Dr Vikas KapilClinical Senior Lecturer in Clinical Pharmacology & Therapeutics, Honorary Consultant in Cardiovascular & Internal Medicine, and WHRI Deputy Lead for Teaching Centre: Cardiovascular Medicine and DevicesEmail: v.kapil@qmul.ac.ukTelephone: +44(0) 20 7882 5720Twitter: @DrVikasKapil ProfileResearchPublicationsSponsorsCollaboratorsProfileORCID iD: 0000-0001-5778-6188 Vikas Kapil read Medicine and Anatomy at Queen’s College Cambridge, achieving first class undergraduate honours and then transferred for his undergraduate clinical training to University College London Medical School. He completed postgraduate training at St Thomas’ and St Bartholomew’s hospitals and was awarded his PhD under the supervision of Professor Amrita Ahluwalia at the William Harvey Research Institute, investigating the effects of inorganic nitrate on the human cardiovascular system. Since 2015, he has been a senior lecturer at WHRI and consultant in the Barts BP Centre of Excellence at Barts Heart Centre. He is heavily involved in leading therapeutics and prescribing training for the MB BS (Medicine) course and also leads a module for the final year BSc Biomedical Sciences degree course.ResearchGroup members - Pharmacology & Therapeutics Members of Vascular Pharmacology Group: Prof Amrita Ahluwalia (Head), Dr Vikas Kapil (Senior Lecturer), Dan Jones (Senior Lecturer), Dr Ray Khambata (Senior post-doctoral researcher), Dr Sven van Eijl (Lab manager PhD Students: Dr Krishnaraj Rathod, Dr Clement Lau, Dr Chris Primus, Sascha Hamers, Federica Filomena, Lorna Gee Members of Blood Pressure Group: Dr Mel Lobo, Dr Ajay Gupta, Mr Sotiris Antoniou, Dr David Collier, Dr Peter Julu, Dr Chris Wolff Summary Inorganic Nitrate in Cardiovascular DiseaseA major research focus of the Vascular Pharmacology group at WHRI, led by Prof Amrita Ahluwalia, is the study of the bioactivity of the reductive nitrate-to nitrite to NO pathway in humans, often dubbed the enterosalivary circuit of inorganic nitrate. Made the first demonstrations of the protective effects of inorganic nitrite against myocardial ischemia-reperfusion injury implicating two enzymes in the conversion of nitrite to NO: xanthine oxidoreductase and eNOS. More recently, the vasodilator activity of nitrite has attracted much attention. In 2008, published the first findings that a dietary nitrate load, in the form of beetroot juice, reduces blood pressure and improves platelet and endothelial function in healthy volunteers. Similar results have been confirmed in longer term studies in patients with hypertension and hypercholesterolaemia. Ongoing research focuses on: discovery of new druggable targets in the renal system involved in pharmacokinetic handling of nitrate and nitrite the effect of inorganic nitrate to hypertensive target organ damage, including adverse cardiac and vascular remodelinte contribution of the oral microbiome to, and sex differences in, the entero-salivary circulation the contribution of the oral microbiome to, and sex differences in, the entero-salivary circulation Refractory Hypertension and Blood Pressure DisordersA multi-disciplinary group of internationally-accredited BP and hypertension physicians, cardio-respiratory physiologists, autonomic neurophysiologist, and pharmacist investigating and developing novel strategies to treat complex circulatory problems. Multiple-drug intolerance in hypertension Defined a new syndrome of multi-drug intolerant hypertension to describe the 10% of patients referred to Barts BP Centre of Excellence who are unable to take guideline-based treatment for hypertension due to both pharmacologically expected and unexpected adverse effects. Published the first evidence in this difficult to treat group having developed a unique, pragmatic approach using a 4-step algorithm based on parallel evidences about dose-dependency of treatment and adverse effects; excipients causing adverse effects; and using off-label use of licensed medications for their anti-hypertensive effect. Autonomic and haemodynamic profiling in circulatory disorders Using a suite of non-invasive autonomic function tests and state-of-art haemodynamic technologies to get insights into regional sympathetic and cardiac parasympathetic function, and vascular regulation in patients with various circulatory