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The William Harvey Research Institute - Faculty of Medicine and Dentistry


Biomarkers in Urine, antihypertensive treatment and blood pressure Control in Hypertensive patients.

Trial objective
To compare the short-term effect of HPLC-MS/MS-guided intervention and the standard care on clinic systolic blood pressure in non-adherent hypertensive patients.

Disease area

Open to recruitment

Prof Maciej Tomaszewski (CI)
Dr David Collier (PI)

University of Manchester

British Heart Foundation (BHF)

Study summary
High blood pressure (also called hypertension) is a condition that affects more than 1 in 4 adults. It can strain the heart and the blood vessels, and increase the risk of stroke, heart attack, heart failure, kidney damage, and death. Failure to take medication as prescribed (i.e. non-adherence) is believed to be common in hypertension because it rarely has noticeable symptoms. The patients recruited in this study will be asked to provide a urine sample at the hypertension clinic to find out if they take their blood pressure medication as prescribed. A group of non-adherent patients will participate in a simple 5-step (Discuss/Explore/Act/Co-operate/Reinforce) intervention in which the patient and the treating doctor will discuss the test result, the reasons for not taking the medication as prescribed, and useful measures to improve adherence. Our aim is to test if the 5-step intervention helps non-adherent patients to comply with their treatment and lower their blood pressure. Adherence, health outcomes and care costs will be measured and compared with groups of nonadherent and adherent patients who did not receive the intervention.

Sample size and duration
321 recruited participants from 8 sites.
2 years: one year of recruitment with one-year follow-up.

Mital Patel – 020 78825664
Anne Zak – 020 7882 5660

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