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Critical Care and Peri-operative Medicine Research Group

Acute Kidney Injury

Acute Kidney Injury (AKI) is a frequent complication of critical illness, major surgery and acute medical admissions that has been independently associated with other complications, prolonged length of stay and in-hospital mortality.


Survivors of even mild AKI have increased risk of death, development of chronic kidney disease, end stage renal disease and cardiovascular complications in the longer term.


Dr John Prowle leads the interdisciplinary critical care nephrology research group. The team focus on innovation across the spectrum of AKI research including clinical and translational research, computational modelling, precision and predictive analytics, and health care delivery. Dr Prowle is also a member of the department of Renal and Transplantation medicine and collaborates with colleagues in renal, acute medicine, trauma surgery and peri-operative medicine on AKI research.


Nationally, Dr Prowle is an active senior participant in the UK AKI Clinical Studies Group and internationally in the Acute Dialysis Quality Initiative and the Kidney Disease Improving Global Outcomes AKI work stream.


Major research domains include:

  • Acute kidney injury
  • Multi-organ failure and organ support
  • Short and long-term outcomes of critical illness

Ongoing and recent projects:

  • Skeletal Muscle Wasting and Renal Dysfunction After Critical Illness and Trauma - Outcomes Study (KRATOS). This study aims to determine changes in kidney function during and after critical illness, comparing conventional creatinine based methods with the gold standard to accurately establish the presence of new or worsened chronic kidney disease. Funding: Rosetrees Trust (PI: Haines)
  • Persistent Critical Illness and Biochemical Signatures of Catabolism. To advance our understanding of prolonged critical care admissions and identify potential therapeutic windows. (PI: Wan)
  • Acute Kidney Injury in hospital admissions: This project studies acute kidney injury across one of the largest NHS Trusts to predict patients at high risk for developing new or progressive CKD after an episode of acute kidney injury (AKI). (PI: Prowle)

The group has a portfolio of industry sponsored research and collaborations.

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