Institute of Dentistry - Barts and The London

Professor Mangala Patel, PhD, MSc, BSc (Hons)

Mangala

Professor in Biomaterials in Relation to Dentistry / Senior Tutor (Dentistry)

Email: m.patel@qmul.ac.uk
Telephone: +44 (0) 020 7882 5982 / 0207 882 2160
Room Number: Office 20, Floor 4, Institute of Dentistry. Also Bancroft Building, Floor 2, Mile End campus.

Profile

Professor Patel graduated with a degree in Chemistry. She went on to become a Research Assistant in the Department of Biomaterials in Relation to Dentistry (now named Dental Physical Sciences), at the former London Hospital Medical College. She also obtained a MSc (Synthetic Organic Chemistry), followed by a PhD on heterocyclic methacrylates for dental and clinical applications during this period. 

Professor Patel's research centres on the development of novel polymeric dental and related biomaterials, for the delivery of therapeutic (active) species, locally within the oral cavity and in the body, aimed at treating a range of pathological conditions. 

Since 2011, Professor Patel has chaired the Institute of Dentistry (IoD) Athena SWAN Self-Assessment Team (SAT) with dedication. Under her leadership, the IoD successfully gained the Athena SWAN Bronze Award in 2013, which was renewed again in 2015, followed by the Silver Award in November 2018. This demonstrates the impact of her actions, in progressing an inclusive environment in which all staff and students can flourish. 

Professor Patel is Senior Tutor for Dentistry, where a major part of her activities concern the pastoral care and welfare of students at all levels, by providing advice and support on academic and personal matters. 

Teaching

Professor Patel has extensive experience with teaching Dental Materials Science and Biomaterials to both undergraduate and postgraduate students. She supervises / examines a number of PhDs, MSc / DClinDent and BEng / BSc projects. She is a module convenor for Graduate Attributes and Academic Advising which runs across the 5 years of the undergraduate BDS curriculum. Additionally, she is a module convenor for 1 DClinDent and 2 MSc modules. 

Research

Research Interests:

Professor Patel's research centres on the development of novel polymeric dental and related biomaterials for the delivery of therapeutic (active) species, locally within the oral cavity and in the body, aimed at treating a range of pathological conditions. 

The detailed kinetics of water absorption and release of active agents from polymeric systems, for the delivery of, for example, proteins across oral mucosa and dermal sites, has benefitted from interdisciplinary research, international / national collaborations, patents, and success in external / internal funding. This has led to the development of a self-disinfecting dental alginate impression material, that is effective against some oral bacteria and viruses. 

Innovative research areas also include iontophoretic drug delivery via the buccal mucosa, development of materials potentially useful in addressing orthodontic white spot lesions, and materials containing LDHs (Layered Double Hydroxide). The latter are capable of absorbing and releasing therapeutic levels of fluoride (and other beneficial ions). The outcomes from this project area will have an impact on reducing early stage caries, which affects 35% of the world's population. 

Publications

Key Publications

Ud Din S, Parker S, Braden M, Patel, M.P. (2018). The effects of cross-linking agent and surfactant on the tear strength of novel vinyl polysiloxane impression materials. Dental Materials Vol.34 Issue 12, pages e334-e343. DOI: 10.1016/j.dental.2018.09.010

Taha, A.A., Fleming, P.S., Hill, R.G, Patel, M.P. (August 2018) Enamel Remineralisation with Novel Bioactive Glass Air Abrasion. J Dent Res, Vol 97, Issue 13, https://journals.sagepub.com/doi/10.1177/0022034518792048

Ud Din, S., Hassan, M., Khalid, S., Zafar, Sohail., Ahmed, B., Patel, M. (2018) Effects of surfactant's molecular weight on the wettability of vinyl polysiloxane impression materials after immersion disinfection. "Materials Express" Journal. Mater. Express, Vol 8, No. 1, 2018; doi: 10.1166/mex.2018.1413

Toprani, D., Patel, M.P., Mordan, D., Gillam, D.G. (2017) Comparison of Two Tricalcium Phosphate Varnishes and a Comparator Fluoride Varnish on Tubular Occlusion. BAOJ Dentistry, 3(2);036 (Open Access)

Taha, A.A., Patel, M.P., Hill, R.G., Fleming, P.S. (2017) The effect of bioactive glasses on enamel remineralisation: A systematic review. J Dent 2017 Dec; 67:9-17. doi: 10.1016/j.dent.2017.09.007 Epub Sep 20. 

