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The William Harvey Research Institute - Faculty of Medicine and Dentistry

Functional consequences of disease susceptibility in Systemic Lupus Erythematosus (BHSLE)

[REC study No. 07/H0718/49] 

Status: Closed to recruitment

Genetic studies define genetic factors that predispose to disease, however, they do not define the mechanism by which the genes affect the disease progress. This study is aimed at exploring the mechanisms by which causal genetic factors influence disease development. DNA and clinical information are used to look for similarities and differences between people with SLE and those unaffected by the disease. These data can be used to identify genetic differences that are more common in SLE patients and then ask how these genetic factors affect the immune system and how they influence the nature and severity of the disease. 220 patients were recruited to this study.

BHSLE Bio & Data-Resource Metrics

Blood samples have been collected for 220 patients along with clinical data. Sample types collected and bio-banked include plasma, DNA, and peripheral blood mononuclear cells (PBMCs).

Supported by NIHR Barts Biomedical Research Centre



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