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Professor Charles Hinds

Charles

Professor (Emeritus) and Consultant in Intensive Care Medicine

Centre: Translational Medicine and Therapeutics

Email: c.j.hinds@qmul.ac.uk
Telephone: +44(0) 20 3765 8878

Profile

Charles Hinds qualified at St. Bartholomew’s Hospital in 1972 and was appointed as Consultant and Senior Lecturer in Anaesthesia and Intensive Care at the same hospital in 1980. Subsequently, he was Director of the Intensive Unit at Barts, and later for the combined Barts and The London NHS Trust, for more than 15 years. He is a past President of the Intensive Care Society and was Chairman of Examiners for the UK Diploma of Intensive Care. He was UK Representative for the European Society of Intensive Care Medicine and a member of the Education and Training Subcommittee of the ESICM. He was for many years a member of the Research Committee of the Intensive Care Society. In January 2007 Professor Hinds was awarded a College Medal by the Royal College of Anaesthetists as a mark of distinction for his work in helping the College to achieve its aims and for his support for the speciality. He was subsequently invited to deliver the Samuel Thompson Rowling oration at the College. In 2013 Prof. Hinds was awarded Honorary Lifetime Memberships of the ESICM and UK Intensive Care Society. Together with Prof. Watson, Professor Hinds has published three editions of their popular textbook: Intensive Care: A concise textbook. Professor Hinds was recently awarded a Gold Medal by the Faculty of Intensive Care Medicine.

Memberships and awards

  • Honorary Lifetime Member of the European Society of Intensive Care Medicine and the UK Intensive Care Society
  • Royal College of Anaesthetists College Medal
  • Gold Medal of the Faculty of Intensive Care Medicine

Research

Critical Care and Perioperative Medicine Research Group


Group members

Professor Gareth Ackland, Professor Mark Griffiths, Professor Rupert Pearse, Dr John Prowle, Dr Zudin Pulthucheary, Dr Parjam Zolfaghari and Dr Alastair Proudfoot.

Summary 

Professor Hinds’ research interests have included the pathophysiology and treatment of sepsis, “goal-directed” haemodynamic therapy, endocrine aspects of critical illness, critical illness polyneuromyopathy and intensive care for patients with malignancy. Professor Hinds helped to establish the UK Critical Care Genomics Group which has recently completed a large National investigation (ukccggains.com), as well as being National Co-ordinator for the European “GenOSept” study (ESICM). Currently the group focusses on “multi-omic” approaches to the investigation of sepsis (GAinS2/Sepsis Immunomics), recently including COVID. Other current research interests include the host response to high-risk surgery.

 

