflammatory arthritis, significantly associates with requirement for biologic therapy at 12 months follow up: results from the pathobiology of early arthritis cohort. nameOfConference


    QMRO: qmroHref
  • Hensor EMA, McKeigue P, Buch MH et al. (2018). O12 Validity of a2-component imaging-derived disease activity score (2C-DAS28) for improved assessment of synovitis in early rheumatoid arthritis. nameOfConference


    QMRO: qmroHref
  • Fisher BA, Emery P, Pitzalis C et al. (2019). Response to: Can ultrasound of the major salivary glands assess histopathological changes induced by treatment with rituximab in primary Sjögren’s syndrome?. nameOfConference


  • Humby F, Romão VC, Manzo A et al. (2018). A Multicenter Retrospective Analysis Evaluating Performance of Synovial Biopsy Techniques in Patients With Inflammatory Arthritis. nameOfConference


  • Thomas BL, Jones HR, Norling LV et al. (2018). Neutrophil extracellular vesicles have a cartilage protective effect during inflammatory arthritis. nameOfConference


    QMRO: qmroHref
  • Fallas MA, Caxaria S, Sherwood J et al. (2018). The role of GCP-2 in cartilage differentiation and repair. nameOfConference


    QMRO: qmroHref
  • James K, Chipeta C, Parker A et al. (2018). B-cell activity markers are associated with different disease activity domains in primary Sjögren’s syndrome. nameOfConference


    QMRO: qmroHref
  • Guo Y, Walsh AM, Canavan M et al. (2018). Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.. nameOfConference


  • Shikh ME, Sayed RE, Fossati-Jimack L et al. (2018). O001 Lymphoid tissue macrophages express peptidylarginine deiminase 2 and 4: new implications in citrullination and anti-citrulline antibodies production in autoimmune arthritis. Oral presentations


    QMRO: qmroHref
  • Lucchesi D, Pontarini E, Coleby R et al. (2018). P079 Interleukin-27 regulates the magnitude of the ectopic germinal centre response in a viral-inducible model of sialadenitis. Poster presentations


    QMRO: qmroHref
  • Boutet M-A, Nerviani A, Afflitto GG et al. (publicationYear). Role of the IL-23/IL-17 Axis in Psoriasis and Psoriatic Arthritis: The Clinical Importance of Its Divergence in Skin and Joints. nameOfConference


  • Dumusc A, Ng W-F, James K et al. (2018). Comparison of ESSDAI and ClinESSDAI in potential optimisation of trial outcomes in primary Sjögren’s syndrome: examination of data from the UK Primary Sjögren’s Syndrome Registry. nameOfConference


  • Rhys HI, Dell'Accio F, Pitzalis C et al. (2018). Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. nameOfConference


  • Ribera GL, Humby F, Kelly S et al. (2018). A LYMPHOID PATHOTYPE AT BASELINE, IN EARLY INFLAMMATORY ARTHRITIS, SIGNIFICANTLY ASSOCIATES WITH REQUIREMENT FOR BIOLOGIC THERAPY AT 12 MONTHS FOLLOW UP: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Notarstefano C, Croia C, Pontarini E et al. (2018). A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sjogren's syndrome. nameOfConference

    DOI: doi

  • Nerviani A, Humby F, Ribera GL et al. (2018). Comparative Histologic and Molecular Analysis of Synovial Tissue in Early Treatment-Naive Psoriatic and Rheumatoid Arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Rivellese F, Mauro D, Congia M et al. (2018). Expression and Functions of the Transcription Factors Ikaros and Aiolos in Sjogren's Syndrome and Systemic Lupus Erythematosus. nameOfConference

    DOI: doi

  • Massey J, Plant D, Hyrich K et al. (2018). GENOME-WIDE ASSOCIATION STUDY OF RESPONSE TO TUMOUR NECROSIS FACTOR INHIBITOR THERAPY IN RHEUMATOID ARTHRITIS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ruiz-Romero C, Picchi F, Fernandez P et al. (2018). Identification of a Panel of Circulating Proteins Associated to Synovial Pathotypes in Early Rheumatoid Arthritis Patients. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ruiz-Romero C, Picchi F, Gonzalez L et al. (2018). Identification of a Protein Profile Useful to Predict Response to Methotrexate in Early Rheumatoid Arthritis Patients. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Cole S, Walsh A, Yin X et al. (2018). Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich rheumatoid arthritis, pre-rheumatoid arthritis and systemic lupus erythematosus. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Lucchesi D, Pontarini E, Coleby R et al. (2018). Interleukin-27 regulates the magnitude of the ectopic germinal centre response in a virus-induced murine model of sialadenitis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bottini A, Wu DJ, Ai R et al. (2018). Non-Receptor Protein Tyrosine Phosphatase 14 (PTPN14) Promotes YAP-Dependent Tgfbeta Signaling in RA FLS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Corsiero E, Jagemann L, Pontarini E et al. (2018). Single-cell VH and VL Ig gene analysis reveal clonal relationship between IgM plus neoplastic B cells and plasmablasts in SS patients with parotid MALT lymphoma. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pontarini E, Murray-Brown W, Croia C et al. (2018). T follicular-helper cells (TFH) enrichment and follicular T regulatory cells (TFR) exclusion from ectopic germinal centers in salivary glands of Sjogren's Syndrome patients. nameOfConference

    DOI: doi

  • Ribera GL, Humby F, Kelly S et al. (2018). THE CLINICAL PHENOTYPE OF INFLAMMATORY ARTHRITIS CORRELATES WITH SYNOVIAL IMMUNE CELL INFILTRATION: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Fisher BA, Everett CC, Rout J et al. (2018). Effect of rituximab on a salivary gland ultrasound score in primary Sjögren’s syndrome: results of the TRACTISS randomised double-blind multicentre substudy. nameOfConference


  • Bezzina OM, Gallagher P, Mitchell S et al. (2017). Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy.. nameOfConference


  • Lownik JC, Luker AJ, Damle SR et al. (2017). ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses. nameOfConference


  • Orr C, Vieira-Sousa E, Boyle DL et al. (2017). Erratum: Synovial tissue research: a state-of-the-art review. nameOfConference


    QMRO: qmroHref
  • Balasubramaniam G, Parker T, Turner D et al. (2017). Feasibility randomised multicentre, double-blind, double-dummy controlled trial of anakinra, an interleukin-1 receptor antagonist versus intramuscular methylprednisolone for acute gout attacks in patients with chronic kidney disease (ASGARD): protocol study.. nameOfConference


  • Oni C, Mitchell S, James K et al. (2017). Eligibility for clinical trials in primary Sjögren’s syndrome: lessons from the UK Primary Sjögren’s Syndrome Registry. nameOfConference


  • Rauber S, Luber M, Weber S et al. (2017). Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells. nameOfConference


  • Humby F, Mahto A, Ahmed M et al. (2017). The Relationship Between Synovial Pathobiology and Magnetic Resonance Imaging Abnormalities in Rheumatoid Arthritis: A Systematic Review.. nameOfConference


  • Ursini F, Leporini C, Bene F et al. (publicationYear). Anti-TNF-alpha agents and endothelial function in rheumatoid arthritis: a systematic review and meta-analysis. nameOfConference


  • Orr C, Vieira-Sousa E, Boyle DL et al. (2017). Synovial tissue research: a state-of-the-art review. nameOfConference


  • Mandelin A, Homan P, Cuda C et al. (2017). AB0220 The promise of ultrasound guided minimally invasive synovial biopsies in the united states. Abstracts Accepted for Publication


    QMRO: qmroHref
  • Fisher B, Everett C, Rout J et al. (2017). AB0444 Effect of rituximab on a salivary gland ultrasound score in primary sjÖgren's syndrome: results of the tractiss multicentre randomised trial sub-study. Abstracts Accepted for Publication


    QMRO: qmroHref
  • Rivellese F, Humby F, Nerviani A et al. (2017). FRI0030 Synovial mast cells identify patients with a severe phenotype in a cohort of dmard naÏve patients with early rheumatoid arthritis. Poster Presentations


  • Pucino V, Smith J, Cucchi D et al. (2017). FRI0076 LACTATE/SLC5A12-induced metabolic signalling network: a new target in rheumatoid arthritis. Poster Presentations


    QMRO: qmroHref
  • Lliso-Ribera G, Humby F, Kelly S et al. (2017). FRI0088 Synovial pathobiology correlates with diagnostic subgroups in early inflammatory arthritis: results from the pathobiology of early arthritis cohort (PEAC). Poster Presentations


    QMRO: qmroHref
  • Corsiero E, Jagemann L, Prediletto E et al. (2017). OP0175 Characterization of novel stromal-derived autoantigens recognized by ra synovial monoclonal antibodies. Oral Presentations


    QMRO: qmroHref
  • Pontarini E, Murray-Brown W, Croia C et al. (2017). OP0300 Enrichment of T follicular-helper cells (TFH) and exclusion of t follicular-regulatory cells (TFR) from ectoPIC germinal centers in salivary glands of sjogren's syndrome patients. Oral Presentations


  • Walsh A, Canavan M, Guo Y et al. (2017). THU0011 Immune signal 2 checkpoint molecule expression in rheumatoid arthritis disease progression. Poster Presentations


    QMRO: qmroHref
  • Lliso-Ribera G, Humby F, Kelly S et al. (2017). THU0100 In early inflammatory arthritis a lymphoid pathotype signficantly associates with requirement for biologic therapy at 12 months follow up: results from the pathobiology of early arthritis cohort (PEAC). Poster Presentations


    QMRO: qmroHref
  • Humby F, Bugatti S, Filer A et al. (2017). THU0667 A qualitative and quantitative comparison of synovial biopsy techniques during clinical trials of inflammatory arthritis. Poster Presentations


    QMRO: qmroHref
  • Muñoz-Atienza E, Aduse-Opoku J, Flak MB et al. (2017). Generation and characterisation of Porphyromonas gingivalis mutant lacking peptidylarginine deiminase activity. nameOfConference


    QMRO: qmroHref
  • El Shikh MEM, El Sayed R, Pitzalis C (publicationYear). Isolation and Characterization of Mouse and Human Follicular Dendritic Cells.. nameOfConference


  • Guo Y, Walsh AM, Fearon U et al. (2017). CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression. nameOfConference


    QMRO: qmroHref
  • Humby FC, Al Balushi F, Lliso G et al. (2017). Can Synovial Pathobiology Integrate with Current Clinical and Imaging Prediction Models to Achieve Personalized Health Care in Rheumatoid Arthritis?. nameOfConference


  • Rivellese F, Nerviani A, Rossi FW et al. (2017). Mast cells in rheumatoid arthritis: friends or foes?. nameOfConference


  • Thorup A-S, Eldridge SE, Caxaria S et al. (2017). A Potency Assay for Assessing the Chondrogenic Efficiency of Bioactive Molecules in Human Cartilage in vivo. nameOfConference


    QMRO: qmroHref
  • Eldridge SE, Thomas BL, Shanmuganathan K et al. (2017). Agrin inhibits canonical WNT signalling through LRP4. nameOfConference


    QMRO: qmroHref
  • Kaneva MK, Greco KV, Headland SE et al. (2017). Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates. nameOfConference


  • Caxaria S, Sherwood J, Roeder E et al. (2017). The Role of CXCl6 in Cartilage Development and Homeostasis. nameOfConference


    QMRO: qmroHref
  • Thomas BL, Nalesso G, Eldridge SE et al. (2017). WNT16 is up-regulated in the joint following inflammation. nameOfConference


    QMRO: qmroHref
  • Bowman SJ, Everett CC, O'Dwyer JL et al. (2017). Randomized Controlled Trial of Rituximab and cost-effectiveness analysis in treating fatigue and oral dryness in primary Sjogren's Syndrome.. nameOfConference


  • Corsiero E, Jagemann L, Prediletto E et al. (2017). 08.34 Ra synovial recombinant monoclonal antibodies from single b cells target citrullinated calreticulin. Autoimmune inflammation


  • Lucchesi D, Pontarini E, Pitzalis C et al. (2017). MYELOID CELLS DRIVE EARLY INFLAMMATION AND ORCHESTRATE SALIVARY GLANDS TERTIARY LYMPHOID STRUCTURES FORMATION IN A MODEL OF INDUCIBLE SIALADENITIS. EWRR


    QMRO: qmroHref
  • Bombardieri M, Lewis M, Pitzalis C (publicationYear). Ectopic lymphoid neogenesis in rheumatic autoimmune diseases. nameOfConference


  • Zhang F, Slowikowski K, Fonseka C et al. (2017). A Novel Statistical Method to Resolve Cellular Heterogeneity in Disease Tissues: Integrating Transcriptomic Data in Accelerating Medicines Partnership (AMP) - RA Network Phase 1 Data. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Eldridge S, Thomas B, Roelofs A et al. (2017). Agrin is a potent WNT inhibitor which supports the healing of osteochondral defects. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Corsiero E, Jagemann L, Pitzalis C et al. (2017). Characterization of Novel Stromal-Derived Autoantigens Recognized By RA Synovial Monoclonal Antibodies. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Fisher B, Everett C, Rout J et al. (2017). Effect of Rituximab on a Salivary Gland Ultrasound Score in Primary Sjgren's Syndrome: Results of Multicentre Double-Blind Randomised Controlled Trial Sub-Study. nameOfConference

    DOI: doi

  • Hill D, Liu X, Uceda J et al. (2017). Global transcriptomic analysis identifies cytokineregulated pathways that determine discrete synovial pathotypes in inflammatory arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Rauber S, Luber M, Weber S et al. (2017). IL-9-Producing Innate Lymphoid Cells - Keyplayers That Orchestrate Resolution of Chronic Inflammation in Arthritis. nameOfConference

