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Pragmatic Clinical Trials Unit

Our Publications

Many academic staff within the unit publish widely and their full publication list can be accessed via their own webpage or at https://www.qmul.ac.uk/research/publications/

Here we list published reports, protocols, and statistical analysis plans for the studies in which the PCTU has formally collaborated. Methodological publications can be found on our methodological publications pages. 

McNamee P, Matanov A, Jerome L, Kerry S, Walker N, Feng Y, Molodynski A, Scott S, Guruvaiah L, Collinson S, McCabe R, Geddes J, Priebe S, Bird V. Clinical- and cost-effectiveness of a technology-supported and solution-focused intervention (DIALOG plus ) in treatment of patients with chronic depression-study protocol for a multi-site, cluster randomised controlled trial [TACK]. Trials 2022;23: https://doi.org/10.1186/s13063-022-06181-4 

Grossi U, Lacy-Colson J, Brown SR, Cross S, Eldridge S, Jordan M, Mason J, Norton C, Scott SM, Stevens N, Taheri S, Knowles CH. Stepped-wedge randomized controlled trial of laparoscopic ventral mesh rectopexy in adults with chronic constipation. Tech Coloproctol 2022; https://doi.org/10.1007/s10151-022-02633-w 

Gillard S, Bremner S, Patel A, Goldsmith L, Marks J, Foster R, Morshead R, White S, Gibson SL, Healey A, Lucock M, Patel S, Repper J, Rinaldi M, Simpson A, Ussher M, Worner J, Priebe S, Grp ETS. Peer support for discharge from inpatient mental health care versus care as usual in England (ENRICH): a parallel, two-group, individually randomised controlled trial. Lancet Psychiatry 2022;9:125-136 https://doi.org/10.1016/S2215-0366(21)00398-9 

Allotey J, Whittle R, Snell KIE, Smuk M, Townsend R, von Dadelszen P, Heazell AEP, Magee L, Smith GCS, Sandall J, Thilaganathan B, Zamora J, Riley RD, Khalil A, Thangaratinam S, Network IC. External validation of prognostic models to predict stillbirth using International Prediction of Pregnancy Complications (IPPIC) Network database: individual participant data meta-analysis. Ultrasound in Obstetrics & Gynecology 2022;59:209-219 https://doi.org/10.1002/uog.23757 

Slade M, Rennick-Egglestone S, Llewellyn-Beardsley J, Yeo C, Roe J, Bailey S, Smith RA, Booth S, Harrison J, Bhogal A, Penas Moran P, Hui A, Quadri D, Robinson C, Smuk M, Farkas M, Davidson L, van der Krieke L, Slade E, Bond C, Nicholson J, Grundy A, Charles A, Hare-Duke L, Pollock K, Ng F. Recorded Mental Health Recovery Narratives as a Resource for People Affected by Mental Health Problems: Development of the Narrative Experiences Online (NEON) Intervention. JMIR Form Res 2021;5:e24417 https://doi.org/10.2196/24417 

Norton C, Syred J, Kerry S, Artom M, Sweeney L, Hart A, Czuber-Dochan W, Taylor SJC, Mihaylova B, Roukas C, Aziz Q, Miller L, Pollok R, Saxena S, Stagg I, Terry H, Zenasni Z, Dibley L, Moss-Morris R. Supported online self-management versus care as usual for symptoms of fatigue, pain and urgency/incontinence in adults with inflammatory bowel disease (IBD-BOOST): study protocol for a randomised controlled trial. Trials 2021;22: https://doi.org/10.1186/s13063-021-05466-4 

Marlin N, Rivas C, Allotey J, Dodds J, Horne A, Ball E. Development and Validation of Clinical Prediction Models for Surgical Success in Patients With Endometriosis: Protocol for a Mixed Methods Study. JMIR Res Protoc 2021;10:e20986 https://doi.org/10.2196/20986

Knowles CH, Booth L, Brown SR, Cross S, Eldridge S, Emmett C, Grossi U, Jordan M, Lacy-Colson J, Mason J, McLaughlin J, Moss-Morris R, Norton C, Scott SM, Stevens N, Taheri S, Yiannakou Y. Non-drug therapies for the management of chronic constipation in adults: the CapaCiTY research programme including three RCTs. Programme Grants for Applied Research 2021;9: https://doi.org/10.3310/pgfar09140 

Jones CI, Bremner S, Hooper R, Gu J, Bartl G, Greenwood K. Statistical analysis plan for the Early Youth Engagement in first episode psychosis (EYE-2) study: a pragmatic cluster randomised controlled trial of implementation, effectiveness and cost-effectiveness of a team-based motivational engagement intervention to improve engagement. Trials 2021;22: https://doi.org/10.1186/s13063-021-05670-2 

Greenwood K, Webb R, Gu J, Fowler D, de Visser R, Bremner S, Abramowicz I, Perry N, Clark S, O'Donnell A, Charlton D, Jarvis R, Garety P, Nandha S, Lennox B, Johns L, Rathod S, Phiri P, French P, Law H, Hodgekins J, Painter M, Treise C, Plaistow J, Irwin F, Thompson R, Mackay T, May CR, Healey A, Hooper R, Peters E. The Early Youth Engagement in first episode psychosis (EYE-2) study: pragmatic cluster randomised controlled trial of implementation, effectiveness and cost-effectiveness of a team-based motivational engagement intervention to improve engagement. Trials 2021;22: https://doi.org/10.1186/s13063-021-05105-y 

Giacco D, Chevalier A, Patterson M, Hamborg T, Mortimer R, Feng Y, Webber M, Xanthopoulou P, Priebe S. Effectiveness and cost-effectiveness of a structured social coaching intervention for people with psychosis (SCENE): protocol for a randomised controlled trial. Bmj Open 2021;11: https://doi.org/10.1136/bmjopen-2021-050627 

Ball E, Karavadra B, Kremer-Yeatman BJ, Mustard C, Lee KM, Bhogal S, Dodds J, Horne AW, Allotey J, Rivas C. Systematic review of patient-specific pre-operative predictors of pain improvement to endometriosis surgery. Reprod Fertil 2021;2:69-80 https://doi.org/10.1530/RAF-20-0057 

Wiggins M, Sawtell M, Wiseman O, McCourt C, Eldridge S, Hunter R, Bordea E, Mustard C, Hanafiah A, Hatherall B, Holmes V, Mehay A, Robinson H, Salisbury C, Sweeney L, Mondeh K, Harden A. Group antenatal care (Pregnancy Circles) for diverse and disadvantaged women: study protocol for a randomised controlled trial with integral process and economic evaluations. Bmc Health Services Research 2020;20: https://doi.org/10.1186/s12913-020-05751-z 

Sohanpal R, Pinnock H, Steed L, Marshall KH, Chan C, Kelly M, Priebe S, Roberts CM, Singh S, Smuk M, Saqi-Waseem S, Healey A, Underwood M, White P, Warburton C, Taylor SJC, Investigators T. Tailored, psychological intervention for anxiety or depression in people with chronic obstructive pulmonary disease (COPD), TANDEM (Tailored intervention for ANxiety and DEpression Management in COPD): protocol for a randomised controlled trial. Trials 2020;21: https://doi.org/10.1186/s13063-019-3800-y 

