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The William Harvey Research Institute - Barts and The London

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New model could improve treatment of rheumatoid arthritis patients with cardiac disease
16 September 2021

Researchers from Queen Mary University of London have developed a new approach to address cardiac disease in rheumatoid arthritis patients.

New study links COVID-19 genetic susceptibility with blood clots, thrombophlebitis and circulatory diseases
7 September 2021

Research led by Queen Mary University of London associates genetically predicted COVID-19 susceptibility with increased blood clot events in the legs and lungs, thrombophlebitis and circulatory diseases.

Hospital sign in London. Credit: georgeclerk/iStock.com.New study reveals patients from minority ethnic groups are more likely to be admitted to hospital
19 August 2021

Patients from minority ethnic groups have a disproportionately higher rate of emergency hospital admissions, according to research by Queen Mary University of London and Barts Health NHS Trust.

The image depicts a postcapillary venule subjected to acute inflammation and captures  neutrophils (green) transmigrating across endothelial cells junctions (blue).  Neutrophils preferably migrate across contacts between autophagy deficient endothelial cells (magenta).New insights into mechanisms of immune cell trafficking in inflammation
16 August 2021

A new study led by researchers at Queen Mary University of London has identified the intracellular catabolic recycling system, Autophagy, within endothelial cells as a new molecular mechanism to limit inflammation.

Image of a pregnant woman. Photo by freestocks on Unsplash.Researchers successfully identify new gene variants that cause hypertension in pregnant women
12 August 2021

An international study, led by researchers from Queen Mary University of London and St Bartholomew’s Hospital, has found a unique pair of gene variants that causes sudden onset high blood pressure in pregnant women.

UK number one position for BSc Pharmacology and Innovative Therapeutics - National Student Survey 2021 
26 July 2021

The BSc Pharmacology & Innovative Therapeutics degree programme led by Dr Sadani Cooray at the William Harvey Research Institute at Barts and the London School of Medicine and Dentistry has topped the national subject leader board and is currently number one in the UK having received the highest overall ratings in the 2021 National Student Survey (NSS).

New insights into uncontrolled inflammation in COVID-19 patients
21 July 2021

Research led by Queen Mary University of London provides new insight into the mechanisms that lead to uncontrolled inflammation in COVID-19 patients.

A photo showing intermediate age-related macular degeneration.Breakthrough into leading cause of blindness
19 July 2021 

A team of scientists, including researchers from Queen Mary University of London, has discovered that the most common form of adult blindness is probably caused by a failure of at least one of five proteins to regulate the immune system.

MiniMed 640G Insulin PumpPTH infused insulin pump used as an alternative treatment for young patients with ADH1
8 July 2021

Researchers from Queen Mary University of London and the University of Oxford have developed an alternative treatment to increase calcium levels and prevent seizures in patients with the genetic condition ADH1.

Heart MRI scan showing the area of fat detected by the AI toolAI predicts diabetes risk by measuring fat around the heart
7 July 2021

A team led by researchers from Queen Mary University of London has developed a new artificial intelligence (AI) tool that is able to automatically measure the amount of fat around the heart from MRI scan images.

SynAct Pharma AB announces positive data from a Phase 2a trial of AP1189 in Covid-19 infected patients
1 July 2021

SynAct Pharma AB (“SynAct”) has just announced topline results from the Phase 2a clinical trial of AP1189 in Covid-19 infected patients with pulmonary insufficiency. Patients treated with 100mg AP1189 orally once-daily for 2-weeks achieved respiratory recovery (time to normalization of oxygen saturation on ambient air) on average 3.5 days (35%) quicker than placebo treated patients (6.4 days and 9.9 days on average respectively). Data from this exploratory pilot clinical trial supports that AP1189 may help Covid-19 infected patients recover impaired lung function.

First nationwide study reveals millions of cancelled operations due to COVID-19 and high risk of deathHospital
18 June 2021

The first nationwide study of the impact of COVID-19 on surgery at NHS hospitals has revealed that more than 1.5 million operations were cancelled or postponed during the pandemic and surgical patients who became infected with COVID were five times more likely to die.

Portrait photo of Dr Zahra Raisi-Estabargh

Dr Zahra-Raisi-Estabragh wins prestigious Royal Society of Medicine Presidents Gold Medal in Cardiology
18 June 2021

Congratulations to Dr Zahra Raisi-Estabragh who was recently awarded the Royal Society of Medicine (RSM) President’s Gold Medal in Cardiology in recognition of her work developing cardiovascular magnetic resonance (CMR) radiomics as a novel imaging biomarker.

Heart rate smart watch

Could your smart watch alert you to risk of sudden death?
8 June 2021

Scientists develop a new algorithm that could allow wearable technology to warn those at risk of dangerous heart rhythm changes.


Renal denervation system Procedure using ultrasound energy found to treat high blood pressure
7 June 2021 

A minimally-invasive procedure that targets the nerves near the kidney has been found to significantly reduce blood pressure in hypertension patients, according to the results of a global multicentre clinical trial led in the UK by researchers at Queen Mary University of London and Barts Health NHS Trust.


