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Dr Zahra Raisi-Estabragh

Zahra

NIHR Academic Clinical Lecturer

Centre: Advanced Cardiovascular Imaging

Email: z.r.raisi-estabragh@qmul.ac.uk
Twitter: @zahra_raisi

Profile

I am an academic trainee cardiologist based at Queen Mary University of London and Barts Health NHS Trust. I have recently completed my PhD (2018-2021), supported by a three-year British Heart Foundation Clinical Research Training Fellowship. My doctoral research was focused on investigating novel cardiovascular disease determinants and their interactions across organ systems using large scale demographic, clinical, and multiorgan imaging data in the UK Biobank. I was awarded the 2021 Cardiology President’s Gold Medal from the Royal Society of Medicine and the 2022 Alfred Thomas Corrie Prize from Barts and the London School of Medicine and Dentistry. I have had leading roles in development of novel imaging biomarkers using cardiovascular magnetic resonance data in the UK Biobank (e.g., radiomics analysis, pericardial adiposity). In October 2021, I was appointed NIHR Academic Clinical Lecturer at QMUL/Barts, which will allow me to complete my clinical training whilst continuing my research activity (50/50 split). I have since expanded my research portfolio to incorporate studies using routine UK primary care data and routine health data from the USA.

Research

My research interests are centred on big data cardiovascular epidemiology, multi-organ health, and development of novel cardiovascular imaging biomarkers. My work spans a diverse range of topics with the common theme of integrating large scale imaging and non-imaging data to answer important health-related questions, using both statistical and machine learning methods. I work within close cross-disciplinary collaborations benefiting from mixed skill teams including academic clinicians, statisticians, data scientists, and engineers.

Key Publications

Google scholar page: https://scholar.google.com/citations?user=rwIb1t0AAAAJ&hl=en&oi=ao