Sohal AH, Feder G, Boomla K, Dowrick A, Hooper R, Howell A, Johnson M, Lewis N, Robinson C, Eldridge S, Griffiths C. Improving the healthcare response to domestic violence and abuse in UK primary care: interrupted time series evaluation of a system-level training and support programme. Bmc Medicine 2020;18: https://doi.org/10.1186/s12916-020-1506-3 

Snell KIE, Allotey J, Smuk M, Hooper R, Chan C, Ahmed A, Chappell LC, Von Dadelszen P, Green M, Kenny L, Khalil A, Khan KS, Mol BW, Myers J, Poston L, Thilaganathan B, Staff AC, Smith GCS, Ganzevoort W, Laivuori H, Odibo AO, Ramirez JA, Kingdom J, Daskalakis G, Farrar D, Baschat AA, Seed PT, Prefumo F, Costa FD, Groen H, Audibert F, Masse J, Skrastad RB, Salvesen KA, Haavaldsen C, Nagata C, Rumbold AR, Heinonen S, Askie LM, Smits LJM, Vinter CA, Magnus P, Eero K, Villa PM, Jenum AK, Andersen LB, Norman JE, Ohkuchi A, Eskild A, Bhattacharya S, McAuliffe FM, Galindo A, Herraiz I, Carbillon L, Klipstein-Grobusch K, Yeo SA, Browne JL, Moons KGM, Riley RD, Thangaratinam S, Network IC. External validation of prognostic models predicting pre-eclampsia: individual participant data meta-analysis. Bmc Medicine 2020;18: https://doi.org/10.1186/s12916-020-01766-9 

Rennick-Egglestone S, Elliott R, Smuk M, Robinson C, Bailey S, Smith R, Keppens J, Hussain H, Pollock K, Cuijpers P, Llewellyn-Beardsley J, Ng F, Yeo C, Roe J, Hui A, van der Krieke L, Walcott R, Slade M. Impact of receiving recorded mental health recovery narratives on quality of life in people experiencing psychosis, people experiencing other mental health problems and for informal carers: Narrative Experiences Online (NEON) study protocol for three randomised controlled trials. Trials 2020;21: https://doi.org/10.1186/s13063-020-04428-6 

Patel S, Achana F, Carnes D, Eldridge S, Ellard DR, Griffiths F, Haywood K, Hee SW, Mistry D, Mistry H, Nichols VP, Petrou S, Pincus T, Potter R, Sandhu HK, Stewart K, Taylor S, Underwood M, Matharu M. Usual care and a self-management support programme versus usual care and a relaxation programme for people living with chronic headache disorders: a randomised controlled trial protocol (CHESS). Bmj Open 2020;10: https://doi.org/10.1136/bmjopen-2019-033520 

Pasu S, Bell L, Zenasni Z, Lanz D, Simmonds IA, Thompson A, Yorston D, Laidlaw DAH, Bunce C, Hooper R, Bainbridge JWB, PIMS PMHS. Facedown Positioning Following Surgery for Large Full-Thickness Macular Hole A Multicenter Randomized Clinical Trial. Jama Ophthalmology 2020;138:725-730 https://doi.org/10.1001/jamaophthalmol.2020.0987 

Panovska-Griffiths J, Sohal AH, Martin P, Capelas EB, Johnson M, Howell A, Lewis NV, Feder G, Griffiths C, Eldridge S. Disruption of a primary health care domestic violence and abuse service in two London boroughs: interrupted time series evaluation. Bmc Health Services Research 2020;20: https://doi.org/10.1186/s12913-020-05397-x 

Killaspy H, Priebe S, McPherson P, Zenasni Z, Greenberg L, McCrone P, Dowling S, Harrison I, Krotofil J, Dalton-Locke C, McGranahan R, Arbuthnott M, Curtis S, Leavey G, Shepherd G, Eldridge S, King M. Predictors of moving on from mental health supported accommodation in England: national cohort study. British Journal of Psychiatry 2020;216:331-337 https://doi.org/10.1192/bjp.2019.101 

Gillard S, Bremner S, Foster R, Gibson SL, Goldsmith L, Healey A, Lucock M, Marks J, Morshead R, Patel A, Priebe S, Repper J, Rinaldi M, Roberts S, Simpson A, White S. Peer support for discharge from inpatient to community mental health services Study protocol clinical trial (SPIRIT Compliant). Medicine 2020;99: https://doi.org/10.1097/MD.0000000000019192 

Chan CL, Smuk M, Sohanpal R, Pinnock H, Taylor SJC, Investigators T. Tailored, psychological intervention for anxiety and/or depression in people with chronic obstructive pulmonary disease (COPD), TANDEM (Tailored intervention for ANxiety and DEpression Management in COPD): statistical analysis plan for a randomised controlled trial. Trials 2020;21: https://doi.org/10.1186/s13063-020-04786-1 

Allotey J, Snell KIE, Smuk M, Hooper R, Chan CL, Ahmed A, Chappell LC, von Dadelszen P, Dodds J, Green M, Kenny L, Khalil A, Khan KS, Mol BW, Myers J, Poston L, Thilaganathan B, Staff AC, Smith GCS, Ganzevoort W, Laivuori H, Odibo AO, Ramirez JA, Kingdom J, Daskalakis G, Farrar D, Baschat AA, Seed PT, Prefumo F, Costa FD, Groen H, Audibert F, Masse J, Skrastad RB, Salvesen KA, Haavaldsen C, Nagata C, Rumbold AR, Heinonen S, Askie LM, Smits LJM, Vinter CA, Magnus PM, Eero K, Villa PM, Jenum AK, Andersen LB, Norman JE, Ohkuchi A, Eskild A, Bhattacharya S, McAuliffe FM, Galindo A, Herraiz I, Carbillon L, Klipstein-Grobusch K, Yeo S, Teede HJ, Browne JL, Moons KGM, Riley RD, Thangaratinam S, Network IC. Validation and development of models using clinical, biochemical and ultrasound markers for predicting pre-eclampsia: an individual participant data meta-analysis. Health Technology Assessment 2020;24:I-+ https://doi.org/10.3310/hta24720 

Townsend R, Khalil A, Premakumar Y, Allotev J, Snell KIE, Chan C, Chappell LC, Hooper R, Green M, Mol BW, Thilaganathan B, Thangaratinam S, Allotey J, Snell K, Dodds J, Rogozinska E, Khan K, Poston L, Kenny L, Myers J, Chappell L, Von Dadelszen P, Ahmed A, Moons K, Riley RD, Network I. Prediction of pre-eclampsia: review of reviews. Ultrasound in Obstetrics & Gynecology 2019;54:16-+ https://doi.org/10.1002/uog.20117 

Sohanpal R, Jumbe S, James WY, Steed L, Yau T, Rivas C, Madurasinghe V, Houlihan C, Berdunisov V, Taylor M, Taylor SJC, Griffiths C, Eldridge S, Walton R. Evaluating the effectiveness and cost-effectiveness of the Smoking Treatment Optimisation in Pharmacies (STOP) intervention: protocol for a cluster randomised controlled trial. Trials 2019;20: https://doi.org/10.1186/s13063-019-3368-6 

Peden CJ, Stephens T, Martin G, Kahan BC, Thomson A, Rivett K, Wells D, Richardson G, Kerry S, Bion J, Pearse RM, Enhanced Peri-Operative Care for High-risk patients trial g. Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial. Lancet 2019; https://doi.org/10.1016/S0140-6736(18)32521-2 