disorders, including idiopathic highly variable blood pressure, postural orthostatic tachycardia syndrome (POTS) and refractory hypertension to determine targeted non-pharmacological and pharmacological approaches to symptomatically improve this diverse population. Device based treatment of hypertension Leading, with Dr Mel Lobo (Director, Barts BP Centre of Excellence) the first UK experience of baroreflex stimulation (Barostim Neo, CVRx) for refractory hypertension and first-in-man use worldwide for symptomatic, highly-variable blood pressure. Involved in sponsor-led trials of device based treatments of hypertension, including renal denervation (radio-frequency, ultrasound etc.), baroreflex amplification (Mobius HD device), central arterio-venous anastomosis creation (ROX fistula) and applying autonomic profiling to understand pathophysiology Awards Austin Doyle Award International Society of Hypertension 2014 ESH Science Award European Society of Hypertension 2012 Investigator Science Award 4th International Nitrite Meeting 2011 GlaxoSmithKline Prize for Oral Communications British Pharmacological Society 2009 Young Investigator Award European Association of Clinical Pharmacology & Therapeutics 2009 Publications Pruna-Guillen R, Ghosh L, Mastracci TM et al. (2024). Challenges and Innovations in Postoperative Care for Acute Type A Aortic Dissection: The Role of Structured Surveillance and Virtual Wards. nameOfConference DOI: 10.31083/j.rcm2511389 QMRO: qmroHref Borghese O, Pisani A, Lopez-Marco A et al. (2024). Aortic Outcome After Implementation of a Treatment Strategy for Type B Aortic Dissection Involving the Aortic Arch. nameOfConference DOI: 10.1016/j.avsg.2024.07.102 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100354 Magavern EF, Kapil V, Saxena M et al. (2024). Use of Genomics to Develop Novel Therapeutics and Personalize Hypertension Therapy. nameOfConference DOI: 10.1161/atvbaha.123.319220 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/96841 del Arroyo AG, Patel A, Abbott TEF et al. (2024). Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin–angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial. nameOfConference DOI: 10.1016/j.bja.2024.01.010 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/96344 Faust SN, Haynes R, Jones CE et al. (2024). Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial. nameOfConference DOI: 10.1016/s2352-4642(23)00316-4 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/94601 Lewis P, George J, Kapil V et al. (2024). Adult hypertension referral pathway and therapeutic management: British and Irish Hypertension Society position statement. nameOfConference DOI: 10.1038/s41371-023-00882-2 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100586 Faconti L, Kulkarni S, Delles C et al. (2024). Diagnosis and management of primary hyperaldosteronism in patients with hypertension: a practical approach endorsed by the British and Irish Hypertension Society. nameOfConference DOI: 10.1038/s41371-023-00875-1 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92111 Thein PM, Guerreiro C, Fhadil S et al. (2023). Risk factor burden in familial hypercholesterolaemia with early onset coronary artery disease. nameOfConference DOI: 10.1093/eurheartj/ehad655.2416 QMRO: qmroHref Ackland G (2023). Discontinuation vs. continuation of renin–angiotensin system inhibition before non-cardiac surgery: the SPACE trial. nameOfConference DOI: 10.1093/eurheartj/ehad716 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91917 Abani O, Abbas A, Abbas F et al. (2023). Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. nameOfConference DOI: 10.1016/s2213-8587(23)00253-x QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/94011 Shabbir A, Chhetri I, Khambata RS et al. (publicationYear). A double-blind, randomised, placebo-controlled parallel study to investigate the effect of sex and dietary nitrate on COVID-19 vaccine-induced vascular dysfunction in healthy men and women: protocol of the DiNOVasc-COVID-19 study. nameOfConference DOI: 10.1186/s13063-023-07616-2 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/90982 Charchar FJ, Prestes PR, Mills C et al. (2024). Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension. nameOfConference DOI: 10.1097/hjh.0000000000003563 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92103 Lobo MD, Rull G, Saxena M et al. (2023). Selecting patients for interventional procedures to treat hypertension. nameOfConference DOI: 10.1080/08037051.2023.2248276 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92110 Thein P, Guerreiro C, Fhadil S et al. (2023). Risk Factor Burden in Familial Hypercholesterolaemia With Early Onset Coronary Artery Disease. nameOfConference DOI: 10.1016/j.hlc.2023.06.546 QMRO: qmroHref Abani O, Abbas A, Abbas F et al. (2023). Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. nameOfConference DOI: 10.1016/s0140-6736(23)00510-x QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/86458 Maniero C, Ng SM, Collett G et al. (2024). Differential impact of COVID-19 on mental health and burnout. nameOfConference DOI: 10.1093/occmed/kqad011 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/85726 Siddiqui I, Gupta J, Collett G et al. (2023). Perceived workplace support and mental health, well-being and burnout among health care professionals during the COVID-19 pandemic: a cohort analysis. nameOfConference DOI: 10.9778/cmajo.20220191 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/84970 Khanji MY, Collett G, Godec T et al. (2023). Improved lifestyle is associated with improved depression, anxiety and well-being over time in UK healthcare professionals during the COVID-19 pandemic: insights from the CoPE-HCP cohort study. nameOfConference DOI: 10.1136/gpsych-2022-100908 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/84159 Rathod KS, Kapil V, Velmurugan S et al. (2023). Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans. nameOfConference DOI: 10.1172/jci168068 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/89143 Robbins AJ, Bakri NAC, Toke‐Bjolgerud E et al. (2023). The effect of TRV027 on coagulation in COVID‐19: A pilot randomized, placebo‐controlled trial. nameOfConference DOI: 10.1111/bcp.15618 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/86478 Kulkarni S, Glover M, Kapil V et al. (2023). Management of hypertensive crisis: British and Irish Hypertension Society Position document. nameOfConference DOI: 10.1038/s41371-022-00776-9 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92107 Kapil V, Collett G, Godec T et al. (2022). Longitudinal comparisons of mental health, burnout and well-being in patient-facing, non-patient-facing healthcare professionals and non-healthcare professionals during the COVID-19 pandemic: findings from the CoPE-HCP study. nameOfConference DOI: 10.1192/bjo.2022.579 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/82609 Doykov I, Baldwin T, Spiewak J et al. (2022). Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response. nameOfConference DOI: 10.1016/j.crmeth.2022.100279 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/80639 Maniero C, Lopuszko A, Papalois K-B et al. (2023). Non-pharmacological factors for hypertension management: a systematic review of international guidelines. nameOfConference DOI: 10.1093/eurjpc/zwac163 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/80647 Reynolds CJ, Pade C, Gibbons JM et al. (2022). Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure. nameOfConference DOI: 10.1126/science.abq1841 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79638 Abani O, Abbas A, Abbas F et al. (2022). Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis. nameOfConference DOI: 10.1016/s0140-6736(22)01109-6 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/80347 Adeyeye E, Kapil V, Lobo MD (2022). Hypertension. nameOfConference DOI: 10.1016/j.mpmed.2022.04.002 QMRO: qmroHref Shabbir A, Rathod K, Primus C et al. (2022). BS37 Leukocytic nitrate reductase activity mitigates systemic inflammation-induced endothelial dysfunction in humans by accelerating resolution. Basic science DOI: 10.1136/heartjnl-2022-bcs.217 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/90350 Siddiqui I, Gupta J, McIntosh I et al. (2022). The Relationship Between Availability and Changes to Perceived Workplace Support and Their Impact on the Mental Health, Well-being and Burn-Out of Healthcare Professionals (HCP): Insight and Mitigating Strategies From the CoPE-HCP Cohort Study. nameOfConference DOI: 10.1192/bjo.2022.215 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/82701 Ng SM, Pan J, Mouyis K et al. (publicationYear). Quantifying the Excess Risk of Adverse COVID-19 Outcomes in Unvaccinated Individuals With Diabetes Mellitus, Hypertension, Ischaemic Heart Disease or Myocardial Injury: A Meta-Analysis. nameOfConference DOI: 10.3389/fcvm.2022.871151 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/78818 Astbury S, Reynolds CJ, Butler DK et al. (2022). HLA‐DR polymorphism in SARS‐CoV‐2 infection and susceptibility to symptomatic COVID‐19. nameOfConference DOI: 10.1111/imm.13450 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/77598 Abani O, Abbas A, Abbas F et al. (2022). Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. nameOfConference DOI: 10.1016/s0140-6736(22)00163-5 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/77323 Abani O, Abbas A, Abbas F et al. (2022). Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. nameOfConference DOI: 10.1016/s0140-6736(21)01825-0 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/75682 Swadling L, Diniz MO, Schmidt NM et al. (2021). Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2. nameOfConference DOI: 10.1038/s41586-021-04186-8 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75248 Group RC (2021). Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. nameOfConference DOI: 10.1016/s2213-2600(21)00435-5 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/75249 Primus C, Masucci M, Whitear C et al. (2021). A pro-resolving phenotype underpins the anti-inflammatory effects of inorganic nitrate. nameOfConference DOI: 10.1093/eurheartj/ehab724.3352 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75507 Lau C, Shabbir A, Rathod KS et al. (2021). Inorganic nitrate attenuates endothelial dysfunction consequent to systemic inflammation. nameOfConference DOI: 10.1093/eurheartj/ehab724.3008 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75511 Shabbir A, Lau C, Rathod KS et al. (2021). Inorganic nitrate attenuates the systemic inflammatory response in typhoid vaccine-induced endothelial dysfunction in healthy volunteers. nameOfConference DOI: 10.1093/eurheartj/ehab724.3009 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75510 Gee LC, Massimo G, Lau C et al. (2022). Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide. nameOfConference DOI: 10.1111/bph.15636 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/73324 Gupta RK, Rosenheim J, Bell LC et al. (2021). Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study.. nameOfConference DOI: 10.1016/S2666-5247(21)00146-4 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73333 Taylor RR, Trivedi B, Patel N et al. (2021). Post-COVID symptoms reported at asynchronous virtual review and stratified follow-up after COVID-19 pneumonia. nameOfConference DOI: 10.7861/CLINMED.2021-0037 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/72723 Abani O, Abbas A, Abbas F et al. (2021). Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. nameOfConference DOI: 10.1016/s0140-6736(21)00897-7 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/72259 Zenner D (2021). The Barts Health NHS Trust COVID-19 cohort: characteristics, outcomes and risk scoring of patients in East London. nameOfConference DOI: 10.5588/ijtld.20.0926 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/71138 Reynolds CJ, Pade C, Gibbons JM et al. (2021). Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose. nameOfConference DOI: 10.1126/science.abh1282 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74478 Abani O, Abbas A, Abbas F et al. (2021). Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. nameOfConference DOI: 10.1016/s0140-6736(21)00676-0 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/72298 Harvey G, Godec T, Kapil V et al. (2021). COMPARING THE DISCRIMINATIVE ABILITY OF DIFFERENT ELECTROGRAPHIC CRITERIA FOR LEFT VENTRICULAR HYPERTROPHY IN PREDICTING CARDIOVASCULAR EVENTS IN HYPERTENSIVE PATIENTS. nameOfConference DOI: 10.1097/01.hjh.0000746232.05690.50 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75509 Bakkum MJ, Richir MC, Papaioannidou P et al. (2021). EurOP2E – the European Open Platform for Prescribing Education, a consensus study among clinical pharmacology and therapeutics teachers. nameOfConference DOI: 10.1007/s00228-021-03101-4 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73322 