Dr Dianne CooperReader in Inflammation BiologyCentre: Biochemical PharmacologyEmail: d.cooper@qmul.ac.ukTelephone: +44(0) 20 7882 5643Twitter: @DrDCoopProfileResearchKey PublicationsSponsorsCollaboratorsProfileORCID iD: 0000-0002-5553-9447 Dianne Cooper is a Reader in Inflammation Biology at the William Harvey Research Institute, Queen Mary University of London. Dianne graduated from the University of Sheffield in 1995 with a BSc in Anatomy and Cell Biology and from the University of Bradford in 1997 with an MSc in Biomedical Sciences. She then completed a PhD at the University of Bradford with Prof. Anne Graham. In 2001 Dianne moved to Shreveport, Louisiana to complete a two-year post-doctoral post in the laboratory of Dr Neil Granger at LSUHSC. Dianne joined the Centre for Biochemical Pharmacology in 2003 and was awarded a Career Development Fellowship from Barts Charity in 2004, a Versus Arthritis Career Development Fellowship in 2007 and a Career Progression Fellowship in 2013. She obtained her lectureship in 2013 and her Senior Lectureship in 2018. Current roles include Deputy Centre Lead for Biochemical Pharmacology and module lead for Drug Design for Pharmacologists for the Pharmacology and Innovative Therapeutics and Inflammation Therapeutics for the iBSc in Experimental Pharmacology. Memberships and Awards Editor British Journal of Pharmacology BIRAs committee member LVBF committee member ResearchGroup members PhD students: Miss Rachael Wright, Miss Beatrice Gittens Summary Role of galectins in inflammationMy research focuses on understanding the function of a family of carbohydrate binding proteins, known as galectins, during an inflammatory response. The focus is to understand how galectin expression within the vasculature is regulated during inflammation and how this altered expression regulates leukocyte trafficking in the microcirculation. To date my research has identified an inhibitory role for Galectin-1 in neutrophil and lymphocyte recruitment during acute inflammation. This research is now being expanded to include more complex models of inflammation in order to understand the function of galectins in pathologies such as rheumatoid arthritis. Specific projects include: Understanding the role of Galectin-1 in inflammatory arthritis. This project forms the basis of an Arthritis Research UK funded fellowship. Role of Galectin-3 in leukocyte trafficking This project forms the basis of a British Heart Foundation funded PhD studentship and aims to address the role of Gal-3 in the trafficking of different leukocyte subsets during acute inflammation. Are galectins protective in osteoarthritis This project, in collaboration with Dr Tina Chowdhury, aims to address the role of galectins in osteoarthritis. Publications Rolas L, Stein M, Barkaway A et al. (2024). Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues. nameOfConference DOI: 10.1038/s44319-024-00182-x QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/98188 Hussain MT, Austin-Williams S, Wright TD et al. (publicationYear). β1-Integrin-Mediated Uptake of Chondrocyte Extracellular Vesicles Regulates Chondrocyte Homeostasis. nameOfConference DOI: 10.3390/ijms25094756 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/97635 Fu H, Vuononvirta J, Fanti S et al. (2023). The Glucose Transporter 2 regulates CD8+ T cell function via environment sensing.. nameOfConference DOI: 10.1038/s42255-023-00913-9 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92475 Sabatucci A, Girella A, Di Bartolomeo M et al. (2023). A possible role for G-quadruplexes formation and DNA methylation at IMOOD gene promoter in Obsessive Compulsive Disorder. nameOfConference DOI: 10.1016/j.jbior.2023.100976 QMRO: qmroHref Norling LV, Cooper D (2023). Being old and female is an inflammatory combination. nameOfConference DOI: 10.1093/jleuko/qiad077 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/95403 D'Acquisto F, D'Addario C, Cooper D et al. (2023). Peripheral control of psychiatric disorders: Focus on OCD. Are we there yet?. nameOfConference DOI: 10.1016/j.comppsych.2023.152388 QMRO: qmroHref Poston RN, Chughtai J, Ujkaj D et al. (publicationYear). Monocytic Cell Adhesion to Oxidised Ligands: Relevance to Cardiovascular Disease. nameOfConference DOI: 10.3390/biomedicines10123083 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/83452 Krautter F, Hussain MT, Zhi Z et al. (2022). Galectin-9: A novel promoter of atherosclerosis progression. nameOfConference DOI: 10.1016/j.atherosclerosis.2022.11.014 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/83092 Law HL, Cooper D (2022). Methods for Assessing the Effects of Galectins on Leukocyte Trafficking and Clearance. nameOfConference DOI: 10.1007/978-1-0716-2055-7_31 QMRO: qmroHref Hamilton A, Rizzo R, Brod S et al. (2022). The immunomodulatory effects of social isolation in mice are linked to temperature control. nameOfConference DOI: 10.1016/j.bbi.2022.02.022 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/83091 View Profile Publication Page Sponsors Arthritis Research UK British Heart Foundation CollaboratorsInternal Prof Tim Warner (Blizard) Prof Shu Ye (WHRI) Dr Robin Poston (WHRI) Dr Tina Chowdhury (SEMS) Dr Egle Solito (WHRI) External Prof Mitsuomi Hirashima (Kagawa University, Japan) Dr Toshiro Niki (GalPharma Inc., Japan) Back to top