Nichols VP, Ellard DR, Griffiths FE, Underwood M, Taylor SJC, Patel S, Bright M, Carnes D, Davies B, Eldridge S, Ellard D, Evans S, Griffiths F, Haywood K, Hee SW, Matharu M, Petrou S, Pincus T, Sandhu H, Taylor S, Wilkie A, Higgins H, Nichols V, Patel S, Potter R, Boss D, White K, Achana F, Mistry H, Caldwell F, Probyn K, Team C. The CHESS trial: protocol for the process evaluation of a randomised trial of an education and self-management intervention for people with chronic headache. Trials 2019;20: https://doi.org/10.1186/s13063-019-3372-x 

Mudway IS, Dundas I, Wood HE, Marlin N, Jamaludin JB, Bremner SA, Cross L, Grieve A, Nanzer A, Barratt B, Beevers S, Dajnak D, Fuller GW, Font A, Colligan G, Sheikh A, Walton R, Grigg J, Kelly FJ, Lee TH, Griffiths CJ. Impact of London's low emission zone on air quality and children's respiratory health: a sequential annual cross-sectional study. Lancet Public Health 2019;4:E28-E40 https://doi.org/10.1016/S2468-2667(18)30202-0 

Miller D, Pavitt S, Sharma V, Forbes G, Hooper R, Bhattacharya S, Kirkman-Brown J, Coomarasamy A, Lewis S, Cutting R, Brison D, Pacey A, West R, Brian K, Griffin D, Khalaf Y. Physiological, hyaluronan-selected intracytoplasmic sperm injection for infertility treatment (HABSelect): a parallel, two-group, randomised trial. Lancet 2019;393:416-422 https://doi.org/10.1016/S0140-6736(18)32989-1 

McRobbie H, Hajek P, Peerbux S, Kahan BC, Eldridge S, Trepel D, Parrott S, Griffiths C, Snuggs S, Smith KM. Randomised controlled trial and economic evaluation of a task-based weight management group programme. BMC Public Health 2019;19:365 https://doi.org/10.1186/s12889-019-6679-3 

McLoughlin C, Roberts TE, Jackson LJ, Moore P, Wilson M, Hooper R, Allard S, Wrench I, Beresford L, Geoghegan J, Daniels J, Catling S, Clark VA, Ayuk P, Robson S, Gao-Smith F, Hogg M, Lanz D, Dodds J, Khan KS, Grp SS. Cost-effectiveness of cell salvage and donor blood transfusion during caesarean section: results from a randomised controlled trial. Bmj Open 2019;9: https://doi.org/10.1136/bmjopen-2018-022352 

Martineau AR, Jolliffe DA, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, Goodall EC, Grant CC, Janssens W, Jensen ME, Kerley CP, Laaksi I, Manaseki-Holland S, Mauger D, Murdoch DR, Neale R, Rees JR, Simpson S, Stelmach I, Kumar GT, Urashima M, Camargo CA, Griffiths CJ, Hooper RL. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis. Health Technology Assessment 2019;23:1-+ https://doi.org/10.3310/hta23020 

Limb ES, Ahmad S, Cook DG, Kerry SM, Ekelund U, Whincup PH, Victor CR, Iliffe S, Ussher M, Fox-Rushby J, Furness C, Ibison J, DeWilde S, Harris T. Measuring change in trials of physical activity interventions: a comparison of self-report questionnaire and accelerometry within the PACE-UP trial. Int J Behav Nutr Phys Act 2019;16:10 https://doi.org/10.1186/s12966-018-0762-5 

Kirkman-Brown J, Pavitt S, Khalaf Y, Lewis S, Hooper R, Bhattacharya S, Coomarasamy A, Sharma V, Brison D, Forbes G, West R, Pacey A, Brian K, Cutting R, Bolton V, Miller D. Sperm selection for assisted reproduction by prior hyaluronan binding: the HABSelect RCT. Efficacy & Mechanism Evaluation 2019;6: https://doi.org/10.3310/eme06010 

Killaspy H, Priebe S, McPherson P, Zenhansi Z, McCrone P, Dowling S, Harrison I, Krotofil J, Dalton-Locke C, McGranahan R, Arbuthnott M, Curtis S, Leavey G, MacPherson R, Eldridge S, King M. Feasibility Randomised Trial Comparing Two Forms of Mental Health Supported Accommodation (Supported Housing and Floating Outreach); a Component of the QuEST (Quality and Effectiveness of Supported Tenancies) Study. Frontiers in Psychiatry 2019;10: https://doi.org/10.3389/fpsyt.2019.00258 

Killaspy H, Priebe S, King M, Eldridge S, McCrone P, Shepherd G, Arbuthnott M, Leavey G, Curtis S, McPherson P, Dowling S. Supported accommodation for people with mental health problems: the QuEST research programme with feasibility RCT. Programme Grants for Applied Research 2019;7: https://doi.org/10.3310/pgfar07070 

Jumbe S, James WY, Madurasinghe V, Steed L, Sohanpal R, Yau TK, Taylor S, Eldridge S, Griffiths C, Walton R. Evaluating NHS Stop Smoking Service engagement in community pharmacies using simulated smokers: fidelity assessment of a theory-based intervention. Bmj Open 2019;9: https://doi.org/10.1136/bmjopen-2018-026841 

Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, Camargo CA, Griffiths CJ, Janssens W, Martineau AR. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax 2019; https://doi.org/10.1136/thoraxjnl-2018-212092 

Edwards MR, Forbes G, MacDonald N, Berdunov V, Mihaylova B, Dias P, Thomson A, Grocott MP, Mythen MG, Gillies MA, Sander M, Phan TD, Evered L, Wijeysundera DN, McCluskey SA, Aldecoa C, Ripolles-Melchor J, Hofer CK, Abukhudair H, Szczeklik W, Grigoras I, Hajjar LA, Kahan BC, Pearse RM, investigators OI. Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery. BMJ Open 2019;9:e023455 https://doi.org/10.1136/bmjopen-2018-023455 

Al Wattar BH, Dodds J, Placzek A, Beresford L, Spyreli E, Moore A, Carreras FJG, Austin F, Murugesu N, Roseboom TJ, Bes-Rastrollo M, Hitman GA, Hooper R, Khan KS, Thangaratinam S, Khan R, Khalil A, Oon V, Gupta M, Ohara C, Grp ES. Mediterranean-style diet in pregnant women with metabolic risk factors (ESTEEM): A pragmatic multicentre randomised trial. Plos Medicine 2019;16: https://doi.org/10.1371/journal.pmed.1002857 

Wiggins M, Sawtell M, Wiseman O, McCourt C, Greenberg L, Hunter R, Eldridge S, Haora P, Kaur I, Harden A. Testing the effectiveness of REACH Pregnancy Circles group antenatal care: protocol for a randomised controlled pilot trial. Pilot Feasibility Stud 2018;4:169 https://doi.org/10.1186/s40814-018-0361-x 

Thangaratinam S, Marlin N, Newton S, Weckesser A, Bagary M, Greenhill L, Rikunenko R, D'Amico M, Rogozinska E, Kelso A, Hard K, Coleman J, Moss N, Roberts T, Middleton L, Dodds J, Pullen A, Eldridge S, Pirie A, Denny E, McCorry D, Khan KS. AntiEpileptic drug Monitoring in PREgnancy (EMPiRE): a double-blind randomised trial on effectiveness and acceptability of monitoring strategies. Health Technol Assess 2018;22:1-152 https://doi.org/10.3310/hta22230 

