Dr Ajay K GuptaSenior Clinical Lecturer, Hon. Consultant in Clinical Pharmacology and Cardiovascular & Internal Medicine Centre: Clinical Pharmacology and Precision MedicineEmail: ajay.gupta@qmul.ac.ukTelephone: +44(0) 20 7882 2858Twitter: @ajaya2000ProfileResearchPublicationsSponsorsCollaboratorsNewsProfileStudy websites: CoPE- HCP: COVID-19 disease and Physical and Emotional Wellbeing of the Health Care Professionals SCRATCH-HTN ORCID iD: 0000-0001-5807-8503 Ajay graduated in medicine (MBBS) with distinction in Pharmacology, and completed his initial core medical training (MD) from Delhi University. Subsequently, Ajay won a prestigious World Bank Scholarship award to do Master of Science (MSc) in epidemiology from London School of Hygiene and Tropical Medicine (University of London). After that, he did his PhD under the supervision of Profs Neil Poulter and Peter Sever from Imperial College, London. He completed his further specialist clinical training in General Internal Medicine and Clinical Pharmacology and Therapeutics from Royal London and St Bartholomew Hospital. Ajay’s research to date has been in a broader field of preventive cardiovascular and metabolic medicine with a particular focus on hypertension, statin therapy, and diabetes. He has extensive experience of population health research, clinical trials design and management, and has been associated with several large phase-3 clinical trials, such as ASCOT. He has been on the end-point and adjudication committees of a few clinical trials and studies, such as PREMIUM, SABRE, and ORBITA. When working in Imperial College, he gained substantial experience in analyses of large databases. Another research interest of Ajay is on reporting of drug-related adverse events in trials, and how are they captured in databases. Recently, he has been involved in setting up a large cohort study - the ASCOT Legacy cohort. Another research focus of Ajay is in the area related to the ethnic differences in the treatment response and the influence of ethnicity on cardiovascular outcomes, particularly amongst South Asian and Asian populations. Ajay also has extensive experience in doing meta-analyses and systematic reviews. He is interested in developing research programmes to inform clinical practice and generate hypothesis; by either utilising previously published data in various trials, studies and surveys or from developing various linkages with the administrative databases. He has been a member of editorial board of several journals and is a Senior Associate Editor of Journal of American Heart Association. Clinically, Ajay works as Hon consultant in the Barts BP Centre of Excellence at Barts Heart Centre. He has a clinical interest in managing complex patients with multiple cardiovascular risk factors, including hypertension, diabetes and obesity. He works with patients with drug intolerance, and those with drug-related adverse effects, to help develop different strategies to manage their risk. In the past, he has been instrumental in developing clinical pathways, for example, he was instrumental in developing an ambulatory care clinic setup and setting up a secondary care diabetes clinic. In the past, he has extensively worked in several other sub-specialties, including Acute Medicine and Diabetes and Endocrinology, and has thus gained wide-based clinical experience in different specialities. Academic Awards Finalist American Society of Hypertension 2008 Young Investigator Award Finalist Austin Doyle Award, International Society of Hypertension Conference, 2006 Joint Japan World Bank Graduate Scholarship, 2003–4 for study in LSHTM, University of London Asian Development Bank Scholarship, 2003, University of Sydney 35th World Heart Federation Fellowship 2001 ResearchGroup members Barts Cardiovascular CTU: Prof Amrita Ahluwalia (Interim Chair), Dr Vivienne Monk (Manager), Dr Saidi Mohiddin, Prof Steffen Peterson, Dr Dan Jones (Senior Lecturer), Jane Field Members of Blood Pressure Group: Dr Mel Lobo, Dr Vikas Kapil, Dr Fu Ng, Dr Gurvinder Rull, Dr David Collier, Dr Manish Saxena, Dr Peter Julu, Dr Chris Wolff, Mr Sotiris Antoniou Cardiovascular Genomics: Prof Mark Caulfield, Prof Patricia Munroe, Prof Moris Brown, Dr Fu Ng, Dr Helen Warren, Dr Claudia Cabrera, Dr Mike Barnes Summary Dr Gupta’s research interests are mainly around the epidemiology and therapeutics related to the cardiovascular and metabolic medicine; the treatment and pathophysiology of hypertension, impact of statin therapy, and prevention of the cardiovascular events amongst those with diabetes. He has a