    DOI: doi

  • Davies K, Mirza K, Tarn J et al. (2017). Longitudinal Analysis of Different Therapeutic Strategies in Patients with Primary Sjogren's Syndrome. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Rao D, Donlin LT, Wei K et al. (2017). Methods for Generating Multiple High-Dimensional Analyses of Cryopreserved Synovial Tissue Developed By the Accelerating Medicines Partnership RA/SLE Network. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Rivellese F, Humby F, Pagani S et al. (2017). Persistence of Mast Cell-Rich Synovitis Is Associated with Lack of Response to Synthetic Disease Modifying Anti-Rheumatic Drugs in Patients with Early Rheumatoid Arthritis. nameOfConference

    DOI: doi

  • Mauro D, Tsang V, Clayton-Lucey IA et al. (2017). Regulation of TLR7 Signalling By UBE2L3 Dependent Linear Ubiquitination Explains Dimethyl Fumarate Suppression of Autoreactive B Cell Development in SLE. nameOfConference

    DOI: doi

  • Secchi C, Doody KM, Svensson MND et al. (2017). Synergistic Reversal of Arthritis By Synoviocyte-Targeted Therapy and TNF Immunomodulation. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pontarini E, Brown WM, Croia C et al. (2017). T Follicular- Helper CELLS (TFH) Enrichment and T Follicular-Regulatory CELLS (TFR) Exclusion from Ectopic Germinal Centers in Salivary Glands of Sjogren's Syndrome Patients. nameOfConference

    DOI: doi

  • Homan PJ, Mandelin AMII, Dominguez S et al. (2017). Transcriptional Profiling of Synovial Macrophages from RA Patients to Capture Disease Heterogeneity. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nerviani A, Pagani S, Mauro D et al. (2017). Tyrosine Kinase Receptor Axl Is Down Regulated in Highly Inflamed Rheumatoid Synovium and Negatively Correlates with Markers of Disease Activity. nameOfConference

    DOI: doi

  • Wei K, Rao D, Zhang F et al. (2017). Using Flow and Mass Cytometry to Demonstrate Robust Tissue Processing to Query Molecular Heterogeneity in Phase 1 of the Accelerating Medicines Partnership (AMP) - RA Network. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ng W-F, Miller A, Bowman SJ et al. (2017). Physical activity but not sedentary activity is reduced in primary Sjögren's syndrome.. nameOfConference


  • Barton A, Pitzalis C (2017). Stratified medicine in rheumatoid arthritis—the MATURA programme. nameOfConference


    QMRO: qmroHref
  • Pucino V, Bombardieri M, Pitzalis C et al. (2017). Lactate at the crossroads of metabolism, inflammation, and autoimmunity. nameOfConference


  • Corsiero E, Nerviani A, Bombardieri M et al. (2016). Ectopic Lymphoid Structures: Powerhouse of Autoimmunity.. nameOfConference


  • Tan WSG, Kelly S, Pitzalis C (2017). Targeted therapies: what they teach us about the pathogenesis of psoriasis and psoriatic arthritis.. nameOfConference


    QMRO: qmroHref
  • Murray-Brown W, Carlotti E, Floyd J et al. (2016). Next-generation sequencing demonstrates dynamic recirculation of B cell clones in ectopic lymphoid structures of Sjogren's syndrome. European League Against Rheumatism

    DOI: doi

  • Lazarou I, Kelly S, Humby F et al. (2016). Ultrasound-guided synovial biopsy of the wrist does not alter subsequent clinical or ultrasound disease activity assessments: a prospective study for incorporation of imaging in clinical trials.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Howard Tripp N, Tarn J, Natasari A et al. (2016). Fatigue in primary Sjögren's syndrome is associated with lower levels of proinflammatory cytokines.. nameOfConference


    QMRO: qmroHref
  • Nerviani A, DiCicco M, Humby F et al. (2016). FRI0157 A Baseline Prediction Model for Response To Certolizumab-Pegol: Role of Synovial Histopathology. nameOfConference


    QMRO: qmroHref
  • Nerviani A, Tan WS, Mahto A et al. (2016). FRI0442 Histopathology of Treatment-Naïve Psoriatic Synovitis: A Comparison with Early Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • Mauro D, Lewis MJ, Pullabhatla V et al. (2016). OP0232 C1qtnf4 Mutation Identified by Exome Sequencing Is Associated with Systemic Lupus Erythematosus and Dysregulation of Tnf-Induced Apoptosis. nameOfConference


    QMRO: qmroHref
  • Humby F, Dicicco M, Kelly S et al. (2016). OP0240 Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease Progression at 12 Months: Results from The Pathobiology of Early Arthritis Cohort. nameOfConference


    QMRO: qmroHref
  • Mahto A, Humby F, Gregoriadou S et al. (2016). OP0263 Synovial B-Cell Gene Signature Predicts Response To Rituximab Therapy. nameOfConference


    QMRO: qmroHref
  • Genovese M, Fleischmann R, Furst D et al. (2016). SAT0148 Improvements in Patient-Reported Outcomes with Olokizumab Treatment in Patients with Active, Moderate To Severe Rheumatoid Arthritis Who Had Failed Previous Anti-TNF Therapy: Results from The Ra0056 Double-Blind, Randomized Controlled Study, and RA0057, Its Open-Label Extension. nameOfConference


    QMRO: qmroHref
  • Astorri E, Lucchesi D, Pitzalis C et al. (2016). Spontaneous and Inducible Animal Models of Sjögren's Syndrome. nameOfConference


    QMRO: qmroHref
  • Mauro D, Lewis MJ, Pullabhatla V et al. (2016). C1QTNF4 MUTATION IDENTIFIED BY EXOME SEQUENCING IS ASSOCIATED WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND DYSREGULATION OF TNF-INDUCED APOPTOSIS. Annual European Congress of Rheumatology EULAR 2016


    QMRO: qmroHref
  • Rivellese F, Humby F, Kelly S et al. (2016). SYNOVIAL MAST CELLS CORRELATE WITH LOCAL AND SYSTEMIC INFLAMMATION AND ARE FUNCTIONALLY ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS. EULAR 2016

    DOI: doi

  • Porter D, van Melckebeke J, Dale J et al. (2016). Tumour necrosis factor inhibition versus rituximab for patients with rheumatoid arthritis who require biological treatment (ORBIT): an open-label, randomised controlled, non-inferiority, trial.. nameOfConference


  • nalesso, thomas, sherwood JC et al. (publicationYear). WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis. nameOfConference


  • Nerviani A, DiCicco M, Kelly S et al. (2016). FIBROID SYNOVIAL PATHOTYPE AND TYROSINE KINASE AXL CORRELATE WITH POOR CLINICAL RESPONSE TO CERTOLIZUMAB PEGOL IN RHEUMATOID ARTHRITIS PATIENTS. Rheumatology 2016


    QMRO: qmroHref
  • Lepse N, Nerviani A, Pitzalis C et al. (2016). 069 T Follicular Helper–Like Cells in the Rheumatoid Arthritis Synovium are Selectively Associated with Interleukin-21 Production and Ectopic Lymphoid Structures. nameOfConference


    QMRO: qmroHref
  • Rivellese F, Humby F, Kelly S et al. (2016). 071 Synovial Mast Cells Correlate with Inflammation and Cellular Infiltration and are Associated with Ectopic Lymphoid Structures in Patients with Early Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • Lewis MJ, Vyse S, Shields AM et al. (2016). 205 Correlation of Soluble Vascular Cell Adhesion Molecule 1 with B Cell Activation and Plasma Cells in Systemic Lupus Erythematosus. nameOfConference


    QMRO: qmroHref
  • Pitzalis C (2016). I27 Stratified Medicine Approaches in Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • DiCicco M, Humby F, Kelly S et al. (2016). O49 Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease Progression at 12 Months: Results from the Pathobiology of Early Arthritis Cohort. nameOfConference


    QMRO: qmroHref
  • Lewis MJ, Vyse S, Shields AM et al. (2016). CORRELATION OF SOLUBLE VASCULAR CELL ADHESION MOLECULE 1 WITH B CELL ACTIVATION AND PLASMA CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS. British Society for Rheumatology annual conference 2016

    DOI: doi

  • Eldridge SE, Petrycki E, Pitzalis C et al. (2016). MMP3 cleaves agrin in cartilage and reduces its chondrogenic potency. nameOfConference


    QMRO: qmroHref
  • Nalesso G, Wagner K, Bertrand J et al. (2016). Pharmacological Blockade of CAMKII is Detrimental for Osteoarthritis Progression. 2016 OARSI World Congress on Osteoarthritis


    QMRO: qmroHref
  • Corsiero E, Carlotti E, Prediletto E et al. (2016). A2.04 The role of somatic hypermutation and n-glycosylation in the anti-nets immunoreactivity of ra synovial monoclonal antibodies. nameOfConference


    QMRO: qmroHref
  • Lepse N, Nerviani A, Pitzalis C et al. (2016). A2.30 TFH-like cells in the ra synovium are selectively associated with IL-21 production and ectopic lymphoid structures. nameOfConference


    QMRO: qmroHref
  • Rivellese F, de Paulis A, Marone G et al. (2016). Reply. nameOfConference


    QMRO: qmroHref
  • De Groof A, Ducreux J, Humby F et al. (2016). Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy. nameOfConference


  • Lewis MJ, Vyse S, Shields AM et al. (2016). Improved monitoring of clinical response in Systemic Lupus Erythematosus by longitudinal trend in soluble vascular cell adhesion molecule-1. nameOfConference


  • Astorri E, Lucchesi D, Pitzalis C et al. (2016). Chapter 7 Spontaneous and Inducible Animal Models of Sjögren’s Syndrome. nameOfConference


    QMRO: qmroHref
  • Oni C, Mitchell S, James K et al. (2016). Eligibility for clinical trials in primary Sjogren's syndrome: lessons from the UK Primary Sjogren's Syndrome Registry. nameOfConference


    QMRO: qmroHref
  • Guo Y, Walsh A, Fearon U et al. (2016). Gene Enrichment Analysis Identifies Active CD40-CD40L Signaling in Early and Established Rheumatoid Arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Taylor JC, Verstappen S, Wang J et al. (2016). Genome-Wide Meta-Analysis of Response to Methotrexate in Rheumatoid Arthritis Patients on behalf of the MATURA Consortium. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Jones GW, Bombardieri M, Greenhill CJ et al. (2016). Interleukin-27 inhibits synovial lymphoid neogenesis in inflammatory arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pitzalis C (2016). STRATIFIED MEDICINE APPROACHES IN RHEUMATOID ARTHRITIS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • DiCicco M, Humby F, Kelly S et al. (2016). SYNOVIAL LYMPHOCYTIC AGGREGATES ASSOCIATE WITH HIGHLY ACTIVE RA AND PREDICT EROSIVE DISEASE PROGRESSION AT 12 MONTHS: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Rivellese F, Humby F, Kelly S et al. (2016). SYNOVIAL MAST CELLS CORRELATE WITH INFLAMMATION AND CELLULAR INFILTRATION AND ARE ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS. nameOfConference

    DOI: doi

  • Rivellese F, Humby F, Kelly S et al. (2016). Synovial Mast Cells Associate with High Disease Activity and Predict Radiographic Progression at 12 Months in Patients with Early Rheumatoid Arthritis. nameOfConference

    DOI: doi

  • Lepse N, Nerviani A, Pitzalis C et al. (2016). T FOLLICULAR HELPER-LIKE CELLS IN THE RHEUMATOID ARTHRITIS SYNOVIUM ARE SELECTIVELY ASSOCIATED WITH INTERLEUKIN-21 PRODUCTION AND ECTOPIC LYMPHOID STRUCTURES. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Corsiero E, Carlotti E, Prediletto E et al. (2016). The role of somatic hypermutation and N-glycosylation in the anti-NET immunoreactivity of RA synovial monoclonal antibodies. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Hensor EMA, McKeigue P, Conaghan PG et al. (2016). Validity of a 2-Component Disease Activity Score for Accurate Assessment of Synovitis in Rheumatoid Arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • James K, Al-Ali S, Tarn J et al. (publicationYear). A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren’s Syndrome. nameOfConference


    QMRO: qmroHref
  • Astorri E, Sutcliffe N, Richards PS et al. (2016). Ultrasound of the salivary glands is a strong predictor of labial gland biopsy histopathology in patients with sicca symptoms. nameOfConference


  • Corsiero E, Bombardieri M, Carlotti E et al. (2015). Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs. nameOfConference


  • Sherwood J, Bertrand J, Nalesso G et al. (2015). A homeostatic function of CXCR2 signalling in articular cartilage.. nameOfConference


  • Headland SE, Jones HR, Norling LV et al. (2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. nameOfConference


    QMRO: qmroHref
  • Ferrari M, Onuoha SC, Pitzalis C (2016). Going with the flow: harnessing the power of the vasculature for targeted therapy in rheumatoid arthritis. nameOfConference


    QMRO: qmroHref
  • Oni C, Mitchell S, James K et al. (2016). Eligibility for clinical trials in primary Sjögren’s syndrome: lessons from the UK Primary Sjögren’s Syndrome Registry. nameOfConference


    QMRO: qmroHref
  • Humby F, Kelly S, Hands R et al. (2015). Use of ultrasound-guided small joint biopsy to evaluate the histopathologic response to rheumatoid arthritis therapy: recommendations for application to clinical trials.. nameOfConference


  • Jones GW, Bombardieri M, Greenhill CJ et al. (2015). Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis. nameOfConference


    QMRO: qmroHref
  • Onuoha SC, Ferrari M, Sblattero D et al. (2015). Rational Design of Antirheumatic Prodrugs Specific for Sites of Inflammation. nameOfConference


    QMRO: qmroHref
  • Rivellese F, Suurmond J, Habets K et al. (2015). Ability of Interleukin‐33– and Immune Complex–Triggered Activation of Human Mast Cells to Down‐Regulate Monocyte‐Mediated Immune Responses. nameOfConference


    QMRO: qmroHref
  • Eldridge S, Nalesso G, Ismail H et al. (2016). Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. nameOfConference