Sohal AH, Feder G, Barbosa E, Beresford L, Dowrick A, El-Shogri F, Howell A, Lewis N, Johnson M, Nightingale C, Boomla K, Morris S, Eldridge S, Griffiths C. Improving the healthcare response to domestic violence and abuse in primary care: protocol for a mixed method evaluation of the implementation of a complex intervention. BMC Public Health 2018;18:971 https://doi.org/10.1186/s12889-018-5865-z 

Sawtell M, Sweeney L, Wiggins M, Salisbury C, Eldridge S, Greenberg L, Hunter R, Kaur I, McCourt C, Hatherall B, Findlay G, Morris J, Reading S, Renton A, Adekoya R, Green B, Harvey B, Latham S, Patel K, Vanlessen L, Harden A. Evaluation of community-level interventions to increase early initiation of antenatal care in pregnancy: protocol for the Community REACH study, a cluster randomised controlled trial with integrated process and economic evaluations. Trials 2018;19:163 https://doi.org/10.1186/s13063-018-2526-6 

McAlees E, Vollebregt PF, Stevens N, Dudding TC, Emmanuel AV, Furlong PL, Hamdy S, Hooper RL, Jones JFX, Norton C, O'Connell PR, Scott SM, Knowles CH. Efficacy and mechanism of sub-sensory sacral (optimised) neuromodulation in adults with faecal incontinence: study protocol for a randomised controlled trial. Trials 2018;19:336 https://doi.org/10.1186/s13063-018-2689-1 

Khan KS, Moore P, Wilson M, Hooper R, Allard S, Wrench I, Roberts T, McLoughlin C, Beresford L, Geoghegan J, Daniels J, Catling S, Clark VA, Ayuk P, Robson S, Gao-Smith F, Hogg M, Jackson L, Lanz D, Dodds J. A randomised controlled trial and economic evaluation of intraoperative cell salvage during caesarean section in women at risk of haemorrhage: the SALVO (cell SALVage in Obstetrics) trial. Health Technol Assess 2018;22:1-88 https://doi.org/10.3310/hta22020 

Kerry SM, Morgan KE, Limb E, Cook DG, Furness C, Carey I, DeWilde S, Victor CR, Iliffe S, Whincup P, Ussher M, Ekelund U, Fox-Rushby J, Ibison J, Harris T. Interpreting population reach of a large, successful physical activity trial delivered through primary care. BMC Public Health 2018;18:170 https://doi.org/10.1186/s12889-018-5034-4 

James WY, Jumbe S, Madurasinghe V, Eldridge S, Taylor S, Houlihan C, Griffiths C, Walton R. Supporting recruitment of community pharmacies for the STOP trial training using an embedded recruitment model ( Russian doll approach). European Respiratory Journal 2018;52: https://doi.org/10.1183/13993003.congress-2018.PA1229 

Harris T, Kerry SM, Limb ES, Furness C, Wahlich C, Victor CR, Iliffe S, Whincup PH, Ussher M, Ekelund U, Fox-Rushby J, Ibison J, DeWilde S, McKay C, Cook DG. Physical activity levels in adults and older adults 3-4 years after pedometer-based walking interventions: Long-term follow-up of participants from two randomised controlled trials in UK primary care. PLoS Med 2018;15:e1002526 https://doi.org/10.1371/journal.pmed.1002526 

Grossi U, Stevens N, McAlees E, Lacy-Colson J, Brown S, Dixon A, Di Tanna GL, Scott SM, Norton C, Marlin N, Mason J, Knowles CH, Grp NCW. Stepped-wedge randomised trial of laparoscopic ventral mesh rectopexy in adults with chronic constipation: study protocol for a randomized controlled trial. Trials 2018;19: https://doi.org/10.1186/s13063-018-2456-3 

Furness C, Howard E, Limb E, Cook DG, Kerry S, Wahlich C, Victor C, Ekelund U, Iliffe S, Ussher M, Whincup P, Fox-Rushby J, Ibison J, DeWilde S, Harris T. Relating process evaluation measures to complex intervention outcomes: findings from the PACE-UP primary care pedometer-based walking trial. Trials 2018;19:58 https://doi.org/10.1186/s13063-017-2428-z 

Flanagan S, Kunkel J, Appleby V, Eldridge SE, Ismail S, Moreea S, Griffiths C, Walton R, Pitt M, Salmon A, Madurasinghe V, Barnes E, Simms E, Agarwal K, Foster GR. Case finding and therapy for chronic viral hepatitis in primary care (HepFREE): a cluster-randomised controlled trial. Lancet Gastroenterol Hepatol 2018; https://doi.org/10.1016/S2468-1253(18)30318-2 

Flanagan S, Appleby VJ, Gaviria J, Kunkel J, Madurasinghe V, Eldridge S, Moreea S, Agarwal K, Barnes E, Griffiths C, Pitt M, Salmon A, Foster G. HepFree: Screening migrant patients for viral hepatitis in primary care. A 90,000 patient randomised controlled trial indicates benefits are most obvious in older patients. Journal of Hepatology 2018;68:S51-S52 https://doi.org/10.1016/S0168-8278(18)30323-4 

Barbosa EC, Verhoef TI, Morris S, Solmi F, Johnson M, Sohal A, El-Shogri F, Dowrick S, Ronalds C, Griffiths C, Eldridge S, Lewis NV, Devine A, Spencer A, Feder G. Cost-effectiveness of a domestic violence and abuse training and support programme in primary care in the real world: updated modelling based on an MRC phase IV observational pragmatic implementation study. BMJ Open 2018;8:e021256 https://doi.org/10.1136/bmjopen-2017-021256 

Ashaye T, Hounsome N, Carnes D, Taylor SJC, Homer K, Eldridge S, Spencer A, Rahman A, Foell J, Underwood MR, 24426731 CSTI. Opioid prescribing for chronic musculoskeletal pain in UK primary care: results from a cohort analysis of the COPERS trial. Bmj Open 2018;8: https://doi.org/10.1136/bmjopen-2017-019491 

Anokye N, Fox-Rushby J, Sanghera S, Cook DG, Limb E, Furness C, Kerry SM, Victor CR, Iliffe S, Ussher M, Whincup PH, Ekelund U, deWilde S, Harris T. Short-term and long-term cost-effectiveness of a pedometer-based exercise intervention in primary care: a within-trial analysis and beyond-trial modelling. BMJ Open 2018;8:e021978 https://doi.org/10.1136/bmjopen-2018-021978 

Waugh J, Hooper R, Lamb E, Robson S, Shennan A, Milne F, Price C, Thangaratinam S, Berdunov V, Bingham J. Spot protein-creatinine ratio and spot albumin-creatinine ratio in the assessment of pre-eclampsia: a diagnostic accuracy study with decision-analytic model-based economic evaluation and acceptability analysis. Health Technol Assess 2017;21:1-90 https://doi.org/10.3310/hta21610 

Thangaratinam S, Allotey J, Marlin N, Mol BW, Von Dadelszen P, Ganzevoort W, Akkermans J, Ahmed A, Daniels J, Deeks J, Ismail K, Barnard AM, Dodds J, Kerry S, Moons C, Riley RD, Khan KS. Development and validation of Prediction models for Risks of complications in Early-onset Pre-eclampsia (PREP): a prospective cohort study. Health Technol Assess 2017;21:1-100 https://doi.org/10.3310/hta21180 