particular interest in developing risk prediction models to help prevent major cardiovascular adverse events. He has worked extensively in evaluating the efficacy and utility of various newer and older antihypertensive agents. Ajay’s other research focus is in the area related to the ethnic differences in treatment response, and the relationship of the ethnicity with cardiovascular risk factors and diseases. In his research, he utilises the information available in the existing databases to develop evaluations that may, in turn, help improve the understanding about some of the less explored (but clinically significant) issues in the field of cardiovascular and metabolic medicine. For example, in the past, he has done several meta-analyses to answer clinically relevant questions. He has also used large clinical trial databases to generate evidence, which in turn has improved clinical practice and have generated the newer hypothesis. He aims to develop a portfolio of such research programme that can deliver tangible research outputs at significantly lower costs. ASCOT legacy cohort, and LATER dementia programmeAjay is a part of the study team for the two ongoing cohort studies that are developed from the patients who were initially randomised in the Anglo-Scandinavian Cardiac Outcomes Trial. This is a cohort of 8600 hypertensive patients, who were initially followed up for 5.5 years as part of the original ASCOT trial, and after that, they are being followed for morbidity and mortality using various database linkages. In LATER Dementia project, the impact of blood pressure and lipid-lowering during mid-life is being examined for the subsequent development of cognitive impairment. Other ongoing research projects Impact of BP control and BP variability on long-term morbidity and mortality. To evaluate the role of drug-related new-onset diabetes on cardiovascular morbidity and mortality. To evaluate the relationship of pulse pressure in comparison to systolic blood pressure as the marker of the future cardiovascular risk. Publications Graham C, Steckelmacher J, Capel M et al. (2024). Nationwide trends in blood pressure control among those with and without diabetes in England over last 2 decades: Health Survey of England 2003-2019. nameOfConference DOI: 10.1093/eurheartj/ehae666.2561 QMRO: qmroHref Gupta A, Graham C, Capel M et al. (2024). Nationwide trends in major cardiovascular risk factors in England in the last 2 decades: Health Survey of England 2003-2019. nameOfConference DOI: 10.1093/eurheartj/ehae666.3603 QMRO: qmroHref Graham C, Steckelmacher J, Prasher J et al. (2024). Trends in hypertension prevalence and control in England over the last 3 decades: Health Survey of England 1994-2019. nameOfConference DOI: 10.1093/eurheartj/ehae666.2562 QMRO: qmroHref Steckelmacher J, Graham C, Maniero C et al. (2024). Managing hypertension in older people: current concepts. nameOfConference DOI: 10.1136/dtb.2023.000031 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100656 Sposato LA, Gupta AK, Wu KC (2024). JAHA Spotlight on Neurocardiology: An Emerging Field Gaining Traction Among Neurologists and Cardiologists.. nameOfConference DOI: 10.1161/jaha.124.038026 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/99878 Collett G, Korszun A, Gupta AK (2024). Potential strategies for supporting mental health and mitigating the risk of burnout among healthcare professionals: insights from the COVID-19 pandemic. nameOfConference DOI: 10.1016/j.eclinm.2024.102562 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/96112 committee W, Reith C, Preiss D et al. (2024). Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis. nameOfConference DOI: 10.1016/s2213-8587(24)00040-8 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/95932 Magavern EF, Kapil V, Saxena M et al. (2024). Use of Genomics to Develop Novel Therapeutics and Personalize Hypertension Therapy. nameOfConference DOI: 10.1161/atvbaha.123.319220 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/96841 Gupta A, Whiteley WN, Godec T et al. (2024). Legacy benefits of blood pressure treatment on cardiovascular events are primarily mediated by improved blood pressure variability: the ASCOT trial. nameOfConference DOI: 10.1093/eurheartj/ehad814 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/94646 Wu R, Williams C, Zhou J et al. (2024). Long-term cardiovascular risks and statin treatment impact on socioeconomic inequalities: microsimulation model. nameOfConference DOI: 10.3399/bjgp.2023.0198 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91103 Bidel Z, Nazarzadeh