  • Barone F, Nayar S, Campos J et al. (2015). IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs. nameOfConference


    QMRO: qmroHref
  • Haas R, Smith J, Rocher-Ros V et al. (publicationYear). Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions. nameOfConference


  • Corsiero E, Carlotti E, Pitzalis C et al. (2015). FRI0007 The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETS)-Citrullinated Autoantigens of Ra Synovial Monoclonal Antibodies. nameOfConference


    QMRO: qmroHref
  • Carlotti E, Floyd J, Murray-Brown W et al. (2015). FRI0008 Longitudinal Analysis of the IGH-VH Gene by High-Throughput Sequencing in Early Rheumatoid Arthritis Paired Biopsies and its Association with Response to Dmards. nameOfConference


    QMRO: qmroHref
  • Murray-Brown W, Carlotti E, Floyd J et al. (2015). FRI0020 Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjögren's Syndrome. nameOfConference


    QMRO: qmroHref
  • Ferrari M, Onuoha SC, Sblattero D et al. (2015). FRI0103 Synovial Specific Prodrug for the Next Generation of Anti-TNF Therapy in Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • Komarowska I, Coe D, Wang G et al. (2015). Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release. nameOfConference


  • Decourcey J, Nerviani A, Melgar S et al. (2015). OP0117 Snare Regulation of TH17 Cells and Ectopic Lymphoid Structure (ELS) Formation in Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • De Groof A, Humby F, Ducreux J et al. (2015). OP0129 Higher Expression of TNF Alpha-Induced Genes in the Synovium of Early RA Patients Correlates with Disease Activity, and Predicts Absence of Response to First Line Therapy. nameOfConference


    QMRO: qmroHref
  • Tan WS, Bellan M, Nerviani A et al. (2015). OP0208 Synovial Immunopathology Defines Clinical Responsiveness to Dmard Therapy in Early Psoriatic Arthritis: A Pre- and Post-Treatment Mechanistic Study Using a Minimally Invasive Ultrasound-Guided Synovial Biopsy Procedure. nameOfConference


    QMRO: qmroHref
  • Nayar S, Campos J, Cloake T et al. (2015). SAT0005 IL22 Regulates Autoantibody Production by Inducing Lymphoid Chemokine Expression in Tertiary Lymphoid Organs. nameOfConference


    QMRO: qmroHref
  • Rivellese F, Suurmond J, Habets K et al. (2015). THU0024 Human Mast Cells Stimulated with IL-33 and Immune Complexes Down-Regulate Monocyte Activation in Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • Nerviani A, Humby F, Kelly S et al. (2015). THU0033 A Functional Inhibitory Role for the GAS6/MERTK Axis in Modulating Synovial Inflammation in Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • Romao VC, DiCicco M, Lazarou I et al. (2015). THU0116 Higher Ultrasound Synovitis in Elderly-Onset Rheumatoid Arthritis as Compared to Younger-Onset: THE Barts Early Arthritis Cohort. nameOfConference


    QMRO: qmroHref
  • Humby F, Kelly S, Bugatti S et al. (2016). Evaluation of Minimally Invasive, Ultrasound-guided Synovial Biopsy Techniques by the OMERACT Filter — Determining Validation Requirements. nameOfConference


  • Mahto A, Lazarou I, Ng N et al. (2015). 109. An Essential Part of the Rheumatologist's Toolkit? An Audit of a Rheumatology Led Ultrasound Guided Synovial Biopsy Service. nameOfConference


    QMRO: qmroHref
  • Sin W, Tan G, Di Cicco M et al. (2015). 229. A Comparison of Clinical and Synovial Immunohistochemical Characteristics between Psoriatic Arthritis and Rheumatoid Arthritis in an Early Arthritis Cohort. nameOfConference


    QMRO: qmroHref
  • Shields AM, Vyse S, Walczak H et al. (2015). O37. The Autoimmune Risk Gene UBE2L3 is Highly Expressed During B Cell Proliferation and is Correlated with Plasmablast and Plasma Cell Expansion in SLE. nameOfConference


    QMRO: qmroHref
  • Di Cicco M, Humby F, Kelly S et al. (2015). Young Investigator AwadrI32. Synovial Pathotype Predicts Response to TNF-Alpha Inhibitors In Patients With Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • Lendrem D, Mitchell S, McMeekin P et al. (2015). Do the EULAR Sjögren's syndrome outcome measures correlate with health status in primary Sjögren's syndrome?. nameOfConference


    QMRO: qmroHref
  • Kelly S, Bombardieri M, Humby F et al. (2015). Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early Rheumatoid Arthritis: an observational study.. nameOfConference


  • Kelly S, Bombardieri M, Humby F et al. (2015). Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early rheumatoid arthritis: an observational study. nameOfConference


    QMRO: qmroHref
  • Ferrari M, Onuoha SC, Pitzalis C (2015). Trojan horses and guided missiles: targeted therapies in the war on arthritis. nameOfConference


    QMRO: qmroHref
  • Kelly S, Humby F, Filer A et al. (2015). Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients.. nameOfConference


    QMRO: qmroHref
  • Romão, DiCicco M, Mahto A et al. (2015). A7.6 Clinical and pathological differences of elderly- and younger-onset rheumatoid arthritis in an early arthritis cohort. nameOfConference


    QMRO: qmroHref
  • Ferrari M, Onuoha S, Sblattero D et al. (2015). A8.18 Tissue specific pro-drug for the next generation of anti-TNF therapy in rheumatoid arthritis. nameOfConference


    QMRO: qmroHref
  • Sin W, Tan G, Di Cicco M et al. (2015). A COMPARISON OF CLINICAL AND SYNOVIAL IMMUNOHISTOCHEMICAL CHARACTERISTICS BETWEEN PSORIATIC ARTHRITIS AND RHEUMATOID ARTHRITIS IN AN EARLY ARTHRITIS COHORT. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Mahto A, Lazarou I, Ng N et al. (2015). AN ESSENTIAL PART OF THE RHEUMATOLOGIST'S TOOLKIT? AN AUDIT OF A RHEUMATOLOGY LED ULTRASOUND GUIDED SYNOVIAL BIOPSY SERVICE. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nayar S, Campos J, Cloake T et al. (2015). IL22 Regulates Autoantibody Production by Inducing Lymphoid Chemokine Expression in Tertiary Lymphoid Organs. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Murray-Brown W, Carlotti E, Floyd J et al. (2015). Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjogren's Syndrome. nameOfConference

    DOI: doi

  • Bowman S, Everett C, Bombardieri M et al. (2015). Preliminary Results of a Double-Blind Randomised Trial of Rituximab Anti-B-Cell Therapy in Patients with Primary Sjogrens Syndrome. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Di Cicco M, Humby F, Kelly S et al. (2015). SYNOVIAL PATHOTYPE PREDICTS RESPONSE TO TNF-ALPHA INHIBITORS IN PATIENTS WITH RHEUMATOID ARTHRITIS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • DiCicco M, Humby F, Kelly S et al. (2015). Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease at 12 Months: Results from the Pathobiology of Early Arthritis Cohort. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Romão VC, Pitzalis C (2015). Synovial heterogeneity in rheumatoid arthritis: the key for rational patient stratification?. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Shields AM, Vyse S, Walczak H et al. (2015). THE AUTOIMMUNE RISK GENE UBE2L3 IS HIGHLY EXPRESSED DURING B CELL PROLIFERATION AND IS CORRELATED WITH PLASMABLAST AND PLASMA CELL EXPANSION IN SLE. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Corsiero E, Carlotti E, Pitzalis C et al. (2015). The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETs)-Citrullinated Autoantigens of RA Synovial Monoclonal Antibodies. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Astorri E, Nerviani A, Bombardieri M et al. (2015). Towards a stratified targeted approach with biologic treatments in rheumatoid arthritis: role of synovial pathobiology.. nameOfConference


    QMRO: qmroHref
  • Corsiero E, Sutcliffe N, Pitzalis C et al. (publicationYear). Accumulation of Self-Reactive Naïve and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjögren’s Syndrome. nameOfConference


  • Bugatti S, Manzo A, Vitolo B et al. (2014). High expression levels of the B cell chemoattractant CXCL13 in rheumatoid synovium are a marker of severe disease.. nameOfConference


    QMRO: qmroHref
  • Genovese MC, Fleischmann R, Furst D et al. (2014). Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study.. nameOfConference


    QMRO: qmroHref
  • Croia C, Astorri E, Murray-Brown W et al. (2014). Implication of Epstein-Barr virus infection in disease-specific autoreactive B cell activation in ectopic lymphoid structures of Sjögren's syndrome.. nameOfConference


  • Pitzalis C (2014). Pathogenesis of rheumatoid arthritis: from systemic autoimmunity to localised joint disease.. nameOfConference


    QMRO: qmroHref
  • Corsiero E, Pitzalis C, Bombardieri M (2014). Peripheral and synovial mechanisms of humoral autoimmunity in rheumatoid arthritis.. nameOfConference


    QMRO: qmroHref
  • Ahmed TJ, Kaneva MK, Pitzalis C et al. (2014). Resolution of inflammation: examples of peptidergic players and pathways.. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Jones GW, Bombardieri M et al. (2014). Ectopic lymphoid-like structures in infection, cancer and autoimmunity.. nameOfConference


    QMRO: qmroHref
  • Lendrem D, Mitchell S, McMeekin P et al. (2014). Health-related utility values of patients with primary Sjögren's syndrome and its predictors. nameOfConference


    QMRO: qmroHref
  • Di Cicco M, Humby F, Kelly S et al. (2014). AB0132 Presence of Synovial Lymphocyte Aggregates Correlates with A More Severe Clinical Phenotype in Patients with Early Inflammatory Arthritis. nameOfConference


    QMRO: qmroHref
  • Di Cicco M, Humby FC, Kelly S et al. (2014). FRI0020 Presence of Synovial Lymphocyte Aggregates Predicts Clinical Response to DMARD Therapy in Patients with Early Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • Lazarou I, Zou L, Mahto A et al. (2014). FRI0243 Ultrasound-Guided Synovial Biopsy Does not Alter Subsequent Ultrasound Assessments. nameOfConference


    QMRO: qmroHref
  • Mahto A, Humby F, Ng N et al. (2014). OP0032 Baseline Synovial B-Cell Status Predicts Response to Rituximab Therapy in RA. nameOfConference


    QMRO: qmroHref
  • Ng N, Kelly S, Humby F et al. (2014). OP0054 Ultrasound Synovitis Reflects Synovial Inflammation at A Histopathological Level. nameOfConference


    QMRO: qmroHref
  • Corsiero E, Carlotti E, Pratesi F et al. (2014). OP0266 Monoclonal Antibodies Derived from Single CD19+ Synovial B Cells of RA Patients with Tertiary Lymphoid Structures Display Preferential Immunoreactivity towards Citrullinated Proteins of Nets. nameOfConference


    QMRO: qmroHref
  • Di Cicco M, Kelly S, Humby F et al. (2014). SAT0048 Synovial Lymphocytic Aggregates Predict Clinical Response to Certolizumab Pegol in Rheumatoid Arthritis (Clinical and Pathological Response to Certolizumab-Pegol (Clip-Cert) Study). nameOfConference


    QMRO: qmroHref
  • Astorri E, Tappuni A, Sutcliffe N et al. (2014). THU0008 A Negative High-Resolution Salivary Gland Ultrasound is Highly Predictive of Negative Labial Gland Biopsy in Patients with SICCA Symptoms. nameOfConference


  • Juarez M, Toms TE, de Pablo P et al. (2014). Cardiovascular Risk Factors in Women With Primary Sjögren's Syndrome: United Kingdom Primary Sjögren's Syndrome Registry Results. nameOfConference


    QMRO: qmroHref
  • Di Cicco M, Kelly S, Humby F et al. (2014). 101. Synovial Ectopic Lymphoneogenesis Predicts Primary Clinical Response to Certolizumab Pegol in Patients with Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • Mahto A, Ng N, DiCicco M et al. (2014). 107. Synovial B-Cells Predict Response/Resistance to Rituximab Therapy in Rheumatoid Arthritis: Preliminary Results from a Pilot Study. nameOfConference


    QMRO: qmroHref
  • Ng N, Humby F, Di Cicco M et al. (2014). 124. Ultrasound-Guided Diagnostic Synovial Biopsies: An Audit of a Rheumatology-Led Service. nameOfConference


    QMRO: qmroHref
  • Al-Mousawi AZ, Shikh MEME, Pitzalis C (2014). 76. Immune Complex Retention by Synovial Fibroblasts in Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • Pitzalis C (2014). I104. From the Disease Tissue to the Whole Patient: The Role of Pathobiology in Patient Stratification. nameOfConference


    QMRO: qmroHref
  • Ng N, Kelly S, Humby F et al. (2014). O37. Ultrasound Measures of Synovitis Reflects Histological Synovial Inflammation in Early Arthritis Patients. nameOfConference


    QMRO: qmroHref
  • Di Cicco M, Humby F, Kelly S et al. (2014). O44. Presence of Synovial Lymphocyte Aggregates Correlates with a More Severe Clinical Phenotype in Patients with Early Inflammatory Arthritis. nameOfConference


    QMRO: qmroHref
  • Headland S, Norling L, Patel H et al. (2014). A novel mechanism for protecting the arthritic joint: microparticles deliver Annexin A1 into cartilage (146.8). nameOfConference


    QMRO: qmroHref
  • Lucchesi D, Pitzalis C, Bombardieri M (2014). EBV and other viruses as triggers of tertiary lymphoid structures in primary Sjögren's syndrome.. nameOfConference


    QMRO: qmroHref
  • Kam NW, Brentano F, Kyburz D et al. (2014). A1.12 Endogenous SLPI released by rheumatoid synovial fibroblasts control BAFF-dependent-B cell activation in vitro and in the CIA and RA/SCID-arthritis models. nameOfConference