Thangaratinam S, Allotey J, Marlin N, Dodds J, Cheong-See F, von Dadelszen P, Ganzevoort W, Akkermans J, Kerry S, Mol BW, Moons KG, Riley RD, Khan KS. Prediction of complications in early-onset pre-eclampsia (PREP): development and external multinational validation of prognostic models. BMC Med 2017;15:68 https://doi.org/10.1186/s12916-017-0827-3 

Steed L, Sohanpal R, James WY, Rivas C, Jumbe S, Chater A, Todd A, Edwards E, Macneil V, Macfarlane F, Greenhalgh T, Griffiths C, Eldridge S, Taylor S, Walton R. Equipping community pharmacy workers as agents for health behaviour change: developing and testing a theory-based smoking cessation intervention. BMJ Open 2017;7:e015637 https://doi.org/10.1136/bmjopen-2016-015637 

Rogozinska E, Marlin N, Jackson L, Rayanagoudar G, Ruifrok AE, Dodds J, Molyneaux E, van Poppel MN, Poston L, Vinter CA, McAuliffe F, Dodd JM, Owens J, Barakat R, Perales M, Cecatti JG, Surita F, Yeo S, Bogaerts A, Devlieger R, Teede H, Harrison C, Haakstad L, Shen GX, Shub A, Beltagy NE, Motahari N, Khoury J, Tonstad S, Luoto R, Kinnunen TI, Guelfi K, Facchinetti F, Petrella E, Phelan S, Scudeller TT, Rauh K, Hauner H, Renault K, de Groot CJ, Sagedal LR, Vistad I, Stafne SN, Morkved S, Salvesen KA, Jensen DM, Vitolo M, Astrup A, Geiker NR, Kerry S, Barton P, Roberts T, Riley RD, Coomarasamy A, Mol BW, Khan KS, Thangaratinam S. Effects of antenatal diet and physical activity on maternal and fetal outcomes: individual patient data meta-analysis and health economic evaluation. Health Technol Assess 2017;21:1-158 https://doi.org/10.3310/hta21410 

Rogozinska E, Marlin N, Betran AP, Astrup A, Bogaerts A, Cecatti JG, Devlieger R, Dodd JM, El Beltagy N, Facchinetti F, Geiker NRW, Guelfi KJ, Haakstad LAH, Harrison CL, Hauner H, Jensen DM, Kinnunen TI, Khoury J, Luoto R, McAuliffe F, Motahari N, Morkved S, Owens J, Perales M, Petrella E, Phelan S, Poston L, Rauh K, Renault KM, Sagedal LR, Salvesen KA, Shen GX, Shub A, Scudeller T, Surita FG, Stafne SN, Teede H, Tonstad S, van Poppel MNM, Vinter CA, Vistad I, Yeo S, Dodds J, Kerry S, Jackson L, Barton P, Molyneaux E, Martin AA, Rayanagoudar G, Ruifrok AE, Roberts T, de Groot CJM, Coomarasamy A, Mol BWJ, Zamora J, Khan KS, Riley RD, Thangaratinam S. Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials The International Weight Management in Pregnancy (i-WIP) Collaborative Group. BMJ 2017;358: https://doi.org/10.1136/bmj.j3119 

Robson J, Dostal I, Madurasinghe V, Sheikh A, Hull S, Boomla K, Griffiths C, Eldridge S. NHS Health Check comorbidity and management: an observational matched study in primary care. Br J Gen Pract 2017;67:e86-e93 https://doi.org/10.3399/bjgp16X688837 

Rivas C, Sohanpal R, MacNeill V, Steed L, Edwards E, Antao L, Griffiths C, Eldridge S, Taylor S, Walton R. Determining counselling communication strategies associated with successful quits in the National Health Service community pharmacy Stop Smoking programme in East London: a focused ethnography using recorded consultations. BMJ Open 2017;7:e015664 https://doi.org/10.1136/bmjopen-2016-015664 

Priebe S, Golden E, Kingdon D, Omer S, Walsh S, Katevas K, McCrone P, Eldridge S, McCabe R. Effective patient-clinician interaction to improve treatment outcomes for patients with psychosis: a mixed-methods design. Programme Grants for Applied Research 2017;5:6 https://doi.org/10.3310/pgfar05060 

Norton C, Emmanuel A, Stevens N, Scott SM, Grossi U, Bannister S, Eldridge S, Mason JM, Knowles CH. Habit training versus habit training with direct visual biofeedback in adults with chronic constipation: study protocol for a randomised controlled trial. Trials 2017;18:139 https://doi.org/10.1186/s13063-017-1880-0 

Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, Goodall EC, Grant CC, Griffiths CJ, Janssens W, Laaksi I, Manaseki-Holland S, Mauger D, Murdoch DR, Neale R, Rees JR, Simpson S, Jr., Stelmach I, Kumar GT, Urashima M, Camargo CA, Jr. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017;356:i6583 https://doi.org/10.1136/bmj.i6583 

Madurasinghe VW, Sohanpal R, James W, Steed L, Eldridge S, Taylor S, Griffiths C, Walton R. Smoking treatment optimisation in pharmacies (STOP): a cluster randomised pilot trial of a training intervention. Pilot Feasibility Stud 2017;3:1 https://doi.org/10.1186/s40814-016-0120-9 

Khan KS, Moore PAS, Wilson MJ, Hooper R, Allard S, Wrench I, Beresford L, Roberts TE, McLoughlin C, Geoghegan J, Daniels JP, Catling S, Clark VA, Ayuk P, Robson S, Gao-Smith F, Hogg M, Lanz D, Dodds J, group Ss. Cell salvage and donor blood transfusion during cesarean section: A pragmatic, multicentre randomised controlled trial (SALVO). PLoS Med 2017;14:e1002471 https://doi.org/10.1371/journal.pmed.1002471 

Jolliffe DA, Greenberg L, Hooper RL, Griffiths CJ, Camargo CA, Jr., Kerley CP, Jensen ME, Mauger D, Stelmach I, Urashima M, Martineau AR. Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data. Lancet Respir Med 2017;5:881-890 https://doi.org/10.1016/S2213-2600(17)30306-5 

Harris T, Kerry SM, Limb ES, Victor CR, Iliffe S, Ussher M, Whincup PH, Ekelund U, Fox-Rushby J, Furness C, Anokye N, Ibison J, DeWilde S, David L, Howard E, Dale R, Smith J, Cook DG. Effect of a Primary Care Walking Intervention with and without Nurse Support on Physical Activity Levels in 45- to 75-Year-Olds: The Pedometer And Consultation Evaluation (PACE-UP) Cluster Randomised Clinical Trial. PLoS Med 2017;14:e1002210 https://doi.org/10.1371/journal.pmed.1002210 

Emmett C, Close H, Mason J, Taheri S, Stevens N, Eldridge S, Norton C, Knowles C, Yiannakou Y. Low-volume versus high-volume initiated trans-anal irrigation therapy in adults with chronic constipation: study protocol for a randomised controlled trial. Trials 2017;18:151 https://doi.org/10.1186/s13063-017-1882-y 

Duncan M, Deane J, White PD, Ridge D, Roylance R, Korszun A, Chalder T, Bhui KS, Thaha MA, Bourke L. A survey to determine usual care after cancer treatment within the United Kingdom national health service. BMC Cancer 2017;17:186 https://doi.org/10.1186/s12885-017-3172-1 