M, Canoy D et al. (2023). Sex-Specific Effects of Blood Pressure Lowering Pharmacotherapy for the Prevention of Cardiovascular Disease: An Individual Participant-Level Data Meta-Analysis. nameOfConference DOI: 10.1161/hypertensionaha.123.21496 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/96842 Maniero C, Ng SM, Collett G et al. (2024). Differential impact of COVID-19 on mental health and burnout. nameOfConference DOI: 10.1093/occmed/kqad011 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/85726 Collett G, Godec T, Gupta AK (2023). Factors influencing attitudes toward vaccine safety and vaccine effectiveness amongst UK healthcare professionals prior to and at the time of COVID-19 vaccine rollout: Insights from the CoPE-HCP cohort study. nameOfConference DOI: 10.1080/21645515.2023.2188823 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/85559 Siddiqui I, Gupta J, Collett G et al. (2023). Perceived workplace support and mental health, well-being and burnout among health care professionals during the COVID-19 pandemic: a cohort analysis. nameOfConference DOI: 10.9778/cmajo.20220191 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/84970 Khanji MY, Collett G, Godec T et al. (2023). Improved lifestyle is associated with improved depression, anxiety and well-being over time in UK healthcare professionals during the COVID-19 pandemic: insights from the CoPE-HCP cohort study. nameOfConference DOI: 10.1136/gpsych-2022-100908 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/84159 Sever P, Gupta A, Whiteley W et al. (2023). S-28-8: THE ASCOT LEGACY COHORT: THE LONG-TERM EFFECTS OF BLOOD PRESSURE AND BLOOD PRESSURE VARIABILITY ON CARDIOVASCULAR AND RENAL OUTCOMES. nameOfConference DOI: 10.1097/01.hjh.0000913376.59859.51 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/99879 Kapil V, Collett G, Godec T et al. (2022). Longitudinal comparisons of mental health, burnout and well-being in patient-facing, non-patient-facing healthcare professionals and non-healthcare professionals during the COVID-19 pandemic: findings from the CoPE-HCP study. nameOfConference DOI: 10.1192/bjo.2022.579 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/82609 Rostamian S, Godec T, Gupta AK et al. (2022). Abstract P325: Visit-To-Visit Blood Pressure Variability Is A Major Risk Factor For Renal Outcomes In Hypertensive Patients: Evidence From The 20-Year Follow-Up Of The Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). nameOfConference DOI: 10.1161/hyp.79.suppl_1.p325 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/82702 Reith C, Baigent C, Blackwell L et al. (2022). Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials. nameOfConference DOI: 10.1016/s0140-6736(22)01545-8 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/82610 Maniero C, Lopuszko A, Papalois K-B et al. (2023). Non-pharmacological factors for hypertension management: a systematic review of international guidelines. nameOfConference DOI: 10.1093/eurjpc/zwac163 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/80647 Nazarzadeh M, Bidel Z, Canoy D et al. (2022). Blood pressure-lowering treatment for prevention of major cardiovascular diseases in people with and without type 2 diabetes: an individual participant-level data meta-analysis. nameOfConference DOI: 10.1016/s2213-8587(22)00172-3 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/82633 Cholesterol Treatment Trialists' Collaboration (2022). Harmonisation of large-scale, heterogeneous individual participant adverse event data from randomised trials of statin therapy. nameOfConference DOI: 10.1177/17407745221105509 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/99877 Kottke TE, Gupta AK, Thomas RJ (2022). Failing Cardiovascular Health A Population Code Blue ∗. nameOfConference DOI: 10.1016/j.jacc.2022.05.008 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/82724 Oggero S, Godec T, van Gorp R et al. (2022). Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients. nameOfConference DOI: 10.1097/hjh.0000000000003178 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79497 George M, Gupta A (2022). Blood Pressure–Lowering Effects of Omega‐3 Polyunsaturated Fatty Acids: Are These the Missing Link to Explain the Relationship Between Omega‐3 Polyunsaturated Fatty Acids and Cardiovascular Disease?. nameOfConference DOI: 10.1161/jaha.121.026258 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/78918 Siddiqui I, Gupta J, McIntosh I et al. (2022). The Relationship Between Availability and Changes to Perceived Workplace Support and Their Impact on the Mental Health, Well-being and Burn-Out of Healthcare Professionals (HCP): Insight and Mitigating Strategies From the CoPE-HCP Cohort Study. nameOfConference DOI: 10.1192/bjo.2022.215 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/82701 Ng SM, Pan J, Mouyis K et al. (publicationYear). Quantifying the Excess Risk of Adverse COVID-19 Outcomes in Unvaccinated Individuals With Diabetes Mellitus, Hypertension, Ischaemic Heart Disease or Myocardial Injury: A Meta-Analysis. nameOfConference DOI: 10.3389/fcvm.2022.871151 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/78818 Ng SM, Pan J, Gupta AK (2022). Poor achievement of lipid targets after acute coronary syndrome: what can we improve?. nameOfConference DOI: 10.5694/mja2.51507 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/78915 Boulestreau R, van den Born BH, Lip GYH et al. (2022). Malignant Hypertension: Current Perspectives and Challenges. nameOfConference DOI: 10.1161/jaha.121.023397 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/78978 Canoy D, Copland E, Nazarzadeh M et al. (2022). Antihypertensive drug effects on long-term blood pressure: an individual-level data meta-analysis of randomised clinical trials. nameOfConference DOI: 10.1136/heartjnl-2021-320171 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/78979 Rathod KS, Jones DA, Jain AK et al. (publicationYear). The influence of biological age and sex on long-term outcome after percutaneous coronary intervention for ST-elevation myocardial infarction.. nameOfConference DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75624 Gee LC, Massimo G, Lau C et al. (2022). Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide. nameOfConference DOI: 10.1111/bph.15636 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/73324 Collaboration TBPLTT, Rahimi K, Bidel Z et al. (2021). Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis. nameOfConference DOI: 10.1016/s0140-6736(21)01921-8 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/76134 Chong JH, Chahal A, Gupta A et al. (2021). COVID-19 and the Digitalisation of Cardiovascular Training and Education—A Review of Guiding Themes for Equitable and Effective Post-graduate Telelearning. nameOfConference DOI: 10.3389/fcvm.2021.666119 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/72518 Gupta AK (2021). Jaha spotlight on air pollution and cardiovascular disease: A call for urgent action. nameOfConference DOI: 10.1161/JAHA.121.022209 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73020 Rahimi K, Bidel Z, Nazarzadeh M et al. (2021). Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis. nameOfConference DOI: 10.1016/s0140-6736(21)00590-0 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/76133 Copland E (2021). Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis. nameOfConference DOI: 10.1016/S1470-2045(21)00033-4 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73031 Harvey G, Godec T, Kapil V et al. (2021). COMPARING THE DISCRIMINATIVE ABILITY OF DIFFERENT ELECTROGRAPHIC CRITERIA FOR LEFT VENTRICULAR HYPERTROPHY IN PREDICTING CARDIOVASCULAR EVENTS IN HYPERTENSIVE PATIENTS. nameOfConference DOI: 10.1097/01.hjh.0000746232.05690.50 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75509 Gupta A, Godec T, Mackay J et al. (2021). INFLUENCE OF AGE, SEX AND AN OCCURRENCE OF CARDIOVASCULAR EVENT ON SEASONAL VARIATIONS IN BLOOD PRESSURES IN HYPERTENSIVE PATIENTS: INSIGHTS FROM THE ASCOT COHORT. nameOfConference DOI: 10.1097/01.hjh.0000745968.04108.7e QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/78920 Gupta A, Whiteley W, Godec T et al. (2021). LONG TERM BENEFITS OF BLOOD PRESSURE TREATMENT ON THE INCIDENCE OF ATRIAL FIBRILLATION, HEART FAILURE AND CARDIOVASCULAR MORBIDITY AND MORTALITY: 20-YEARS FOLLOW-UP OF ASCOT-LEGACY. nameOfConference DOI: 10.1097/01.hjh.0000744436.51700.9f QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/78914 Gupta A, Rostamian S, Mackay J et al. (2021). THE DEVELOPMENT OF RESISTANT HYPERTENSION INDEPENDENT OF THE PRECEDING PERIOD OF THE BLOOD PRESSURE CONTROL IS ASSOCIATED WITH THE INCREASED RISK OF CARDIOVASCULAR EVENTS AND DEATH. nameOfConference DOI: 10.1097/01.hjh.0000748680.76723.07 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/78919 Gupta A, Whiteley W, Godec T et al. (2021). THE RELATIONSHIP BETWEEN BP-CONTROL, BP -VARIABILITY AND ANTIHYPERTENSIVE TREATMENT WITH THE LONG-TERM RISK OF CARDIOVASCULAR EVENT: LESSONS FROM THE ASCOT-LEGACY 20 YEAR FOLLOW-UP. nameOfConference DOI: 10.1097/01.hjh.0000745996.70900.76 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/78916 Khanji MY, Maniero