Dr Elisa CorsieroLecturer in Immunology, Career Development FellowCentre: Experimental Medicine and RheumatologyEmail: e.corsiero@qmul.ac.ukTelephone: +44(0) 20 7882 8193Twitter: @TheRealARGOsLab ProfileResearchKey PublicationsSponsorsCollaboratorsProfileI am a Lecturer and Versus Arthritis Research Fellow at the Centre for Experimental Medicine & Rheumatology in the Immuno-Rheumatology group led by Prof Bombardieri. I graduated from the University of Milan (Italy) with an MSc in Industrial Biotechnology. In 2009, I joined the group of Prof Pitzalis and Prof Bombardieri at the Centre for Experimental Medicine & Rheumatology in London for my PhD. In 2014, I was awarded an Arthritis Research UK Foundation Fellowship which I completed in 2018. In November 2019, I was awarded with a competitive Career Development Fellowship from Versus Arthritis, which is going to fund my research for the next 3 years.ResearchGroup members Group Leader: Prof Michele BombardieriPost-doctoral Fellows: Dr Lucas Jagemann; Dr Elena Pontarini; Dr Edoardo PredilettoPhD Students: Mr Mattia Caliste; Miss Mareike Werle Summary My major research interests focus on the elucidation of the cellular and molecular mechanisms regulating autoreactive B cell activation, breach of self-tolerance and perpetuation of autoimmunity in Sjögren’s syndrome and rheumatoid arthritis. In particular, my research is focused on characterizing the fine specificity and function of monoclonal antibodies derived from single B cells in patients with rheumatic autoimmune diseases and cancer.Key Publications Heavy and light chain affinity maturation and/or Fab N-glycosylation influence immunoreactivity towards NETs antigens in RA synovial B-cell clones. Corsiero, Carlotti, Jagemann, Perretti, Pitzalis and Bombardieri. Journal of Immunology, 2020 Mar 27. B cells in the formation of tertiary lymphoid organs in autoimmunity, transplantation and tumorigenesis. Corsiero, Delvecchio, Bombardieri, Pitzalis. Curr Opin Immunol, 2019. Generation of recombinant monoclonal antibodies from single B cells isolated from synovial tissue of rheumatoid arthritis patients. Corsiero, Jagemann, Bombardieri and Pitzalis. Methods Mol Biol, 2018. Characterization of a synovial B cell-derived recombinant monoclonal antibody targeting stromal calreticulin in the rheumatoid joints. Corsiero, Jagemann, Perretti, Pitzalis and Bombardieri. Journal of Immunology, July 2018. NETosis as Source of Autoantigens in Rheumatoid Arthritis. Corsiero, Pratesi, Prediletto, Bombardieri, Migliorini. Front Immunol, 2016. Ectopic Lymphoid Structures: Powerhouse of Autoimmunity. Corsiero, Nerviani, Bombardieri, Pitzalis. Front. Immunol, 2016 Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs. Corsiero, Bombardieri, Carlotti, Pratesi, Robinson, Migliorini, and Pitzalis. Ann Rheum Dis, 2016. Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Headland, Jones, Norling, Kim, Souza, Corsiero, Gil, Nerviani, Dell'Accio, Pitzalis, Oliani, Jan, Perretti. Sci Transl Med, 2015. Accumulation of Self-Reactive Naive and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjögren’s Syndrome. Corsiero, Sutcliffe, Pitzalis, Bombardieri. Plos One, 2014. Peripheral and synovial mechanisms of humoral autoimmunity in rheumatoid arthritis. Corsiero, Pitzalis and Bombardieri. Drug Discovery Today, 2014 Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases. Corsiero, Bombardieri, Manzo, Bugatti, Uguccioni and Pitzalis Immunology Letters, 2012. Sponsors Versus Arthritis Barts Charity CollaboratorsInternal: Prof Ahuva Nissim; Prof Hemant Kocher External: Prof Rene Toes (Leiden University); Prof Paola Migliorini (Pisa University); Prof Karl Skriner (Berlin); Prof Gordon Lauc (Zagreb); Prof Kristi Kuhn (Denver) Back to top