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Critical Care and Peri-operative Medicine Research Group


Please see below the top five publications from each of the academics at the Critical Care and Perioperative Medicine Research Group.


Rupert Pearse

Rupert Pearse

Gareth Ackland

John Prowle

Zudin Puthucheary


tim stephens



  • PRISM trial group [Pearse RM, chief investigator]. Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial. Lancet Respir Med 2021; 9: 1221-1230. 
  • ASOS-2 Investigators [Pearse RM, senior author]. Enhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2): a cluster-randomised controlled trial. Lancet Global Health 2021; 10: e1391-e1401.
  • ASOS-Paeds Investigators [Pearse RM, senior investigator]. Outcomes after surgery for children in Africa (ASOS-Paeds): a 14-day prospective observational cohort study. Lancet. 2024: S0140-6736(24)00103-X. PMID: 38527482
  • Peden C, Stephens T, Martin G, Kahan B, Thomson A, Rivett K, Wells D, Richardson G, Kerry S, Bion J, Pearse RM, on behalf of the EPOCH trial group. Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery: A stepped-wedge cluster randomised trial. Lancet 2019; 393: 2213-21.
  • Bishop D, Dyer R, Maswime S, …, Pearse RM, Biccard B; ASOS investigators. Maternal and neonatal outcomes after caesarean delivery in the African Surgical Outcomes Study: 7-day prospective observational study. Lancet Global Health 2019. 7: e513-e522. 
  • Biccard BM, Madiba TE, Kluyts HL, …., Pearse RM; African Surgical Outcomes Study (ASOS) investigators. Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study. Lancet. 2018; 391:1589-1598. 
  • Wijeysundera DN, Pearse RM, Shulman MA, Abbott TEF, Torres E, Ambosta A, Croal BL, Granton JT, Thorpe KE, Grocott MPW, Farrington C, Myles PS, Cuthbertson BH, on behalf of the METS study investigators. Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study. Lancet. 2018; 391: 2631-40. 
  • Kahan BC, Koulenti D, Arvaniti K, …, Pearse RM; International Surgical Outcomes Study group. Critical care admission following elective surgery was not associated with survival benefit: Analysis of data from 27 countries. Intensive Care Med. 2017; 43: 971-79.
  • Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MP, Ahern A, Griggs K, Scott R, Hinds C, Rowan K; OPTIMISE Trial Group. Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: Randomized trial and systematic review. JAMA. 2014; 311: 2181-90. 
  • Pearse RM, Moreno R, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent J-L, Hoeft A, Rhodes A. Mortality after surgery in Europe: a seven-day cohort study. Lancet 2012; 380: 1059-65.
  • Ackland GL, Patel A, Abbott TEF, Begum S, Dias P, Crane DR, Somanath S, Middleditch A, Cleland S, Gutierrez Del Arroyo A, Brealey D, Pearse RM; SPACE trial investigators. Discontinuation vs. continuation of renin-angiotensin system inhibition before non-cardiac surgery: the SPACE trial. Eur Heart J. 2023 Nov 7: ehad716. PMID: 37935833


For a full list of publications click here.

  • Molecular mechanisms linking dysautonomia and impaired cardiac contractility in critical illness.  Critical Care Medicine, 2016: in press.
  • Randomized controlled trial of vagal modulation by sham feeding in elective non-gastrointestinal (orthopaedic) surgery.Br J Anaesth. 2015;115(5):727-35
  • Metabolic dysfunction in lymphocytes promotes postoperative morbidity. Clin Sci (Lond). 2015;129(5):423-37
  • Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial. Lancet Respir Med. 2015 ;3(1):33-41. 
  • Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes. VISION Investigators. Anesthesiology. 2014;120(3):564-78

For a full list of publications click here.

  • Chaudery H, MacDonald N, Ahmad T, Chandra S, Tantri A, Sivasakthi V, Mansor M, Matos R, Pearse RM, Prowle JR; International Surgical Outcomes Study (ISOS) Group. Acute Kidney Injury and Risk of Death After Elective Surgery: Prospective Analysis of Data From an International Cohort Study. Anesth Analg. 2018 Nov 9.
  • Haines RW, Lin SP, Hewson R, Kirwan CJ, Torrance HD, O'Dwyer MJ, West A, Brohi K, Pearse RM, Zolfaghari P, Prowle JR. Acute Kidney Injury in Trauma Patients Admitted to Critical Care: Development and Validation of a Diagnostic Prediction Sci Rep. 2018 Feb 26;8(1):3665.
  • Kellum JA, Prowle JR. Paradigms of acute kidney injury in the intensive care setting. Nat Rev Nephrol. 2018 Apr;14(4):217-230.
  • Ravn B, Prowle JR, Mårtensson J, Martling CR, Bell M. Superiority of Serum Cystatin C Over Creatinine in Prediction of Long-Term Prognosis at Discharge From ICU. Crit Care Med. 2017 Sep;45(9):e932-e940.
  • O'Connor ME, Hewson RW, Kirwan CJ, Ackland GL, Pearse RM, Prowle JR. Acute kidney injury and mortality 1 year after major non-cardiac surgery. Br J Surg. 2017 Jun;104(7):868-876.

