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The William Harvey Research Institute - Faculty of Medicine and Dentistry

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Illustration of a group social distancing
Herd immunity by infection is not an option

In an article, published today in Science, from Queen Mary University of London and Devi Sridhar from the University of Edinburgh explain why herd immunity by infection is not a strategy that should be considered for COVID-19.

Date added: Friday, January 15, 2021


WHRI New Year PhD Symposium

Wednesday 27th January from 1.00pm on Microsoft Teams

Date added: Thursday, January 21, 2021


Hospital
Patients from Asian and black backgrounds are more likely to die from COVID-19, large study reveals

Patients of Asian and black backgrounds suffered disproportionate rates of premature death from COVID-19, according to a study of 1,737 patients by Queen Mary University of London and Barts Health NHS Trust.

Date added: Friday, January 22, 2021


Professor Costantino Pitzalis
Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): outcomes of a stratified, biopsy-driven, multicentre, RCT

A new study published today in The Lancet is the first stratified, biopsy-driven, multicentre, open-label, randomised controlled trial that takes the first steps in the integration of molecular pathology into treatment decision making in Rheumatoid Arthritis.  In this Q&A Professor Costantino Pitzalis from the Centre for Experimental Medicine and Rheumatology at Queen Mary's William Harvey Research Institute explains why the R4RA trial represents the first step towards precision medicine.

Date added: Friday, January 22, 2021


WHRI academic wins prestigious Wellcome Trust Career Re-Entry fellowship for research into Type 2 diabetes

Dr Dunja Aksentijevic, Senior Lecturer in Cardiovascular Physiology and Metabolism at Queen Mary University of London, awarded £630,000 for examining immunometabolic cross-talk in the inflamed type 2 diabetic heart.

Date added: Monday, January 25, 2021


Heart
Having an unhealthy heart could lead to a higher risk of being diagnosed with COVID-19

People with unhealthy heart structures and poorer functioning hearts have a significantly higher risk of being diagnosed with COVID-19 infection, according to research by Queen Mary University of London, in collaboration with the Medical Research Council Lifecourse Epidemiology Unit (The University of Southampton).

Date added: Tuesday, March 9, 2021


Illustration of a group social distancing
School reopening without robust COVID-19 mitigation risks accelerating the pandemic

A group of academics have set out a series of recommendations for schools to reduce the risk of COVID-19 transmission now that they have re-opened, in a letter published in The Lancet.

Date added: Wednesday, March 10, 2021


Why the Dutch are the tallest people in the world

'Humans are growing taller around the world. The average adult today is 5% taller than they were a century ago. But how tall could humans get in the future, and what can we learn from the tallest people in the world – the Dutch?'

Date added: Tuesday, March 16, 2021


WHRI research funding success

In the past few months, the William Harvey Research Institute at Queen Mary University of London has seen major funding success in the areas of endocrine and inflammation research.

Date added: Friday, March 19, 2021


£54-million-award-to-transform-health-through-data-science
New genetic clues point to new treatments for ‘silent’ stroke

Scientists from Queen Mary University of London have helped identify new genetic clues in people who’ve had small and often apparently ‘silent’ strokes that are difficult to treat and a major cause of vascular dementia.

Date added: Friday, March 26, 2021


Call for cardiovascular scientists to contribute data to multinational platform

The first international platform for sharing cardiovascular data has been launched by euCanSHare, an EU-Canada funded project. Cardiovascular researchers are encouraged to use the platform to browse, deposit and analyse data.

Date added: Tuesday, April 6, 2021


How preprints accelerated science communication during the pandemic

A new study led by Queen Mary University of London researchers has found that during the early phase of the pandemic, approximately 35 per cent of the COVID-19 scientific literature was shared as preprints – freely available manuscripts that are shared prior to peer-review in a journal.

Date added: Thursday, April 8, 2021


A brain scan
Scientists uncover secret of the hunger switch in the brain

A 3D structure reveals how a unique molecular switch in our brain causes us to feel full – and may help develop improved anti-obesity drugs.

Date added: Friday, April 16, 2021


Ramadan fasting: recommendations for patients with cardiovascular disease

A new publication led by cardiologists and researchers at the Barts Heart Centre and Queen Mary University of London has developed a framework for triaging and where possible, facilitating safe fasting in patients with cardiovascular disease.

