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Critical Care and Peri-operative Medicine Research Group

High-Risk Surgical Patient

In a technical sense, surgery and anaesthesia are very safe, yet a small group of patients are at high-risk of developing complications in the days and weeks following surgery.


Our research aims to identify which patients are at risk of complications after surgery and to understand why complications occur in the first place. Our on-going programme of research seeks to prevent complications and minimise the lasting human and financial cost of poor outcomes after surgery.


Our Projects

Optimising Shared decision-makIng for high-RIsk major Surgery (OSIRIS Programme) - better decision making for high-risk surgical patients

The OSIRIS programme is a major project of research, to understand and improve the shared decision making process for patients at high risk of medical complications as they contemplate major surgery.

To find out more information, please check out the OSIRIS website.

OPtimisation of Peri-operaTive CardIovascular Management to Improve Surgical outcomE II (OPTIMISE II) trial

To determine whether cardiac output-guided fluid therapy, with a low dose inotrope infusion is clinically effective when compared to usual care in patients undergoing major gastrointestinal surgery.

To find out more information, please check out the OPTIMISE II website.

Prevention of Respiratory Insufficiency after Surgical Management (PRISM) trial

To determine whether early postoperative continuous positive airway pressure (CPAP) reduces the incidence of subsequent respiratory complications and improves one year survival following major intra-peritoneal surgery.

To find out more information, please check out the PRISM website and read the PRISM trial report in The Lancet Respiratory Medicine.

Measurement of Exercise Tolerance before Surgery (METS) study

To compare preoperative subjective assessment with alternative markers of fitness (CPET, scores on the DASI questionnaire, and serum NT pro-BNP concentrations) for predicting death or complications after major elective non-cardiac surgery.

To find out more information, please check out the METs report in The Lancet.

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