Professor Ken Parkinson , BSc (Hons), PhD
Professor of Head & Neck Cancer
Email: email@example.comTelephone: 0207 882 7185 Room Number: G81, Blizard Building, Institute of Dentistry
During my PhD work in Professor Adam Curtis’ Department of Cell Biology at the University of Glasgow, I developed an interest in epithelial cell biology and quickly realised that understanding neoplastic transformation in this cell class was key to understanding most human cancers.
More recently, I have become interested in senescent cell metabolism and have pioneered the analysis of extracellular metabolites produced by senescent cells ( the extracellular senescence metabolome -James et al Journal of Proteome Research 2015) with a view for identifying non-invasive (blood, urine) tests for senescent cells and drugs that delete them (senolytics).
MSc Experimental Oral Pathology Seminars Tutorials Practical Thesis examination and project supervision and M.Clin Dent Seminar 1 lecture (1 hour)
BDS Year 1 3 lectures
BDS Year 2 1 lecture
BDS Year 3 SSC Tutorials
Senescent cells are known to be important to many age-related diseases and cancer as well as the side effects of cancer therapy and perhaps the poor health of cancer survivors. My current research concentrates of the mechanism by which extracellular citrate (EC) accumulates outside senescent fibroblasts and whether this mechanism can be used as a drug target to slow age-related diseases and cancer.
2. de Castro A., Minty F., Hattinger E., Wolf R. and Parkinson E.K. The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators. Longevity & Healthspan (2014), 3:8.
3. James E.L., Michalek R., Pitiyage G.N., de Castro A.M., Vignola K.S., Jones J., Mohney R.P., Karoly E., Prime S.S. and Parkinson E.K. Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage, aging, and disease. J. Proteome Res. (2015) 14:1854-71. doi: 10.1021/pr501221g. Epub 2015 Feb 26.
4. Dale, T.P., de Castro A., Kuiper, N.J., Parkinson E.K. and Forsyth N.R. Immortalisation with hTERT Impacts on Sulphated Glycosaminoglycan Secretion and Immunophenotype in a Variable and Cell Specific Manner. PLoS ONE (2015). 10: e0133745. doi: 10.1371/journal.pone.0133745. eCollection 2015.
5. Rehman, A., Ali, S., Lone, M.A., Atif, M., Hassona, Y., Prime, S.S., Pitiyage, G.N., James, E.N.L. and Parkinson E.K. Areca nut alkaloids induce irreparable DNA damage and senescence in fibroblasts and may create a favourable environment for tumour progression. J Oral Pathol Med. (2016) 45: 365-72. doi: 10.1111/jop.12370. Epub 2015 Sep 28.
6. Kabir, T.D., Leigh, R.J., Tasena, H., Mellone, M., Coletta, R.D., Parkinson, E.K., Prime, S.S., Thomas, G.J., Paterson, I.C., Zhou, D., McCall, J., Speight, P.M., Lambert, D.W. A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts. Aging (Albany NY). (2016) 8:1608-35. doi: 10.18632/aging.100987.
7. James, E.L., Lane, J.A.E., Michalek, R.D., Karoly, E.D., Parkinson, E.K. Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism. Sci. Rep. (2016) 6:38489. doi: 10.1038/srep38489.
8. Cirillo, N., Hassona, Y.,Lim, K.P., Celentano, A., Manchella, S., Parkinson, E.K., Prime, S.S. Cancer asscoaited fibroblasts regulate keratinocyte cell-cell adhesion via TGF-β-dependent patwhays in genotype-spcific oral cancer. Carcinogenesis (2017) 38: 76-85. doi: 10.1093/carcin/bgw113. Epub 2016 Nov 1.
9. Melling, G.E. , Flannery, S..E ., Abidin, S.A.. , Prajapati P.. , Hinsley E.E. , Hunt S., Catto, J.W.F., Coletta, R.D. , Mellone, M. , Thomas, G.J. , Parkinson E.K. , Prime, S.S. , Paterson I.C. , Buttle D.J. ,Lambert D.W. A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype Carcinogenesis (2018). 39:798-807. doi: 10.1093/carcin/bgy032.
11. Veeramachaneni R., Walker T., Revil T., De Weck A., Badescu D., O’Sullivan J., Higgins C., Elliott L., Liloglou T., Risk J.M., Shaw R., Hampson L., Hampson, I, Dearden S., Woodwards R., Prime S., Hunter, K. Parkinson, E.K., Ragoussis J., Nalin Thakker, N. Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific changes associated with immortalisation and malignancy. Sci. Rep. (2019). ;9:11992. doi: 10.1038/s41598-019-48229-7.
12. Rehman A., Cai Y., Hünefeld C., Jedličková H., Huang Y., Teh M. T., Sharif Ahmad U., Uttagomol J., Wang Y., Kang A., Warnes G., Harwood C., Bergamaschi D., Parkinson E.K., Röcken M., Wan H. The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53. Cell Death & Disease (2019) 10: 750. doi: 10.1038/s41419-019-1988-0.
13. Li X., Sharif Ahmad U., Huang Y., Uttagomol J., Rehman A., Zhou K., Warnes G., McArthur S., Parkinson E.K., Wan, H. Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells. Mech. Aging Dev. (2019) Dec;184:111174. doi: 10.1016/j.mad.2019.111174. Epub 2019 Oct 31
14. Lai S.L., Tan M.L., Hollows R.J., Robinson M,, Ibrahim M, Margielewska S., Parkinson E.K., Ramananthan A., Mehanna H., Watkins R.J., Wei W., Chung I., Murray P.G., Yap L.F., Paterson I.C. Collagen expression in head and neck cancer promotes proliferation, migration and chemo-resistance via DDR1. Cancers (2019) 11: 1766. doi: 10.3390/cancers11111766.
15. Houacine S., Kang A., Parkinson E.K., Wan, H., Farida Fortune F. Induction of p53 in keratinocyte cultures treated with Behçet's patient sera J. Oral Path.Med. (2020) 49: 435-442. doi: 10.1111/jop.13005. Epub 2020 Mar 1.
17.Tan M.L., Parkinson E.K., Yap L.F., Paterson I.C. Autophagy is deregulated in cancer-associated fibroblasts from oral cancer and is stimulated during the induction of fibroblast senescence by TGF-β1 Sci. Rep. (2020) In Press