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The William Harvey Research Institute - Barts and The London

Professor Anthony Mathur

Anthony

Centre for Cardiovascular Medicine and Device Innovation, Centre Lead

Centre: Clinical Pharmacology

Email: a.mathur@qmul.ac.uk
Telephone: +44(0) 20 3765 8740

Profile

I divide my time equally between clinical work and translational medicine and research. My research focuses on examining the role of biologics (stem cells, gene therapy, cellular bioenergetics, megakaryocyte biology) in the treatment of cardiovascular disease. As the Clinical Director for Interventional Cardiology at Barts Health, my clinical work is directed towards the management of patients who have failed conventional therapy for heart failure and angina. Furthermore, I Chair the ESC Task Force on stem cells in cardiovascular disease and, previously, I Chaired the British Cardiac Stem Cells Collaborative set up by Prof. John Martin. I also lead the Compassionate Stem Cell Treatment Unit for patients with cardiac disease at Barts Heart Centre.

Within the Centre for Cardiovascular Medicine and Device Innovation, I lead the Cardiovascular Devices Hub. The CVDHub supports collaborations between academic, clinical, engineering and industrial innovators to develop clinically and commercially viable cardiovascular devices. This novel, cross-speciality unit helps small to medium enterprises (SMEs) over the hurdles involved in taking innovations to human trials. Within device innovation, I focus on first-in-man trials, digital technologies (e.g Avatars) and artificial intelligence.

Research

I lead a collaborative group with several investigators (including Prof. John Martin (UCL), Prof. Amrita Ahluwalia (Queen Mary), Prof. Andreas Baumbach (Queen Mary) and Prof. Alexandra Lansky (Yale)) seeking to address the role of biologics in the treatment of cardiovascular disease; translating basic research into therapeutic approaches in man. My interventional cardiology research aims to develop new treatments for patients that fall outside the remit of current recognised therapies. I have designed a series of trials addressing the use of stem cells in the treatment of cardiovascular disease, and am currently the CI for one of the first Phase III clinical trials of cell therapy in acute myocardial infarction. I am also interested in the use of advanced cardiac imaging, and established the first Cardiac CMR service at Barts Health.

Key Publications

For a full list of publications click here

  • Mathur A, Martin JF (2004). Stem cells and repair of the heart. Lancet Vol.364, (9429) 183-192.
  • Martin JF, Kristensen SD, Mathur A et al. (2012). The causal role of megakaryocyte-platelet hyperactivity in acute coronary syndromes. NATURE REVIEWS CARDIOLOGY Vol.9, (11) 1759-5002 658-670. 
  • Bartunek J, Dimmeler S, Drexler H et al. (2006). The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart. EUR HEART J Vol.27, (11) 0195-668X 1338-1340. 10.1093/eurheartj.ehi793
  • Fisher SA, Dorée C, Brunskill SJ et al. (2013). Bone Marrow Stem Cell Treatment for Ischemic Heart Disease in Patients with No Option of Revascularization: A Systematic Review and Meta-Analysis. PLoS One Vol.8, (6) e64669-.
  • Clifford DM, Fisher SA, Brunskill SJ et al. (2012). Long-term effects of autologous bone marrow stem cell treatment in acute myocardial infarction: factors that may influence outcomes. PLoS One Vol.7, (5) e37373 10.1371/journal.pone.0037373.