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Critical Care and Peri-operative Medicine Research Group

Publications

Please see below the top five publications from each of the academics at the Critical Care and Perioperative Medicine Research Group.

 

Rupert Pearse

Charles Hinds

Gareth Ackland

John Prowle

 

Zudin Puthucheary

 

Rupert Pearse

  • Peden C, Stephens T, Martin G, Kahan B, Thomson A, Rivett K, Wells D, Richardson G, Kerry S, Bion J, Pearse RM, on behalf of the Enhanced Peri-Operative Care for High-risk patients (EPOCH) trial group. Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery: A stepped-wedge cluster randomised trial. Lancet  2019. pii: S0140-6736(18)32521-2. PMID: 31030986
  • Biccard BM, Madiba TE, Kluyts HL, …., Pearse RM; African Surgical Outcomes Study (ASOS) investigators. Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study. Lancet. 2018; 391:1589-1598. PMID: 29306587
  • Wijeysundera DN, Pearse RM, Shulman MA, Abbott TEF, Torres E, Ambosta A, Croal BL, Granton JT, Thorpe KE, Grocott MPW, Farrington C, Myles PS, Cuthbertson BH, on behalf of the METS study investigators. Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study.Lancet. 2018; 391: 2631-40. PMID: 30070222
  • Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MP, Ahern A, Griggs K, Scott R, Hinds C, Rowan K; OPTIMISE Study Group. Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA. 2014; 311: 2181-90.  PMID: 24842135
  • Pearse RM, Moreno R, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent J-L, Hoeft A, Rhodes A. Mortality after surgery in Europe: a seven day cohort study. Lancet 2012; 380: 1059-65.  PMID: 22998715

For a full list of publications click here.

Gareth Ackland

  • Molecular mechanisms linking dysautonomia and impaired cardiac contractility in critical illness.  Critical Care Medicine, 2016: in press.
  • Randomized controlled trial of vagal modulation by sham feeding in elective non-gastrointestinal (orthopaedic) surgery.Br J Anaesth. 2015;115(5):727-35
  • Metabolic dysfunction in lymphocytes promotes postoperative morbidity. Clin Sci (Lond). 2015;129(5):423-37
  • Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial. Lancet Respir Med. 2015 ;3(1):33-41. 
  • Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes. VISION Investigators. Anesthesiology. 2014;120(3):564-78

For a full list of publications click here.

John Prowle

  • Chaudery H, MacDonald N, Ahmad T, Chandra S, Tantri A, Sivasakthi V, Mansor M, Matos R, Pearse RM, Prowle JR; International Surgical Outcomes Study (ISOS) Group. Acute Kidney Injury and Risk of Death After Elective Surgery: Prospective Analysis of Data From an International Cohort Study. Anesth Analg. 2018 Nov 9.
  • Haines RW, Lin SP, Hewson R, Kirwan CJ, Torrance HD, O'Dwyer MJ, West A, Brohi K, Pearse RM, Zolfaghari P, Prowle JR. Acute Kidney Injury in Trauma Patients Admitted to Critical Care: Development and Validation of a Diagnostic Prediction Sci Rep. 2018 Feb 26;8(1):3665.
  • Kellum JA, Prowle JR. Paradigms of acute kidney injury in the intensive care setting. Nat Rev Nephrol. 2018 Apr;14(4):217-230.
  • Ravn B, Prowle JR, Mårtensson J, Martling CR, Bell M. Superiority of Serum Cystatin C Over Creatinine in Prediction of Long-Term Prognosis at Discharge From ICU. Crit Care Med. 2017 Sep;45(9):e932-e940.
  • O'Connor ME, Hewson RW, Kirwan CJ, Ackland GL, Pearse RM, Prowle JR. Acute kidney injury and mortality 1 year after major non-cardiac surgery. Br J Surg. 2017 Jun;104(7):868-876.

For a full list of publications click here.

Charles Hinds

For a full list of publications click here.

Zudin Puthucheary

  • Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, Hopkinson N, Padhke R, Dew T, Sidhu PS, Velloso C, Seymour J, Agley CC, Selby A, Limb M , Edwards L,Smith K, Rowlerson  A, Rennie MJ, Moxham J,  and Harridge SDR,  Hart N, Montgomery HE. “Acute skeletal muscle wasting in critical illness”JAMA (2013). 310(15): p. 1591-600
  • Zudin A Puthucheary; Ronan Astin; Mark M McPhail; Saeed S; Pasha  Y; Bear DE; Constantin D; Velloso C; Manning S; Calvert L; Mervyn Singer;  Rachel L Batterham; Gomez-Romero M; Holmes E; Steiner M; Atherton PJ; Paul Greenhaff; Lindsay Edwards;  Smith K; and Stephen D Harridge; Nicholas Hart; Hugh E Montgomery.” The metabolic phenotype of skeletal muscle in early critical illness” Thorax 2018 ;73:926-935.
  • Puthucheary, ZA, Phadke R,Rawal J, McPhail MJW, Sidhu PS, Rowlerson A, Moxham J, Harridge S, Hart N, Montgomery HE. “Qualitative ultrasound in acute critical illness muscle wasting” Critical Care Medicine (2015) 43(8); 1603-1611. 
  • Angela S McNelly, Jai Rawal, Dinesh Shrikrishna, Nicholas S Hopkinson, John Moxham, Stephen D Harridge, Nicholas Hart, Hugh E Montgomery, and Zudin A Puthucheary. “An Exploratory Study of Long-term Outcome Measures in Critical Illness Survivors: Construct Validity of Physical Activity, Frailty and Health-Related Quality of Life Measures“ Critical Care Medicine. 2016; 44(6):e362-369.10.1097/CCM.0000000000001645 
  • Puthucheary ZA, Sun Y, Zeng K, Vu LH, Zhang ZW, Lim RZL, Chew NSY, Cove ME. “Sepsis reduces bone strength before morphologic changes are identifiable”. Crit Care Med 2017; 45: e1254-e1261 doi: 10.1097/CCM.0000000000002732 

For a full list of publications click here.

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