Skip to main content
Pragmatic Clinical Trials Unit

Current Studies

The PCTU is actively engaged in a wide variety of trials (including CTIMPS), systematic reviews and observational studies at different stages of their development. The Unit supports high quality research across many different clinical areas with particular strengths in primary care, psychiatry, women’s health, critical care, colorectal surgery and perioperative medicine. 

Click on the study name below for details of our current studies.   

 

ASSURED 

Study: ASsuRED: Improving outcomes in patients who self-harm – Adapting and evaluating a brief pSychological inteRvention in Emergency Departments

Chief Investigator: Professor Rose McCabe

Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0617-20004)

Sponsor: City, University of London

PCTU Ref: P264

ATTACK MS

Study: Natalizumab for the acute treatment of people at high risk of relapsing multiple sclerosis

Chief Investigator: Professor Klaus Schmierer

Funder/Funding Stream: Biogen Idec Ltd 

Sponsor: Queen Mary university of London

PCTU Ref: P327

BLIPA

Study: Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis; a randomised placebo controlled trial (BLIPA; Bacterial Lysate in Preventing Asthma)

Chief Investigator: Professor Jonathan Grigg

Funder/Funding Stream: NIHR Efficacy and Mechanism Evaluation (EME) (NIHR128778)

Sponsor: Queen Mary University of London

PCTU Ref: P310

CHARIOT-MS

Study: Cladribine to halt deterioration in people with advanced Multiple Sclerosis 

Chief Investigator: Professor Klaus Schmierer 

Funder/Funding Stream: NIHR Efficacy and Mechanism Evaluation (EME) (17/145/09)

Sponsor: Queen Mary university of London

PCTU Ref: P258

CHILL

Study: Investigating the impact of London's Ultra Low Emission Zone on children's respiratory health.  A cohort study to evaluate Ultra Low Emission Zone

Chief Investigator: Professor Chris Griffiths, Queen Mary University of London

Funder/Funding Stream: NIHR Public Health Research (16/139/01)

Sponsor: Barts NHS Trust

PCTU Ref: P242

ENRICH

Study: Enhanced discharge from inpatient to community mental health care (ENRICH): a programme of applied research to manualise, pilot and trial a Peer Worker intervention

Chief Investigator: Professor Steve Gillard, St George's, University of London

Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-1212-20019)

Sponsor: South West London and St George’s Healthcare NHS Trust

PCTU Ref: P154

ERA

Study: Effectiveness Of Group Arts Therapy Compared To Group Counselling For Diagnostically Heterogeneous Psychiatric Community Patients: Randomised Controlled Trial In Mental Health Services   

Chief Investigators: Dr Catherine Carr, Queen Mary University of London and Professor Stefan Priebe, Queen Mary University of London

Funder/Funding Stream: NIHR Health Technology Assessment (17/29/01)

Sponsor: East London NHS Foundation Trust

PCTU Ref:P262

Eye-2-i

Study: The Early Youth Engagement in first episode psychosis (EYE-2) study: pragmatic cluster randomised controlled trial of implementation, effectiveness & cost effectiveness of a team-based motivational engagement intervention to improve engagement

Chief Investigator: Dr Kathy Greenwood, University of Sussex

Funder/Funding Stream: NIHR Health Services & Delivery Research Programme (16/31/87)

Sponsor: Sussex Partnership NHS Foundation Trust 

PCTU Ref: P252

FLO-ELA

Study: FLuid Optimisation in Emergency LAparotomy. Open, multi-centre, randomised controlled trial of cardiac output -guided haemodynamic therapy compared to usual care in patients undergoing emergency bowel surgery

Chief Investigator: Dr Mark Edwards, University Hospital Southampton NHS Foundation Trust

Funder/Funding Stream: NIHR Health Technology Assessment Clinical Trials & Evaluation (15/80/54)

Spondor: University Hospital Southampton NHS Foundation Trust

PCTU Ref: P217

FReDA

Study: The FReDA Project: Family Recovery after Domestic Abuse

Chief Investigator: Dr Emma Howarth

Funder/Funding Stream: Public Health Research (NIHR127793)

Sponsor: University of East London 

PCTU Ref: P341

IBD-BOOST

Study: Living well with Inflammatory Bowel Disease: improving symptoms of chronic abdominal pain, fatigue and incontinence by guided self-management

Chief Investigator: Professor Christine Norton

Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0216-20001)

Sponsor: London North West University Healthcare NHS Trust

PCTU Ref: P211

IMP2ART

Study: Implementing supported asthma self-management in routine clinical care: designing, refining, piloting and evaluating clinical and cost-effectiveness of a whole systems implementation strategy

Chief Investigator: Dr Hilary Pinnock, University of Edinburgh and Professor Stephanie Taylor, Queen Mary University of London

Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-1016-20008)

Sponsor: NHS Kent and Medway CCG 

PCTU Ref: P243

Included information

INCLUDED

Study: The INCLUDED study focuses on improving inclusion and diversity in UK clinical trials through understanding how ethnicity data are collected, used, and reported in order to make recommendations to improve engagement with trials and impact of trials for under-served groups.