  1. Salih, A., Nichols, T., Szabo, L., Petersen, S.E., Raisi-Estabragh, Z (2022). Conceptual overview of biological age estimation. Aging and Disease (Accepted in press)
  2. Szabo, L., McCracken, C., Cooper, J., Rider, O. J., Vago, H., Merkely, B., Harvey, N. C., Neubauer, S., Petersen, S. E., and Raisi-Estabragh, Z. (2023). The role of obesity-related cardiovascular remodelling in mediating incident cardiovascular outcomes: A population-based observational study. European Heart Journal - Cardiovascular Imaging, jeac270. https://doi.org/10.1093/ehjci/jeac270
  3. Raisi-Estabragh, Z., Cooper, J., Salih, A., Raman, B., Lee, A. M., Neubauer, S., Harvey, N. C., and Petersen, S. E. (2023). Cardiovascular disease and mortality sequelae of COVID-19 in the UK Biobank. Heart, 109(2), 119–126. https://doi.org/10.1136/heartjnl-2022-321492
  4. McCracken, C., Raisi-Estabragh, Z., Veldsman, M., Raman, B., Dennis, A., Husain, M., Nichols, T. E., Petersen, S. E., and Neubauer, S. (2022). Multi-organ imaging demonstrates the heart-brain-liver axis in UK Biobank participants. Nature Communications, 13(1), Article 1. https://doi.org/10.1038/s41467-022-35321-2
  5. Ardissino, M., McCracken, C., Bard, A., Antoniades, C., Neubauer, S., Harvey, N. C., Petersen, S. E., and Raisi-Estabragh, Z. (2022). Pericardial adiposity is independently linked to adverse cardiovascular phenotypes: A CMR study of 42 598 UK Biobank participants. European Heart Journal - Cardiovascular Imaging, jeac101. https://doi.org/10.1093/EHJCI/JEAC101
  6. Raisi-Estabragh, Z., McCracken, C., Hann, E., Condurache, D.-G., Harvey, N. C., Munroe, P. B., Ferreira, V. M., Neubauer, S., Piechnik, S. K., and Petersen, S. E. (2022). Incident clinical and mortality associations of myocardial native T1 in the UK Biobank. JACC: Cardiovascular Imaging. https://doi.org/10.1016/j.jcmg.2022.06.011
  7. Raisi-Estabragh, Z., McCracken, C., Condurache, D.-G., Aung, N., Vargas, J. D., Naderi, H., Munroe, P. B., Neubauer, S., Harvey, N. C., and Petersen, S. E. (2021). Left atrial structure and function are associated with cardiovascular outcomes independent of left ventricular measures: A UK Biobank CMR study. European Heart Journal - Cardiovascular Imaging, jeac119. https://doi.org/10.1093/EHJCI/JEAB266
  8. Raisi-Estabragh, Z., Kobo, O., Freeman, P., Petersen, S. E., Kolman, L., Miller, R. J. H., Roguin, A., Van Spall, H. G. C., Vuong, J., Yang, E. H., and Mamas, M. A. (2022). Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019. European Heart Journal - Quality of Care and Clinical Outcomes, qcac016. https://doi.org/10.1093/ehjqcco/qcac016
  9. Raisi‐Estabragh, Z., Kobo, O., Elbadawi, A., Velagapudi, P., Sharma, G., Bullock‐Palmer, R. P., Petersen, S. E., Mehta, L. S., Ullah, W., Roguin, A., Sun, L. Y., and Mamas, M. A. (2022). Differential patterns and outcomes of 20.6 million cardiovascular emergency department encounters for men and women in the United States. Journal of the American Heart Association, 11(19), e026432. https://doi.org/10.1161/JAHA.122.026432
  10. Raisi‐Estabragh, Z., Kobo, O., Elbadawi, A., Velagapudi, P., Sharma, G., Bullock‐Palmer, R. P., Petersen, S. E., Mehta, L. S., Ullah, W., Roguin, A., Sun, L. Y., and Mamas, M. A. (2022). Differential patterns and outcomes of 20.6 million cardiovascular emergency department encounters for men and women in the United States. Journal of the American Heart Association, 11(19), e026432. https://doi.org/10.1161/JAHA.122.026432
  11. Raisi-Estabragh, Z., Cooper, J., Bethell, M. S., McCracken, C., Lewandowski, A. J., Leeson, P., Neubauer, S., Harvey, N. C., and Petersen, S. E. (2022). Lower birth weight is linked to poorer cardiovascular health in middle-aged population-based adults. Heart, heartjnl-2022-321733. https://doi.org/10.1136/heartjnl-2022-321733
  12. Kankowski, L., Ardissino, M., McCracken, C., Lewandowski, A. J., Leeson, P., Neubauer, S., Harvey, N. C., Petersen, S. E., and Raisi-Estabragh, Z. (2022). The Impact of Maternal Obesity on Offspring Cardiovascular Health: A Systematic Literature Review. Frontiers in Endocrinology, 13, 868441. https://doi.org/10.3389/FENDO.2022.868441
  13. Pujadas, E. R., Raisi-Estabragh, Z., Szabo, L., Morcillo, C. I., Campello, V. M., Martin-Isla, C., Vago, H., Merkely, B., Harvey, N. C., Petersen, S. E., and Lekadir, K. (2022). Atrial fibrillation prediction by combining ECG markers and CMR radiomics. Scientific Reports, 12(1), Article 1. https://doi.org/10.1038/s41598-022-21663-w