Agha A, Parker S, Patel MP. (2017) The properties of experimental resin-modified glass-ionomer luting cements (RMGICs) containing novel monomers. Dent Mater; 33(12):1331-1339. doi: 10.1016/j.dental.2017.08.189. Epub Sep 20.

Taha, A.A., Hill, R.G., Fleming, P.S., Patel, M.P. (2017) Development of a novel bioactive glass for air-abrasion to selectively remove orthodontic adhesives. Clinical Oral Investigations, Nov 28. doi: 10.1007/s00784-017-2279-8. [Epub ahead of print]

Patel J, Granger C, Parker S, Patel MP (2017) The effect of instrument lubricant on the diametral tensile strength and water uptake of posterior composite restorative material. Journal of Dentistry, 56, 33-38. 10.1016/j.dent.2016.10.006

Ud Din S, Parker S, Braden M, Tomlins P, Patel MP (2017). Experimental hydrophilic vinyl polysiloxane (VPS) impression materials incorporating a novel surfactant compared with commercial VPS. Dental Materials. 33(8): e301-e309. Epub (2017) May 20. 

Ud Din S, Hassan M, Parker S, Patel MP (2016) Setting characteristics of three commercial vinyl polysiloxane impression materials measured by an oscillating rheometer. Pakistan Oral & Dental Journal Vol 36, No. 3.

Agha A, Parker S, Patel MP (2016) Development of experimental resin modified glass ionomer cements (RMGICs) with reduced water uptake and dimensional change. Dent Mater. 32(6):713-22. 10.1016/j.dental.2016.03.004.

Abdulmohsen B, Parker S, Braden M, Patel MP (2016) A study to investigate and compare the physicomechanical properties of experimental and commercial temporary crown and bridge materials. Dent Mater. 32(2):200-10. 10.1016/j.dental.2015.11.025

Nallamuthu NA, Braden M, Oxford J, Williams D, Patel MP (2015) Modification of pH Conferring Virucidal Activity on Dental Alginates. Materials, 8, 1966.1975.10.3390/ma8041966 (Open Access)

Mustaza TA, Braden M and Patel MP (2014) Comparison of various properties of a Silorane Based Dental Composite with Two Methacrylate Based Dental Composites. GSTF International Journal of Advances in Medical Research (JAMR) Vol.1(1),78-83 doi: 10.7603/s40782-014-0012-y

Patel MP, Churchman ST, Cruchley AT, Braden M and Williams DM (2013). Electrically induced transport of macromolecules through oral buccal mucosa. Dent Mater, 29(6): 674-681; 10.1016/j.dental.2013.03.016

Patel MP, Churchman ST, Cruchley AT, Braden M and Williams DM (2013). Delivery of macromolecules across oral mucosa from polymeric hydrogels is enhanced by electrophoresis (iontophoresis). Dent Mater, 29(11): e299-e307; 10.1016/j.dental.2013.09.00

Nallamuthu NA, Braden M, Patel MP (2012). Some aspects of the formulation of alginate dental impression materials - setting characteristics and mechanical properties. Dent Mater, 28(7); 756-762. 

Siddiqui A, Braden M, Patel MP, Parker S.  An experimental and theoretical study of the effect of sample thickness on the shore hardness of elastomers. Dent Mater, 26(6): 560-4, (2010)

Methananda I, Parker S, Patel MP, Braden M.  the relationship between shore A hardness of elastomeric dental materials and Young’s Modulus.  Dent Mater, 25: 956-959, (2009)

Darr JA, Gong K, Braden M, Patel MP, Rehman IU, Zhang D. Controlled release of chlorhexidine diacetate from a porous methacrylate system: supercritical fluid assisted foaming and impregnation. J.Pharm.Sci 96: (2007)

Anderson P, Ahmed Y, Patel MP, Davis GR, Braden M. X-ray microtomographic studies of novel radio-opaque polymeric materials for dental applications. Materials Science and Technology 22: 1094-1097. (2006)

Nallamuthu, N, Braden M, Patel MP. Dimensional changes of alginate dental impression materials. J.Mater.Sci: Mater Med.17: 1205-1210 (2006)