For a full list of publications click here.

  • Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, Hopkinson N, Padhke R, Dew T, Sidhu PS, Velloso C, Seymour J, Agley CC, Selby A, Limb M , Edwards L,Smith K, Rowlerson  A, Rennie MJ, Moxham J,  and Harridge SDR,  Hart N, Montgomery HE. “Acute skeletal muscle wasting in critical illness”JAMA (2013). 310(15): p. 1591-600
  • Zudin A Puthucheary; Ronan Astin; Mark M McPhail; Saeed S; Pasha  Y; Bear DE; Constantin D; Velloso C; Manning S; Calvert L; Mervyn Singer;  Rachel L Batterham; Gomez-Romero M; Holmes E; Steiner M; Atherton PJ; Paul Greenhaff; Lindsay Edwards;  Smith K; and Stephen D Harridge; Nicholas Hart; Hugh E Montgomery.” The metabolic phenotype of skeletal muscle in early critical illness” Thorax 2018 ;73:926-935.
  • Puthucheary, ZA, Phadke R,Rawal J, McPhail MJW, Sidhu PS, Rowlerson A, Moxham J, Harridge S, Hart N, Montgomery HE. “Qualitative ultrasound in acute critical illness muscle wasting” Critical Care Medicine (2015) 43(8); 1603-1611. 
  • Angela S McNelly, Jai Rawal, Dinesh Shrikrishna, Nicholas S Hopkinson, John Moxham, Stephen D Harridge, Nicholas Hart, Hugh E Montgomery, and Zudin A Puthucheary. “An Exploratory Study of Long-term Outcome Measures in Critical Illness Survivors: Construct Validity of Physical Activity, Frailty and Health-Related Quality of Life Measures“ Critical Care Medicine. 2016; 44(6):e362-369.10.1097/CCM.0000000000001645 
  • Puthucheary ZA, Sun Y, Zeng K, Vu LH, Zhang ZW, Lim RZL, Chew NSY, Cove ME. “Sepsis reduces bone strength before morphologic changes are identifiable”. Crit Care Med 2017; 45: e1254-e1261 doi: 10.1097/CCM.0000000000002732 

For a full list of publications click here.