Bell L, Hooper R, Bunce C, Pasu S, Bainbridge J. Positioning In Macular hole Surgery (PIMS): statistical analysis plan for a randomised controlled trial. Trials 2017;18:274 https://doi.org/10.1186/s13063-017-2020-6 

Allotey J, Snell KIE, Chan C, Hooper R, Dodd J, Rogozinska E, Khan KS, Poston L, Kenny L, Myers J, Thilaganathan B, Chapell L, Mol BW, Von Dadelszen P, Ahmed A, Green M, Poon L, Khalil A, Moons KGM, Riley RD, Thangaratinam S. External validation, update and development of prediction models for preeclampsia using an Individual Participant Data (IPD) meta-analysis: the International Prediction of Pregnancy Complication Network (IPPIC pre-eclampsia) protocol. Diagn Progn Res 2017;1:16 https://doi.org/10.1186/s41512-017-0016-z 

Witt KD, Beresford L, Bhattacharya S, Brian K, Coomarasamy A, Cutting R, Hooper R, Kirkman-Brown J, Khalaf Y, Lewis SE, Pacey A, Pavitt S, West R, Miller D. Hyaluronic Acid Binding Sperm Selection for assisted reproduction treatment (HABSelect): study protocol for a multicentre randomised controlled trial. BMJ Open 2016;6:e012609 https://doi.org/10.1136/bmjopen-2016-012609 

Taylor SJC, Carnes D, Homer K, Pincus T, Kahan BC, Hounsome N, Eldridge S, Spencer A, Diaz-Ordaz K, Rahman A, Mars TS, Foell J, Griffiths CJ, Underwood MR. Improving the self-management of chronic pain: COping with persistent Pain, Effectiveness Research in Self-management (COPERS). Programme Grants for Applied Research 2016;4:14 https://doi.org/10.3310/pgfar04140 

Taylor SJ, Carnes D, Homer K, Kahan BC, Hounsome N, Eldridge S, Spencer A, Pincus T, Rahman A, Underwood M. Novel Three-Day, Community-Based, Nonpharmacological Group Intervention for Chronic Musculoskeletal Pain (COPERS): A Randomised Clinical Trial. PLoS Med 2016;13:e1002040 https://doi.org/10.1371/journal.pmed.1002040 

Sohanpal R, Rivas C, Steed L, MacNeill V, Kuan V, Edwards E, Griffiths C, Eldridge S, Taylor S, Walton R. Understanding recruitment and retention in the NHS community pharmacy stop smoking service: perceptions of smoking cessation advisers. BMJ Open 2016;6:e010921 https://doi.org/10.1136/bmjopen-2015-010921 

Robson J, Dostal I, Sheikh A, Eldridge S, Madurasinghe V, Griffiths C, Coupland C, Hippisley-Cox J. The NHS Health Check in England: an evaluation of the first 4 years. BMJ Open 2016;6:e008840 https://doi.org/10.1136/bmjopen-2015-008840 

Priebe S, Savill M, Wykes T, Bentall RP, Reininghaus U, Lauber C, Bremner S, Eldridge S, Rohricht F. Effectiveness of group body psychotherapy for negative symptoms of schizophrenia: multicentre randomised controlled trial. Br J Psychiatry 2016;209:54-61 https://doi.org/10.1192/bjp.bp.115.171397 

Priebe S, Savill M, Wykes T, Bentall R, Lauber C, Reininghaus U, McCrone P, Mosweu I, Bremner S, Eldridge S, Rohricht F. Clinical effectiveness and cost-effectiveness of body psychotherapy in the treatment of negative symptoms of schizophrenia: a multicentre randomised controlled trial. Health Technol Assess 2016;20:vii-xxiii, 1-100 https://doi.org/10.3310/hta20110 

Priebe S, Pavlickova H, Eldridge S, Golden E, McCrone P, Ockenden N, Pistrang N, King M. Effectiveness of one-to-one volunteer support for patients with psychosis: protocol of a randomised controlled trial. BMJ Open 2016;6:e011582 https://doi.org/10.1136/bmjopen-2016-011582 

Priebe S, Bremner SA, Pavlickova H. Discontinuing financial incentives for adherence to antipsychotic depot medication: long-term outcomes of a cluster randomised controlled trial. BMJ Open 2016;6:e011673 https://doi.org/10.1136/bmjopen-2016-011673 

Priebe S, Bremner SA, Lauber C, Henderson C, Burns T. Financial incentives to improve adherence to antipsychotic maintenance medication in non-adherent patients: a cluster randomised controlled trial. Health Technol Assess 2016;20:1-122 https://doi.org/10.3310/hta20700 

Normansell R, Holmes R, Victor C, Cook DG, Kerry S, Iliffe S, Ussher M, Fox-Rushby J, Whincup P, Harris T. Exploring non-participation in primary care physical activity interventions: PACE-UP trial interview findings. Trials 2016;17:178 https://doi.org/10.1186/s13063-016-1299-z 

McRobbie H, Hajek P, Peerbux S, Kahan BC, Eldridge S, Trepel D, Parrott S, Griffiths C, Snuggs S, Myers Smith K. Tackling obesity in areas of high social deprivation: clinical effectiveness and cost-effectiveness of a task-based weight management group programme - a randomised controlled trial and economic evaluation. Health Technol Assess 2016;20:1-150 https://doi.org/10.3310/hta20790 

McCabe R, John P, Dooley J, Healey P, Cushing A, Kingdon D, Bremner S, Priebe S. Training to enhance psychiatrist communication with patients with psychosis (TEMPO): cluster randomised controlled trial. Br J Psychiatry 2016;209:517-524 https://doi.org/10.1192/bjp.bp.115.179499 

MacInnes D, Kinane C, Parrott J, Mansfield J, Craig T, Eldridge S, Marsh I, Chan C, Hounsome N, Harrison G, Priebe S. A pilot cluster randomised trial to assess the effect of a structured communication approach on quality of life in secure mental health settings: The Comquol Study. BMC Psychiatry 2016;16:335 https://doi.org/10.1186/s12888-016-1046-8 

Knowles CH, Horrocks EJ, Stevens N, Norton C, Eldridge S. The CONFIDeNT trial - Authors' reply. Lancet 2016;387:644-5 https://doi.org/10.1016/S0140-6736(15)01342-2 

Killaspy H, Priebe S, Bremner S, McCrone P, Dowling S, Harrison I, Krotofil J, McPherson P, Sandhu S, Arbuthnott M, Curtis S, Leavey G, Shepherd G, Eldridge S, King M. Quality of life, autonomy, satisfaction, and costs associated with mental health supported accommodation services in England: a national survey. Lancet Psychiatry 2016;3:1129-1137 https://doi.org/10.1016/S2215-0366(16)30327-3 

Hewett N, Buchman P, Musariri J, Sargeant C, Johnson P, Abeysekera K, Grant L, Oliver EA, Eleftheriades C, McCormick B, Halligan A, Marlin N, Kerry S, Foster GR. Randomised controlled trial of GP-led in-hospital management of homeless people ('Pathway'). Clin Med 2016;16:223-9 https://doi.org/10.7861/clinmedicine.16-3-223 