Date added: Monday, May 17, 2021


Professor Munroe elected to prestigious fellowship

Congratulations to Professor Patricia Munroe who has been elected to the highly prestigious Academy of Medical Sciences Fellowship.

Date added: Thursday, May 13, 2021


Heart
Having a healthier heart is associated with better problem-solving and reaction time

People with healthier heart structure and function appear to have better cognitive abilities, including increased capacity to solve logic problems and faster reaction times, according to research led by Queen Mary University of London and the Radcliffe Department of Medicine at University of Oxford.

Date added: Friday, May 14, 2021


Renal denervation system
Procedure using ultrasound energy found to treat high blood pressure

A minimally-invasive procedure that targets the nerves near the kidney has been found to significantly reduce blood pressure in hypertension patients, according to the results of a global multicentre clinical trial led in the UK by researchers at Queen Mary University of London and Barts Health NHS Trust.

Date added: Monday, June 7, 2021


Heart rate smart watch
Could your smart watch alert you to risk of sudden death?

Scientists develop a new algorithm that could allow wearable technology to warn those at risk of dangerous heart rhythm changes.

Date added: Tuesday, June 8, 2021


Portrait photo of Dr Zahra Raisi-Estabargh
Dr Zahra Raisi-Estabragh wins prestigious Royal Society of Medicine President's Gold Medal in Cardiology

Congratulations to Dr Zahra Raisi-Estabragh who was recently awarded the Royal Society of Medicine (RSM) President’s Gold Medal in Cardiology in recognition of her work developing cardiovascular magnetic resonance (CMR) radiomics as a novel imaging biomarker.

Date added: Friday, June 18, 2021


Hospital
First nationwide study reveals millions of cancelled operations due to COVID-19 and high risk of death

The first nationwide study of the impact of COVID-19 on surgery at NHS hospitals has revealed that more than 1.5 million operations were cancelled or postponed during the pandemic and surgical patients who became infected with COVID were five times more likely to die.

Date added: Friday, June 18, 2021


SynAct Pharma AB announces positive data from a Phase 2a trial of AP1189 in Covid-19 infected patients

SynAct Pharma AB (“SynAct”) has just announced topline results from the Phase 2a clinical trial of AP1189 in Covid-19 infected patients with pulmonary insufficiency. Patients treated with 100mg AP1189 orally once-daily for 2-weeks achieved respiratory recovery (time to normalization of oxygen saturation on ambient air) on average 3.5 days (35%) quicker than placebo treated patients (6.4 days and 9.9 days on average respectively). Data from this exploratory pilot clinical trial supports that AP1189 may help Covid-19 infected patients recover impaired lung function.

Date added: Thursday, July 1, 2021


MiniMed 640G Insulin Pump
PTH infused insulin pump used as an alternative treatment for young patients with ADH1

Researchers from Queen Mary University of London and the University of Oxford have developed an alternative treatment to increase calcium levels and prevent seizures in patients with the genetic condition ADH1.

Date added: Thursday, July 8, 2021


Heart MRI scan showing the area of fat detected by the AI tool
AI predicts diabetes risk by measuring fat around the heart

A team led by researchers from Queen Mary University of London has developed a new artificial intelligence (AI) tool that is able to automatically measure the amount of fat around the heart from MRI scan images.

Date added: Wednesday, July 7, 2021


A photo showing intermediate age-related macular degeneration.
Breakthrough into leading cause of blindness

A team of scientists, including researchers from Queen Mary University of London, has discovered that the most common form of adult blindness is probably caused by a failure of at least one of five proteins to regulate the immune system.

Date added: Monday, July 19, 2021


New insights into uncontrolled inflammation in COVID-19 patients

Research led by Queen Mary University of London provides new insight into the mechanisms that lead to uncontrolled inflammation in COVID-19 patients.

Date added: Wednesday, July 21, 2021


UK number one position for BSc Pharmacology and Innovative Therapeutics - National Student Survey 2021

The BSc Pharmacology & Innovative Therapeutics degree programme led by at the William Harvey Research Institute at Barts and the London School of Medicine and Dentistry has topped the national subject leader board and is currently number one in the UK having received the highest overall ratings in the 2021 National Student Survey (NSS).

