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Pragmatic Clinical Trials Unit

Completed Studies

This section lists studies that PCTU has been involved in that have been completed and published.

Study Acronym

Calcitriol

Study Title

A randomised control trial to test whether active vitamin D can improve the clinical response to steroids in asthmatic patients.

PCTU Ref

0024               

Chief Investigator

Prof Christopher Corrigan 

Publications

 

CapaCITY

Study: Development of a UK evidence-based pathway for the management of chronic constipation in adults

Chief Investigator: Professor Charles Knowles, Queen Mary University of London

Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0612-20001)

Sponsor: Barts Health NHS Trust

PCTU Ref: P127

Study Acronym

Chronic Constipation

Study Title

Development of a UK evidence-based algorithm for management of chronic constipation

PCTU Ref

P100

Chief Investigator

Professor Charles Knowles, Queen Mary University of London 

Publications

 

Study Acronym

Comm Skill/ Psychosis

Study Title

Developing and piloting a new intervention to improve psychiatrist-patient communication about psychosis

PCTU Ref

P019

Chief Investigators

Professor Rose McCabe, City University of London 

Publications

 

Study Acronym

ComQuol                                                           

Study Title

A pilot trial to assess the effect of a structured COMmunication approach on QUality Of Life in secure mental health settings                                                           

PCTU Ref

P018                             

Chief Investigator

Dr. Douglas MacInnes, Canterbury Christ Church University

Publications

MacInnes D, Kinane C, Parrott J, Mansfield J, Craig T, Eldridge S, Marsh I, Chan C, Hounsome N, Harrison G, Priebe S. A pilot cluster randomised trial to assess the effect of a structured communication approach on quality of life in secure mental health settings: The Comquol Study. BMC Psychiatry 2016;16:335.

MacInnes D, Kinane C, Beer D, Parrott J, Craig T, Eldridge S, Marsh I, Krotofil J, Priebe S. Study to assess the effect of a structured communication approach on quality of life in secure mental health settings (Comquol): study protocol for a pilot cluster randomized trial. Trials 2013;14:257.

Study Acronym

CONFIDeNT                                                         

Study Title

CONtrol of Faecal Incontinence using Distal NeuromodulaTion                                     

PCTU Ref

P028

Chief Investigator 

Professor Charles Knowles, Queen Mary University of London

Publications

Knowles CH, Horrocks EJ, Bremner SA, Stevens N, Norton C, O'Connell PR, Eldridge S ( 2015 ) Percutaneous tibial nerve stimulation versus sham electrical stimulation for the treatment of faecal incontinence in adults (CONFIDeNT): A double-blind, multicentre, pragmatic, parallel-group, randomised controlled trial . The Lancet vol. 386 , ( 10004 ) 1640 - 1648  10.1016/S0140-6736(15)60314-2

Knowles CH, Horrocks EJ, Stevens N, Norton C, Eldridge S. The CONFIDeNT trial - Authors' reply. Lancet 2016;387:644-5. 

Study Acronym

COPERS                                                              

Study Title

COping with persistent Pain, Effectiveness Research for Self-management: a randomised controlled trial  

PCTU Ref

P054                           

Chief Investigator 

Professor Stephanie Taylor, Queen Mary University of London

Publications

Taylor SJ, Carnes D, Homer K, Kahan BC, Hounsome N, Eldridge S, Spencer A, Pincus T, Rahman A, Underwood M. Novel Three-Day, Community-Based, Nonpharmacological Group Intervention for Chronic Musculoskeletal Pain (COPERS): A Randomised Clinical Trial. PLoS Med 2016;13:e1002040. 

Taylor SJC, Carnes D, Homer K, Pincus T, Kahan BC, Hounsome N, Eldridge S, Spencer A, Diaz-Ordaz K, Rahman A, Mars TS, Foell J, Griffiths CJ, Underwood MR. Improving the self-management of chronic pain: COping with persistent Pain, Effectiveness Research in Self-management (COPERS). Programme Grants for Applied Research 2016;4:14.

Kahan BC, Diaz-Ordaz K, Homer K, Carnes D, Underwood M, Taylor SJ, Bremner SA, Eldridge S. Coping with persistent pain, effectiveness research into self-management (COPERS): statistical analysis plan for a randomised controlled trial. Trials 2014;15:59

Carnes D, Taylor SJ, Homer K, Eldridge S, Bremner S, Pincus T, Rahman A, Underwood M. Effectiveness and cost-effectiveness of a novel, group self-management course for adults with chronic musculoskeletal pain: study protocol for a multicentre, randomised controlled trial (COPERS). BMJ Open 2013;3:

Study Acronym CRESCENDO                                                              
Study Title                                      Development of a screening tool to predict the success of laparoscopic surgery for women                                                                                                 
PCTU Ref P263               
Chief Investigator

Miss Elizabeth Ball, Queen Mary University, London

Funder/Funding Stream  NIHR Research for Patient Benefit (PB-PG-0317-20018)                                                                                                                    
Sponsor Barts NHS Trust

 

Study Acronym

 DAPPA                          

Study Title

Spot protein creatinine ratio (SPCr) and spot albumin creatinine ratio (SACr) in the assessment of pre-eclampsia: A diagnostic accuracy study with decision analytic model based economic evaluation and acceptability analysis

PCTU Ref

P071

Chief Investigator

Dr Elizabeth Ball, Queen Mary University of London

Publications

 Waugh J, Hooper R, Lamb E, Robson S, Shennan A, Milne F, Price C, Thangaratinam S et al. ( 2017 ). Spot protein-creatinine ratio and spot albumin-creatinine ratio in the assessment of pre-eclampsia: A diagnostic accuracy study with decision-analytic model-based economic evaluation and acceptability analysis . Health Technology Assessment vol. 21 , ( 61 ) 1 - 90 10.3310/hta21610