C, Sher NG et al. (2021). Early and Mid-Term Implications of the COVID-19 Pandemic on the Physical, Behavioral and Mental Health of Healthcare Professionals: The CoPE-HCP Study Protocol. nameOfConference DOI: 10.3389/fpsyg.2021.616280 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/70448 Siddiqui I, Aurelio M, Gupta A et al. (2021). COVID-19: Causes of anxiety and wellbeing support needs of healthcare professionals in the UK: A cross-sectional survey. nameOfConference DOI: 10.7861/CLINMED.2020-0502 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/72982 Whiteley WN, Gupta AK, Godec T et al. (2021). Long-Term Incidence of Stroke and Dementia in ASCOT. nameOfConference DOI: 10.1161/STROKEAHA.120.033489 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73011 London B, Ahmad F, Eitzman DT et al. (2020). Diversity, equity, and inclusiveness in medicine and cardiology: Next steps for the journal of the American heart association. nameOfConference DOI: 10.1161/JAHA.120.019307 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67287 Simon MA, Ahmad F, Eitzman DT et al. (2020). Equity, Diversity, and Inclusiveness in Cardiovascular Medicine and Healthcare.. nameOfConference DOI: 10.1161/JAHA.120.019137 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67270 Sinha S, Ghosh B, Bandyopadhyay S et al. (2020). Comparative evaluation of efficacy, pharmacodynamics, and safety of Hetero’s adalimumab (Mabura®, Hetero Biopharma Ltd.) and reference adalimumab (Humira®, Abbvie Inc.) in patients with active rheumatoid arthritis on concomitant methotrexate therapy. nameOfConference DOI: 10.1186/s41927-020-00124-9 QMRO: qmroHref Gupta AK, Jneid H, Addison D et al. (2020). Current perspectives on Coronavirus 2019 (COVID-19) and cardiovascular disease: A white paper by the JAHA editors.. nameOfConference DOI: 10.1161/JAHA.120.017013 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64744 Kapil V, Gupta AK (2020). Solar UV Radiation: A Potential Modifiable Risk Factor for Hypertension. nameOfConference DOI: 10.1161/JAHA.120.015627 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64194 Cabrera CP, Ng F, Nicholls HL et al. (2019). Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated.. nameOfConference DOI: 10.1093/hmg/ddz197 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/61878 Maniero C, Gupta A, Lobo MD (2019). Impact of the new acc/aha and esc/ESH hypertension guidelines in the UK. nameOfConference DOI: 10.1093/eurheartj/ehz544 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/60745 Rahimi K, Canoy D, Nazarzadeh M et al. (2019). Investigating the stratified efficacy and safety of pharmacological blood pressure-lowering: an overall protocol for individual patient-level data meta-analyses of over 300 000 randomised participants in the new phase of the Blood Pressure Lowering Treatment Trialists’ Collaboration (BPLTTC). nameOfConference DOI: 10.1136/bmjopen-2018-028698 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/61118 Poulter NR, Dolan E, Gupta AK et al. (2019). Efficacy and Safety of Incremental Dosing of a New Single-Pill Formulation of Perindopril and Amlodipine in the Management of Hypertension.. nameOfConference DOI: 10.1007/s40256-018-00314-4 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/57519 Berkelmans GFN, Gudbjörnsdottir S, Visseren FLJ et al. (2019). Prediction of individual life-years gained without cardiovascular events from lipid, blood pressure, glucose, and aspirin treatment based on data of more than 500 000 patients with Type 2 diabetes mellitus. nameOfConference DOI: 10.1093/eurheartj/ehy839 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/57399 Gupta AK, Sen S, Kumari R et al. (2019). Influence of weathering on coking properties of coals used in coke making. nameOfConference DOI: doi QMRO: qmroHref Gupta A, Mackay J, Whitehouse A et al. (2018). A17615 Baseline predictors of all-cause- and cardiovascular- mortality amongst 8580 hypertensive patients followed up for 16 years in the ASCOT legacy study. nameOfConference DOI: 10.1097/01.hjh.0000549027.33566.04 QMRO: qmroHref Gupta A, Mackay J, Whitehouse A et al. (2018). Long-term mortality after blood pressure-lowering and lipid-lowering treatment in patients with hypertension in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) Legacy study: 16-year follow-up results of a randomised factorial trial. nameOfConference DOI: 10.1016/s0140-6736(18)31776-8 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/49865 Pushpasekaran N, Gupta D, Kashyap A et al. (2018). Concomitant methicillin-resistant Staphylococcus aureus