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The William Harvey Research Institute - Barts and The London

Dr Matthew Traylor

Lecturer in Statistical Genetics

Email: m.traylor@qmul.ac.uk
Telephone: +44(0) 20 7882 6838

Profile

ORCID iD: https://orcid.org/0000-0001-6624-8621 

Twitter: @mtraylor_

Matthew is a statistical geneticist with a focus on cerebrovascular disease. After completing his PhD working on the WTCCC2 Stroke Genetics study, he undertook post-doctoral research at King’s College London and University of Cambridge before joining QMUL as a lecturer in 2019.

Dr Traylor’s research is focused on understanding the causes of cerebrovascular disease and their impact of dementia, using genetics. Through genome-wide association meta-analyses his work has identified dozens of genetic loci associated with stroke and cerebral small vessel disease.

Memberships and awards

  • Member of the International Stroke Genetics Consortium

Research

Summary

As a statistical geneticist, Dr Traylor works primarily on genetic studies of cerebrovascular disease.

His work focuses on several key areas:

  • Large Scale GWAS Meta-analyses of Stroke and Stroke subtypes
  • Genetic studies of MRI markers of cerebral small vessel disease
  • Understanding the causal mechanisms leading to cerebrovascular disease and dementia
  • Developing and implementing methods to tackle the challenge of stroke heterogeneity

 

Key Publications

  • Malik R*, Chauhan G*, Traylor M*, et al. Multi-ancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet. 2018;50:524-537
  • Traylor M, Malik R, Nalls MA, et al. Genetic variation at 16q24.2 is associated with small vessel stroke. Ann Neurol. 2017;81:383-394
  • Traylor M, Tozer J, et al. Novel Association with PLEKHG1 in a Genome-wide Analysis of White Matter Hyperintensities in 11,226 Subjects. Neurology 2019;92:e749-757
  • Rutten-Jacobs LC, Larsson SC, Malik R, Rannikmae K, Sudlow CL, Dichgans M, Markus HS, Traylor M. Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306473 UK Biobank participants. BMJ. 2018;363:k4168.
  • Larsson SC, Traylor M, Markus HS. Homocysteine and small vessel stroke: A mendelian randomization analysis. Ann Neurol. 2019;85:495-501
  • Larsson SC, Traylor M, Malik R, Dichgans M, Burgess SC, Markus HS; On behalf of the International Genomics of Alzheimer's Project (IGAP), for the CoSTREAM Consortium. Modifiable Causal Pathways in Alzheimer’s Disease: A Mendelian Randomization Analysis. BMJ 2017;359:j5375

Collaborators

Internal: Prof Mark Caulfield

External: Prof Hugh Markus (University of Cambridge), Prof Cathryn Lewis (KCL), Dr Chris Anderson (MGH, USA), Dr Rainer Malik (LMU Munich, Germany), Prof Martin Dichgans (LMU Munich, Germany), Dr Susanna Larsson (Uppsala, Sweden)