Khanji MY, Maniero C, Sher NG et al. (2021). Early and Mid-Term Implications of the COVID-19 Pandemic on the Physical, Behavioral and Mental Health of Healthcare Professionals: The CoPE-HCP Study Protocol. nameOfConference DOI: 10.3389/fpsyg.2021.616280 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/70448 Maniero C, Julu P, Shah M et al. (2021). Dysregulation of central respiratory modulation of cardiac vagal tone is a novel, early sign of dysautonomia in patients with α-synucleinopathies. nameOfConference DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75512 Shabbir A, Lau C, Rathod KS et al. (2021). Inorganic nitrate attenuates the systemic inflammatory response in typhoid vaccine-induced endothelial dysfunction in healthy volunteers. nameOfConference DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/76139 Reynolds CJ, Swadling L, Gibbons JM et al. (2020). Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection. nameOfConference DOI: 10.1126/SCIIMMUNOL.ABF3698 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/71077 Chung R, Tyebally S, Chen D et al. (publicationYear). Hypertensive Cardiotoxicity in Cancer Treatment—Systematic Analysis of Adjunct, Conventional Chemotherapy, and Novel Therapies—Epidemiology, Incidence, and Pathophysiology. nameOfConference DOI: 10.3390/jcm9103346 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68104 Augusto JB, Menacho K, Andiapen M et al. (2020). Healthcare Workers Bioresource: Study outline and baseline characteristics of a prospective healthcare worker cohort to study immune protection and pathogenesis in COVID-19. nameOfConference DOI: 10.12688/wellcomeopenres.16051.1 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68098 Bakkum MJ, Tichelaar J, Papaioannidou P et al. (2021). Harmonizing and improving European education in prescribing: An overview of digital educational resources used in clinical pharmacology and therapeutics. nameOfConference DOI: 10.1111/bcp.14453 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73340 Kapil V, Khambata RS, Jones DA et al. (2020). The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway. nameOfConference DOI: 10.1124/pr.120.019240 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65767 Gupta AK, Jneid H, Addison D et al. (2020). Current perspectives on Coronavirus 2019 (COVID-19) and cardiovascular disease: A white paper by the JAHA editors.. nameOfConference DOI: 10.1161/JAHA.120.017013 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64744 Lawson AJ, Hameed MA, Brown R et al. (2020). Nonadherence to antihypertensive medications is related to pill burden in apparent treatment-resistant hypertensive individuals.. nameOfConference DOI: 10.1097/HJH.0000000000002398 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/64040 Kapil V, Gupta AK (2020). Solar UV Radiation: A Potential Modifiable Risk Factor for Hypertension. nameOfConference DOI: 10.1161/JAHA.120.015627 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64194 Lau CWZ, Hamers AJP, Rathod KS et al. (2020). Randomised, double-blind, placebo-controlled clinical trial investigating the effects of inorganic nitrate in hypertension-induced target organ damage: Protocol of the NITRATE-TOD study in the UK. nameOfConference DOI: 10.1136/bmjopen-2019-034399 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64122 Harvey G, Godec T, Kapil V et al. (2020). Comparing the discriminative ability of electrocardiographic criteria for left ventricular hypertrophy in predicting cardiovascular events in hypertensive patients: post-hoc analysis from the Anglo-Scandinavian cardiovascular outcome trial. nameOfConference DOI: doi QMRO: qmroHref Lobo MD, Sharp ASP, Kapil V et al. (2019). Joint UK societies’ 2019 consensus statement on renal denervation. nameOfConference DOI: 10.1136/heartjnl-2019-315098 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/59562 Elechi F, Antoniou S, Kapil V (2019). 