infection in tubercular sacroiliitis masquerading as anti-tubercular drug resistance: Role for molecular diagnosis. nameOfConference DOI: 10.1016/j.ijtb.2018.05.022 QMRO: qmroHref Saxena M, Shour T, Shah M et al. (2018). Attenuation of Splanchnic Autotransfusion Following Noninvasive Ultrasound Renal Denervation: A Novel Marker of Procedural Success.. nameOfConference DOI: 10.1161/JAHA.118.009151 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/43325 Gupta A, Mackay J, Whitehouse A et al. (2018). DETERMINANTS OF LONG-TERM ALL-CAUSE AND CARDIOVASCULAR MORTALITY IN HYPERTENSIVE PATIENTS – FINDINGS FROM 16-YEAR FOLLOW-UP OF THE ASCOT LEGACY STUDY. nameOfConference DOI: 10.1097/01.hjh.0000539034.54178.d3 QMRO: qmroHref Gupta AK (2018). Hypertensive Disorders in Pregnancy and the Risk of Cardiovascular Disease: A Need for Postpartum Strategies for the Primary Prevention. nameOfConference DOI: 10.1161/JAHA.118.009648 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/46107 McGlone ER, Gupta AK, Reddy M et al. (2018). Antral resection versus antral preservation during laparoscopic sleeve gastrectomy for severe obesity: Systematic review and meta-analysis. nameOfConference DOI: 10.1016/j.soard.2018.02.021 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/55784 Godec T, Mackay J, Whitehouse A et al. (2018). The role of pulse pressure in comparison to systolic blood pressure in the prediction of long-term risk of all-cause-and cardiovascular-mortality, and the influence of age on these relationships, amongst hypertensive patients in the ASCOT-legacy study. nameOfConference DOI: doi QMRO: qmroHref Gupta A, Godec T, Sever P (2017). Concerns related to the nocebo effect - Authors’ reply. nameOfConference DOI: 10.1016/s0140-6736(17)32423-6 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/47926 Gupta AK, Poulter N, Ariti C et al. (2017). 5943Clinical efficacy of the combination of atorvastatin and perindopril in prevention of cardiovascular outcomes and mortality among high-risk hypertensive patients randomized to the ASCOT-LLA trial. nameOfConference DOI: 10.1093/eurheartj/ehx493.5943 QMRO: qmroHref Marcano-Belisario JS, Gupta AK, O Donoghue J et al. (2017). Implementation of depression screening in antenatal clinics through tablet computers: results of a feasibility study. nameOfConference DOI: 10.1186/s12911-017-0459-8 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/47983 Gupta A, Thompson D, Whitehouse A et al. (2017). Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase. nameOfConference DOI: 10.1016/s0140-6736(17)31075-9 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/47943 Gupta A, Malik N, Jain S (2017). Sustainability in competitive market through innovation and creativity-quality up-gradation and operational excellence-a case study contributing to orient's growth journey. nameOfConference DOI: doi QMRO: qmroHref Gupta AK, Poulter N, Ariti C (2017). Clinical efficacy of the combination of atorvastatin and perindopril in prevention of cardiovascular outcomes and mortality among high-risk hypertensive patients randomized to the ASCOT-LLA trial. nameOfConference DOI: doi QMRO: qmroHref Sever P, Gupta A, Thompson D et al. (2016). LBOS 01-04 THE TRUE INCIDENCE OF STATIN -RELATED ADVERSE EVENTS IN HYPERTENSIVE PATIENTS REVEALED BY COMPARISON OF BLINDED AND UN-BLINDED USE OF STATIN IN THE ANGLO-SCANDINAVIAN CARDIAC OUTCOMES TRIAL (ASCOT). nameOfConference DOI: 10.1097/01.hjh.0000501498.29676.64 QMRO: qmroHref Stam-Slob MC, Visseren FL, Wouter Jukema J et al. (2016). Personalized absolute benefit of statin treatment for primary or secondary prevention of vascular disease in individual elderly patients. nameOfConference DOI: 10.1007/s00392-016-1023-8 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/47963 McGlone ER, Gupta A, Maclean W et al. (2016). Antral-preserving or antral-resecting sleeve gastrectomy for morbid obesity: a systematic review and meta-analysis. nameOfConference DOI: doi QMRO: qmroHref Marcano-Belisario JS, Gupta AK, O Donoghue J et al. (2016). Tablet computers for implementing NICE antenatal mental health guidelines: protocol of a feasibility study. nameOfConference DOI: 10.1136/bmjopen-2015-009930 QMRO: qmroHref Watson S, Gupta AK, Poulter N (2014). Influence of a short-term school-based intervention on the health behaviours and prevalence of obesity among schoolchildren and their parents: results of the RATIONAL HEALTH pilot programme. nameOfConference DOI: doi QMRO: qmroHref Prieto-Merino D, Dobson J, Gupta AK et al. (2013). ASCORE: an up-to-date cardiovascular risk score for