Dr Dan Jones

Profile

Daniel Jones completed his medical degree (MBBS) at St Georges Hospital Medical School in 2004, which involved an Intercalated BSc (2:1) in basic medical science awarded in 2001. He completed his PhD funded through an NIHR Doctoral Research Fellowship in 2015 at Queen Mary University of London based on the Investigation of the effect of nitrite in the management and treatment of myocardial infarction’ performed with Professors Anthony Mathur and Amrita Ahluwalia.

His primary research interests are based around translational interventional clinical trials, having completing an MSc in clinical trial design. Other interests include the treatment of reperfusion injury following myocardial infarction, novel therapies for myocardial regeneration, the cost-effectiveness of cardiovascular therapies and the study of outcomes after percutaneous coronary intervention.

Awards

• 2017 Young Investigator Award ‘Outcome after PCI’ Awarded by European Society of Cardiology
• 2017  2^nd Place 'EuroPCR Got Talent. Awarded by EACPI
• 2017  Awards for Academic Achievement 150th Anniversary Prize Awarded by University of London
• 2015 Young Investigator Award 6th International Meeting on the Role of Nitrite and Nitrate in Physiology, Pathophysiology, and Therapeutics
• 2014 2^nd Place Young Investigator Award ‘Thrombosis’ Awarded by European Society of Cardiology

Membership

• European Association of Percutaneous Coronary Intervention (EAPCI)
• Royal College Of Physicians (RCP)
• British Cardiac Society (BCS)
• British Junior Cardiologists' Association (BJCA)
• British Cardiovascular Intervention Society (BCIS)

Research

Group members

Vascular Pharmacology Group
Prof Amrita Ahluwalia (Head), Vikas Kapil (Senior Lecturer), Dr Ray Khambata (Senior post-doctoral researcher), Dr Sven van Eijl (Lab manager)

Barts Cardiovascular CTU
Prof Amrita Ahluwalia (Interim Chair), Dr Vivienne Monk (Manager), Dr Saidi Mohiddin, Prof Steffen Peterson, Dr Ajay Gupta (Senior Lecturer), Jane Field 

Interventional Cardiology Research Department
Prof Anthony Mathur, Prof Andreas Baumbach, Mervyn Andiapen, Jessry Veerapen, Ruth Bowles

Summary 

Dr Jones research interests are centred around clinical trials in interventional cardiology specifically ways in optimising and improving outcomes for patients and the cost-effectiveness of interventions.

Inorganic Nitrite/Nitrate in Cardiovascular Disease
A major research focus is the use of inorganic nitrate/nitrite and ischaemia-reperfusion injury. In 2015 as part of his PhD he helped demonstrate that intracoronary nitrite reduces infarct size and improve outcomes after primary angioplasty for myocardial infarction in a first in man phase II study.  

On-going research focuses on: 

1) The effect on intracoronary nitrite on clinical outcomes after acute myocardial infarction
2) Inorganic nitrate for prevention of contrast nephropathy after percutaneous coronary intervention (PCI) - https://heartresearch.org.uk/grants/coronary-angiography 

Clinical Trials
Focus of clinical trials in interventional cardiology alongside Prof Anthony Mathur and Prof Andreas Baumbach

Current areas include:

• Stem Cell Therapy for treatment of Heart Failure/Refractory Angina
• Improving revascularisation in the post-surgical patient
• Optimisation of Anti-platelet therapy post ACS
• Risk-stratification in MI with normal coronary arteries (MINOCA)

Health Economics and Outcome Research
Observational research experience using databases from the London Chest Hospital, Barts Heart Centre, a Pan-London Angioplasty database (containing 125,000 patients from 8 hospitals) and a national dataset from the British Cardiovascular Intervention Society (>500,000 patients). This has been supplemented by the recent completion of an MSc (Distinction) in Health Economics, Outcomes and Management in Cardiovascular Sciences conducted under the LSE/European Society of Cardiology, resulting in active collaborations with Dr Huseyin Naci at LSE.