    QMRO: qmroHref
  • Corsiero E, Carlotti E, Wardemann H et al. (2014). A1.31 Monoclonal antibodies from CD19+ synovial B cells of RA patients with tertiary lymphoid structures display a strong immunoreactivity towards citrullinated histones from neutrophils NETs. nameOfConference


    QMRO: qmroHref
  • Ferrari M, Onuoha S, Sblattero D et al. (2014). A1.54 Development of a novel bispecific therapeutic for rheumatoid arthritis. nameOfConference


    QMRO: qmroHref
  • Corsiero E, Sutcliffe N, Wardemann H et al. (2013). AB0022 Accumulation of circulating autoreactive naïve b cells reveal defects of early b cell tolerance checkpoints in patients with sjögren’s syndrome. nameOfConference


    QMRO: qmroHref
  • Corsiero E, Sutcliffe N, Wardemann H et al. (2013). AB0044 Analysis of recombinant monoclonal antibodies from single B cells reveals early defects of B cell tolerance checkpoints in patients with sjÖgren’s syndrome. nameOfConference


    QMRO: qmroHref
  • Kam NW, Bombardieri M, Filter A et al. (2013). AB0099 Aberrant basal and TLR-stimulated expression of TSLP in rheumatoid synovial fibroblasts. nameOfConference


    QMRO: qmroHref
  • Croia C, Bombardieri M, Serafini B et al. (2013). AB0155 Anti-VCA and EBNA1 antibodies are produced in the rheumatoid synovium in the presence of ectopic lymphoid structures and correlate with ACPA production. nameOfConference


    QMRO: qmroHref
  • Murray-Brown W, Picarelli G, Vartoukian S et al. (2013). AB0222 Monocyte-derived IL-32 expression correlates with the level of inflammation in salivary glands of sjÖgren’s syndrome. nameOfConference


    QMRO: qmroHref
  • Ng N, Humby F, Kelly S et al. (2013). AB0247 Rheumatoid arthritis patient characteristics at different therapeutic timepoints. nameOfConference


    QMRO: qmroHref
  • Ng N, Di Cicco M, Humby F et al. (2013). AB0742 Minimally invasive ultrasound guided synovial biopsy as a clinical diagnostic tool. nameOfConference


    QMRO: qmroHref
  • Croia C, Serafini B, Tappuni A et al. (2013). FRI0259 Ectopic lymphoid structures support epstein-barr virus persistence and autoreactive plasma cell infection in sjogren’s syndrome salivary glands. nameOfConference


    QMRO: qmroHref
  • Ng W-F, Miller A, Bowman S et al. (2013). FRI0323 Level of physical activity in primary sjögren’s syndrome and its predictors. nameOfConference


    QMRO: qmroHref
  • Murray-Brown W, Croia C, Sutcliffe N et al. (2013). OP0080 Lesional IL-21 Expression Correlates with Functional Germinal Center Formation and T Follicular Helper Cell Infiltration in the Salivary Glands of Sjögren’s Syndrome. nameOfConference


    QMRO: qmroHref
  • Nayar S, Cloake T, Lane P et al. (2013). OP0258 IL-22 Regulates Lymphoid Stromal Cell Expansion, Development of Germinal Centers and Humoral Response in Mucosal Ectopic Lymphoneogenesis. nameOfConference


    QMRO: qmroHref
  • Bombardieri M, Rocher V, Mittereder N et al. (2013). OP0303 Mavrilimumab Reduces Pro-Inflammatory Cytokines and CD68 Positive Macrophages in Synovial Explants from Rheumatoid Arthritis Subjects Engrafted Into SCID/Beige Mice. nameOfConference


    QMRO: qmroHref
  • Deidda S, Humby F, Kelly S et al. (2013). SAT0014 Synovial Sublining Macrophages: A Sensitive Biomarker for Response to Treatment in Early RA Patients.. nameOfConference


    QMRO: qmroHref
  • Di Cicco M, Dadoun S, Humby F et al. (2013). THU0087 Synovial Ectopic Lymphoid-like Structures are Associated with Diagnosis of Rheumatoid Arthritis, Disease Activity and Antibody Status in Early Arthritis Patients. nameOfConference


    QMRO: qmroHref
  • Eldridge S, Vicente-Greco K, Nalesso G et al. (2014). Agrin expression is downregulated in OA and is required for chondrocyte differentiation. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Juarez M, Toms TE, de Pablo P et al. (2014). Cardiovascular Risk Factors in Women With Primary Sjogren's Syndrome: United Kingdom Primary Sjogren's Syndrome Registry Results. nameOfConference


    QMRO: qmroHref
  • Corsiero E, Bombardieri M, Carlotti E et al. (2014). Citrullinated histones from neutrophil extracellular traps (NETs) fuel ectopic germinal centre responses and ACPA production in rheumatoid joints. nameOfConference

    DOI: doi

  • Pitzalis C (2014). FROM THE DISEASE TISSUE TO THE WHOLE PATIENT: THE ROLE OF PATHOBIOLOGY IN PATIENT STRATIFICATION. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Haas R, Smith J, Rocher-Ros V et al. (2014). How the microenvironment contributes to the establishment of chronic inflammatory diseases: lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and functions. nameOfConference

    DOI: doi

  • Al-Mousawi AZ, El Shikh MEM, Pitzalis C (2014). IMMUNE COMPLEX RETENTION BY SYNOVIAL FIBROBLASTS IN RHEUMATOID ARTHRITIS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Lucchesi D, Pontarini E, Pitzalis C et al. (2014). Innate immune system early activation precedes the formation of functional tertiary lymphoid structures in a novel model of salivary gland ectopic lymphoid neogenesis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Di Cicco M, Humby F, Kelly S et al. (2014). PRESENCE OF SYNOVIAL LYMPHOCYTE AGGREGATES CORRELATES WITH A MORE SEVERE CLINICAL PHENOTYPE IN PATIENTS WITH EARLY INFLAMMATORY ARTHRITIS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Mahto A, Ng N, DiCicco M et al. (2014). SYNOVIAL B-CELLS PREDICT RESPONSE/RESISTANCE TO RITUXIMAB THERAPY IN RHEUMATOID ARTHRITIS: PRELIMINARY RESULTS FROM A PILOT STUDY. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Di Cicco M, Kelly S, Humby F et al. (2014). SYNOVIAL ECTOPIC LYMPHONEOGENESIS PREDICTS PRIMARY CLINICAL RESPONSE TO CERTOLIZUMAB PEGOL IN PATIENTS WITH RHEUMATOID ARTHRITIS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • James K, Lendrem D, Mitchell S et al. (2014). THE UK PRIMARY SJOGREN'S SYNDROME REGISTRY (UKPSSR): A VALUABLE RESOURCE FOR FUTURE SJOGREN'S SYNDROM RESEARCH. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ahmed TJ, Perretti M, Pitzalis C (2014). TRANSLATIONAL MEDICINE IN RHEUMATOID ARTHRITIS: EXPLOITING MELANOCORTIN RECEPTORS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brown S, Coy NN, Pitzalis C et al. (2014). The TRACTISS Protocol: a randomised double blind placebo controlled clinical TRial of Anti-B-Cell Therapy In patients with primary Sjogren's Syndrome. nameOfConference


    QMRO: qmroHref
  • Nalesso G, Thomas B, Wagner K et al. (2014). The WNT/CaMKII pathway is activated in human and experimental osteoarthritis and promotes chondrocyte de-differentiation. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ng N, Kelly S, Humby F et al. (2014). ULTRASOUND MEASURES OF SYNOVITIS REFLECTS HISTOLOGICAL SYNOVIAL INFLAMMATION IN EARLY ARTHRITIS PATIENTS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ng N, Humby F, Di Cicco M et al. (2014). ULTRASOUND-GUIDED DIAGNOSTIC SYNOVIAL BIOPSIES: AN AUDIT OF A RHEUMATOLOGY-LED SERVICE. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ng N, Kelly S, Humby F et al. (2014). Ultrasound Synovitis Reflects Synovial Inflammation at a Histopathological Level.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nalesso G, Thomas BL, Sherwood J et al. (2014). WNT16 IS INDUCED BY OXIDATIVE STRESS FOLLOWING CARTILAGE INJURY AND CONTRIBUTES TO CARTILAGE HOMEOSTASIS IN OSTEOARTHRITIS. nameOfConference


    QMRO: qmroHref
  • Thomas BL, Nalesso G, Sherwood J et al. (2014). WNT16 SUPPORTS THE PHENOTYPE OF THE SUPERFICIAL ZONE CELLS IN CARTILAGE. nameOfConference


    QMRO: qmroHref
  • El Shikh ME, Kmieciak M, Manjili MH et al. (2013). Multi-therapeutic potential of autoantibodies induced by immune complexes trapped on follicular dendritic cells.. nameOfConference


    QMRO: qmroHref
  • Nordmark G, Wang C, Vasaitis L et al. (2013). Association of Genes in the NF‐κB Pathway with Antibody‐Positive Primary Sjögren's Syndrome. nameOfConference


    QMRO: qmroHref
  • Croia C, Serafini B, Bombardieri M et al. (2013). Epstein-Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis.. nameOfConference


    QMRO: qmroHref
  • Lendrem D, Mitchell S, McMeekin P et al. (2013). Health-related utility values of patients with primary Sjögren's syndrome and its predictors. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Kelly S, Humby F (2013). New learnings on the pathophysiology of RA from synovial biopsies.. nameOfConference


    QMRO: qmroHref
  • Eldridge S, Vicent-Greco K, Nalesso G et al. (2013). Agrin expression is downregulated in OA and is required for chondrocyte differentiation. nameOfConference


    QMRO: qmroHref
  • Tarn J, Natasari A, Mitchell S et al. (2013). Soluble molecule profiling and network analysis of primary Sjögren's Syndrome patient serum. nameOfConference


    QMRO: qmroHref
  • Pitzalis C (2013). "HUMAN SCID CHIMERAS: MODELS TO DISSECT AUTOIMMUNITY AND INFLAMMATION". nameOfConference


    QMRO: qmroHref
  • Sherwood J, Nalesso G, Bertrand J et al. (2013). A NOVEL ROLE FOR ELR plus CXC CHEMOKINE SIGNALING IN CARTILAGE HOMEOSTASIS. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Nalesso G, Bertrand J et al. (2013). A homoeostatic role for ELR plus CXC chemokine signalling in articular and epiphyseal cartilage. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Corsiero E, Sutcliffe N, Wardemann H et al. (2013). ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEAL DEFECTS OF EARLY B CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Corsiero E, Sutcliffe N, Wardemann H et al. (2013). ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEALS DEFECTS OF EARLY B-CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Corsiero E, Sutcliffe N, Wardemann H et al. (2013). Accumulation of Circulating Autoreactive Naive B Cells Reveal Defects of Early B Cell Tolerance Checkpoints in Patients with Sjogren's Syndrome. nameOfConference


    QMRO: qmroHref
  • Patel HB, Bombardieri M, Pitzalis C et al. (2013). Activation of Melanocortin Receptor 3 as a new strategy to control experimental and rheumatoid arthritis. nameOfConference


    QMRO: qmroHref
  • Ng N, Humby F, Bombardieri M et al. (2013). CLINICAL, IMAGING AND HISTOLOGICAL CHARACTERISTICS OF PATIENTS WITH RHEUMATOID ARTHRITIS AT DIFFERENT STAGES OF DISEASE PROGRESSION. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ahmed TJ, Montero-Melendez T, Perretti M et al. (2013). Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides.. nameOfConference


  • Ferrari M, Onuoha S, Kamalati T et al. (2013). Development Of a Novel Bispecific Therapeutic For Arthritic Diseases. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Croia C, Serafini B, Tappuni A et al. (2013). ECTOPIC LYMPHOID STRUCTURES SUPPORT EPSTEIN-BARR VIRUS PERSISTENCE AND AUTOREACTIVE PLASMA CELL INFECTION IN SJOGREN'S SYNDROME SALIVARY GLANDS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ng W-F, Lendrem D, Mitchell S et al. (2013). EVALUATING HEALTH STATUS OF 620 PATIENTS WITH PRIMARY SJOGREN'S SYNDROME USING EQ-5D. nameOfConference


    QMRO: qmroHref
  • Ng W-F, Mitchell S, Lendrem D et al. (2013). HOW GOOD ARE THE EULAR SJOGREN'S SYNDROME DISEASE ACTIVITY INDEX (ESSDAI), AND EULAR SJOGREN'S SYNDROME PATIENTS REPORTED INDEX (ESSPRI) IN PREDICTING HEALTH STATUS IN PRIMARY SJOGREN'S SYNDROME?. nameOfConference


    QMRO: qmroHref
  • Nayar S, Cloake T, Lane P et al. (2013). IL-22 REGULATES LYMPHOID STROMAL CELL EXPANSION, DEVELOPMENT OF GERMINAL CENTERS AND HUMORAL RESPONSE IN MUCOSAL ECTOPIC LYMPHONEOGENESIS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Lucchesi D, Bombardieri M, Barone F et al. (2013). INDUCIBLE TERTIARY LYMPHOID STRUCTURES AND AUTOIMMUNITY IN A NOVEL MODEL OF SIALOADENITIS IN WILD-TYPE MICE. nameOfConference


    QMRO: qmroHref
  • Jones GW, Bombardieri M, Greenhill CJ et al. (2013). Interleukin-27 as a novel antagonist of ectopic lymphoid-like structure development in early inflammatory arthritis. nameOfConference


