Dr Mohey Eldin El ShikhSenior Lecturer, Education Lead (Centre for Experimental Medicine and Rheumatology), Lead (WHRI Work Experience Programme)Centre: Experimental Medicine and RheumatologyEmail: m.elshikh@qmul.ac.ukTelephone: +44(0) 20 7882 8202ResearchKey PublicationsSponsorsCollaboratorsResearch In 2009 Dr El Shikh discovered the ability of immune-complex-loaded follicular dendritic cells (FDCs) to induce T cell-independent immunity to T cell-dependent antigens in responses co-stimulated with FDC-derived BAFF and C4bBP. He has recently described a novel pathway of antigen processing and presentation by FDCs to B cells in germinal centres that is potentially involved in autoreactive B cell activation, breach of B cell tolerance, and perpetuation of autoimmunity. His recent findings that B cell tolerance to self-TNF-alpha, -IgE, -ECDII, and -HEL can be broken in well verified models of tolerance by self-antigen presentation by FDCs support the hypothesis that presentation of self/neo-antigens to B cells by activated FDCs induces autoreactive GC formation, auto-Ab secretion, and perpetuation of B cell autoimmunity. He is currently dissecting the molecular mechanisms underpinning this hypothesis which will not only advance our understanding of the mechanisms involved in autoreactive B cell activation and breakage of tolerance but also potentially open up a novel therapeutic avenue by inducing high affinity self-regulated auto-Abs to target endogenous mediators of chronic autoimmune and hypersensitivity diseases like TNF-alpha IgE, and ECDII. Publications Aly NAR, Rizk S, Enein AA et al. (publicationYear). The role of lymphoid tissue SPARC in the pathogenesis and response to treatment of multiple myeloma. nameOfConference DOI: 10.3389/fonc.2022.1009993 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/83762 Shikh MEME, Sayed RE, Aly NAR et al. (publicationYear). Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis. nameOfConference DOI: 10.3389/fmed.2022.1013660 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/82586 Elsayed R, Kurago Z, Cutler CW et al. (2020). Role of dendritic cell‐mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw. nameOfConference DOI: 10.1096/fj.201901819rr QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66199 El Shikh MEM, El Sayed R, Nerviani A et al. (2019). Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis. nameOfConference DOI: 10.1016/j.jaut.2019.06.008 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/58983 Rivellese F, Mauro D, Nerviani A et al. (2018). Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production. nameOfConference DOI: 10.1136/annrheumdis-2018-213418 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/44263 Shikh ME, Sayed RE, Fossati-Jimack L et al. (2018). O001 Lymphoid tissue macrophages express peptidylarginine deiminase 2 and 4: new implications in citrullination and anti-citrulline antibodies production in autoimmune arthritis. Oral presentations DOI: 10.1136/annrheumdis-2018-ewrr2018.1 QMRO: qmroHref Elsayed R, Celis E, Sultan H et al. (2018). Impaired Dendritic Cell Function and Bacterial Load Increase in the Oral Microenvironment as Contributing Factors to the Induction of MRONJ. nameOfConference DOI: doi QMRO: qmroHref Altamimi A-MS, Alafeefy AM, Balode A et al. (2017). Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A. nameOfConference DOI: 10.1080/14756366.2017.1404593 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/32141 Lownik JC, Luker AJ, Damle SR et al. (2017). ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses. nameOfConference DOI: 10.4049/jimmunol.1700833 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/25831 El Shikh MEM, El Sayed R, Pitzalis C (publicationYear). Isolation and Characterization of Mouse and Human Follicular Dendritic Cells.. nameOfConference DOI: 10.1007/978-1-4939-7095-7_10 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/28692 View Profile Publication Page Sponsors William Harvey Research Foundation CollaboratorsInternal Costantino Pitzalis (QMUL) Francesco Dell'Accio (QMUL) Michele Bombardieri (QMUL) External John G. Tew, (School of Medicine, VA, USA) Daniel H. Conrad, (School of Medicine, VA, USA) Masoud H. Manjili, (School of Medicine, VA, USA) Harvey A. Schenkein, (VCU School of Dentistry) Christopher G. Mueller ,Immunologie et Chimie Therapeutiques) Back to top