  14. Raisi-Estabragh, Z., M’Charrak, A., McCracken, C., Biasiolli, L., Ardissino, M., Curtis, E. M., Aung, N., Suemoto, C. K., Mackay, C., Suri, S., Nichols, T. E., Harvey, N. C., Petersen, S. E., and Neubauer, S. (2022). Associations of cognitive performance with cardiovascular magnetic resonance phenotypes in the UK Biobank. European Heart Journal - Cardiovascular Imaging, 23(5), 663–672. https://doi.org/10.1093/ehjci/jeab075
  15. Xie, C. X., Robson, J., Williams, C., Carvalho, C., Rison, S., and Raisi-Estabragh, Z. (2022). Dual antithrombotic therapy and gastroprotection in atrial fibrillation: An observational primary care study. BJGP Open, 6(4). https://doi.org/10.3399/BJGPO.2022.0048
  16. Maggioni, A. P., Petersen, S. E., Huculeci, R., Kazakiewicz, D., de Benito Rubio, V., Ignatiuk, B., Raisi-Estabragh, Z., Pawlak, A., Karagiannidis, E., Treskes, R., Gaita, D., Beltrame, J. F., … Sebastiao, D. (2022). European Society of Cardiology: Cardiovascular disease statistics 2021. European Heart Journal, 43(8), 716–799. https://doi.org/10.1093/EURHEARTJ/EHAB892
  17. Szabo, L., Raisi-Estabragh, Z., Salih, A., McCracken, C., Ruiz Pujadas, E., Gkontra, P., Kiss, M., Maurovich-Horvath, P., Vago, H., Merkely, B., Lee, A. M., Lekadir, K., and Petersen, S. E. (2022). Clinician’s guide to trustworthy and responsible artificial intelligence in cardiovascular imaging. Frontiers in Cardiovascular Medicine, 9. https://www.frontiersin.org/articles/10.3389/fcvm.2022.1016032
  18. Salih, A., Galazzo, I. B., Raisi-Estabragh, Z., Petersen, S. E., Gkontra, P., Lekadir, K., Menegaz, G., and Radeva, P. (2021). A new scheme for the assessment of the robustness of Explainable Methods Applied to Brain Age estimation. 2021 IEEE 34th International Symposium on Computer-Based Medical Systems (CBMS), 492–497. https://doi.org/10.1109/CBMS52027.2021.00098
  19. Carvalho, C., Williams, C., Raisi-Estabragh, Z., Rison, S., Patel, R. S., Timmis, A., and Robson, J. (2021). Application of a risk stratification tool for familial hypercholesterolaemia in primary care: An observational cross-sectional study in an unselected urban population. Heart, 107(15), 1220–1225. https://doi.org/10.1136/heartjnl-2020-318714
  20. Raisi-Estabragh, Z., Jaggi, A., Gkontra, P., McCracken, C., Aung, N., Munroe, P. B., Neubauer, S., Harvey, N. C., Lekadir, K., and Petersen, S. E. (2021). Cardiac magnetic resonance radiomics reveal differential impact of sex, age, and vascular risk factors on cardiac structure and myocardial tissue. Frontiers in Cardiovascular Medicine, 8, 763361. https://doi.org/10.3389/FCVM.2021.763361
  21. Bard, A., Raisi-Estabragh, Z., Ardissino, M., Lee, A. M., Pugliese, F., Dey, D., Sarkar, S., Munroe, P. B., Neubauer, S., Harvey, N. C., and Petersen, S. E. (2021). Automated quality-controlled cardiovascular magnetic resonance pericardial fat quantification using a convolutional neural network in the UK Biobank. Frontiers in Cardiovascular Medicine, 8. https://www.frontiersin.org/articles/10.3389/fcvm.2021.677574
  22. Salih, A., Boscolo Galazzo, I., Raisi-Estabragh, Z., Rauseo, E., Gkontra, P., Petersen, S. E., Lekadir, K., Altmann, A., Radeva, P., and Menegaz, G. (2021). Brain age estimation at tract group level and its association with daily life measures, cardiac risk factors and genetic variants. Scientific Reports, 11(1), 20563. https://doi.org/10.1038/s41598-021-99153-8
  23. Raisi-Estabragh, Z., Kenawy, A. A. M., Aung, N., Cooper, J., Munroe, P. B., Harvey, N. C., Petersen, S. E., and Khanji, M. Y. (2020). Variation in left ventricular cardiac magnetic resonance normal reference ranges: Systematic review and meta-analysis. European Heart Journal - Cardiovascular Imaging, 1–11. https://doi.org/10.1093/ehjci/jeaa089
  24. Raisi-Estabragh, Z., Harvey, N. C., Neubauer, S., and Petersen, S. E. (2020). Cardiovascular magnetic resonance imaging in the UK Biobank: A major international health research resource. European Heart Journal - Cardiovascular Imaging, 22(3), 251–258. https://doi.org/10.1093/ehjci/jeaa297
  25. Raisi-Estabragh, Z., Izquierdo, C., Campello, V. M., Martin-Isla, C., Jaggi, A., Harvey, N. C., Lekadir, K., and Petersen, S. E. (2020). Cardiac magnetic resonance radiomics: Basic principles and clinical perspectives. European Heart Journal - Cardiovascular Imaging, 21(4), 349–356. https://doi.org/10.1093/EHJCI/JEAA028

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