    QMRO: qmroHref
  • Murray-Brown W, Croia C, Sutcliffe N et al. (2013). LESIONAL IL-21 EXPRESSION CORRELATES WITH FUNCTIONAL GERMINAL CENTER FORMATION AND T FOLLICULAR HELPER CELL INFILTRATION IN THE SALIVARY GLANDS OF SJOGREN'S SYNDROME. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ng W-F, Miller A, Bowman S et al. (2013). LEVEL OF PHYSICAL ACTIVITY IN PRIMARY SJOGREN'S SYNDROME AND ITS PREDICTORS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Murray-Brown W, Croia C, Sutcliffe N et al. (2013). Lesional Intereukin-21 Expression Correlates With Functional Germinal Center Formation and T Follicular Helper Cell Infiltration In The Salivary Glands Of Sjogren's Syndrome. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bombardieri M, Rocher V, Mittereder N et al. (2013). MAVRILIMUMAB REDUCES PRO-INFLAMMATORY CYTOKINES AND CD68 POSITIVE MACROPHAGES IN SYNOVIAL EXPLANTS FROM RHEUMATOID ARTHRITIS SUBJECTS ENGRAFTED INTO SCID/BEIGE MICE. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kam NW, Filer A, Buckley C et al. (2013). MEMBRANE-BOUND AND SOLUBLE BAFF EXPRESSION BY HUMAN RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTES IN RESPONSE TO TLR STIMULATION. nameOfConference


    QMRO: qmroHref
  • Ng N, Di Cicco M, Humby F et al. (2013). MINIMALLY INVASIVE ULTRASOUND GUIDED SYNOVIAL BIOPSY AS A CLINICAL DIAGNOSTIC TOOL. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • El Shikh ME, Biggioggero M, El Sayed R et al. (2013). REGULATION OF AUTO-ANTIBODY PRODUCTION BY AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS. nameOfConference


    QMRO: qmroHref
  • Ng N, Humby F, Kelly S et al. (2013). RHEUMATOID ARTHRITIS PATIENT CHARACTERISTICS AT DIFFERENT THERAPEUTIC TIMEPOINTS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Corsiero E, Bombardieri M, Carlotti E et al. (2013). Recombinant Monoclonal Antibodies Derived From Single CD19+Synovial B Cells Of RA Patients With Tertiary Lymphoid Structures Display a Strong Immunoreactivity Towards Citrullinated Histones. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Tarn J, Mitchell S, Bowman S et al. (2013). SERUM CYTOKINE AND CHEMOKINE PROFILING IN PRIMARY SJOGREN'S SYNDROME. nameOfConference


    QMRO: qmroHref
  • Di Cicco M, Dadoun S, Humby F et al. (2013). SYNOVIAL ECTOPIC LYMPHOID-LIKE STRUCTURES ARE ASSOCIATED WITH DIAGNOSIS OF RHEUMATOID ARTHRITIS, DISEASE ACTIVITY AND ANTIBODY STATUS IN EARLY ARTHRITIS PATIENTS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Di Cicco M, Humby F, Kelly S et al. (2013). SYNOVIAL LYMPHOCYTE AGGREGATES IN EARLY INFLAMMATORY ARTHRITIS: CORRELATION WITH DIAGNOSIS, DISEASE ACTIVITY AND ANTIBODY STATUS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Croia C, Serafini B, Bombardieri M et al. (2013). SYNOVIAL LYMPHOID STRUCTURES SUPPORT EPSTEIN-BARR VIRUS PERSISTENCE AND AUTOREACTIVE PLASMA CELL INFECTION IN RHEUMATOID ARTHRITIS. nameOfConference


    QMRO: qmroHref
  • Deidda S, Humby F, Kelly S et al. (2013). SYNOVIAL SUBLINING MACROPHAGES: A SENSITIVE BIOMARKER FOR RESPONSE TO TREATMENT IN EARLY RA PATIENTS.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kam YNW, Filer A, Buckley CD et al. (2013). Secretory Leukocyte Protease Inhibitor Released By Rheumatoid Synovial Fibroblasts Exerts a Negative Control Of BAFF-Dependent B Cell Activation In Vitro and In Vivo In The Collagen-Induced and Chimeric RA/SCID Arthritis Models. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Di Cicco M, Kelly S, Humby F et al. (2013). Synovial Ectopic Lymphoneogenesis Predicts Clinical Response To Certolizumab Pegol In Patients With Rheumatoid Arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Sherwood J, Bertrand J, Nalesso G et al. (2013). THE ROLE OF CXCR2 SIGNALING IN ARTICULAR CARTILAGE HOMEOSTASIS. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Bertrand J, Nalesso G et al. (2013). THE ROLE OF CXCR2 SIGNALLING IN ARTICULAR CARTILAGE HOMEOSTASIS. nameOfConference


    QMRO: qmroHref
  • Wythe SE, DiCara D, Taher TEI et al. (2013). Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide.. nameOfConference


    QMRO: qmroHref
  • Nalesso G, Thomas BL, Eldridge SE et al. (2013). WNT5A/CAMKII PATHWAY IS ACTIVATED IN OSTEOARTHRITIS AND PROMOTES LOSS OF CHONDROCYTE PHENOTYPE. nameOfConference


    QMRO: qmroHref
  • Patel HB, Kornerup KN, Sampaio ALF et al. (2012). The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis.. nameOfConference


  • Bombardieri M, Barone F, Lucchesi D et al. (2012). Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in C57BL/6 mice.. nameOfConference


    QMRO: qmroHref
  • Bombardieri M, Pitzalis C (2012). Ectopic lymphoid neogenesis and lymphoid chemokines in Sjogren's syndrome: at the interplay between chronic inflammation, autoimmunity and lymphomagenesis.. nameOfConference


    QMRO: qmroHref
  • Corsiero E, Bombardieri M, Manzo A et al. (2012). Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases.. nameOfConference


    QMRO: qmroHref
  • Patel HB, Kornerup KN, Sampaio ALFS et al. (2012). The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis. nameOfConference


    QMRO: qmroHref
  • Whitehead MA, Bombardieri M, Pitzalis C et al. (2012). Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter.. nameOfConference


    QMRO: qmroHref
  • De Bari C, Pitzalis C, Dell'Accio F (2007). Joint Tissue Engineering. nameOfConference


    QMRO: qmroHref
  • Pitzalis C (2012). ADVANCES IN PATHOGENESIS: THE RHEUMATOLOGY VIEW: WHAT BIOLOGICAL PROCESSES DRIVE DIFFERENT DISEASE EXPRESSIONS IN PSA?. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Croia C, Bombardieri M, Francesca A et al. (2012). ANTI-VCA AND EBNA1 ANTIBODIES ARE PRODUCED IN THE RHEUMATOID SYNOVIUM IN THE PRESENCE OF ECTOPIC LYMPHOID STRUCTURES AND CORRELATE WITH ACPA PRODUCTION. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Corsiero E, Sutcliffe N, Wardemann H et al. (2012). Accumulation of circulating autoreactive naive B cells reveal defects of early B cell tolerance checkpoints in patients with Sjogren's syndrome. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Newton JL, Frith J, Powell D et al. (2012). Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjogren's syndrome. nameOfConference


    QMRO: qmroHref
  • Coates LC, Aslam T, Burden AD et al. (2012). Comparison of Three Screening Tools in Psoriatic Arthritis: The Contest Study.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ferrari M, Kamalati T, Pitzalis C (2012). DEVELOPMENT OF A NOVEL RECOMBINANT BIOTHERAPEUTIC WITH APPLICATIONS IN TARGETED THERAPY OF HUMAN ARTHRITIS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nayar S, Cloake T, Bombardieri M et al. (2012). ECTOPIC LYMPHONEOGENESIS IN A NOVEL MURINE MODEL OF SALIVARY GLANDS SIALOADENITIS IS CHARACTERIZED BY ASYNCHRONY IN THE LYMPHANGIOGENETIC AND ANGIOGENETIC PROGRAM. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Sherwood J, Nalesso G, Bertrand J et al. (2012). ELR plus CXC CHEMOKINE SIGNALLING IN ARTICULAR CHONDROCYTE PHENOTYPIC STABILITY. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Nalesso G, Bertrand J et al. (2012). ELR plus CXC CHEMOKINE SIGNALLING IN CARTILAGE HOMEOSTASIS. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Nalesso G, Bertrand J et al. (2012). ELR plus CXC chemokine signaling is required for phenotypic stability of human articular chondrocytes. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Lendrem D, Mitchell S, Bowman S et al. (2012). EVALUATING HEALTH STATUS OF 620 PATIENTS WITH PRIMARY SJOGREN'S SYNDROME USING EQ-5D. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Scheinberg M, Filippi RZ, Hands R et al. (2012). Failure to Control Progression of Rheumatoid Arthritis After a Decade of Biologic Therapy. nameOfConference


    QMRO: qmroHref
  • EL SHIKH ME, PITZALIS C (2012). Follicular dendritic cells in health and disease. nameOfConference


  • Lendrem D, Mitchell S, Bowman S et al. (2012). HOW GOOD ARE THE EULAR SJOGREN'S SYNDROME DISEASE ACTIVITY INDEX, AND EULAR SJOGREN'S SYNDROME PATIENTS REPORTED INDEX IN PREDICTING HEALTH STATUS IN PRIMARY SJOGREN'S SYNDROME?. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Jones GW, Greenhill CJ, Williams AS et al. (2012). IL-27 control of ectopic lymphoid structures in inflammatory arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Lucchesi D, Bombardieri M, Barone F et al. (2012). Inducible tertiary lymphoid structures formation in a novel model of sialoadenitis in wild-type mice is preceded by ectopic expression of lymphoid chemokines. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pitzalis C, Veale D, Dayer J-M (2012). Introduction to "Synovitis--an inflammation of joints destroying the bone".. nameOfConference


    QMRO: qmroHref
  • Murray-Brown W, Croia C, Sutcliffe N et al. (2012). Lesional IL-21 expression correlates with functional germinal center formation and T follicular helper cell infiltration in the salivary glands of Sjogren's syndrome. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nayar S, Chung MM, Rankin P et al. (2012). Lymphotoxin beta regulates lymphatic vessel expansion in mucosal ectopic lymphoneogenesis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Murray-Brown W, Priori R, Tappuni T et al. (2012). MONOCYTE-DERIVED IL-32 EXPRESSION CORRELATES WITH THE LEVEL OF INFLAMMATION IN SALIVARY GLANDS OF SJOGREN'S SYNDROME. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kam NW, Filer A, Buckley C et al. (2012). Membrane-bound and soluble BAFF expression by human rheumatoid fibroblast-like synoviocytes in response to TLR stimulation. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • El Shikh MEM, Biggioggero M, El Sayed RM et al. (2012). REGULATION OF AUTO-ANTIBODY PRODUCTION BY PERSISTING AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS. nameOfConference


    QMRO: qmroHref
  • Vila J, Mitchell S, Bowman S et al. (2012). THE CLINICAL RELEVANCE OF ANTI-RO52 AND ANTI-RO60 IN PATIENTS IN THE UNITED KINGDOM PRIMARY SJOGREN'S SYNDROME REGISTRY (UKPSSR). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • DiCicco M, Humby F, Kelly S et al. (2012). THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT: A PRELIMINARY ANALYSIS CORRELATING HISTOMORPHOLOGY AND DISEASE ACTIVITY. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Macor P, Durigutto P, De Maso L et al. (2012). Treatment of experimental arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5. nameOfConference


    QMRO: qmroHref
  • Kelly S, Bombardieri M, Humby F et al. (2012). ULTRASOUND GUIDED SYNOVIAL BIOPSIES: SAFETY, TOLERABILITY, AND TISSUE QUALITY. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Seymour MW, Kelly S, Beals CR et al. (2012). Ultrasound of metacarpophalangeal joints is a sensitive and reliable endpoint for drug therapies in rheumatoid arthritis: results of a randomized, two-center placebo-controlled study. nameOfConference


    QMRO: qmroHref
  • Nalesso G, Sherwood J, Bertrand J et al. (2012). WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kamperidis P, Kamalati T, Ferrari M et al. (2011). Development of a novel recombinant biotherapeutic with applications in targeted therapy of human arthritis.. nameOfConference


    QMRO: qmroHref
  • Bombardieri M, Kam N-W, Brentano F et al. (2011). A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells.. nameOfConference


    QMRO: qmroHref
  • Miossec P, Verweij CL, Klareskog L et al. (2011). Biomarkers and personalised medicine in rheumatoid arthritis: a proposal for interactions between academia, industry and regulatory bodies. nameOfConference


    QMRO: qmroHref
  • Ingegnoli F, Blades M, Manzo A et al. (2002). Role of cell migration in the pathogenesis of rheumatoid arthritis: in vivo studies in SCID mice transplanted with human synovial membrane. nameOfConference


    QMRO: qmroHref
  • Ingegnoli F, Manzo A, Fantini F et al. (2002). Role of chemokines in the pathogenesis of rheumatoid synovitis. nameOfConference


    QMRO: qmroHref
  • de Hair MJH, Harty LC, Gerlag DM et al. (2011). Synovial Tissue Analysis for the Discovery of Diagnostic and Prognostic Biomarkers in Patients with Early Arthritis. nameOfConference


    QMRO: qmroHref
  • Macor P, Durigutto P, De Maso L et al. (2011). Treatment of antigen-induced and collagen-induced arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5. nameOfConference


    QMRO: qmroHref
  • Nalesso G, Sherwood J, Bertrand J et al. (2011). WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways.. nameOfConference


  • El Shikh ME, El Sayed R, Kmieciak M et al. (2011). BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pitzalis C (2011). CAN PATHOBIOLOGY INFORM DISEASE OUTCOME AND RESPONSE TO THERAPY?. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Marrelli A, Bombardieri M, Kelly S et al. (2011). DIGITAL IMAGE ANALYSIS FOR THE EVALUATION OF BLOOD VESSEL DENSITY IN RHEUMATOID SYNOVIUM: CORRELATION WITH QUANTITATIVE REAL-TIME PCR EXPRESSION OF ENDOTHELIAL ANTIGEN AND ANGIOGENIC GROWTH FACTORS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Croia C, Serafini B, Bombardieri M et al. (2011). EBV INFECTION IN THE RHEUMATOID ARTHRITIS SYNOVIUM: RELATIONSHIP TO ECTOPIC LYMPHOID STRUCTURES AND CD8 T CELL ACTIVATION. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Astorri E, Bombardi M, Peakman M et al. (2011). EVOLUTION OF ECTOPIC LYMPHOID NEOGENESIS AND IN SITU AUTOANTIBODY PRODUCTION IN AUTOIMMUNE DIABETIC NOD MICE: CELLULAR AND MOLECULAR CHARACTERIZATION OF TERTIARY LYMPHOID STRUCTURES IN PANCREATIC ISLETS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Priori R, Barone F, Alessandri C et al. (2011). Markedly increased IL-18 liver expression in adult-onset Still's disease-related hepatitis.. nameOfConference