Ramadan fasting: recommendations for people with cardiovascular disease
17 May 2021 

A new publication led by cardiologists and researchers at the Barts Heart Centre and Queen Mary University of London has developed a framework for triaging and where possible, facilitating safe fasting in patients with cardiovascular disease.

HeartHaving a healthy heart is associated with better problem solving and reaction time 
14 May 2021 

People with healthier heart structure and function appear to have better cognitive abilities, including increased capacity to solve logic problems and faster reaction times, according to research led by Queen Mary University of London and the Radcliffe Department of Medicine at University of Oxford.

New joint study applies pharmacogenetics to a novel therapy for Rheumatoid Arthritis
13 May 2021 

This new study, led by Dr Trinidad Montero-Melendez will investigate how genetic variations in a gene called melanocortin 1 receptor, MC1R, affects the anti-arthritic property of a novel drug called AP1189.

Professor Munroe elected to prestigious fellowship
13 May 2021 

Congratulations to Professor Patricia Munroe who has been elected to the highly prestigious Academy of Medical Sciences Fellowship.

A brain scanScientists uncover secret of the hunger switch in the brain
15 April 2021 

A 3D structure reveals how a unique molecular switch in our brain causes us to feel full – and may help develop improved anti-obesity drugs.

How preprints accelerated science communication during the pandemic
8 April 2021 

A new study led by Queen Mary University of London researchers has found that during the early phase of the pandemic, approximately 35 per cent of the COVID-19 scientific literature was shared as preprints – freely available manuscripts that are shared prior to peer-review in a journal.

Call for cardiovascular scientists to contribute data to multinational platform
6 April 2021 

The first international platform for sharing cardiovascular data has been launched by euCanSHare, an EU-Canada funded project. Cardiovascular researchers are encouraged to use the platform to browse, deposit and analyse data.

New genetic clues point to new treatments for 'silent' stroke
26 March 2021 

£54-million-award-to-transform-health-through-data-scienceScientists from Queen Mary University of London have helped identify new genetic clues in people who’ve had small and often apparently ‘silent’ strokes that are difficult to treat and a major cause of vascular dementia.

WHRI Research funding success
19 March 2021 

In the past few months, the William Harvey Research Institute at Queen Mary University of London has seen major funding success in the areas of endocrine and inflammation research.

Why the Dutch are the tallest people in the world
16 March 2021 

Dr Eirini Marouli, Lecturer in Computational Biology at Queen Mary University of London, was interviewed by the BBC for the development of a BBC Reel on the genetics of adult height.

Schools reopening without robust COVID-19 mitigation risks accelerating the pandemic
10 March 2021 

Illustration of a group social distancing A group of academics have set out a series of recommendations for schools to reduce the risk of COVID-19 transmission now that they have re-opened, in a letter published in The Lancet.

Having an unhealthy heart could lead to a higher risk of being diagnosed with COVID-19
9 March 2021 

HeartPeople with unhealthy heart structures and poorer functioning hearts have a significantly higher risk of being diagnosed with COVID-19 infection, according to research by Queen Mary University of London, in collaboration with the Medical Research Council Lifecourse Epidemiology Unit (The University of Southampton).

WHRI academic wins prestigious Wellcome Trust Career Re-Entry fellowship for research into Type 2 diabetes 
25 January 2021 

Dr Dunja Aksentijevic awarded £630,000 for examining immunometabolic cross-talk in the inflamed type 2 diabetic heart.

Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): outcomes of a stratified, biopsy-driven, multicentre, RCT
22 January 2021 

Professor Costantino PitzalisA new study published today in The Lancet is the first stratified, biopsy-driven, multicentre, open-label, randomised controlled trial that takes the first steps in the integration of molecular pathology into treatment decision making in Rheumatoid Arthritis.

In this Q&A Professor Costantino Pitzalis from the Centre for Experimental Medicine and Rheumatology at Queen Mary's William Harvey Research Institute explains why the R4RA trial represents the first step towards precision medicine.

Patients from Asian and black backgrounds are more likely to die from COVID-19, large study reveals
22 January 2021 

HospitalPatients of Asian and black backgrounds suffered disproportionate rates of premature death from COVID-19, according to a study of 1,737 patients by Queen Mary University of London and Barts Health NHS Trust.

WHRI New Year PhD Symposium
21 January 2021 

Join us on Wednesday 27th January from 1.00 pm as we celebrate the new year with our annual PhD Symposium. This years programme features excellent talks from our 3rd year PhD students and a keynote lecture on 'Adaptive immunity and immune memory to COVID-19' by Prof Shane Crotty from La Jolla Institute, USA

Herd immunity is not an option
15 January 2021 

Illustration of a group social distancing In an article, published today in Science, Dr Deepti Gurdasani from Queen Mary University of London and Devi Sridhar from the University of Edinburgh explain why herd immunity by infection is not a strategy that should be considered COVID-19.

 

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