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Institute of Dentistry - Barts and The London

Professor Nikolaos Donos, DDS, MS, FHEA, FDSRCSEng, PhD

Nikolaos

Professor & Chair Periodontology and Implant Dentistry, Lead Centre for Immunobiology & Regenerative Medicine, Head Centre for Oral Clinical Research

Email: n.donos@qmul.ac.uk
Telephone: +44 (0) 20 7882 6318
Room Number: Office 3, Floor 5, Institute of Dentistry
Website: http://www.dentistry.qmul.ac.uk

Profile

Professor Nikos Donos
DDS, MS, FHEA, FDSRCSEng, PhD

 

Professor Nikos Donos is the Chair of Periodontology & Implant Dentistry, the Director of Clinical Research, the Head of the Centre for Oral Clinical Research and the Lead for the Centre of Oral Immunobiology & Regenerative Medicine at the Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London (QMUL). Prof. Donos is also the Director of the ITI scholarship Centre and the Director of the Osteology Research Scholarship Centre, both at QMUL. Furthermore, he is an Hr Consultant in Periodontics at Royal Dental Hospital, BartsHealth Trust.

In 2009, Professor Donos was awarded the title of Honorary Professor at the Faculty of Dentistry in Hong Kong, in 2012 the title of Adjunct Professor at the Dental School, Griffith University, Australia,  in 2015 the title of Honorary Professor at UCL-Eastman Dental Institute and in 2019 the title of Honorary Professor, School of Dentistry,  University of Queensland, Australia.

In 2011, Professor Donos was awarded the prestigious IADR-Periodontology Group Award in Periodontal Regenerative Medicine. Professor Donos is the President (2020) of the British Society of Periodontology (BSP), a board member at the Osteology Foundation and the Academic Representative at the Committee for Association of Dental Implantology (ADI)(U.K).
Professor Donos is involved as editorial board member in a number of international peer-reviewed journals in the field of Periodontology and Implant Dentistry where he has published more than 220 scientific publications.
The clinical expertise of Professor Donos is in the field of Periodontics and Implant Dentistry. Within the clinical setting, Prof Donos provides advanced treatment modalities to patients suffering from severe periodontal disease which include periodontal and bone tissue regeneration, implant related surgical procedures, as well as, treatment of peri-implantitis which are topics that he regularly lectures on a national and international level.

Research

Research Interests:

Research Profile

 

Professor Nikos Donos research profile include a wide range of activities including systematic reviews leading to treatment guidelines, translational research, experimental medicine studies as well as randomized controlled clinical trials in the area of Wound Healing, Soft & Hard Tissue Regeneration  Implant Dentistry and Periodontal Medicine. These areas of research are part of the established research themes in COIRM and COCR 

Together with his team, Professor Donos has developed preclinical and clinical research expertise in the above mentioned areas, which attract funding from Charities, research funding bodies and industry.

Currently, Professor Donos is involved in a number of wound healing studies following different treatment modalities in healthy and systemically compromised patients  COIRM/COCR. Furthermore, together with his team, he is developing experimental medicine studies where biologic samples are used through a number of platform technologies to develop novel diagnostic and prognostic information in relation to periodontal and peri-implant diseases COIRM/COCR

Publications

Further details can be found at:

https://www.ncbi.nlm.nih.gov/pubmed/?term=Donos+N

 

Randomized Clinical trials

 

Donos N, Horvath A, Calciolari E, Mardas N Immediate provisionalization of bone level implants with a  hydrophilic surface. A five-year follow-up of a randomized controlled clinical trial Clin Oral Implants  Res. 2019 Feb; 30 (2): 139-149.

Donos N, Horvath A, Mezzomo LA, Dedi D, Calciolari E, Mardas N. The role of immediate provisional  restorations on implants with a hydrophilic surface: A randomised, single-blind controlled clinical trial. Clin Oral Implants Res. 2018 Jan; 29 (1): 55-66.

D'Aiuto F, Gkranias N, Bhowruth D, Khan T, Orlandi M, Suvan J, Masi S, Tsakos G, Hurel S, Hingorani AD,  Donos N, Deanfield JE; TASTE Group Systemic effects of periodontitis treatment in patients with type 2   diabetes: a 12 month, single-centre, investigator – masked, randomised trail Lancet Diabetes Endocrinol.  2018 Dec; 6 (12): 954-965.

Rakmanee T, Griffiths GS, Auplish G, Darbar U, Petrie A, Olsen I, Donos N. Treatment of intrabony defects  with guided tissue regeneration in aggressive periodontitis: clinical outcomes at 6 and 12 months.  Clin Oral Investig. 2016 Jul; 20(6): 1217-122

 

Experimental studies:

Tatarakis N, GkraniasN, Darbar U, Donos N Blood flow changes using a 3D xenogeneic collagen matrix or a subepithelial connective tissue graft for root coverage procedures: a pilot study. Clin Oral Invest 2018 May;22(4):1697-1705

Nizam N, Eren G, Akcalı A, Donos N. Maxillary sinus augmentation with  leukocyte and platelet-rich fibrin and deproteinized bovine bone mineral: A split-mouth histological and histomorphometric study. Clin Oral Implants Res. 2018 Jan;29(1):67-75

Sousa V, Nibali L, Spratt D, Dopico J, Mardas N, Petrie A, Donos N.  Peri-implant and periodontal microbiome diversity in aggressive periodontitis patients: a pilot study Clin Oral Implants Res 2017 May; 28(5): 558-570.