hypertensive patients reflecting contemporary clinical practice developed using the (ASCOT-BPLA) trial data. nameOfConference DOI: 10.1038/jhh.2013.3 QMRO: qmroHref Kelishadi R, de Ferranti SD, Majdzadeh R et al. (2013). Childhood obesity: today and tomorrow’s health challenge. nameOfConference DOI: 10.1155/2013/208392 QMRO: qmroHref Thom S, Poulter N, Field J et al. (2013). Effects of a fixed-dose combination strategy on adherence and risk factors in patients with or at high risk of CVD: the UMPIRE randomized clinical trial. nameOfConference DOI: 10.1001/jama.2013.277064 QMRO: qmroHref Chapman N, Dixon F, Gupta AK (2013). Incidence of angioedema in randomised controlled trials of angiotensin receptor blockers: a meta-analysis. nameOfConference DOI: doi QMRO: qmroHref Kelishadi R, Amin MM, Haghdoost AA et al. (2013). Pollutants source control and health effects. nameOfConference DOI: 10.1155/2013/209739 QMRO: qmroHref Gupta A, Udupa N, Sreedhar D (2012). Fixed-dose combinations. nameOfConference DOI: doi QMRO: qmroHref Sever PS, Chang CL, Prescott MF et al. (2012). Is plasma renin activity a biomarker for the prediction of renal and cardiovascular outcomes in treated hypertensive patients? Observations from the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). nameOfConference DOI: 10.1093/eurheartj/ehs241 QMRO: qmroHref Elley CR, Gupta AK, Webster R et al. (2012). The efficacy and tolerability of ’polypills’: meta-analysis of randomised controlled trials. nameOfConference DOI: 10.1371/journal.pone.0052145 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/76135 Bangalore S, Kumar S, Kjeldsen SE et al. (2011). Antihypertensive drugs and risk of cancer: network meta-analyses and trial sequential analyses of 324,168 participants from randomised trials. nameOfConference DOI: 10.1016/s1470-2045(10)70260-6 QMRO: qmroHref Gupta AK, Nasothimiou EG, Chang CL et al. (2011). Baseline predictors of resistant hypertension in the Anglo-Scandinavian Cardiac Outcome Trial (ASCOT): a risk score to identify those at high-risk. nameOfConference DOI: 10.1097/HJH.0b013e32834a8a42 QMRO: qmroHref Gupta AK, Chang CL, Dahlof B et al. (2011). Cardiovascular and all-cause mortality outcomes among hypertensive patients with moderate renal dysfunction in the ASCOT-LLA, and its extended follow-up. nameOfConference DOI: doi QMRO: qmroHref Gupta AK, Prieto-Merino D, Dahlof B et al. (2011). Metabolic syndrome, impaired fasting glucose and obesity, as predictors of incident diabetes in 14 120 hypertensive patients of ASCOT-BPLA: comparison of their relative predictability using a novel approach. nameOfConference DOI: 10.1111/j.1464-5491.2011.03330.x QMRO: qmroHref Gupta AK, Savopoulos CG, Ahuja J et al. (2011). Role of phytosterols in lipid-lowering: current perspectives. nameOfConference DOI: 10.1093/qjmed/hcr007 QMRO: qmroHref Sever PS, Chang CL, Gupta AK et al. (2011). The Anglo-Scandinavian Cardiac Outcomes Trial: 11-year mortality follow-up of the lipid-lowering arm in the U.K. nameOfConference DOI: 10.1093/eurheartj/ehr333 QMRO: qmroHref Gupta AK (2011). The efficacy and cost-effectiveness of statins in low-risk patients. nameOfConference DOI: 10.1503/cmaj.111674 QMRO: qmroHref Gupta AK, Arshad S, Poulter NR (2010). Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis. nameOfConference DOI: 10.1161/hypertensionaha.109.139816 QMRO: qmroHref Gupta AK, Poulter NR, Dobson J et al. (2010). Ethnic differences in blood pressure response to first and second-line antihypertensive therapies in patients randomized in the ASCOT Trial. nameOfConference DOI: 10.1038/ajh.2010.105 QMRO: qmroHref Gupta AK, Dahlof B, Sever PS et al. (2010). Metabolic syndrome, independent of its components, is a risk factor for stroke and death but not for coronary heart disease among hypertensive patients in the ASCOT-BPLA. nameOfConference DOI: 10.2337/dc09-2208 QMRO: qmroHref Gupta AK (2010). Racial differences in response to antihypertensive therapy: does one size fits all?. nameOfConference DOI: doi QMRO: qmroHref Gupta AK, Poulter NR (2010). The concept of the metabolic syndrome is it dead yet?. nameOfConference DOI: 10.1016/j.jacc.2010.06.026 QMRO: qmroHref Prieto-Merino D, Gupta AK, Dobson J et al. (2009). ASCORE: AN UP-TO-DATE CARDIOVASCULAR RISK SCORE FOR HYPERTENSIVE PATIENTS REFLECTING CONTEMPORARY CLINICAL PRACTICES DEVELOPED USING THE ASCOT TRIAL DATABASE. nameOfConference DOI: doi QMRO: qmroHref Prieto-Merino D, Gupta AK, Dobson J et al. (2009). ASCORE: an up-to-date cardiovascular risk score for hypertensive patients reflecting contemporary clinical practices