  • Wan YI, Apea VJ, Orkin CM, Dhairyawan R, Puthucheary ZA, Pearse RM, Prowle JR. ‘Ethnic disparities in hospitalisation and hospital-outcomes during the second wave of COVID-19 infection in east London.’ Sci Rep 2022; 12(1):3721. PMID: 35260620.
  • Wan YI, Robbins AJ, Apea VJ, Orkin CM, Pearse RM, Puthucheary ZA, Prowle JR. ‘Ethnicity and acute hospital admissions: Multi-centre analysis of routine hospital data.’ EClinicalMedicine 2021; 39;10177. PMID: 34611614.
  • Apea VJ*, Wan YI* (equal contributors), Dhairyawan R, Puthucheary AZ, Pearse RM, Orkin CM, Prowle JR. ‘Ethnicity and outcomes in patients hospitalised with COVID-19 infection in East London: an observational cohort study.’ BMJ Open 2021; 11:e042140. PMID: 33455936.
  • Wan YI, McGuckin D, Fowler AJ, et al. ‘Socioeconomic deprivation and long-term outcomes after elective surgery: Analysis of prospective data from two observational studies’. Br J Anaesth 2020; 126(3):642-651. PMID: 33220938.
  • Wan YI, Shrine NR, Soler-Artigas M, et al. ‘Genome-wide association study to identify genetic determinants of severe asthma'. Thorax 2012; 67(9):762-8. PMID: 22561531.
  • Glasbey, J., ABBOTT, T., Ademuyiwa, A., Adisa, A., et al. (2022) Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries. The Lancet. doi: 10.1016/S0140-6736(22)01846-3
  • Nepogodiev, D., Abbott, T. E., Ademuyiwa, A. O., AlAmeer, E., Bankhead-Kendall, B. K., Biccard, B. M., . . . Bhangu, A. (2022). Projecting COVID-19 disruption to elective surgery. The Lancet399(10321), 233-234. doi: 10.1016/S0140-6736(21)02836-1
  • Pearse, R., Abbott, T.E.F., Patel, A., Dias, P., Hewson, R., & Stephens, T. (2021). Postoperative continuous positive airways pressure (CPAP) to prevent pneumonia, re-intubation and death after major abdominal surgery: An international randomised trial. The Lancet Respiratory Medicine. doi: 10.1016/S2213-2600(21)00089-8 
  • Abbott, T. E. F., & Pearse, R. M. (2019). Depth of Anesthesia and Postoperative Delirium. JAMA: the Journal of the American Medical Association321(5), 459–460.
  • Wijeysundera, D. N., Pearse, R. M., Shulman, M. A., Abbott, T. E. F., Torres, E., Ambosta, A., et al. (2018). Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study. Lancet391(10140), 2631–2640.
  • Waksman R, Pahuja M, van Diepen S, Proudfoot A, David Morrow…… Krucoff M, Abraham W Standardized definitions for cardiogenic shock research: Scientific expert panel from the Shock Academic Research Consortium (SHARC) Circulation. 2023 Oct 3;148(14):1113-1126. doi: 10.1161/CIRCULATIONAHA
  • Samsky MD, Morrow DA, Proudfoot AG, Hochman JS, Thiele H, Rao SV Cardiogenic Shock Associated with Acute Myocardial Infarction Journal of the American Medical Association (JAMA) 2021;326 (18): 1840-50
  • Warren A. McCarthy C, Andiapen M, Crouch M, Finney S, Hamilton, Jain A, Jones D, Proudfoot A Early versus delayed quantitative infrared pupillometry for prediction of neurological outcome in patients admitted to intensive care following out-of-hospital cardiac arrest Br J Anaesth. 2022;128(5):849-856. 
  • Proudfoot A, Bayliffe A, O'Kane CM, Wright T, Serone A, Bareille PJ, Brown V, Hamid UI, Chen Y, Wilson R, Cordy J, Morley P, de Wildt R, Elborn S, Hind M, Chilvers ER, Griffiths M, Summers C, McAuley DF. A novel TNFR1-targeting domain antibody attenuates pulmonary inflammation in a human model of lung injury, via actions on the lung micro-vascular endothelium. Thorax 2018; 3(8):723-730
  • Miller FR, Summers C, Griffiths MJ, Toshner MR, Proudfoot AG The pulmonary endothelium in the Acute Respiratory Distress Syndrome – insights and therapeutic opportunities. Thorax 2014 May; 71(5):462-73
  • Bedwell, G. J., Dias, P., Hahnle, L., Anaeli, A., Baker, T., Beane, A., ... & Stephens, TJ. Barriers to quality perioperative care delivery in low-and middle-income countries: a qualitative rapid appraisal study. Anesthesia & Analgesia, 2022; 135(6), 1217-1232.
  • Vickery N, Stephens T, du Toit L, van Straaten D, Pearse R, Torborg A, Rolt L, Puchert M, Martin G, Biccard B, ASOS-2 Investigators. Understanding the performance of a pan-African intervention to reduce postoperative mortality: a mixed-methods process evaluation of the ASOS-2 trial. British Journal of Anaesthesia. 2021 Nov 1;127(5):778-88.
  • Biccard BM, du Toit L, Lesosky M, Stephens T, Myer L, Prempeh AB, Vickery N, Kluyts HL, Torborg A, Omigbodun A, Ademuyiwa A. Enhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2): a cluster-randomised controlled trial. The Lancet Global Health. 2021 Oct 1;9(10):e1391-401.
  • Stephens TJ, Peden CJ, Haines R, Grocott MP, Murray D, Cromwell D, Johnston C, Hare S, Lourtie J, Drake S, Martin GP. Hospital-Level evaluation of the effect of a national quality improvement programme: time-series analysis of registry data. BMJ quality & safety. 2019 Sep 12
  • Peden CJ, Stephens T, Martin G, Kahan BC, Thomson A, Rivett K, Wells D, Richardson G, Kerry S, Bion J, Pearse RM. Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial. The Lancet. 2019 Apr 25.


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