Date added: Monday, July 26, 2021


Image of a pregnant woman. Photo by freestocks on Unsplash.
Researchers successfully identify new gene variants that cause hypertension in pregnant women

An international study, led by researchers from Queen Mary University of London and St Bartholomew’s Hospital, has found a unique pair of gene variants that causes sudden onset high blood pressure in pregnant women.

Date added: Thursday, August 12, 2021


The image depicts a postcapillary venule subjected to acute inflammation and captures  neutrophils (green) transmigrating across endothelial cells junctions (blue).  Neutrophils preferably migrate across contacts between autophagy deficient endothelial cells (magenta).
New insights into mechanisms of immune cell trafficking in inflammation

A new study led by researchers at Queen Mary University of London has identified the intracellular catabolic recycling system, Autophagy, within endothelial cells as a new molecular mechanism to limit inflammation. 

Date added: Monday, August 16, 2021


Hospital sign in London. Credit: georgeclerk/iStock.com.
New study reveals patients from minority ethnic groups are more likely to be admitted to hospital

Patients from minority ethnic groups have a disproportionately higher rate of emergency hospital admissions, according to research by Queen Mary University of London and Barts Health NHS Trust.

Date added: Thursday, August 19, 2021


New study links COVID-19 genetic susceptibility with blood clots, thrombophlebitis and circulatory diseases

Research led by Queen Mary University of London associates genetically predicted COVID-19 susceptibility with increased blood clot events in legs and lungs, thrombophlebitis, and circulatory diseases.

Date added: Tuesday, September 7, 2021


New model could improve treatment of rheumatoid arthritis patients with cardiac disease

Researchers from Queen Mary University of London have developed a new approach to address cardiac disease in rheumatoid arthritis patients.

Date added: Thursday, September 16, 2021


Researcher holding a pipette in a laboratory.
WHRI research technician recognised for contribution to endocrine research

A research technician from the William Harvey Research Institute at Queen Mary University of London has been shortlisted for a Papin Prize, the UK’s only award dedicated to celebrating technical excellence and innovation in higher education and research.

Date added: Wednesday, October 13, 2021


PhD student to co-host COP26 event

Nikita Patel has been selected to co-host an event at the United Nations Climate Change Conference (COP26) in Glasgow on November 4th.

Date added: Tuesday, November 2, 2021


New app helps parents identify treatable childhood growth disorders earlier

A new mobile phone app, ‘GrowthMonitor’, places the accurate measurement of children’s height in the hands of parents and carers. 

Date added: Tuesday, November 9, 2021


Whole genome sequencing improves diagnosis of rare diseases and shortens diagnostic journeys for patients

A world-first scientific study, published today in the New England Journal of Medicine, has shown that whole genome sequencing (WGS) can uncover new diagnoses for people across the broadest range of rare diseases investigated to date and could deliver enormous benefits across the NHS.

Date added: Thursday, November 11, 2021


Researcher holding a pipette in a laboratory.
Outstanding technician awarded Papin Prize at HETS2021

A technician from the William Harvey Research Institute at Queen Mary University of London has been presented with a prestigious award which recognises excellence in academia at the UK’s only event dedicated to celebrating the success and achievements of technical staff. 

Date added: Monday, November 15, 2021


New £11.6 million PhD Programme for health research in underrepresented populations

The Health Advances in Underrepresented Populations and Diseases (HARP) PhD Programme focuses research towards people and diseases that have traditionally been underrepresented in healthcare studies.

Date added: Tuesday, November 30, 2021


More diversity improves genetic research into cardiovascular disease, according to new study

A new study, co-led by Queen Mary University of London, has made the case for more diversity in genetic research.

Date added: Wednesday, December 8, 2021


Radiomics analysis of cardiac MRI scans
Risk factors for heart disease change heart structure and appearance

A new study led by researchers at Queen Mary University of London suggests that certain risk factors for heart disease are linked to common changes in the structure and appearance of the heart.

Date added: Wednesday, December 22, 2021


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