Key Publications

For a full list of publications click here

  • Andrew J. Kwok, Alice Allcock, Ricardo C. Ferreira, Eddie Cano-Gamez, Madeleine Smee, Katie L. Burnham, Yasemin-Xiomara Zurke, Emergency Medicine Research Oxford (EMROx)*, Stuart McKechnie, Alexander J. Mentzer, Claudia Monaco, Irina A. Udalova, Charles J. Hinds, John A. Todd, Emma E. Davenport & Julian C. Knight , Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis, Nature Immunology 2023; 24: 767-779. https://doi.org/10.1038/s41590-023-01490-5 
  • Cano-Gamez E, Burnham KL, Goh C, Allcock A, Malick ZH, Overend L, Kwok A, Smith DA, Peters-Sengers H, Antcliffe D; GAinS Investigators; McKechnie S, Scicluna BP, van der Poll T, Gordon AC, Hinds CJ, Davenport EE, Knight JC. An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression. Sci Transl Med. 2022 Nov 2;14(669):eabq4433. doi: 10.1126/scitranslmed.abq4433. Epub 2022 Nov 2. PMID: 36322631; PMCID: PMC7613832.
  • Kousathanas A, --- Hinds CJ, et al. Whole genome sequencing reveals host factors underlying critical Covid-19. Nature. https://doi.org/10.1038/s41586-022-04576-6 (2022).
  • Ahern DJ --- Hinds CJ, et al, A blood atlas of COVID-19 defines hallmarks of disease severity and specificity, Cell (2022). DOI: 10.1016/j.cell.2022.01.012
  • Cyndi Goh C, K.L. Burnham, M. Azim Ansari, Mariateresa de Cesare, Tanya Golubchik, Paula Hutton, Lauren E. Overend, Emma E. Davenport, Charles J. Hinds, Rory Bowden, Julian C. Knight. Epstein-Barr virus reactivation in sepsis due to community-acquired pneumonia is associated with increased morbidity and an immunosuppressed host transcriptomic endotype. Scientific Reports Nature Research (2020) https://doi.org/10.1038/s41598-020-66713-3
  • Pairo-Castineira, E., Clohisey, S., Klaric, L. ---- Hinds C. J. ---et al. Genetic mechanisms of critical illness in COVID-19. Nature (2021) 591, 92–98 https://doi.org/10.1038/s41586-020-03065-y
  • David B. Antcliffe, Katie L. Burnham, Farah Al-Beidh, Shalini Santhakumaran, Stephen J. Brett,Charles J. Hinds, Deborah   Ashby, Julian C. Knight, and Anthony C. Gordon Transcriptomic Signatures in Sepsis and a Differential Response to Steroids from the VANISH Randomized Trial. American Journal of Respiratory and Critical Care Medicine 2019; 199: 980-986.
  • Timothy Sweeney, Thanneer Perumal, Ricardo Henao, Marshall Nichols, Judith Howrylak, Augustine Choi, Jesus Bermejo-Martin, Raquel Almansa, Eduardo Tamayo, Emma Davenport, Katie Burnham, Charles Hinds, Julian Knight, Chris Woods, Stephen Kingsmore, Geoffrey Ginsburg, Hector Wong, Grant Parnell, Benjamin Tang, Lyle Moldawer, Frederick Moore, Larsson Omberg, Purvesh Khatri, Ephraim Tsalik, Lara Mangravite, and Raymond Langley, A community approach to mortality prediction in sepsis via gene expression analysis. Nature Communications, 2018;9:694.
  • Hew D. T. Torrance, E. Rebecca Longbottom, Mark E. Vivian, Bagrat Lalabekyan, Tom E. F. Abbott, Gareth L. Ackland, Charles J. Hinds, Rupert M. Pearse, Michael J. O'Dwyer Post-operative immune suppression is mediated via reversible, Interleukin-10 dependent pathways in circulating monocytes following major abdominal surgery. Plos ONE 13(9): e0203795.https://doi.org/10.1371/journal.pone.0203795.
  • Katie L. Burnham, Emma E. Davenport, Jayachandran Radhakrishnan, Peter Humburg, Anthony C. Gordon, Paula Hutton, Eduardo Svoren-Jabalera, Christopher Garrard, Adrian V. S. Hill, Charles J. Hinds, and Julian C. Knight. Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia. American Journal of Respiratory and Critical Care Medicine 2017; 196: 328-339.
  • Brendon P. Scicluna, Lonneke A. van Vught, Aeilko H. Zwinderman, Maryse A. Wiewel, Emma E. Davenport, Katie L. Burnham, Peter Nürnberg, Marcus J. Schultz, Janneke Horn, Olaf L. Cremer, Marc J. Bonten, Charles J. Hinds, Hector R. Wong, Julian C. Knight and Tom van der Poll, Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study Lancet Respiratory Medicine 2017; 5: 816-826.