Griffiths C, Bremner S, Islam K, Sohanpal R, Vidal DL, Dawson C, Foster G, Ramsay J, Feder G, Taylor S, Barnes N, Choudhury A, Packe G, Bayliss E, Trathen D, Moss P, Cook V, Livingstone AE, Eldridge S. Effect of an Education Programme for South Asians with Asthma and Their Clinicians: A Cluster Randomised Controlled Trial (OEDIPUS). PLoS One 2016;11:e0158783 https://doi.org/10.1371/journal.pone.0158783 

Ayerbe L, Gonzalez E, Gallo V, Coleman CL, Wragg A, Robson J. Clinical assessment of patients with chest pain; a systematic review of predictive tools. BMC Cardiovasc Disord 2016;16:18 https://doi.org/10.1186/s12872-016-0196-4 

Al Wattar BH, Dodds J, Placzek A, Spyreli E, Moore A, Hooper R, Beresford L, Roseboom TJ, Bes-Rastrollo M, Hitman G, Khan KS, Thangaratinam S. Effect of simple, targeted diet in pregnant women with metabolic risk factors on maternal and fetal outcomes (ESTEEM): study protocol for a pragmatic multicentre randomised trial. BMJ Open 2016;6:e013495 https://doi.org/10.1136/bmjopen-2016-013495 

Wood HE, Marlin N, Mudway IS, Bremner SA, Cross L, Dundas I, Grieve A, Grigg J, Jamaludin JB, Kelly FJ, Lee T, Sheikh A, Walton R, Griffiths CJ. Effects of Air Pollution and the Introduction of the London Low Emission Zone on the Prevalence of Respiratory and Allergic Symptoms in Schoolchildren in East London: A Sequential Cross-Sectional Study. PLoS One 2015;10:e0109121 https://doi.org/10.1371/journal.pone.0109121 

Thin NN, Taylor SJ, Bremner SA, Emmanuel AV, Hounsome N, Williams NS, Knowles CH. Randomized clinical trial of sacral versus percutaneous tibial nerve stimulation in patients with faecal incontinence. Br J Surg 2015;102:349-58 https://doi.org/10.1002/bjs.9695 

Stansfeld SA, Kerry S, Chandola T, Russell J, Berney L, Hounsome N, Lanz D, Costelloe C, Smuk M, Bhui K. Pilot study of a cluster randomised trial of a guided e-learning health promotion intervention for managers based on management standards for the improvement of employee well-being and reduction of sickness absence: GEM Study. BMJ Open 2015;5:e007981 https://doi.org/10.1136/bmjopen-2015-007981 

Stansfeld SA, Berney L, Bhui K, Chandola T, Costelloe C, Hounsome N, Kerry S, Lanz D, Russell J. Pilot study of a randomised trial of a guided e-learning health promotion intervention for managers based on management standards for the improvement of employee well-being and reduction of sickness absence: the GEM (Guided E-learning for Managers) study. Public Health Research 2015;3:9 https://doi.org/10.3310/phr03090 

Robson J, Dostal I, Madurasinghe V, Sheikh A, Hull S, Boomla K, Page H, Griffiths C, Eldridge S. The NHS Health Check programme: implementation in east London 2009-2011. BMJ Open 2015;5:e007578 https://doi.org/10.1136/bmjopen-2015-007578 

Pavlickova H, Bremner SA, Priebe S. The effect of financial incentives on adherence to antipsychotic depot medication: does it change over time? J Clin Psychiatry 2015;76:e1029-34 https://doi.org/10.4088/JCP.14m09669 

Pasu S, Bunce C, Hooper R, Thomson A, Bainbridge J. PIMS (Positioning In Macular hole Surgery) trial - a multicentre interventional comparative randomised controlled clinical trial comparing face-down positioning, with an inactive face-forward position on the outcome of surgery for large macular holes: study protocol for a randomised controlled trial. Trials 2015;16:527 https://doi.org/10.1186/s13063-015-1048-8 

Nwokoro C, Pandya H, Turner S, Eldridge S, Griffiths CJ, Vulliamy T, Price D, Sanak M, Holloway JW, Brugha R, Koh L, Dickson I, Rutterford C, Grigg J. Parent-determined oral montelukast therapy for preschool wheeze with stratification for arachidonate 5-lipoxygenase (ALOX5) promoter genotype: a multicentre, randomised, placebo-controlled trial. Efficacy and Mechanism Evaluation 2015;2:6 https://doi.org/10.3310/eme02060 

Norton C, Dibley LB, Hart A, Duncan J, Emmanuel A, Knowles CH, Stevens N, Terry H, Verjee A, Kerry S, Hounsome N. Faecal incontinence intervention study (FINS): self-management booklet information with or without nurse support to improve continence in people with inflammatory bowel disease: study protocol for a randomized controlled trial. Trials 2015;16:444 https://doi.org/10.1186/s13063-015-0962-0 

Martineau AR, MacLaughlin BD, Hooper RL, Barnes NC, Jolliffe DA, Greiller CL, Kilpin K, McLaughlin D, Fletcher G, Mein CA, Hoti M, Walton R, Grigg J, Timms PM, Rajakulasingam RK, Bhowmik A, Rowe M, Venton TR, Choudhury AB, Simcock DE, Sadique Z, Monteiro WR, Corrigan CJ, Hawrylowicz CM, Griffiths CJ. Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs). Thorax 2015;70:451-7 https://doi.org/10.1136/thoraxjnl-2014-206449 

Martineau AR, James WY, Hooper RL, Barnes NC, Jolliffe DA, Greiller CL, Islam K, McLaughlin D, Bhowmik A, Timms PM, Rajakulasingam RK, Rowe M, Venton TR, Choudhury AB, Simcock DE, Wilks M, Degun A, Sadique Z, Monteiro WR, Corrigan CJ, Hawrylowicz CM, Griffiths CJ. Vitamin D3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trial. Lancet Respir Med 2015;3:120-130 https://doi.org/10.1016/S2213-2600(14)70255-3 

Martineau AR, Hanifa Y, Witt KD, Barnes NC, Hooper RL, Patel M, Stevens N, Enayat Z, Balayah Z, Syed A, Knight A, Jolliffe DA, Greiller CL, McLaughlin D, Venton TR, Rowe M, Timms PM, Clark D, Sadique Z, Eldridge SM, Griffiths CJ. Double-blind randomised controlled trial of vitamin D3 supplementation for the prevention of acute respiratory infection in older adults and their carers (ViDiFlu). Thorax 2015;70:953-60 https://doi.org/10.1136/thoraxjnl-2015-206996 

Leber W, McMullen H, Anderson J, Marlin N, Santos AC, Bremner S, Boomla K, Kerry S, Millett D, Mguni S, Creighton S, Figueroa J, Ashcroft R, Hart G, Delpech V, Brown A, Rooney G, Sampson M, Martineau A, Terris-Prestholt F, Griffiths C. Promotion of rapid testing for HIV in primary care (RHIVA2): a cluster-randomised controlled trial. Lancet HIV 2015;2:e229-35 https://doi.org/10.1016/S2352-3018(15)00059-4 

Knowles CH, Horrocks EJ, Bremner SA, Stevens N, Norton C, O'Connell PR, Eldridge S. Percutaneous tibial nerve stimulation versus sham electrical stimulation for the treatment of faecal incontinence in adults (CONFIDeNT): a double-blind, multicentre, pragmatic, parallel-group, randomised controlled trial. Lancet 2015;386:1640-8 https://doi.org/10.1016/S0140-6736(15)60314-2 