Aguayo S, Donos N, Spratt D, Bozec L. Nanoadhesion of Staphylococcus aureus onto Titanium Implant Surfaces. J Dent Res. 2015 Aug; 94(8): 1078-1084. 

Retzepi M, Calciolari E, Wall I, Lewis MP, Donos N. The effect of experimental diabetes and glycaemic control on guided bone regeneration: histology and gene expression analyses. Clin Oral Implants Res.2018 Feb;29(2):139-154

Calciolari E, Hamlet S, Ivanovski S, Donos N Pro-osteogenic properties of hydrophilic and hydrophobic titanium surfaces: Crosstalk between signalling pathways in in vivo models  J Periodont Res. 2018 Aug;53(4):598-609

Nibali L, Sousa V, Davrandi M, Spratt D, Alyahya Q, Dopico J, Donos N. Differences in the periodontal microbiome of successfully treated and persistent aggressive periodontitis.  J Clin Periodontol. 2020 Aug;47(8):980-990.

 

Systematic Reviews:

Donos N, Calciolari E, Brusselaers N, Goldoni M, Bostanci N, Belibasakis GN. The   Adjunctive use of host modulators in non-surgical periodontal therapy. A systematic review of randomized, placebo controlled clinical studies J Clin Periodontol 2020  Jul:47 Supp 22:199 - 238

Koidou VP, Chatzopoulos GS, Tomas I, Nibali L, Donos N. Expression of gingival  crevicular fluid markers during early and late healing of intrabony defects after surgical treatment: a systematic review  Clinical Oral Investig 2020  Jan;24(1):487-502.

Arias-Bujanda N, Regueira-Iglesias A, Balsa-Castro C, Nibali L, Donos N, Tomás I Accuracy of single molecular biomarkers in gingival crevicular fluid for the diagnosis of periodontitis: A systematic review and meta-analysis J Clin Periodontol 2019 Dec;46(12):1166-1182

Arias-Bujanda N, Regueira-Iglesias A, Balsa-Castro C, Nibali L, Donos N, Tomás I. Accuracy of single moecluar biomarkers in saliva for the diagnosis of periodontitis:  a systematic review and meta analysis J Clin Periodontal 2020 Jan;47(1):2-18

Halai H, Somani C, Donos N, Nibali L   Periodontal status of children with primary                 immunodeficiencies:a systematic review Clin Oral Investig 2019 Oct 2018 doi 10:1007/s00784-019-03055-z [Epub ahead of print]

Nibali L, Koidou VP, Hamborg T, Donos N. Empirical or microbiologically guided  Systemic antimicrobials as adjuncts to non-surgical periodontal therapy? A systematic review. J Clin Periodontol. 2019 Oct;46(10):999-1012

Liu LS, Gkranias N, Farias B, Spratt D, Donos N. Differences in the subginigval microbial population of chronic periodontitis in subjects with and without type 2 diabetes mellitus-a systematic review.  Clin Oral Invest 2018 Nov;22(8):2743-2762

Akcali A, Trullenque-Eriksson A, Sun C, Petrie A, Nibali L, Donos N. What is the effect of soft tissue thickness on crestal bone loss around dental implants? A systematic review. Clin Oral Implants Res. 2017 Sep; 28(9): 1046-1053.

Mardas N, Trullenque-Eriksson A, MacBeth N, Petrie A, Donos N. Does ridge preservation following tooth extraction improve implant treatment outcomes: a systematic review: Group 4: Therapeutic concepts & methods. Clin Oral Implants Res. 2015 Sept;26 Suppl 11:180-201.

 

Invited reviews:

Donos N, Dereka X, Calciolari E. The use of bioactive factors to enhance bone regeneration. A narrative review J Clin Periodontol. 2019 Jun;46 Suppl 21:124-16

Calciolari E, Donos N Proteomic and transcriptomic approaches for studying Bone         Regeneration in Health and Systemically compromised conditions.  Proteomics Clin  Appl  2020 May;14(3):e1900084

Donos N, Park JC, Vajgel A, de Carvalho Farias B, Dereka X Description of the periodontal pocket in preclinical models: limitation and considerations. Periodontol 2000 2018 Feb;76(1):16-34

Graziani F, Karapetsa D, Mardas N, Leow N, Donos N. Surgical treatment of the residual periodontal pocket. Periodontol 2000. 2018 Feb;76 (1):150-163.

Calciolari E, Donos N The use of omics profiling to improve outcomes of bone regeneration and osseointegration. How far are we from personalized medicine in dentistry? J. Proteomics. 2018 Sep 30;188:85-96