119 Appropriateness of prescribing of direct oral anticoagulants in a university teaching hospital network. Stable IHD/Prevention/Hypertension/Lipids DOI: 10.1136/heartjnl-2019-bcs.116 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64477 Bhagani S, Kapil V, Lobo MD (2018). Hypertension. nameOfConference DOI: 10.1016/j.mpmed.2018.06.009 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66757 Kapil V, Rathod KS, Khambata RS et al. (2018). Sex differences in the nitrate-nitrite-NO• pathway: Role of oral nitrate-reducing bacteria. nameOfConference DOI: 10.1016/j.freeradbiomed.2018.07.010 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/55110 Saxena M, Shour T, Shah M et al. (2018). Attenuation of Splanchnic Autotransfusion Following Noninvasive Ultrasound Renal Denervation: A Novel Marker of Procedural Success.. nameOfConference DOI: 10.1161/JAHA.118.009151 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/43325 Brinkman DJ, Tichelaar J, Mokkink LB et al. (2018). Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study. nameOfConference DOI: 10.1002/cpt.962 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73341 Kapil V, Green JL, Le Lait C et al. (2014). Misuse of benzodiazepines and Z-drugs in the UK. nameOfConference DOI: 10.1192/bjp.bp.114.149252 QMRO: qmroHref Kapil V, Sobotka PA, Lobo MD et al. (2018). Central arteriovenous anastomosis to treat resistant hypertension.. nameOfConference DOI: 10.1097/MNH.0000000000000379 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64019 Kapil V (2017). Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017.. nameOfConference DOI: 10.1186/s40360-017-0170-5 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66725 Saxena M, Shour T, Shah M et al. (2017). [LB.03.06] ATTENUATION OF SPLANCHNIC AUTOTRANSFUSION FOLLOWING NON-INVASIVE ULTRASOUND RENAL DENERVATION. nameOfConference DOI: 10.1097/01.hjh.0000523177.11308.8c QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65260 Kapil V, Louthan J, Hamedi N et al. (2017). [PP.22.06] TRANSDERMAL CLONIDINE IN DIFFICULT-TO-TREAT HYPERTENSION PATIENTS ATTENDING A SPECIALIST BP CLINIC IN THE UNITED KINGDOM. nameOfConference DOI: 10.1097/01.hjh.0000523811.90036.ac QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64386 Rathod K, Kapil V, Velmurugan S et al. (2017). Sex differences in the inflammatory response and inflammation-induced vascular dysfunction. FASEB DOI: 10.1016/s0140-6736(17)30416-6 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/22462 Kapil V (2017). Nitrite and Nitrate as a Treatment for Hypertension. nameOfConference DOI: 10.1007/978-3-319-46189-2_17 QMRO: qmroHref Saxena M, Shour T, Shah M et al. (2017). Attenuation of splanchnic autotransfusion following non-invasive ultrasound renal denervation: a novel marker of procedural success. nameOfConference DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64765 Pontikaki K, Kapil V, Lobo M et al. (2017). Factors contributing to antihypertensive medication intolerance (MI-HTN). nameOfConference DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65647 Patel M, Maudhoo A, Shah K et al. (2017). Fundal examination in patients with hypertension. nameOfConference DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65653 Lawson A, Brown R, Cappuccio FP et al. (2017). Non-adherence to Antihypertensive Medications is related to Total Pill Burden. nameOfConference DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67271 Kapil V, Louthan J, Hamedi N et al. (2017). Transdermal clonidine in difficult-to-treat hypertension patients attending a specialist blood pressure (BP) clinic in the United Kingdom. nameOfConference DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66223 Rathod KS, Jones DA, Van-Eijl TJA et al. (2016). Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study. nameOfConference DOI: 10.1136/bmjopen-2016-012728 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18455 AHLUWALIA A (2016). Accelerated resolution underlies sex differences in the inflammatory response in human. nameOfConference DOI: 10.1172/JCI89429. QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18792 Floyd CN, Adeel MY, Wolff CB et al. (2016). First-in-man treatment of severe blood pressure variability with baroreflex activation therapy. nameOfConference DOI: 10.1016/j.ijcard.2016.06.308 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64021 Lobo MD, Adeel MY, Wolff CB et al. (2016). [OP.8D.02] FIRST IN MAN TREATMENT OF SEVERE BP VARIABILITY WITH BAROREFLEX ACTIVATION THERAPY.. nameOfConference DOI: 10.1097/01.hjh.0000491609.58838.67 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/61614 Wolff C, Julu PO, Collier DJ et