Dr Lucy NorlingSenior Lecturer, Versus Arthritis Senior FellowCentre: Biochemical Pharmacology Email: l.v.norling@qmul.ac.ukTelephone: +44(0) 20 7882 5644ProfileResearchKey PublicationsSponsorsCollaboratorsNewsProfileORCID iD: 0000-0001-5316-9115 Lucy Norling graduated with a Masters in Research and PhD from the William Harvey Research Institute, Queen Mary University of London in 2008. Her research focused on galectin-1; an endogenous regulator of inflammatory resolution. Dr. Norling was then awarded a 3 year Arthritis Research UK Foundation Fellowship to study the generation and bioactions of novel lipid mediators derived from omega-3 fatty acids and spent two years training at Harvard Medical School, Boston, with the mentorship of Professor Charles Serhan. In 2012 Dr Norling attained a 5 year Arthritis Research UK Career Development Fellowship to investigate the protective actions of omega-3 fatty acid derived specialized pro-resolving lipid mediators (SPM) in inflammatory arthritis. SPM provide a molecular mechanism for the beneficial effects of fish oil supplementation in patients with arthritis, and offer novel therapeutic approaches to treat inflammatory diseases. In 2019 Dr Norling was awarded a 5 year Versus Arthritis Senior Fellowship entitled “Reprogramming Resolution in the Arthritic Joint”. Her current research aims to determine whether inflammatory joint diseases persist due to an inadequate synthesis of SPM and explores how SPM protect and repair joint tissue.ResearchGroup members Hannah Law, Silvia Oggero, Shani Austin-Williams, Chiara Cecconello, Michele Padaovan. Summary Our understanding of how the inflammatory process is terminated has evolved, with the appreciation that protective mediators actively resolve inflammation. The discovery of omega-3 fatty acid derived specialized pro-resolving lipid mediators (SPM) provides a molecular mechanism for the beneficial effects of fish oil supplementation in patients with arthritis, and offer novel therapeutic approaches to treat inflammatory diseases. Supported by my Foundation Fellowship, I demonstrated that SPM inhibit PMN-endothelial interactions, dampen acute inflammation, and help fight infection. During my Career Development Fellowship I investigated the bioactions of SPM in experimental arthritis and found that resolvin D1 limits joint leukocyte infiltration, arthritis severity and protected from cartilage damage. We also determined that production of specific SPM including resolvin D3 is dysregulated in experimental arthritis, and that local SPM within murine joints can be modulated by omega-3 dietary supplementation. There is a clear need to develop new innovative therapeutic agents for arthritis that can both reduce the inflammation that drives disease AND initiate tissue repair and regeneration. With the support of a Versus Arthritis Senior Fellowship I aim to establish how SPM reprogram innate immune cells and stromal cells within the joint tissue to switch on repair mechanisms that temper the aggressive and inappropriate behaviour of cells within the joint tissue to ultimately protect the cartilage from erosion. The overarching goal of our research is to establish novel leads for the restoration of joint function to ultimately limit disability and improve the lives of patients with arthritis.Publications Thomas BL, Montero‐Melendez T, Oggero S et al. (2024). Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis. nameOfConference DOI: 10.1002/art.42958 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/98715 Hussain MT, Austin-Williams S, Wright TD et al. (publicationYear). β1-Integrin-Mediated Uptake of Chondrocyte Extracellular Vesicles Regulates Chondrocyte Homeostasis. nameOfConference DOI: 10.3390/ijms25094756 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/97635 Norling LV, Cooper D (2023). Being old and female is an inflammatory combination. nameOfConference DOI: 10.1093/jleuko/qiad077 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/95403 Chen J, Austin-Williams S, O'Riordan CE et al. (2023). Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction. nameOfConference DOI: 10.1159/000530284 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/85560 Norling LV, Headland SE, Dalli J et al. (2023). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. nameOfConference DOI: 10.1172/jci.insight.168728 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/88868 Norling LV, Halade GV (2022). Helpful inflammation turned harmful in non-communicable diseases. nameOfConference DOI: 10.1016/j.coph.2022.102317 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/83342 Qin CX, Norling LV, Vecchio EA et al. (2022). Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35. nameOfConference DOI: 10.1111/bph.15919 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/82714 Oggero S, Godec T, van Gorp R et al. (2022). Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients. nameOfConference DOI: 10.1097/hjh.0000000000003178 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79497 Cecconello C, Ribas PC, Norling LV (2022). Chapter 4 Resolving acute inflammation; what happens when inflammation goes haywire? How can it get back in line?. nameOfConference DOI: 10.1016/b978-0-12-822130-3.00018-1 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/85555 Iqbal AJ, Krautter F, Blacksell IA et al. (2022). Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner. nameOfConference DOI: 10.1096/fj.202100832r QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/76220 View Profile Publication Page Sponsors Versus Arthritis Barts Charity European Union’s Horizon 2020 research and innovation Marie Curie Actions Versus Arthritis OA Centre for Pathogenesis Centre for Inflammation & Therapeutic Innovation CollaboratorsInternal Prof. Jesmond Dalli (QMUL) Dr. Tina Chowdury (QMUL) External Prof. Charles Serhan, Brigham & Women’s Hospital & Harvard Medical School, USA Dr. Daniel Irimia, Massachusetts General Hospital, Boston, USA Prof. Philippa Hulley, NDORMS, University of Oxford News Isolated white blood cell packages from patients with rheumatoid arthritis shown to be protective against inflammationQueen Mary University of London, November 2018 How microvesicles could revolutionise arthritis treatment, The Conversation, November 2015 Injection to end pain of arthritis: New Treatment will stop agony without side-effects, Express, November 2015 Back to top