  • Davenport EE, Burnham KL, Radhakrishnan J, Humburg P, Hutton P, Mills TC, Rautanen A, Gordon AC, Garrard C, Hill AVS, Hinds CJ, Knight JC. Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respiratory Medicine 2016; 4: 259-71. 
  • Rauntanen A, Mills TC, Gordon AC, Hutton P, Steffens M, Nuamah R, Chiche J-D, Parks T, Chapman SJ, Davenport EE, Elliott KS, Bion J, Lichtner P, Meitinger T, Wienker TF, Caulfield MJ, Mein C, Bloos F, Bobek I, Cotogni P, Sramek V, Sarapuu S, Kobilay M, Ranieri M, Rello J, Sirgo G, Weiss YG, Russwurm S, Schneider M, Reinhart K, Holloway PA, Knight JC, Garrard CS, Russell JA, Walley KR, Stuber F, Hill ADS, Hinds CJ for the ESICM/ECCRN GenOSept Investigators. Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respiratory Medicine 2015; 3: 53-60.
  • Mills TC, Chapman S, Hutton P, Gordon AC, Bion J, Chiche J-D, Holloway PAH, Stuber F, Garrard CS, Hinds CJ, Hill AVS, Rautanen A for the ESICM/ECCRN GenOSept Investigators. Variants in the mannose-binding lectin gene MBL2 do not associate with sepsis susceptibility or survival in a large European cohort. Clinical Infectious Diseases 2015; on-line.
  • Mills TC, Rautanen A, Elliott KS, Parks T, Naranbhai V, Ieven MM, Butler CC, Little P, Verheij T, Garrard CS, Hinds CJ, Goossens H, Chapman S, Hill AVS. IFITM3 and susceptibility to respiratory viral infections in the community. Journal of Infectious Diseases 2014; 209: 1028-1031.
  • Jesmond Dalli, Lucy V Norling, Trinidad Montero-Melendez, Donata F Canova, Hazem Lashin, Anton M Pavlov, Gleb B Sukhorukov, Charles J Hinds & Mauro Perretti. Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Molecular Medicine 2014; 6: 27-42.
  • Tridente A, Clarke GM, Walden A, McKechnie S, Hutton P, Mills GH, Gordon AC, Holloway PAH, Chiche J-D, Bion J, Stuber F, Garrard C, Hinds C and the GenOSept Investigators. Patients with faecal peritonitis admitted to European Intensive Care Units: An epidemiological survey of the GenOSept cohort. Intensive Care Medicine 2014; 40: 202-210.
  • Walden AP, Clarke GM, McKechnie S, Hutton P, Gordon AC, Rello J, Chiche J-D, Stuber F, Garrard CS, Hinds CJ. Patients with community-acquired pneumonia admitted to European Intensive Care Units: an epidemiological survey of the GenOSept cohort. Critical Care 2014; 18: R58.
  • Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O’Dwyer MJ. Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured Polytrauma Patients. Annals of Surgery 2014;
  • Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocoss MPW, Ahern A, Griggs K, Scott R, Hinds CJ, Rowan K for the OPTIMISE study group. Effect of a peri-operative, cardiac output-guided, hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: A multi-center randomized controlled trial. JAMA 2014; doi:10.1001/jama.2014.5052.
  • Gordon AC, Lagan AL, Aganna E, Cheung L, Peters CJ, McDermott MF, Millo JL, Welsh KI, Holloway P, Hitman GA, Piper RD, Garrard CS, Hinds CJ. TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study. Genes and Immunity 2004; 5: 631-640.
  • Takala J, Ruokonen E, Webster NR, Nielsen MS, Zandstra DF, Vundelinckx G, Hinds CJ. Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med 1999; 341: 785-792.
  • Hayes MA, Timmins AC, Yau EHS, Palazzo M, Hinds CJ, Watson JD.  Elevation of systemic oxygen delivery in the treatment of critically ill patients. New Engl J Med 1994; 330: 1717-1722. 

Collaborators

External

  • Professor Julian Knight (Wellcome Trust Centre for Human Genomics, Oxford)
  • Professor Tony Gordon (Imperial College)
  • Dr Emma Davenport (Sanger Institute, Cambridge)
  • Dr Kate Burnham (Sanger Institute, Cambridge)
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