    QMRO: qmroHref
  • Mahoney DJ, Swales C, Athanasou NA et al. (2011). TSG-6 Inhibits Osteoclast Activity via an Autocrine Mechanism and Is Functionally Synergistic With Osteoprotegerin. nameOfConference


    QMRO: qmroHref
  • Nalesso G, Sherwood J, Ramachandran M et al. (2011). Biology of bone, cartilage and connectve tissue disease. nameOfConference


    QMRO: qmroHref
  • Ciurtin C, Majeed Y, Naylor J et al. (2011). Cell receptor-ligand interaction, signalling, activation and apoptosis. nameOfConference


    QMRO: qmroHref
  • Nesbitt A, Fossati G, Whittall CE et al. (2011). Cytokines and inflammatory mediators. nameOfConference


    QMRO: qmroHref
  • Rajak R, Amos N, Camilleri J et al. (2011). Rheumatoid arthritis - aetiopathogenesis and animal models. nameOfConference


    QMRO: qmroHref
  • Bugatti S, Manzo A, Vitolo B et al. (2011). B CELL DISTRIBUTION AND ACTIVATION-INDUCED CYTIDINE DEAMINASE EXPRESSION IN RHEUMATOID SYNOVITIS: CLINICAL AND BIO-MOLECULAR CORRELATES. nameOfConference


    QMRO: qmroHref
  • El Shikh ME, El Sayed RM, Kmieciak M et al. (2011). BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS. nameOfConference


    QMRO: qmroHref
  • Astorri E, Bombardieri M, Gabba S et al. (2011). EVOLUTION OF ECTOPIC LYMPHOID NEOGENESIS AND IN SITU AUTOANTIBODIES PRODUCTION IN AUTOIMMUNE DIABETIC NOD MICE: CELLULAR AND MOLECULAR CHARACTERISATION OF TERTIARY LYMPHOID STRUCTURES IN PANCREATIC ISLETS. nameOfConference


    QMRO: qmroHref
  • de Sande MGHV, Gerlag DM, Lodde BM et al. (2011). Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials. nameOfConference


    QMRO: qmroHref
  • Astorri E (2011). Interplay between inflammation, autoimmunity and regeneration in the NOD mouse model of type 1 diabetes and Sjogren’s syndrome.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Humby F (2011). The clinical and immunological significance of ectopic lymphoneogenesis within the rheumatoid synovial membrane. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bombardieri M, Kam YNW, Filer A et al. (2011). Aberrant Basal and TLR-Stimulated Expression of TSLP in Rheumatoid Synovial Fibroblasts. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kam NW, Bombardieri M, Filer A et al. (2011). Aberrant basal and TLR-stimulated expression of TSLP in rheumatoid synovial fibroblasts. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Corsiero E, Sutcliffe N, Wardemann H et al. (2011). Analysis of recombinant monoclonal antibodies from single B cells reveals early defects of B cell tolerance checkpoints in patients with Sjogren's syndrome. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kamperidis P, Kamalati T, Ferrari M et al. (2011). Development of a Novel Recombinant Biotherapeutic with Applications in Targeted Therapy of Human Arthritis.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Croia C, Bombardieri M, Serafini B et al. (2011). EBV Infection In the Rheumatoid Synovium: Relationship with Ectopic Lymphoid Structures, In Situ Autoantobody Production and CD8 T Cell Activation. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nayar S, Barone F, Choy P et al. (2011). Ectopic lymphoneogenesis in a novel murine model of salivary glands sialoadenitis is characterized by asynchrony in the lymphangiogenetic and angiogenetic program. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bombardieri M, Lucchesi D, Barone F et al. (2011). Inducible functional tertiary lymphoid structures, autoimmunity and exocrine dysfunction in wild-type mouse salivary glands via local adenoviral delivery. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bugatti S, Manzo A, Bombardieri M et al. (2011). Synovial Tissue Heterogeneity and Peripheral Blood Biomarkers. nameOfConference


    QMRO: qmroHref
  • Pitzalis C (2011). THE ROLE OF SYNOVIAL BIOPSY IN THE DIAGNOSIS OF INFLAMMATORY ARTHRITIS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kurunadalingam H, Parwaiz I, Kumar K et al. (2011). THE SAFETY AND ACCEPTABILITY OF ULTRASOUND-GUIDED BIOPSY IN EARLY ARTHRITIS PATIENTS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Burmester GR, Lipsky PE, Dörner T et al. (2010). Kitasato symposium 2010: new prospects for cytokines. nameOfConference


    QMRO: qmroHref
  • Patel HB, Bombardieri M, Sampaio ALF et al. (2010). Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis.. nameOfConference


    QMRO: qmroHref
  • Corsiero E, Bombardieri M, Humby F et al. (2010). Characterization of inter follicular large B cells, a new subpopulation of B lymphocytes, in tertiary lymphoid organs in rheumatic autoimmune diseases. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Astorri E, Guglielmi C, Bombardieri M et al. (2010). Circulating Reg1α proteins and autoantibodies to Reg1α proteins as biomarkers of β-cell regeneration and damage in type 1 diabetes.. nameOfConference


    QMRO: qmroHref
  • Croia C, Serafini B, Bombardieri M et al. (2010). EBV infection in the rheumatoid arthritis synovium: relationship to tertiary lymphoid structures and CD8 T cell activation. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Astorri E, Bombardieri M, Gabba S et al. (2010). Evolution of ectopic lymphoid neogenesis and in-situ autoantibodies production in autoimmune diabetic NOD mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islet. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Lucchesi D, Astorri E, Bombardieri M et al. (2010). Molecular and cellular evolution of functional tertiary lymphoid structures in salivary glands of NOD mice. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kam NW, Bombardieri M, Brentano F et al. (2010). Rheumatoid synovial fibroblasts support AID expression and Ig class-switching in B cells via a Baff-dependent TLR3-stimulated pathway. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ciccia F, Bombardieri M, Rizzo A et al. (2010). Over-expression of paneth cell-derived anti-microbial peptides in the gut of patients with ankylosing spondylitis and subclinical intestinal inflammation.. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Key S, Achan P et al. (2010). CXCR1 AND CXCR2 SIGNALLING IS REQUIRED BUT IS NOT SUFFICIENT TO MAINTAIN THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES. nameOfConference


    QMRO: qmroHref
  • Nalesso G, Achan P, Pitzalis C et al. (2010). WNT3A MODULATES CHONDROCYTE PHENOTYPE THROUGH ACTIVATION OF BOTH CANONICAL AND NON-CANONICAL PATHWAYS. nameOfConference


    QMRO: qmroHref
  • Astorri E, Bombardieri M, Gabba S et al. (2010). Evolution of ectopic lymphoid neogenesis and in situ autoantibody production in autoimmune nonobese diabetic mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islets.. nameOfConference


    QMRO: qmroHref
  • Shirlaw P, Hullah E, Barone F et al. (2010). Changes in parameters of Sjogrens syndrome (SS) assessed after 10 years on a combined SS clinic. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Patel HB, Bombardieri M, Sampaio ALF et al. (2010). Anti‐inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. nameOfConference


    QMRO: qmroHref
  • Ng W-F, Bowman SJ, Griffiths B (2011). United Kingdom Primary Sjögren's Syndrome Registry—a united effort to tackle an orphan rheumatic disease. nameOfConference


    QMRO: qmroHref
  • Connolly M, Marrelli A, Blades M et al. (2010). Acute Serum Amyloid A Induces Migration, Angiogenesis, and Inflammation in Synovial Cells In Vitro and in a Human Rheumatoid Arthritis/SCID Mouse Chimera Model. nameOfConference


    QMRO: qmroHref
  • Mahoney DJ, Swales C, Athanasou N et al. (2010). TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with OPG. nameOfConference


    QMRO: qmroHref
  • Sherwood JC, Achan P, Ramachandran M et al. (2010). CXCR1/2 SIGNALLING IS REQUIRED FOR THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Sherwood JC, Pitzalis C, Dell'Accio F (2010). CXCR1/2 signalling in the phenotypic stability of in vitro expanded adult human articular chondrocytes. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nalesso G, Eltawil NM, Pitzalis C et al. (2010). Effects of the modulation of Wnt-canonical pathway on the phenotypic stability of human articular chondrocytes. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Astorri E, Bombardieri M, Corsiero E et al. (2010). MOLECULAR AND CELLULAR EVOLUTION OF FUNCTIONAL TERTIARY LYMPHOID STRUCTURES IN SALIVARY GLANDS OF NOD MICE. nameOfConference


    QMRO: qmroHref
  • Eltawil N, Pitzalis C, Dell'Accio F (2010). Molecular response of articular cartilage to injury: Wnt signaling in an in vivo model of joint surface injury. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bombardieri M, Kam YNW, Brentano F et al. (2010). RHEUMATOID SYNOVIAL FIBROBLASTS SUPPORT AID EXPRESSION AND IG CLASS-SWITCHING IN B CELLS VIA A BAFF-DEPENDENT TLR3-STIMULATED PATHWAY. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Swales C, Mahoney DJ, Athanasou NA et al. (2010). TSG-6: AN AUTOCRINE REGULATOR OF INFLAMMATORY JOINT DISEASE?. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Gillespie J, Savic S, Wong C et al. (2010). Concurrent Oral 4 – Basic Science [OP24–OP31]. nameOfConference


    QMRO: qmroHref
  • Ritchlin CT, Qureshi AA, de Vlam K et al. (2010). Biomarkers in Psoriasis and Psoriatic Arthritis: GRAPPA 2008. nameOfConference


    QMRO: qmroHref
  • Bombardieri M, Astorri E, Corsiero E et al. (2010). MOLECULAR AND CELLULAR EVOLUTION OF FUNCTIONAL TERTIARY LYMPHOID STRUCTURES IN SALIVARY GLANDS OF NOD MICE. nameOfConference


    QMRO: qmroHref
  • Manzo A, Bombardieri M, Humby F et al. (2010). Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling. nameOfConference


    QMRO: qmroHref
  • Duchene J, Cayla C, Vessillier S et al. (2009). Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis.. nameOfConference


    QMRO: qmroHref
  • Scheiermann C, Colom B, Meda P et al. (2009). Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury.. nameOfConference


    QMRO: qmroHref
  • Macor P, Durigutto P, De Maso L et al. (2009). Prevention of antigen-induced arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5. nameOfConference


    QMRO: qmroHref
  • Garrood T, Blades M, Haskard DO et al. (2009). A novel model for the pre-clinical imaging of inflamed human synovial vasculature.. nameOfConference


    QMRO: qmroHref
  • Robinson H, Kelly S, Pitzalis C (2009). Basic synovial biology and immunopathology in psoriatic arthritis.. nameOfConference


    QMRO: qmroHref
  • Eltawil NM, De Bari C, Achan P et al. (2009). A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury.. nameOfConference


    QMRO: qmroHref
  • Evans HG, Gullick NJ, Kelly S et al. (2009). In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses.. nameOfConference


    QMRO: qmroHref
  • Patel HB, Bombardieri M, Pitzalis C et al. (2009). Activation of melanocortin receptor type 3 as a new strategy to control experimental and rheumatoid arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bombardieri M, Ciccia F, Principato A et al. (2009). IL-23 OVEREXPRESSION AS IMMUNOLOGICAL SIGNATURE OF SUBCLINICAL INTESTINAL INFLAMMATION IN ANKYLOSING SPONDYLITIS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ciccia F, Bombardieri M, Principato A et al. (2009). Overexpression of Interleukin-23, but Not Interleukin-17, as an Immunologic Signature of Subdinical Intestinal Inflammation in Ankylosing Spondylitis. nameOfConference


    QMRO: qmroHref
  • Garrood T, Lee L, Blades M et al. (2009). TNF-ALPHA MODULATES TISSUE-SPECIFIC VASCULAR DETERMINANTS RECOGNIZED IN VIVO BY A PHAGE CLONE DISPLAYING A SYNOVIAL-HOMING PEPTIDE IN THE HUMAN/SCID MOUSE TRANSPLANTATION MODEL. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Conigliaro P, Priori R, Bombardieri M et al. (2009). Lymph node IL-18 expression in adult-onset Still’s disease. nameOfConference


    QMRO: qmroHref
  • Dell'Accio F, Eltawil NM, De Bari C et al. (2009). WNT16 in joint surface injury and osteoarthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kamperidis P (2009). Identification of Single-Chain Antibody Fragments Specific for Human Synovial Microvasclar Endothelium by In-Vivo Phage Display. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Keeble J, Blades M, Pitzalis C et al. (2005). The role of substance P in microvascular responses in murine joint inflammation. nameOfConference


    QMRO: qmroHref
  • Humby F, Bombardieri M, Manzo A et al. (2009). Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium.. nameOfConference


  • Colom B, Scheiermann C, Woodfin A et al. (2009). Effect of soluble JAM-C on leukocyte transmigration in models of ischemia/reperfusion injury. nameOfConference


    QMRO: qmroHref
  • Evans HG, Gullick NJ, Kelly S et al. (2008). Potent induction of Th17 cells by synovial monocytes from active rheumatoid arthritis patients. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Manzo A, Vitolo B, Humby F et al. (2008). Mature Antigen-Experienced T Helper Cells Synthesize and Secrete the B Cell Chemoattractant CXCL13 in the Inflammatory Environment of the Rheumatoid Joint. nameOfConference


