Dr Yize Wan

Profile

ORCID iD: 0000-0001-6445-8991

Dr Wan is an NIHR Clinical Lecturer in Intensive Care Medicine and Anaesthesia with the Critical Care and Perioperative Medicine Research Group within the Faculty of Medicine and Dentistry at Queen Mary University of London. She is a dual specialty registrar in anaesthesia and intensive care medicine in London.

Dr Wan completed her undergraduate medical training and PhD at Nottingham University. Her research is centred on the epidemiology of patient populations needing acute healthcare, with a focus on socioeconomic and ethnic determinants. She also leads studies in data science using electronic health record data to investigate persistent critical illness and long-term outcomes following critical care.

Dr Wan co-leads the Research and Audit methodology module for the Critical Care Medicine MSc. She is an editorial fellow for the British Journal of Anaesthesia and sits on the editorial advisory board for BMJ Open.

Research

I lead epidemiological and data science studies aimed at identifying risk factors for acute illness and hospitalisation, development of persistent critical illness, and long-term outcomes following critical care. This research aims to better understand the interaction between acute declines in health and development of long-term illness. It seeks to identify opportunities to intervene and address determinants of long-term poor health, particularly for disadvantaged patient groups.

Key Publications

For a full list of publications click here

1. Wan YI, Puthucheary ZA, Pearse RP, Prowle JR. Characterising biological mechanisms underlying ethnicity associated outcomes in COVID-19. Br J Anaesth 2023; S0007-0912(23)00183-6. PMID: 37198030.
2. Toal CM, Fowler AJ, Pearse RM, Puthucheary Z, Prowle JR, Wan YI. Health resource utilisation and disparities: an ecological study of admission patterns across ethnicity in England between 2017-2020. J Racial Ethn Health 2022:1–10. PMID: 36471147.
3. Fowler AJ, Wan YI, Prowle JR, Chew M, Campbell D, Cuthbertson B, Wijeysundera DN, Pearse R, Abbott A. Long-term mortality following complications after elective surgery: a secondary analysis of pooled data from two prospective cohort studies. Br J Anaesth 2022; 129(4):588-597. PMID: 35989114.
4. Haines RW, Fowler AJ,Wan YI, Flower L, Heyland DK, Day A, Pearse RM, Prowle JR, Puthucheary Z. Catabolism in Critical Illness: A Reanalysis of the REducing Deaths due to OXidative Stress (REDOXS) Trial. Crit Care Med. 2022; 50(7):1072-1082. PMID: 35220340.
5. Wan YI, Apea VJ, Orkin CM, Dhairyawan R, Puthucheary ZA, Pearse RM, Prowle JR. Ethnic disparities in hospitalisation and hospital-outcomes during the second wave of COVID-19 infection in east London. Sci Rep 2022; 12(1):3721. PMID: 35260620.
6. Wan YI, Robbins AJ, Apea VJ, Orkin CM, Pearse RM, Puthucheary ZA, Prowle JR. Ethnicity and acute hospital admissions: Multi-centre analysis of routine hospital data. EClinicalMedicine 2021; 39;10177. PMID: 34611614.
7. Wan YI*, Bien Z* (equal contributors), Apea VJ, Orkin CM, Dhairyawan R, Kirwan CJ, Pearse RM, Puthucheary ZA, Prowle JR. Acute Kidney Injury in COVID-19: multicentre prospective analysis of registry data. CKJ 2021: sfab071. PMID: 34751235.
8. Wan YI, Patel A, Achary C, et al. Prospective observational cohort study of post-operative infection and mortality following elective surgery: International Surgical Outcomes Study (ISOS) sub-study. Br J Surg 2020; 108(2):220-227. PMID: 33711143.
9. Apea VJ*, Wan YI* (equal contributors), Dhairyawan R, Puthucheary AZ, Pearse RM, Orkin CM, Prowle JR. Ethnicity and outcomes in patients hospitalised with COVID-19 infection in East London: an observational cohort study. BMJ Open 2021; 11:e042140. PMID: 33455936.
10. Wan YI, McGuckin D, Fowler AJ, et al. Socioeconomic deprivation and long-term outcomes after elective surgery: Analysis of prospective data from two observational studies. Br J Anaesth 2020; 126(3):642-651. PMID: 33220938.
11. Wan YI, Brayne AB, Haines RW, et al. Prognostic association of routinely measured biomarkers in patients admitted to critical care: a systematic review. Biomarkers 2020;1-12. PMID: 33103483.
12. Haines RW, Zolfaghari P,Wan Y, et al. Elevated urea-to-creatinine ratio provides a biochemical signature of muscle catabolism and persistent critical illness after major trauma. Intensive Care Med 2019; 45(12):1718-1731. PMID: 31531715.
13. Wan YI, Patel A, Abbott TEF, et al. Prospective observational study of post-operative infection and outcomes after non-cardiac surgery: Analysis of prospective data from the VISION cohort. Br J Anaesth 2020; 125(1):87-97. PMID: 32482502
14. Wan YI, Shrine NR, Soler-Artigas M, et al. Genome-wide association study to identify genetic determinants of severe asthma. Thorax 2012; 67(9):762-8. PMID: 22561531.
15. Wan YI, Strachan DP, Evans DM, et al. A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom. J Allergy Clin Immunol. 2011; 127(1):223-31, 231.e1-3. PMID: 21094521.

Collaborators

Internal

• Prof Rupert Pearse
• Dr John Prowle
• Dr Zudin Puthucheary
• Prof Chloe Orkin
• Dr Vanessa Apea
• Dr Tom Abbott   
• Dr Tim Stephens

External

• Dr Brij Patel (Imperial College London)
• The PRECIOUS Study (Glasgow Caledonian University, Edinburgh University, NHS Lanarkshire, and Glasgow University)

Teaching

Dr Wan is faculty on the Critical Care Medicine MSc and co-leads the Research and Audit methodology module. She is faculty for the European Perioperative Intensive Care Curriculum Course for the European Society of Intensive Care Medicine.

Disclosures

No disclosures.