al. (2016). [PP.38.09] EFFECTS OF MILD DYNAMIC EXERCISE ON CIRCULATORY AND AUTONOMIC FUNCTION IN HEALTHY VOLUNTEERS. nameOfConference DOI: 10.1097/01.hjh.0000492374.65972.56 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65595 Lobo MD, Kapil V (2016). Central Iliac Arteriovenous Anastomosis for Hypertension. nameOfConference DOI: 10.1007/978-3-319-34141-5_23 QMRO: qmroHref Saxena M, Antoniou S, Hamedi N et al. (2016). Multiple drug-intolerant hypertension: a case series utilising a novel-treatment algorithm. nameOfConference DOI: 10.3399/bjgp16x684709 QMRO: qmroHref Antoniou S, Saxena M, Hamedi N et al. (2016). Management of Hypertensive Patients With Multiple Drug Intolerances: A Single-Center Experience of a Novel Treatment Algorithm. nameOfConference DOI: 10.1111/jch.12637 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68960 Wolff CB, Collier DJ, Shah M et al. (2016). A Discussion on the Regulation of Blood Flow and Pressure. nameOfConference DOI: 10.1007/978-1-4939-3023-4_16 QMRO: qmroHref Antoniou S, Saxena M, Hamedi N et al. (2016). Management of Hypertensive Patients With Multiple Drug Intolerances: A Single-Center Experience of a Novel Treatment Algorithm. nameOfConference DOI: 10.1111/jch.12637 QMRO: qmroHref Kapil V, Sobotka PA, Saxena M et al. (2015). Central Iliac Arteriovenous Anastomosis for Hypertension: Targeting Mechanical Aspects of the Circulation. nameOfConference DOI: 10.1007/s11906-015-0585-6 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/11058 Antoniou S, Saxena M, Hamedi N et al. (2015). PP.21.35. nameOfConference DOI: 10.1097/01.hjh.0000468387.93679.ef QMRO: qmroHref Velmurugan S, Kapil V, Ghosh SM et al. (2015). Erratum: Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex (Free Radical Biology and Medicine (2013) 65 (1521-1532)). nameOfConference DOI: 10.1016/j.freeradbiomed.2015.03.015 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/10411 Velmurugan S, Kapil V, Ghosh SM et al. (2015). Erratum to “Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex” [Free Radic. Biol. Med. 65 (2013) 1521–1532]. nameOfConference DOI: 10.1016/j.freeradbiomed.2015.03.015 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/7745 Antoniou S, Hamedi N, Lidder S et al. (2015). CP-081 Management of uncontrolled blood pressure in patients with multiple drug intolerance referred to a specialist hypertension clinic. nameOfConference DOI: 10.1136/ejhpharm-2015-000639.77 QMRO: qmroHref Kapil V, Khambata RS, Robertson A et al. (2015). Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: A randomized, phase 2, double-blind, placebo-controlled study. nameOfConference DOI: 10.1161/HYPERTENSIONAHA.114.04675 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6639 Lobo MD, de Belder MA, Cleveland T et al. (2015). Joint UK societies’ 2014 consensus statement on renal denervation for resistant hypertension. nameOfConference DOI: 10.1136/heartjnl-2014-307029 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6575 Kapil V, Khambata RS, Robertson A et al. (2015). Dietary Nitrate Provides Sustained Blood Pressure Lowering in Hypertensive Patients. nameOfConference DOI: 10.1161/hypertensionaha.114.04675 QMRO: qmroHref Kapil V, Lobo MD (2014). Hypertension. nameOfConference DOI: 10.1016/j.mpmed.2014.06.004 QMRO: qmroHref Scourfield A, Dubrey S, Kapil V (2014). Book Reviews. nameOfConference DOI: 10.12968/hmed.2014.75.8.477 QMRO: qmroHref Kapil V, Green JL, Le Lait M et al. (2014). Misuse of the γ‐aminobutyric acid analogues baclofen, gabapentin and pregabalin in the UK. nameOfConference DOI: 10.1111/bcp.12277 QMRO: qmroHref Kapil V, Weitzberg E, Lundberg JO et al. (2014). Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health. nameOfConference DOI: 10.1016/j.niox.2014.03.162 QMRO: qmroHref Kapil V, Weitzberg E, Lundberg JO et al. (2014). Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health. nameOfConference DOI: 10.1016/j.niox.2014.03.162 QMRO: qmroHref Saxena M, Antoniou S, Hamedi N et al. (2014). Anti-hypertensive medicine intolerance - an overlooked and important cause of failed compliance. nameOfConference DOI: doi QMRO: qmroHref Antoniou S, Hamedi N, Choudhury R et al. (2014). Management of uncontrolled blood pressure in patients referred to a specialist hypertension clinic with multiple medicines intolerance. nameOfConference DOI: doi QMRO: qmroHref Velmurugan S, Kapil V, Ghosh SM et al. (2013). Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex. nameOfConference DOI: 10.1016/j.freeradbiomed.2013.06.031 QMRO: qmroHref Ghosh SM, Kapil V, Fuentes-Calvo I et al. (2013). Enhanced Vasodilator Activity of Nitrite in Hypertension. nameOfConference DOI: 10.1161/hypertensionaha.111.00933 QMRO: qmroHref Ghosh SM, Kapil V, Bubb K et al. (2013). P28 Mechanisms underlying nitrite reduction in hypertension: Role for erythrocytic xanthine oxidoreductase. nameOfConference DOI: 10.1016/j.niox.2013.02.030 QMRO: qmroHref Velmurugan S, Kapil V, Ghosh SM et al. (2013). Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex. nameOfConference DOI: 10.1016/j.freeradbiomed.2013.06.031 QMRO: qmroHref Huang C, Ng F, Kapil V et al. (2013). Prognostic significance of short term blood pressure variability in a tertiary referral centre population. nameOfConference DOI: doi QMRO: qmroHref Kapil V, Haydar SMA, Pearl V et al. (2013). Physiological role for nitrate-reducing oral bacteria in blood pressure control. nameOfConference DOI: 10.1016/j.freeradbiomed.2012.11.013 QMRO: qmroHref Velmurugan S, Pearl V, Davies S et al. (2012). Inorganic nitrate supplementation attenuates platelet reactivity in healthy male volunteers. nameOfConference DOI: 10.1016/j.niox.2012.04.099 QMRO: qmroHref Ghosh S, Kapil V, Bubb K et al. (2012). Mechanisms underlying nitrite reduction in hypertension: Role for erythrocyte xanthine oxidoreductase. nameOfConference DOI: 10.1016/j.niox.2012.04.109 QMRO: qmroHref Bahra M, Kapil V, Pearl V et al. (2012). Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers. nameOfConference DOI: 10.1016/j.niox.2012.01.004 QMRO: qmroHref Velmurugan S, Pearl V, Ghosh SM et al. (2012). Inorganic Nitrate Attenuates Platelet Reactivity in Healthy Males but not Females: Role of the Erythrocyte and Cyclic GMP. nameOfConference DOI: doi QMRO: qmroHref Bahra M, Kapil V, Pearl V et al. (2012). Inorganic nitrate ingestion decreases blood pressure and improves vascular compliance in healthy volunteers. nameOfConference DOI: doi QMRO: qmroHref Velmurugan S, Kapil V, McKnight AHO et al. (2011). Dietary nitrate attenuates platelet reactivity: Role of the erythrocyte and influence of sex. nameOfConference DOI: 10.1016/j.niox.2011.03.285 QMRO: qmroHref Kapil V, Syed M, Pearl V et al. (2011). Interruption of the entero-salivary metabolism of nitrate to nitrite increases blood pressure in healthy volunteers. nameOfConference DOI: 10.1016/j.niox.2011.03.282 QMRO: qmroHref Kapil V, Benjamin N, Hobbs A et al. (2011). Response to Inorganic Nitrate for Blood Pressure Lowering?. nameOfConference DOI: 10.1161/HYPERTENSIONAHA.110.164814 QMRO: qmroHref Kapil V, Jain AK, Lobo MD (2011). Renal Sympathetic Denervation - A Review of Applications in Current Practice.. nameOfConference DOI: 10.15420/icr.2011.9.1.54 QMRO: qmroHref Kapil V, Webb AJ, Ahluwalia A (2010). Inorganic nitrate and the cardiovascular system.. nameOfConference DOI: 10.1136/hrt.2009.180372 QMRO: qmroHref Kapil V, Milsom AB, Okorie M et al. (2010). Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.. nameOfConference DOI: 10.1161/HYPERTENSIONAHA.110.153536 QMRO: qmroHref Kapil V, Maleki-Toyserkani S, Rehman F et al. (2010). Oral inorganic nitrate lowers blood pressure in healthy male, but not female, volunteers, via bioconversion to nitrite. nameOfConference DOI: doi QMRO: qmroHref Kapil V, Rehman F, Arghandawi S et al. (2009). BLOOD PRESSURE LOWERING EFFECTS OF ORAL INORGANIC NITRATE VIA BIOCONVERSION TO NITRITE. nameOfConference DOI: doi QMRO: qmroHref Kapil V, Okorie M, Akram F et al. (2009). Oral inorganic nitrate lowers blood pressure and protects against endothelial ischaemia-reperfusion injury in humans. nameOfConference DOI: doi QMRO: qmroHref Kapil V, Rull G, Wadley J et al. (2009). Severe uncontrolled hypertension treated with microvascular decompression of the brainstem. nameOfConference DOI: doi QMRO: qmroHref Sponsors Barts Charity National Institute for Health and Care Research British Heart Foundation The Rahere Association Collaborators Dr Mike Barnes (WHRI) Prof William Wade (Blizard) Dr Ben Walsh (UCL) Dr Iasonas Triantis (City University) Prof Julian Paton (Auckland) Dr Emma Hart (Bristol) Back to top