    QMRO: qmroHref
  • Eltawil NM, De Bari C, Achan P et al. (2008). 54 A NOVEL AGE- AND STRAIN-DEPENDENT IN VIVO MODEL OF ARTICULAR CARTILAGE HEALING IN MICE. nameOfConference


    QMRO: qmroHref
  • El Tawil NM, De Bari C, Pitzalis C et al. (2008). A mouse model of joint surface injury and repair in mice. Age and strain-dependent outcome. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Connolly M, McCormick J, Marelli A et al. (2008). A-SAA induces rho GTPase-dependent cytoskeletal rearrangement and in vivo migration of fluorochrome labelled monocytic (u937) cells in a human RA/SCID mice chimera model. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Humby F, Bombardieri M, Antonio M et al. (2008). Ectopic lymphoid structures expressing AID drive self sustained in situ prodction of autoantibodies in rheumatoid synovium. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bugatti S, Manzo A, Caporali R et al. (2008). Lymphocyte organisation and lymphatic angiogenesis in rheumatoid synovitis: Clinical and radiographic correlates. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Evans HG, Gullick NJ, Kelly S et al. (2008). Potent induction of Th17 cells by synovial monocytes from active rheumatoid arthritis patients. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Evans HG, Gullick NJ, Kelly S et al. (2008). Potent induction of th17 cells by synovial monocytes from active rheumatoid arthritis patients. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Humby F, Gullick N, Kelly S et al. (2008). A synovial pathergy reaction leading to a pseudo-septic arthritis and a diagnosis of Behcet's disease. nameOfConference


    QMRO: qmroHref
  • Kelly S, Taylor P, Pitzalis C (2008). Ultrasound imaging in spondyloathropathies: from imaging to diagnostic intervention.. nameOfConference


    QMRO: qmroHref
  • Costantinides Y, Kingsley G, Pitzalis C et al. (2008). Inhibition of lymphocyte proliferation by a monoclonal antibody (RFT2) against CD7. nameOfConference


    QMRO: qmroHref
  • RODRIGUEZ RM, PITZALIS C, KINGSLEY GH et al. (2008). T lymphocyte adhesion to fibronectin (FN): a possible mechanism for T cell accumulation in the rheumatoid joint. nameOfConference


    QMRO: qmroHref
  • Lymphoma RTRTALBOISS-RMSAL-GPB-C, Quartuccio L, Fabris M et al. (2008). Resistance to Rituximab Therapy and Local BAFF Overexpression in Sjögren’s Syndrome-Related Myoepithelial Sialadenitis and Low-Grade Parotid B-Cell Lymphoma. nameOfConference


    QMRO: qmroHref
  • Dell'accio F, De Bari C, Eltawil NM et al. (2008). Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis.. nameOfConference


    QMRO: qmroHref
  • Bombardieri M, Barone F, Humby F et al. (2008). Activation-induced cytidine deaminase expression supports functionality of ectopic lymphoid neogenesis in patients with and animal models of Sjogren's syndrome. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Humby F, Bombardieri M, Manzo A et al. (2008). Activation-induced cytidine deaminase supports self sustained autoantibody production within RA synovium. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Barone F, Bombardieri M, Rosado MM et al. (2008). CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: Association with reactive and malignant areas of lymphoid organization. nameOfConference


    QMRO: qmroHref
  • Garrood T, Blades M, Mather S et al. (2008). Imaging E-selectin expression in human synovium in a scid mouse transplantation model. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Evans HG, Gullick NJ, Kelly S et al. (2008). Potent induction of interleukin-17 producing CD4+ T cells (TH17 cells) by synovial monocytes from active RA patients. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Dell'Accio F, Eltawil NM, De Bari C et al. (2008). Wnt16 in joint surface injury and osteoarthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bombardieri M, Barone F, Pitzalis C (2008). Response to comment on "Activation-Induced Cyridine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis aud MALT Lymphoma in Sjogren's Syndrome". nameOfConference


    QMRO: qmroHref
  • De Bari C, Dell'Accio F, Karystinou A et al. (2008). A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells.. nameOfConference


    QMRO: qmroHref
  • Astorri E, Bombardieri M, Guglielmi C et al. (2008). Beta cell regeneration in type 1 diabetes: the role of Reg genes in NOD mice. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Evans H, Gullick N, Kelly S et al. (2008). Potent induction of interleukin-17 producing CD4+T cells (Th17 cells) by synovial monocytes from active RA patients. nameOfConference


    QMRO: qmroHref
  • Manzo A (2008). Re-programming of the CXCL13-CCL21 Lymphoid Chemokine System in Ectopic Lymphoid Neogenesis during Chronic Arthritis.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Gerli R, Lunardi C, Bocci EB et al. (2008). Anti-tumor necrosis factor-alpha response in rheumatoid arthritis is associated with an increase in serum soluble CD30.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Manzo A, Bugatti S, Caporali R et al. (2007). CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis. nameOfConference


    QMRO: qmroHref
  • Manzo A, Pitzalis C (2007). Lymphoid tissue reactions in rheumatoid arthritis.. nameOfConference


    QMRO: qmroHref
  • Barone F, Bombardieri M, Spencer J et al. (2007). CXCL13, CCL21 and CXCL12 are upregulated in mucosal-associated lymphoid tissue lymphomas in patients with Sjorgen's syndrome and cooperate in the maintenance of the immune response and malignant cell survival. nameOfConference


    QMRO: qmroHref
  • Bombardieri M, Barone F, Humby F et al. (2007). Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjögren's syndrome.. nameOfConference


    QMRO: qmroHref
  • Choy EHS, Smith CM, Farewell V et al. (2008). Factorial randomised controlled trial of glucocorticoids and combination disease modifying drugs in early rheumatoid arthritis. nameOfConference


    QMRO: qmroHref
  • de Bari C, Guillot PV, Fisk NM et al. (2007). Mathematical modeling to predict bone forming potency of human mesenchymal stem cells. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brunton F, Lee L, Nissim A et al. (2007). Targeting osteoclasts in rheumatoid arthritis via the alpha(v)beta(3) integrin. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Humby F, Manzo A, Kirkham B et al. (2007). The synovial membrane as a prognostic tool in rheumatoid arthritis.. nameOfConference


    QMRO: qmroHref
  • Tyndall A, Walker UA, Cope A et al. (2007). Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005. nameOfConference


    QMRO: qmroHref
  • Kamperidis PS, Lee L, Blades M et al. (2007). Identification of single-chain antibody fragments specific for human synovial microvascular endothelium by in vivo phage display. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Scire CA, Epis O, Codullo V et al. (2007). Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure. nameOfConference


  • Lee L, Garrood T, Pitzalis C (2007). In vivo phage display selection in the human/SCID mouse chimera model for defining synovial specific determinants.. nameOfConference


    QMRO: qmroHref
  • Bombardieri M, McInnes IB, Pitzalis C (2007). Interleukin-18 as a potential therapeutic target in chronic autoimmune/inflammatory conditions.. nameOfConference


    QMRO: qmroHref
  • Brunton F, Lee L, Nissim A et al. (2007). Modulating osteoclast function by targeting the alphavbeta3 integrin. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • De Bari C, Pringle S, Pitzalis C et al. (2006). The stem cell niche: a new target in medicine. nameOfConference


    QMRO: qmroHref
  • DELL'ACCIO F, Pitzalis C, Barone F et al. (2006). Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury. nameOfConference


  • KINGSLEY G, PITZALIS C, KYRIAZIS N et al. (1988). Abnormal Helper‐Inducer/Suppressor–Inducer T‐Cell Subset Distribution and T‐Cell Activation Status are Common to All Types of Chronic Synovitis. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Garrood T (2006). From ubiquitous antigens to joint-specific inflammation: could local vascular permeability be the missing link?. nameOfConference


    QMRO: qmroHref
  • Filer A, Pitzalis C, Buckley CD (2006). Targeting the stromal microenvironment in chronic inflammation. nameOfConference


    QMRO: qmroHref
  • PITZALIS C, Barone F, Peakman M et al. (2006). Atorvastatin fails to prevent the development of autoimmune diabetes despite inhibition of pathogenic beta-cell-specific CD8 T-cells. nameOfConference


    QMRO: qmroHref
  • De Bari C, Dell'Accio F, Vanlauwe J et al. (2006). Mesenchymal multipotency of adult human periosteal cells demonstrated by single‐cell lineage analysis. nameOfConference


    QMRO: qmroHref
  • Garrood T, Pitzalis C (2006). Targeting the inflamed synovium: The quest for specificity. nameOfConference


    QMRO: qmroHref
  • DeBari C, Pitzalis C, Dell'Accio F (2006). Reparative medicine: from tissue engineering to joint surface regeneration. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Kingsley GH, Haskard DO et al. (1989). Comment on the article by Lasky et a1. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Cauli A, Pipitone N et al. (1996). Cutaneous lymphocyte antigen‐positive T lymphocytes preferentially migrate to the skin but not to the joint in psoriatic arthritis. nameOfConference


    QMRO: qmroHref
  • Choy EHS, Pitzalis C, Cauli A et al. (1996). Percentage of anti‐CD4 monoclonal antibody‐coated lymphocytes in the rheumatoid joint is associated with clinical improvement. Implications for the development of immunotherapeutic dosing regimens. nameOfConference


    QMRO: qmroHref
  • Sieper J, Kingsley G, Palacios‐Boix A et al. (1991). Synovial T lymphocyte–specific immune response to Chlamydia trachomatis in Reiter's disease. nameOfConference


    QMRO: qmroHref
  • Garrood T, Lee L, Pitzalis C (2006). Molecular mechanisms of cell recruitment to inflammatory sites: general and tissue-specific pathways. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Kingsley G, Haskard D et al. (1988). The preferential accumulation of helper‐inducer T lymphocytes in inflammatory lesions: evidence for regulation by selective endothelial and homotypic adhesion. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Kingsley GH, Covelli M et al. (1991). Selective migration of the human helper‐inducer memory T cell subset: confirmation by in vivo cellular kinetic studies. nameOfConference


    QMRO: qmroHref
  • Bugatti S, Caporali R, Manzo A et al. (2005). Involvement of subchondral bone marrow in rheumatoid arthritis: Lymphoid neogenesis and in situ relationship to subchondral bone marrow osteoclast recruitment. nameOfConference


    QMRO: qmroHref
  • PITZALIS C, Manzo A, Bombardieri M et al. (2005). Association of CXCL13 and CCL21 Expression With the Progressive Organization of Lymphoid-like Structures in Sjogren’s Syndrome. nameOfConference


    QMRO: qmroHref
  • PITZALIS C, Manzo A, Uguccioni M et al. (2005). Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis. nameOfConference


    QMRO: qmroHref
  • Pipitone N, Pitzalis C (2004). Recent advances in the treatment of psoriatic arthritis. nameOfConference


    QMRO: qmroHref
  • Manzo A, Bugatti S, Buckley C et al. (2005). CCL21 relationship with lymphoid neogenesis and lymphatic vascular system in chronically inflamed synovium. nameOfConference


    QMRO: qmroHref
  • De Bari C, Dell'Accio F, Vanlauwe J et al. (2005). Distinct biological properties of human mesenchymal stem cells from different sources. nameOfConference


    QMRO: qmroHref
  • Bombardieri M, Barone F, Proctor G et al. (2005). Efficient IL-18 and IL-18BPc adenoviral gene transfer to cultured murine submandibular gland epithelial cells and successful murine retrograde submandibular duct cannulation to modulate IL-18 function in the salivary gland of animal models of Sjogren's syndrome. nameOfConference


    QMRO: qmroHref
  • Dell'Accio F, De Bari C, Pitzalis C (2005). Molecular response to cartilage injury. nameOfConference


    QMRO: qmroHref
  • Barone F, Bombardieri M, Blades M et al. (2004). Lymphoid chemokine expression in Sjogren's syndrome: relationship with the lymphoid organization of the periductal inflammatory aggregates. nameOfConference


    QMRO: qmroHref
  • Pipitone N, Pitzalis C (2004). Arthritides in the elderly.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bombardieri M, Barone F, Pittoni V et al. (2004). Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Manzo A, Paoletti S et al. (2003). Lymphoid neogenesis in chronic inflammation. nameOfConference


    QMRO: qmroHref
  • De Benedetti F, Pignatti P, Biffi M et al. (2003). Increased expression of alpha(1,3)-fucosyltransferase-VII and P-selectin binding of synovial fluid T cells in juvenile idiopathic arthritis.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pipitone N, Kingsley GH, Manzo A et al. (2003). Current concepts and new developments in the treatment of psoriatic arthritis. nameOfConference


    QMRO: qmroHref
  • George AJT, Lee L, Pitzalis C (2003). Isolating ligands specific for human vasculature using in vivo phage selection. nameOfConference


    QMRO: qmroHref
  • Manzo A, Carulli M, Paoletti S et al. (2003). BCA-1 (CXCL13) and SLC (CCL21) production and lymphoid neogenesis in rheumatoid synovitis. nameOfConference


    QMRO: qmroHref
  • Barone F, Blades M, Manzo A et al. (2003). CXCL13 and CCL21 play a key role in ectopic lymphoneogenesis in Sjögren's syndrome. nameOfConference


    QMRO: qmroHref
  • Lee L, Buckley C, Blades M et al. (2003). Identification of homing peptides specific for human synovium by in vivo phage display selection. nameOfConference


    QMRO: qmroHref
  • Manzo A, Caporali R, Montecucco C et al. (2003). Role of chemokines and chemokine receptors in regulating specific leukocyte trafficking in the immune/inflammatory response.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Gerli R, Lunardi C, Pitzalis C (2002). Unmasking the anti‐inflammatory cytokine response in rheumatoid synovitis. nameOfConference