Horrocks EJ, Bremner SA, Stevens N, Norton C, Gilbert D, O'Connell PR, Eldridge S, Knowles CH. Double-blind randomised controlled trial of percutaneous tibial nerve stimulation versus sham electrical stimulation in the treatment of faecal incontinence: CONtrol of Faecal Incontinence using Distal NeuromodulaTion (the CONFIDeNT trial). Health Technol Assess 2015;19:1-164 https://doi.org/10.3310/hta19770 

Henderson C, Knapp M, Yeeles K, Bremner S, Eldridge S, David AS, O'Connell N, Burns T, Priebe S. Cost-Effectiveness of Financial Incentives to Promote Adherence to Depot Antipsychotic Medication: Economic Evaluation of a Cluster-Randomised Controlled Trial. PLoS One 2015;10:e0138816 https://doi.org/10.1371/journal.pone.0138816 

Nwokoro C, Pandya H, Turner S, Eldridge S, Griffiths CJ, Vulliamy T, Price D, Sanak M, Holloway JW, Brugha R, Koh L, Dickson I, Rutterford C, Grigg J. Intermittent montelukast in children aged 10 months to 5 years with wheeze (WAIT trial): a multicentre, randomised, placebo-controlled trial. Lancet Respir Med 2014;2:796-803 https://doi.org/10.1016/S2213-2600(14)70186-9 

Kahan BC, Diaz-Ordaz K, Homer K, Carnes D, Underwood M, Taylor SJ, Bremner SA, Eldridge S. Coping with persistent pain, effectiveness research into self-management (COPERS): statistical analysis plan for a randomised controlled trial. Trials 2014;15:59 https://doi.org/10.1186/1745-6215-15-59 

Underwood M, Lamb SE, Eldridge S, Sheehan B, Slowther AM, Spencer A, Thorogood M, Atherton N, Bremner SA, Devine A, Diaz-Ordaz K, Ellard DR, Potter R, Spanjers K, Taylor SJ. Exercise for depression in elderly residents of care homes: a cluster-randomised controlled trial. Lancet 2013;382:41-9 https://doi.org/10.1016/S0140-6736(13)60649-2 

Underwood M, Lamb SE, Eldridge S, Sheehan B, Slowther A, Spencer A, Thorogood M, Atherton N, Bremner SA, Devine A, Diaz-Ordaz K, Ellard DR, Potter R, Spanjers K, Taylor SJ. Exercise for depression in care home residents: a randomised controlled trial with cost-effectiveness analysis (OPERA). Health Technol Assess 2013;17:1-281 https://doi.org/10.3310/hta17180 

Priebe S, Yeeles K, Bremner S, Lauber C, Eldridge S, Ashby D, David AS, O'Connell N, Forrest A, Burns T. Effectiveness of financial incentives to improve adherence to maintenance treatment with antipsychotics: cluster randomised controlled trial. BMJ 2013;347:f5847 https://doi.org/10.1136/bmj.f5847 

Priebe S, Savill M, Reininghaus U, Wykes T, Bentall R, Lauber C, McCrone P, Rohricht F, Eldridge S. Effectiveness and cost-effectiveness of body psychotherapy in the treatment of negative symptoms of schizophrenia--a multi-centre randomised controlled trial. BMC Psychiatry 2013;13:26 https://doi.org/10.1186/1471-244X-13-26 

MacInnes D, Kinane C, Beer D, Parrott J, Craig T, Eldridge S, Marsh I, Krotofil J, Priebe S. Study to assess the effect of a structured communication approach on quality of life in secure mental health settings (Comquol): study protocol for a pilot cluster randomized trial. Trials 2013;14:257 https://doi.org/10.1186/1745-6215-14-257 

Harris T, Kerry SM, Victor CR, Shah SM, Iliffe S, Ussher M, Ekelund U, Fox-Rushby J, Whincup P, David L, Brewin D, Ibison J, DeWilde S, Limb E, Anokye N, Furness C, Howard E, Dale R, Cook DG. PACE-UP (Pedometer and consultation evaluation--UP)--a pedometer-based walking intervention with and without practice nurse support in primary care patients aged 45-75 years: study protocol for a randomised controlled trial. Trials 2013;14:418 https://doi.org/10.1186/1745-6215-14-418 

Carnes D, Taylor SJ, Homer K, Eldridge S, Bremner S, Pincus T, Rahman A, Underwood M. Effectiveness and cost-effectiveness of a novel, group self-management course for adults with chronic musculoskeletal pain: study protocol for a multicentre, randomised controlled trial (COPERS). BMJ Open 2013;3: https://doi.org/10.1136/bmjopen-2012-002492 

Taylor SJ, Sohanpal R, Bremner SA, Devine A, McDaid D, Fernandez JL, Griffiths CJ, Eldridge S. Self-management support for moderate-to-severe chronic obstructive pulmonary disease: a pilot randomised controlled trial. Br J Gen Pract 2012;62:e687-95 https://doi.org/10.3399/bjgp12X656829 

Sturdy P, Bremner S, Harper G, Mayhew L, Eldridge S, Eversley J, Sheikh A, Hunter S, Boomla K, Feder G, Prescott K, Griffiths C. Impact of asthma on educational attainment in a socioeconomically deprived population: a study linking health, education and social care datasets. PLoS One 2012;7:e43977 https://doi.org/10.1371/journal.pone.0043977 

Priebe S, Bhatti N, Barnicot K, Bremner S, Gaglia A, Katsakou C, Molosankwe I, McCrone P, Zinkler M. Effectiveness and cost-effectiveness of dialectical behaviour therapy for self-harming patients with personality disorder: a pragmatic randomised controlled trial. Psychother Psychosom 2012;81:356-65 https://doi.org/10.1159/000338897 

Underwood M, Eldridge S, Lamb S, Potter R, Sheehan B, Slowther AM, Taylor S, Thorogood M, Weich S. The OPERA trial: protocol for a randomised trial of an exercise intervention for older people in residential and nursing accommodation. Trials 2011;12:27 https://doi.org/10.1186/1745-6215-12-27 

Martineau AR, Timms PM, Bothamley GH, Hanifa Y, Islam K, Claxton AP, Packe GE, Moore-Gillon JC, Darmalingam M, Davidson RN, Milburn HJ, Baker LV, Barker RD, Woodward NJ, Venton TR, Barnes KE, Mullett CJ, Coussens AK, Rutterford CM, Mein CA, Davies GR, Wilkinson RJ, Nikolayevskyy V, Drobniewski FA, Eldridge SM, Griffiths CJ. High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet 2011;377:242-50 https://doi.org/10.1016/S0140-6736(10)61889-2 

Feder G, Davies RA, Baird K, Dunne D, Eldridge S, Griffiths C, Gregory A, Howell A, Johnson M, Ramsay J, Rutterford C, Sharp D. Identification and Referral to Improve Safety (IRIS) of women experiencing domestic violence with a primary care training and support programme: a cluster randomised controlled trial. Lancet 2011;378:1788-95 https://doi.org/10.1016/S0140-6736(11)61179-3 

Gregory A, Ramsay J, Agnew-Davies R, Baird K, Devine A, Dunne D, Eldridge S, Howell A, Johnson M, Rutterford C, Sharp D, Feder G. Primary care identification and referral to improve safety of women experiencing domestic violence (IRIS): protocol for a pragmatic cluster randomised controlled trial. BMC Public Health 2010;10:54 https://doi.org/10.1186/1471-2458-10-54 

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