Key Publications

For a full list of publications click here

• Antoniou S, Colicchia M, Guttmann O, Rathod K, Wright P, Fhadil S, Knight C, Jain AK, Smith EJ, Mathur A, Weerackody R, Wragg A, Jones DA. Risk Scoring to guide anti-platelet therapy post percutaneous coronary intervention (PCI) for acute-coronary syndrome (ACS) results in improved clinical outcomes. Eur Heart J Qual Care Clin Outcomes. 2017 Nov 8. doi: 10.1093/ehjqcco/qcx041
• Choudhury T, Choudhury F, Mozid A, Hamshere S, Yeo C, Pellaton C, Arnous S, Saunders N, Brookman P, Jain A, Locca D, Archbold RA, Knight CJ, Wragg A, Davies LC, Mills PG, Parmar M, Rothman MT, Jones DA, Agrawal S, Martin J, Mathur A. An exploratory randomised control study of combination cytokine and adult autologous bone marrow progenitor cell administration in patients with ischaemic cardiomyopathy: the REGENERATE-IHD clinical trial. European Journal of Heart Failure 2017; 19(1):138-47
• Jones DA, Khambata RS, Rathod KS, Andiapen M, Mathur A, Ahluwalia A. Intra-coronary nitrite suppresses the inflammatory response following primary percutaneous coronary intervention. Heart 2017;103(7):508-516.
• Choudry F, Hamshere S, Saunders N, Veerapen J, Bavnbek K, Knight C, Pellerin D, Locca D, Westwood M, Rakhit R, Crake T, Kastrup J, Parmar M, Agrawal S, Jones D, Martin J, Mathur A. A randomized double-blind control study of early intra-coronary  autologous bone marrow cell infusion in acute myocardial infarction: the REGENERATE-AMI clinical trial. Eur Heart J. 2016;37:256-263.
• Hamshere, S, Arnous S, Choudhury T, Choudry F, Mozid A, Yeo C, Barrett C, Saunders N, Gulati A, Knight C, Locca D, Davies C, Cowie MR, Prasad S, Parmar M, Agrawal S, Jones D, Martin J, McKenna W, Mathur A. Randomized trial of combination cytokine and adult autologous bone marrow progenitor cell administration in patients with non-ischaemic dilated cardiomyopathy: the REGENERATE-DCM clinical trial. Eur Heart J 2015;36(44):3061-9 
• Jones DA, Rathod KS, Gallagher S, Jain AK, Kalra SS, Lim P, Crake T, Ozkor M, Rakhit R, Knight CJ, Iqbal MB, Dalby MC, Malik IS, Whitbread M, Mathur A1, Redwood S, MacCarthy PA, Weerackody R, Wragg A. Manual Thrombus aspiration is not associated with reduced mortality in Patients Treated with Primary Percutaneous Coronary Intervention: An Observational Study of 10,929 patients with ST-Elevation Myocardial Infarction from the London Heart Attack Group. JACC Cardiovasc Interv. 2015 Apr 20;8(4):575-84. doi: 10.1016/j.jcin.2014.11.021. 
• Jones DA, Pellaton C, Velmurugan S, Rathod KS, Andiapen M, Antoniou S, van Eijl S, Webb AJ, Westwood MJ, Parmar MK, Mathur A, Ahluwalia A. 2015. Randomized phase 2 trial of intracoronary nitrite during acute myocardial infarction. Circ Res 2015; 116: 437-447.
• Jones DA, Gallagher S, Rathod K, Jain AK, Mathur A, Uppal R, Westwood M, Wong K, Rothman MT, Shipolini A, Smith EJ, Mills PG, Timmis AD, Knight CJ, Archbold RA, Wragg A. Clinical outcomes after myocardial revascularization according to operator training status: cohort study of 22 697 patients undergoing percutaneous coronary intervention or coronary artery bypass graft surgery. Eur Heart J. 2013 2013;34(37):2887-95

Collaborators

• Prof Magdi Yaqoob (WHRI)
• Dr Andrew Wragg (WHRI)
• Dr Saidi Mohiddin 
• Dr Huseyin Naci (LSE)