Braden M, Latham D, Patel MP. Observations on the swelling of cross-linked poly(dimethyl siloxane) networks by solvents. European Polymer Journal 41: 3069-3071 (2005)

Forrester-Baker L, Seymour KG, Samarawickrama D, Zou L, Patel M. A comparison of dimensional accuracy between three different addition cured silicone impression materials. Eur. J. Prosthodont. Res. Dent., 13:No2, 69-74 (2005)

Rahman FF, Bonfield W, Cameron RE, Patel MP, Braden M, Pearson GJ, Tavakoli S.M Water uptake of poly(ethyl methacrylate) tetrahydrofurfuryl methacrylate polymer systems modified with tricalcium phosphate and hydroxyapatite. Bioceramics 16: 513-516; (Key Engineering Materials 254-256), (2004).

Chowdbury M, Hill DJT, Whittaker AK, Braden M, Patel M.P. NMR imaging of water diffusion into PEMP/P(HEMA-co-THFMA) semi-IPN Matrices. Polymer Preprints 45: 517 (2004)

Chowdhury MA, Hill DJT, Whittaker AK, Braden M, Patel MP. NMR Imaging of water diffusion at 310K into semi -IPN's of PEM and Poly(HEMA-c- THFM) with and without chlorhexidine diacetate. Biomacromolecules 5: 1405-1411, (2004)

Scott G, Patel M P, Braden M. Use of prepolymerised cement spacers to augment the femoral component in revision total knee arthroplasty. Journal of Arthroplasty 18: 769-774, (2003)

Patel, M.P., Pavlovic, P., Hughes, F.J., King, G.N., Cruchley, A. and Braden, M. Release of recombinant human bone morphogenetic protein-2 from heterocyclic methacrylate polymer systems. 22: 2081-2086, (2001).

Nazhat, S.N., Parker, S., Patel, M.P. and Braden, M. Isoprene-styrene copolymer elastomer and terahydrofurfuryl methacrylate mixtures for soft prosthetic applications. Biomaterials, 22(17), 2411-2416, (2001).

Patel, M.P., Cruchley, A.T., Coleman, D.C., Swai, H., Braden, M. and Williams, D.M. A polymeric system for the intra-oral delivery of an antifungal agent. Biomaterials, 22(17), 2319-2324, (2001).

Riggs, P.D., Kinchesh, P., Braden, M. and Patel, M.P. Nuclear magnetic imaging of an osmotic water uptake and delivery process. Biomaterials 22, (No 5), 419-427, (2001).

Riggs, P.D., Clough, A.S., Jenneson, P.M., Braden, M. and Patel, M.P. 3He ion-beam analysis of water uptake and drug delivery. Journal of Controlled Release, 61, 165-174, (1999).

Patel, M. P., Pearson, G. J., Braden, M. and Mirza, M. A. Fluoride ion release from two methacrylate polymer systems. Biomaterials, 19, 1911-1917, (1998).

Downes, S., Archer, R. S., Kayser, M. V., Patel, M. P. and Braden, M. The regeneration of articular cartilage using a new polymer system. J. Mater. Sci., Mater. Med., 5, 88-95, (1994).

Patel, M.P., Braden, M. and Davy, K.W.M., Polymerisation shrinkage of methacrylate esters, Biomaterials, 8, 53-56, (1987).

 

Patents

Bhusate, M. and Braden, M.  Low shrinkage monomer/polymer curable compositions useful in biomedical applications. U.K. Patent, G.B. 2, 107, 341B, 1985.

Braden, M., Downes, S., Patel, M.P. and Davy, K.W.M. The use of biomaterials for tissue repair. UK Patent Appl. GB210734.1 (1992), European Application. 92923088.6, PCT/GB92/02128, US No5,468,787, 1995

Braden, M., Patel, M. P.and Pearson, G. J.  Fluoride releasing biomaterials.  UK granted, European Patent Appl., 96300314.0, 1996, US Patent No: 5,718,924, 1998

Pearson, G.J., Williams, J., Todhunter, R., Clements, D., Patel, M.P. and Braden, M. Polymerisable resin compositions for use in dentistry.  European Patent Appl, 2001, US Patent No: US 7,166,652 B2, 2007