Skip to main content
Critical Care and Peri-operative Medicine Research Group


Please see below the top five publications from each of the academics at the Critical Care and Perioperative Medicine Research Group.


Rupert Pearse

Rupert Pearse

Gareth Ackland

John Prowle

Zudin Puthucheary




  • Peden C, Stephens T, Martin G, Kahan B, Thomson A, Rivett K, Wells D, Richardson G, Kerry S, Bion J, Pearse RM, on behalf of the Enhanced Peri-Operative Care for High-risk patients (EPOCH) trial group. Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery: A stepped-wedge cluster randomised trial. Lancet. 2019. pii: S0140-6736(18)32521-2. PMID: 31030986
  • Biccard BM, Madiba TE, Kluyts HL, …., Pearse RM; African Surgical Outcomes Study (ASOS) investigators. Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study. Lancet. 2018; 391:1589-1598. PMID: 29306587
  • PRISM trial group. Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial. The Lancet Respiratory Medicine. 2021. doi: 10.1016/S2213-2600(21)00089-8. PMID: 34153272.
  • Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MP, Ahern A, Griggs K, Scott R, Hinds C, Rowan K; OPTIMISE Study Group. Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA. 2014; 311: 2181-90.  PMID: 24842135
  • Pearse RM, Moreno R, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent J-L, Hoeft A, Rhodes A. Mortality after surgery in Europe: a seven day cohort study. Lancet 2012; 380: 1059-65.  PMID: 22998715

For a full list of publications click here.

  • Molecular mechanisms linking dysautonomia and impaired cardiac contractility in critical illness.  Critical Care Medicine, 2016: in press.
  • Randomized controlled trial of vagal modulation by sham feeding in elective non-gastrointestinal (orthopaedic) surgery.Br J Anaesth. 2015;115(5):727-35
  • Metabolic dysfunction in lymphocytes promotes postoperative morbidity. Clin Sci (Lond). 2015;129(5):423-37
  • Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial. Lancet Respir Med. 2015 ;3(1):33-41. 
  • Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes. VISION Investigators. Anesthesiology. 2014;120(3):564-78

For a full list of publications click here.

  • Chaudery H, MacDonald N, Ahmad T, Chandra S, Tantri A, Sivasakthi V, Mansor M, Matos R, Pearse RM, Prowle JR; International Surgical Outcomes Study (ISOS) Group. Acute Kidney Injury and Risk of Death After Elective Surgery: Prospective Analysis of Data From an International Cohort Study. Anesth Analg. 2018 Nov 9.
  • Haines RW, Lin SP, Hewson R, Kirwan CJ, Torrance HD, O'Dwyer MJ, West A, Brohi K, Pearse RM, Zolfaghari P, Prowle JR. Acute Kidney Injury in Trauma Patients Admitted to Critical Care: Development and Validation of a Diagnostic Prediction Sci Rep. 2018 Feb 26;8(1):3665.
  • Kellum JA, Prowle JR. Paradigms of acute kidney injury in the intensive care setting. Nat Rev Nephrol. 2018 Apr;14(4):217-230.
  • Ravn B, Prowle JR, Mårtensson J, Martling CR, Bell M. Superiority of Serum Cystatin C Over Creatinine in Prediction of Long-Term Prognosis at Discharge From ICU. Crit Care Med. 2017 Sep;45(9):e932-e940.
  • O'Connor ME, Hewson RW, Kirwan CJ, Ackland GL, Pearse RM, Prowle JR. Acute kidney injury and mortality 1 year after major non-cardiac surgery. Br J Surg. 2017 Jun;104(7):868-876.

For a full list of publications click here.

  • Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, Hopkinson N, Padhke R, Dew T, Sidhu PS, Velloso C, Seymour J, Agley CC, Selby A, Limb M , Edwards L,Smith K, Rowlerson  A, Rennie MJ, Moxham J,  and Harridge SDR,  Hart N, Montgomery HE. “Acute skeletal muscle wasting in critical illness”JAMA (2013). 310(15): p. 1591-600
  • Zudin A Puthucheary; Ronan Astin; Mark M McPhail; Saeed S; Pasha  Y; Bear DE; Constantin D; Velloso C; Manning S; Calvert L; Mervyn Singer;  Rachel L Batterham; Gomez-Romero M; Holmes E; Steiner M; Atherton PJ; Paul Greenhaff; Lindsay Edwards;  Smith K; and Stephen D Harridge; Nicholas Hart; Hugh E Montgomery.” The metabolic phenotype of skeletal muscle in early critical illness” Thorax 2018 ;73:926-935.
  • Puthucheary, ZA, Phadke R,Rawal J, McPhail MJW, Sidhu PS, Rowlerson A, Moxham J, Harridge S, Hart N, Montgomery HE. “Qualitative ultrasound in acute critical illness muscle wasting” Critical Care Medicine (2015) 43(8); 1603-1611. 
  • Angela S McNelly, Jai Rawal, Dinesh Shrikrishna, Nicholas S Hopkinson, John Moxham, Stephen D Harridge, Nicholas Hart, Hugh E Montgomery, and Zudin A Puthucheary. “An Exploratory Study of Long-term Outcome Measures in Critical Illness Survivors: Construct Validity of Physical Activity, Frailty and Health-Related Quality of Life Measures“ Critical Care Medicine. 2016; 44(6):e362-369.10.1097/CCM.0000000000001645 
  • Puthucheary ZA, Sun Y, Zeng K, Vu LH, Zhang ZW, Lim RZL, Chew NSY, Cove ME. “Sepsis reduces bone strength before morphologic changes are identifiable”. Crit Care Med 2017; 45: e1254-e1261 doi: 10.1097/CCM.0000000000002732 

For a full list of publications click here.

  • Wan YI, Apea VJ, Orkin CM, Dhairyawan R, Puthucheary ZA, Pearse RM, Prowle JR. ‘Ethnic disparities in hospitalisation and hospital-outcomes during the second wave of COVID-19 infection in east London.’ Sci Rep 2022; 12(1):3721. PMID: 35260620.
  • Wan YI, Robbins AJ, Apea VJ, Orkin CM, Pearse RM, Puthucheary ZA, Prowle JR. ‘Ethnicity and acute hospital admissions: Multi-centre analysis of routine hospital data.’ EClinicalMedicine 2021; 39;10177. PMID: 34611614.
  • Apea VJ*, Wan YI* (equal contributors), Dhairyawan R, Puthucheary AZ, Pearse RM, Orkin CM, Prowle JR. ‘Ethnicity and outcomes in patients hospitalised with COVID-19 infection in East London: an observational cohort study.’ BMJ Open 2021; 11:e042140. PMID: 33455936.
  • Wan YI, McGuckin D, Fowler AJ, et al. ‘Socioeconomic deprivation and long-term outcomes after elective surgery: Analysis of prospective data from two observational studies’. Br J Anaesth 2020; 126(3):642-651. PMID: 33220938.
  • Wan YI, Shrine NR, Soler-Artigas M, et al. ‘Genome-wide association study to identify genetic determinants of severe asthma'. Thorax 2012; 67(9):762-8. PMID: 22561531.
  • Glasbey, J., ABBOTT, T., Ademuyiwa, A., Adisa, A., et al. (2022) Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries. The Lancet. doi: 10.1016/S0140-6736(22)01846-3
  • Nepogodiev, D., Abbott, T. E., Ademuyiwa, A. O., AlAmeer, E., Bankhead-Kendall, B. K., Biccard, B. M., . . . Bhangu, A. (2022). Projecting COVID-19 disruption to elective surgery. The Lancet399(10321), 233-234. doi: 10.1016/S0140-6736(21)02836-1
  • Pearse, R., Abbott, T.E.F., Patel, A., Dias, P., Hewson, R., & Stephens, T. (2021). Postoperative continuous positive airways pressure (CPAP) to prevent pneumonia, re-intubation and death after major abdominal surgery: An international randomised trial. The Lancet Respiratory Medicine. doi: 10.1016/S2213-2600(21)00089-8 
  • Abbott, T. E. F., & Pearse, R. M. (2019). Depth of Anesthesia and Postoperative Delirium. JAMA: the Journal of the American Medical Association321(5), 459–460.
  • Wijeysundera, D. N., Pearse, R. M., Shulman, M. A., Abbott, T. E. F., Torres, E., Ambosta, A., et al. (2018). Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study. Lancet391(10140), 2631–2640.


Back to top