    QMRO: qmroHref
  • Gerli R, Pitzalis C, Lunardi C (2002). The role of T cell cytokines in modulating joint inflammation in rheumatoid arthritis.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Perretti M, Ingegnoli F, Wheller SK et al. (2002). Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model.. nameOfConference


    QMRO: qmroHref
  • PITZALIS C, Lee L, Panayi G et al. (2002). Identification of Synovium-Specific Homing Peptides by In Vivo Phage Display Selection. nameOfConference


    QMRO: qmroHref
  • Blades MC, Manzo A, Ingegnoli F et al. (2002). Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice. nameOfConference


    QMRO: qmroHref
  • Perretti M, Blades MC, Wheller SK et al. (2002). Monocytic cells over-expressing annexin 1 have reduced transmigration in vitro and elicitation in vivo. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Blades MC, Ingegnoli F, Wheller SK et al. (2002). Stromal cell-derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID mice. nameOfConference


    QMRO: qmroHref
  • Matsuno H, Yudoh K, Katayama R et al. (2002). The role of TNF‐α in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA/SCID mouse chimera. nameOfConference


    QMRO: qmroHref
  • Lee L, Buckley C, Blades M et al. (2002). Identification of homing peptides specific for synovial microvascular endothelium using in vivo phage display selection. nameOfConference


    QMRO: qmroHref
  • Blades M, Manzo A, Ingegnoli F et al. (2002). Stromal cell derived factor-1 (CXCL12) induces cell migration into lymph nodes transplanted into SCID MICE. An investigation of lymphocyte migration to secondary lymphoid organs. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Pipitone N, Perretti M (2002). Regulation of leukocyte-endothelial interactions by glucocorticoids. nameOfConference


    QMRO: qmroHref
  • Goulding NJ, Ogbourn S, Pipitone N et al. (2001). The inhibitory effect of dexamethasone on lymphocyte adhesion molecule expression and intercellular aggregation is not mediated by lipocortin 1. nameOfConference


    QMRO: qmroHref
  • Wahid S, Blades MC, De Lord D et al. (2001). Tumour necrosis factor-alpha (TNF-α) enhances lymphocyte migration into rheumatoid synovial tissue transplanted into severe combined immunodeficient (SCID) mice. nameOfConference


    QMRO: qmroHref
  • Pipitone N, Sinha M, Theodoridis E et al. (2001). The glucocorticoid inhibition of LFA-1 and CD2 expression by human mononuclear cells is reversed by IL-2, IL-7 and IL-15. nameOfConference


    QMRO: qmroHref
  • Panayi GS, Corrigall VM, Pitzalis C (2001). PATHOGENESIS OF RHEUMATOID ARTHRITIS The Role of T Cells and Other Beasts. nameOfConference


    QMRO: qmroHref
  • Pitzalis C (2001). In vivoselection of synovial specific targets using phage display technology. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Pipitone N, Pipitone V et al. (2001). Rheumatoid arthritis. Recent findings and new pathogenic concepts.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Gerli R, Lunardi C, Vinante F et al. (2001). Role of CD30+ T cells in rheumatoid arthritis: a counter-regulatory paradigm for Th1-driven diseases. nameOfConference


    QMRO: qmroHref
  • Pipitone N, Fioravanti A, Marcolongo R et al. (2001). Articular involvement in the course of primary hypogammaglobulinemia.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pitzalis C, Pipitone N, Perretti M (2001). Glucocorticoids and leukocyte adhesion. nameOfConference


    QMRO: qmroHref
  • Pipitone N, Pipitone V, Pitzalis C (2001). Glucocorticoids at the threshold of the new millennium: recent findings on the anti-inflammatory and immunomodulator mechanisms of action and future perspectives.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Huizinga TW, Keijsers V, Yanni G et al. (2000). Are differences in interleukin 10 production associated with joint damage?. nameOfConference


    QMRO: qmroHref
  • Pipitone N, Jolliffe VA, Cauli A et al. (2000). Do B cells influence disease progression in chronic synovitis? Lessons from primary hypogammaglobulinaemia. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Koch A (2000). THE VASCULAR ENDOTHELIAL SYSTEM IN THE PATHOGENESIS OF INFLAMMATION AND SYSTEMIC RHEUMATIC DISEASES: RELATION TO THE NEUROENDOCRINE SYSTEM. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Pipitone N (2000). Psoriatic arthritis. nameOfConference


    QMRO: qmroHref
  • Cauli A, Pitzalis C, Yanni G et al. (2000). CD1 expression in psoriatic and rheumatoid arthritis. nameOfConference


    QMRO: qmroHref
  • Gerli R, Pitzalis C, Bistoni O et al. (2000). CD30+ T Cells in Rheumatoid Synovitis: Mechanisms of Recruitment and Functional Role. nameOfConference


    QMRO: qmroHref
  • Pipitone N, Pitzalis C (2000). The role of chemokines in inflammation and rheumatoid arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Gerli R, Bistoni O, Lunardi C et al. (1999). Soluble CD30 in early rheumatoid arthritis as a predictor of good response to second-line therapy. nameOfConference


    QMRO: qmroHref
  • Masi AT, Bijlsma JWJ, Chikanza IC et al. (1999). Neuroendocrine, immunologic, and microvascular systems interactions in rheumatoid arthritis: physiopathogenetic and therapeutic perspectives. nameOfConference


    QMRO: qmroHref
  • Perretti M, Wheller SK, Flower RJ et al. (1999). Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions. nameOfConference


    QMRO: qmroHref
  • Howie D, Spencer J, DeLord D et al. (1998). Extrathymic T cell differentiation in the human intestine early in life.. nameOfConference


    QMRO: qmroHref
  • Choy EH, Schantz A, Pitzalis C et al. (1998). The pharmacokinetics and human anti-mouse antibody response in rheumatoid arthritis patients treated with a chimeric anti-CD4 monoclonal antibody.. nameOfConference


    QMRO: qmroHref
  • Pitzalis C (1998). Skin and joint disease in psoriatic arthritis: what is the link?. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Choy E (1998). Fourth International Symposium on the Immunotherapy of the Rheumatic Diseases. 21-25 May 1997, Cyprus.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pitzalis C, Choy E (1998). Fourth International Symposium on the Immunotherapy of the Rheumatic Diseases. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pitzalis C, Pipitone N, Bajocchi G et al. (1997). Corticosteroids inhibit lymphocyte binding to endothelium and intercellular adhesion: an additional mechanism for their anti-inflammatory and immunosuppressive effect.. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Sharrack B, Gray IA et al. (1997). Comparison of the effects of oral versus intravenous methylprednisolone regimens on peripheral blood T lymphocyte adhesion molecule expression, T cell subsets distribution and TNF alpha concentrations in multiple sclerosis. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Pipitone N, Marcolongo R et al. (1997). Monoclonal antibody therapy.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • PITZALIS C (1996). ROLE OF ADHESION MECHANISMS IN THE PATHOGENESIS OF CHRONIC SYNOVITIS. nameOfConference


    QMRO: qmroHref
  • Yanni G, Ramage W, Pitzalis C et al. (1996). Th1 and Th2 cytokines in rheumatoid arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Cauli A, Yanni G, Pitzalis C et al. (1995). Cytokine and adhesion molecule expression in the minor salivary glands of patients with Sjögren's syndrome and chronic sialoadenitis.. nameOfConference


    QMRO: qmroHref
  • Pipitone N, Bajocchi G, Pitzalis C (1995). Leucocyte adhesion and migration mechanism during inflammation: Role in pathogenesis and prospects for therapy. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Meliconi R, Uguccioni M, Chieco-Bianchi F et al. (1995). The role of interleukin-8 and other cytokines in the pathogenesis of Felty's syndrome.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pitzalis C, Kingsley G, Panayi G (1994). Adhesion molecules in rheumatoid arthritis: role in the pathogenesis and prospects for therapy.. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Choy E, Kingsley G (1994). Monoclonal antibody therapy in rheumatic disease.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Arnold MH, Pitzalis C, Corrigall VM et al. (1994). CD8 lymphocytes in polymyalgia rheumatica and giant cell arteritis: a reply.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Lanchbury JS, Pitzalis C (1993). Cellular immune mechanisms in rheumatoid arthritis and other inflammatory arthritides. nameOfConference


    QMRO: qmroHref
  • (1993). BSR Poster Session a. nameOfConference


    QMRO: qmroHref
  • Pitzalis C (1993). Adhesion and migration of inflammatory cells.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Arnold MH, Corrigall VM, Pitzalis C et al. (1993). The sensitivity and specificity of reduced CD8 lymphocyte levels in the diagnosis of polymyalgia rheumatica/giant cell arteritis.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kirkham BW, Thien F, Pelton BK et al. (1992). Chimeric CD7 monoclonal antibody therapy in rheumatoid arthritis.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Panayi GS, Kingsley GH, Pitzalis C (1992). Adhesion of peripheral blood lymphocytes to high endothelial venules of gut mucosa.. nameOfConference


    QMRO: qmroHref
  • Meliconi R, Kingsley GH, Pitzalis C et al. (1992). Analysis of lymphocyte phenotype and T cell receptor genotype in Felty's syndrome.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Groves RW, Simpson KJ, Koblar S et al. (1992). Tryptophan Induced Eosinophilia-Myalgia Syndrome: Clinical and Microscopic Findings. nameOfConference


    QMRO: qmroHref
  • KIRKHAM BW, PITZALIS C, KINGSLEY GH et al. (1991). MONOCLONAL ANTIBODY TREATMENT IN RHEUMATOID ARTHRITIS: THE CLINICAL AND IMMUNOLOGICAL EFFECTS OF A CD7 MONOCLONAL ANTIBODY. nameOfConference


    QMRO: qmroHref
  • Meliconi R, Pitzalis C, Kingsley GH et al. (1991). γδ T cells and their subpopulations in blood and synovial fluid from rheumatoid arthritis and spondyloarthritis. nameOfConference


    QMRO: qmroHref
  • Wellicome SM, Thornhill MH, Pitzalis C et al. (1990). A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1, or lipopolysaccharide.. nameOfConference


    QMRO: qmroHref
  • RIDLEY MG, KINGSLEY G, PITZALIS C et al. (1990). MONOCYTE ACTIVATION IN RHEUMATOID ARTHRITIS: EVIDENCE FOR IN SITU ACTIVATION AND DIFFERENTIATION IN JOINTS. nameOfConference


    QMRO: qmroHref
  • MARKEY AC, ALLEN MH, PITZALIS C et al. (1990). T‐cell inducer populations in cutaneous inflammation: a predominance of T helper‐inducer lymphocytes (THi) in the infiltrate of inflammatory dermatoses. nameOfConference


    QMRO: qmroHref
  • KINGSLEY G, PITZALIS C, PANAYI GS (1990). IMMUNOGENETIC AND CELLULAR IMMUNE MECHANISMS IN RHEUMATOID ARTHRITIS: RELEVANCE TO NEW THERAPEUTIC STRATEGIES. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Sieper J, Kingsley G et al. (1990). The immunopathology of sexually acquired reactive arthritis: The role of Chlamydia trachomatis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Dasgupta B, Pitzalis C, Panayi GS (1989). Inflammation of the uveal tract as a presenting feature of temporal arteritis.. nameOfConference


    QMRO: qmroHref
  • Dasgupta B, Duke O, Timms AM et al. (1989). Selective depletion and activation of CD8+ lymphocytes from peripheral blood of patients with polymyalgia rheumatica and giant cell arteritis.. nameOfConference


    QMRO: qmroHref
  • Kirkham BW, Pitzalis C, Kingsley GH et al. (1989). Rheumatoid T lymphocyte MHC class II expression: in vitro stimulation produces normal MHC class II expression, independent of proliferation.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Haskard DO, Strobel S, Thornhill M et al. (1989). Mechanisms of lymphocyte adhesion to endothelial cells: studies using a LFA-1-deficient cell line.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kingsley G, Pitzalis C, Waugh AP et al. (1988). Correlation of immunoregulatory function with cell phenotype in cord blood lymphocytes.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kirkham B, Chikanza I, Pitzalis C et al. (1988). RESPONSE TO MONOCLONAL CD7 ANTIBODY IN RHEUMATOID ARTHRITIS. nameOfConference


    QMRO: qmroHref
  • Pitzalis C, Kingsley G, Murphy J et al. (1987). Abnormal distribution of the helper-inducer and suppressor-inducer T-lymphocyte subsets in the rheumatoid joint. nameOfConference


    QMRO: qmroHref
  • Kingsley GH, Pitzalis C, Panayi GS (1987). Abnormal lymphocyte reactivity to self-major histocompatibility antigens in rheumatoid arthritis.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Pitzalis C, Kingsley G, Lanchbury JS et al. (1987). Expression of HLA-DR, DQ and DP antigens and interleukin-2 receptor on synovial fluid T lymphocyte subsets in rheumatoid arthritis: evidence for "frustrated" activation.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nicholas NS, Panayi GS, Murphy J et al. (1986). Human retroplacental sera inhibit the expression of class II major histocompatibility antigens. nameOfConference


    QMRO: qmroHref

Sponsors

Collaborators

Internal

External

  • Professor Anne Barton
  • Professor Simon Jones
  • Professor Chris Buckley
  • Professor Iain McInnes
  • Professor Peter Taylor
  • Professor Marta Alarcón Riquelme
  • Professor Maya Buch
  • Dr Juan Cañete
  • Professor Eduardo Collantes
  • Professor Patrick Durez
  • Professor Alberto Cauli
  • Professor Ronald Van Vollenhoven
  • Professor João E Fonseca
  • Professor Pier Paolo Sainaghi

News

Disclosures

  • AbbVie: Consultant/Speaker/Contract Research
  • Janssen: Consultant/Speaker/Contract Research
  • Kinikska: Consultant
  • Norvartis: Contract Research
  • Sanofi: Contract Research
  • Exagen: Consultant
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