JavaScript is unavailable or disabled; so you are probably going to miss out on a few things. Everything should still work, but with a little less pzazz! Skip to main content
The William Harvey Research Institute - Barts and The London

Dr Elisa Corsiero

Elisa

Lecturer in Immunology / Career Development Fellow

Centre: Experimental Medicine and Rheumatology

Email: e.corsiero@qmul.ac.uk
Telephone: +44(0) 20 7882 8193
Twitter: @elisa_corsiero

Profile

I am a Lecturer and Versus Arthritis Research Fellow at the Centre for Experimental Medicine & Rheumatology in the Immuno-Rheumatology group led by Prof Bombardieri. I graduated from University of Milan (Italy) with an MSc in Industrial Biotechnology. In 2009, I joined the group of Prof Pitzalis and Prof Bombardieri at the Centre for Experimental Medicine & Rheumatology in London for my PhD. In 2014, I was awarded an Arthritis Research UK Foundation Fellowship which I completed in 2018. In November 2019, I was awarded with a competitive Career Development Fellowship from Versus Arthritis, which is going to fund my research for the next 3 years.

Research

Group members

Group Leader: Prof Michele Bombardieri
Post-doctoral Fellows: Dr Lucas Jagemann; Dr Elena Pontarini; Dr Davide Lucchesi; Dr Edoardo Prediletto
Visiting Research Fellows: Mr Mattia Caliste

Summary

My major research interests focus on the elucidation of the cellular and molecular mechanisms regulating autoreactive B cell activation, breach of self-tolerance and perpetuation of autoimmunity in Sjögren’s syndrome and rheumatoid arthritis. In particular, my research is focused on characterizing the fine specificity and function of monoclonal antibodies derived from single B cells in patients with rheumatic autoimmune diseases and cancer.

Twitter: @TheRealARGOsLab 

Key Publications

  • Heavy and light chain affinity maturation and/or Fab N-glycosylation influence immunoreactivity towards NETs antigens in RA synovial B-cell clones. Corsiero, Carlotti, Jagemann, Perretti, Pitzalis and Bombardieri. Journal of Immunology, 2020 Mar 27.
  • B cells in the formation of tertiary lymphoid organs in autoimmunity, transplantation and tumorigenesis. Corsiero, Delvecchio, Bombardieri, Pitzalis. Curr Opin Immunol, 2019.
  • Generation of recombinant monoclonal antibodies from single B cells isolated from synovial tissue of rheumatoid arthritis patients. Corsiero, Jagemann, Bombardieri and Pitzalis. Methods Mol Biol, 2018.
  • Characterization of a synovial B cell-derived recombinant monoclonal antibody targeting stromal calreticulin in the rheumatoid joints. Corsiero, Jagemann, Perretti, Pitzalis and Bombardieri. Journal of Immunology, July 2018.
  • NETosis as Source of Autoantigens in Rheumatoid Arthritis. Corsiero, Pratesi, Prediletto, Bombardieri, Migliorini. Front Immunol, 2016.
  • Ectopic Lymphoid Structures: Powerhouse of Autoimmunity. Corsiero, Nerviani, Bombardieri, Pitzalis. Front. Immunol, 2016
  • Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs. Corsiero, Bombardieri, Carlotti, Pratesi, Robinson, Migliorini, and Pitzalis. Ann Rheum Dis, 2016.
  • Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Headland, Jones, Norling, Kim, Souza, Corsiero, Gil, Nerviani, Dell'Accio, Pitzalis, Oliani, Jan, Perretti. Sci Transl Med, 2015.
  • Accumulation of Self-Reactive Naive and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjögren’s Syndrome. Corsiero, Sutcliffe, Pitzalis, Bombardieri. Plos One, 2014.
  • Peripheral and synovial mechanisms of humoral autoimmunity in rheumatoid arthritis. Corsiero, Pitzalis and Bombardieri. Drug Discovery Today, 2014
  • Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases. Corsiero, Bombardieri, Manzo, Bugatti, Uguccioni and Pitzalis, Immunology Letters, 2012

Collaborators

Internal

Prof Ahuva NissimProf Hemant Kocher

External

Prof Rene Toes (Leiden University); Prof Paola Migliorini (Pisa University); Prof Karl Skriner (Berlin); Prof Gordon Lauc (Zagreb); Prof Kristi Kuhn (Denver)