developed using the ASCOT trial database. nameOfConference DOI: doi QMRO: qmroHref Arshad S, Gupta AK, Poulter NR (2008). Comparison of effectiveness and safety of fixed-dose combinations of antihypertensive agents with the free-drug combination of its components when given separately in hypertensive patients: a meta-analysis of 32 134 patients. nameOfConference DOI: doi QMRO: qmroHref Gupta AK, Dahlof B, Dobson J et al. (2008). Determinants of new-onset diabetes among 19,257 hypertensive patients randomized in the Anglo-Scandinavian Cardiac Outcomes Trial–Blood Pressure Lowering Arm and the relative influence of antihypertensive medication. nameOfConference DOI: 10.2337/dc07-1768 QMRO: qmroHref Gupta AK, Poulter NR, Eldridge S et al. (2008). Ethnic differences in blood pressure response to atenolol and amlodipine monotherapy and to add on diuretic and ACE inhibitor dual therapy in hypertensive patients from UK in ASCOT-BPLA. nameOfConference DOI: doi QMRO: qmroHref Poulter NR, Chang CL, Dahlof B et al. (2008). Evaluating the efficacy of the stepped-care anti-hypertensive strategies used in the Anglo-Scandinavian Cardiac Outcomes Trial BP Lowering Arm (ASCOT-BPLA). nameOfConference DOI: doi QMRO: qmroHref Gupta A, Kamineni S, Patten DK et al. (2008). Displaced Operable Radial Head Fractures. nameOfConference DOI: 10.1007/s00068-007-7902-y QMRO: qmroHref Gupta AK, Poulter N (2007). Improving the Prognosis in Patients With Diabetes: What Will ADVANCE Tell Us?. nameOfConference DOI: 10.1016/j.amjhyper.2007.04.006 QMRO: qmroHref Gupta AK, Poulter NR (2007). Antihypertensive-associated incident diabetes: controversy persists. nameOfConference DOI: 10.1001/archinte.167.13.1433-a QMRO: qmroHref Gupta AK, Poulter NR, Dahlof B et al. (2007). Role of metabolic syndrome, independent of its components, in prediction of cardiovascular outcomes in hypertensive patients in the ASCOT-BPLA. nameOfConference DOI: doi QMRO: qmroHref Gupta AK, Poulter NR, Dahlof B et al. (2006). Determinants of new onset diabetes among hypertensive patients randomised in the ASCOT-BPLA trial. nameOfConference DOI: doi QMRO: qmroHref Ahuja J, Gupta M, Gupta AK et al. (2004). Pharmacoeconomics. nameOfConference DOI: doi QMRO: qmroHref Makkar RP, Arora A, Monga A et al. (2003). Alport’s syndrome with blue sclera. nameOfConference DOI: doi QMRO: qmroHref Makkar RP, Arora A, Monga A et al. (2003). Burning feet syndrome. A clinical review. nameOfConference DOI: doi QMRO: qmroHref Monga A, Makkar RP, Arora A et al. (2003). Case report: Acute hepatitis E infection with coexistent glucose-6-phosphate dehydrogenase deficiency. nameOfConference DOI: 10.1155/2003/913679 QMRO: qmroHref Monga A, Arora A, Makkar RP et al. (2003). Hypertriglyceridemia-induced acute pancreatitis–treatment with heparin and insulin. nameOfConference DOI: doi QMRO: qmroHref Makkar RP, Mukhopadhyay S, Monga A et al. (2003). Palmar erythema and hoarseness: an unusual clinical presentation of sarcoidosis. nameOfConference DOI: 10.5694/j.1326-5377.2003.tb05068.x QMRO: qmroHref Makkar RP, Monga A, Arora A et al. (2003). Self-referral to specialists–a dodgy proposition. nameOfConference DOI: 10.1108/09526860310465591 QMRO: qmroHref Singh NP, Arora SK, Gupta A et al. (2003). Stroke: a rare presentation of cardiac hydatidosis. nameOfConference DOI: doi QMRO: qmroHref Monga A, Arora A, Makkar RP et al. (2002). A rare site for tuberculosis. nameOfConference DOI: doi QMRO: qmroHref Anuradha S, Agarwal SK, Singh NP et al. (2002). An unusual presentation of the Papillon-Lefevre syndrome as recurrent liver abscesses. nameOfConference DOI: doi QMRO: qmroHref Anuradha S, Bansal R, Gupta A et al. (2002). Embolisation of haemodialysis catheter. nameOfConference DOI: doi QMRO: qmroHref Makkar RP, Mukhopadhyay S, Monga A et al. (2002). Plasmodium vivax malaria presenting with severe thrombocytopenia. nameOfConference DOI: 10.1590/s1413-86702002000500008 QMRO: qmroHref Sponsors Barts Charity CollaboratorsInternal Jesmond Dalli (WHRI) External Peter Sever (Imperial) Neil Poulter (Imperial Clinical Trials Unit) Timothy Collier (LSHTM) Teck Khong (St George’s) Neil Chapman (St Mary’s) News Blood pressure medications and statins found to provide long-term cardiovascular benefits (QMUL), August 2017 Some statin-related side-effects are due to 'nocebo' effect (QMUL), May 2017 Statin side effects: Muscle pain, memory loss and erectile dysfunction might be all in the mind(Newsweek) Getting the right hypertension drug(American Renaissance), August 2010 Getting the right hypertension drug (Wall Street Journal) Back to top