Lead: Professor Sandra Eldridge

Funder/Funding Stream: NIHR CTU Support Funding

Sponsor: Queen Mary University of London 

PCTU Ref: P364

Invite to INCLUDED study (Gujarati)

Invite to INCLUDED study (Hindi)

IPPIC

Study: Accuracy of clinical characteristics, biochemical and ultrasound markers in the prediction of preeclampsia: an Individual Patient Data (IPD) Meta-analysis                                                                                                   

Chief Investigator: Professor Shakila Thangaratinam, Queen Mary University of London

Funder/Funding Stream: NIHR Health Technology Assessment (14/158/02)

Sponsor: Barts NHS Trust

PCTU Ref: P177

NEON

Study: Personal experience as a recovery resource in severe mental illness: Narrative Experiences ONline 

Chief Investigator: Professor Mike Slade, University of Nottingham

Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0615-20016)

Sponsor: Nottinghamshire Healthcare NHS Foundation Trust 

PCTU Ref: P227

OPTIMISE II

Study: OPTimisation of cardIovascular Management to Improve Surgical outcomE II

Chief Investigator: Professor Rupert Pearse, Queen Mary University of London

Funder/Funding Stream: Edwards Lifesciences

Sponsor: Barts Health NHS Trust

PCTU Ref: P221

OSIRIS

Study: Optimising Shared Decision Making for High Risk Major Surgery

Chief Investigator: Professor Rupert Pearse, Queen Mary University of London

Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0218-20001)

Sponsor: Barts Health NHS Trust

PCTU Ref: P249

PROMETHEUS

Study: Routinely embedding recruitment and retention interventions within randomised controlled trials

Chief Investigator: Professor David Torgerson, University of York

Funder/Funding Stream: MRC Methodology Research Panel (MR/R013748/1)

Sponsor: University of York 

PCTU Ref: P268

REACH

Study: The REACH Pregnancy Programme (Research for Equitable Antenatal Care and Health)

Chief Investigator: Professor Angela Harden, University of East London

Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-1211-20015)

Sponsor: University of East London 

PCTU Ref: P123

SENSE-MS

Study: Validity of Floodlight remote patient monitoring -substudy to MS-Chariot

Chief Investigator: Professor Klaus Schmierer  

Funder/Funding Stream: Roche

Sponsor: Queen Mary university of London 

PCTU Ref: P326

SUBSoNIC

Study: Randomised Double-Blind Efficacy and Mechanism Study Of Sacral Neuromodulation In Adults With Faecal Incontinence

Chief Investigator: Professor Charles Knowles, Queen Mary University of London

Funder/Funding Stream: NIHR Efficacy and Mechanism Evaluation (EME) (14/144/08) and Medtronic Inc

Sponsor: Barts NHS Trust

PCTU Ref: P178 

SURECAN

Study: SUrvivors Rehabilitation Evaluation after CANcer

Chief Investigator: Professor Stephanie Taylor, Queen Mary University of London

Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0616-20002)

Sponsor: Barts NHS Trust

PCTU Ref: P228

TACK

Study: Tackling chronic depression - Adapting and testing a technology supported, patient-centred and solution focused intervention (DIALOG+) in primary care

Chief Investigator: Dr Vicky Bird, Queen Mary University of London

Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0615-20010)

Sponsor: East London NHS Foundation Trust

PCTU Ref: P207

TANDEM

Study: A tailored, cognitive behavioural approach intervention for mild to moderate anxiety and/or depression in people with chronic obstructive pulmonary disease (COPD): A randomised controlled trial (TANDEM Tailored intervention for ANxiety and DEpression Management in COPD)

Chief Investigator: Professor Stephanie Taylor, Queen Mary University of London

Funder/Funding Stream: NIHR Health Technology Assessment (13/146/02)

Sponsor: Barts NHS Trust

PCTU Ref: P159

VidiKIDS

Study: Trial of vitamin D supplementation to prevent acquisition of latent tuberculosis infection in schoolchildren

Chief Investigator: Professor Adrian Martineau, Queen Mary University of London

Funder/Funding Stream: Medical Research Council (MRC) (MR/M026639/1)

Sponsor: Barts NHS Trust

PCTU Ref: P186

Back to top