Study Acronym

EMPiRE                                                            

Study Title

 AntiEpileptic drug Monitoring in PREgnancy: an evaluation of effectiveness, cost-effectiveness and acceptability of monitoring strategies                                                                           

PCTU Ref

P067                          

Chief Investigator

Professor Khalid Khan, Queen Mary University of London

Publications

Thangaratinam S, Marlin N, Newton S, Weckesser A, Bagary M, Greenhill L, Rikunenko R, D'Amico M, Rogozinska E, Kelso A, Hard K, Coleman J, Moss N, Roberts T, Middleton L, Dodds J, Pullen A, Eldridge S, Pirie A, Denny E, McCorry D, Khan KS. AntiEpileptic drug Monitoring in PREgnancy (EMPiRE): a double-blind randomised trial on effectiveness and acceptability of monitoring strategies. Health Technol Assess 2018;22:1-152. https://doi.org/10.3310/hta22230 

EMPOWER

Study: Enabling and Motivating People (with a Personality Disorder) in Occupation, Wellbeing, Education and Responsibility

Chief Investigator: Dr Janet Feigenbaum, North East London NHS Foundation Trust

Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-1212-20011)

Sponsor: North East London NHS Foundation Trust

PCTU Ref: P257

Study Acronym

EPOCH                                                           

Study Title

Enhanced Peri-Operative Care for High-risk patients (EPOCH) Trial:

A stepped wedge cluster randomised trial of a quality improvement intervention for patients undergoing emergency laparotomy                                                                      

PCTU Ref

P111                       

Chief Investigator

Professor Rupert Pearse, Queen Mary University of London

Publications

 

Study Acronym

EPOS                                                           

Study Title

Effective Patient-Clinician Communication in Community Mental Health Care 

PCTU Ref

P026                              

Chief Investigator

Professor Stefan Priebe, University College London

Publications

 

Study Acronym

ESTEEM          

Study Title

Effect of simple, targeted diet in pregnant women with metabolic risk factors on pre-eclampsia: A randomised trial

PCTU Ref

P138

Chief Investigator

Professor Shakila Thangaratinam, Queen Mary University of London

Publications

Al Wattar HB, Dodds J, Hooper R, Khan KK, Thangaratinam S ( 2018 ) . Effects of Mediterranean-style diet in pregnancies with metabolic risk factors (ESTEEM): A pragmatic multicentre randomized trial. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY . vol. 125 , 108 - 108.                                                            

Study Acronym

 FINS Active Case Finding

Study Title

Improving Continence in people with inflammatory bowel disease: active-finding and a randomised controlled trial

PCTU Ref

P143

Chief Investigator

Professor Christine Norton, King's College London

Publications

Norton C, Dibley LB, Hart A, Duncan J, Emmanuel A, Knowles CH, Stevens N, Terry H, Verjee A, Kerry S, Hounsome N. Faecal incontinence intervention study (FINS): self-management booklet information with or without nurse support to improve continence in people with inflammatory bowel disease: study protocol for a randomized controlled trial. Trials 2015;16:444. 

FRESH STREET

Study: A cluster trial of the benefits of a place and household-level subsidy for fresh fruit and vegetables on diet, health and the wider environment

Chief Investigator: Dr Clare Relton, Queen Mary University of London

Funder/Funding Stream: NIHR Public Health Research (NIHR129937)

Sponsor: Queen Mary university of London

PCTU Ref: P318

Study Acronym

GEM                                                

Study Title

Randomised trial of a guided e-learning health promotion intervention for managers based on management standards for the improvement of employee wellbeing and reduction of sickness absence

PCTU Ref

P084

Chief Investigator 

Professor Stephen A Stansfeld, Queen Mary University of London 

Publications

Stansfeld SA, Berney L, Bhui K, Chandola T, Costelloe C, Hounsome N, Kerry S, Lanz D, Russell J. Pilot study of a randomised trial of a guided e-learning health promotion intervention for managers based on management standards for the improvement of employee well-being and reduction of sickness absence: the GEM (Guided E-learning for Managers) study. Public Health Research 2015;3:9.

Stansfeld SA, Kerry S, Chandola T, Russell J, Berney L, Hounsome N, Lanz D, Costelloe C, Smuk M, Bhui K. Pilot study of a cluster randomised trial of a guided e-learning health promotion intervention for managers based on management standards for the improvement of employee well-being and reduction of sickness absence: GEM Study. BMJ Open 2015;5:e007981. 

Study Acronym

HABSelect                                                              

Study Title

Selection of sperm for Intracytoplasmic Sperm Injection (ICSI) by prior hyaluronic acid binding: improving the outcomes of Assisted Conception procedures and reducing miscarriage rates. 

PCTU Re 

P095                             

Chief Investigator 

Dr David Miller, University of Leeds

Publications

 

Study Acronym

HEPFree                                                                                                                          

Study Title

Chronic viral hepatitis in ethnic minorities. Strategies to prevent the predicted increase in mortality                                        

PCTU Ref

P047

Chief Investigator

Professor Graham Foster, Queen Mary University of London

Publications

Flanagan S, Kunkel J, Appleby V, Eldridge SE, Ismail S, Moreea S, Griffiths C, Walton R, Pitt M, Salmon A, Madurasinghe V, Barnes E, Simms E, Agarwal K, Foster GR. Case finding and therapy for chronic viral hepatitis in primary care (HepFREE): a cluster-randomised controlled trial. Lancet Gastroenterol Hepatol 2018; https://doi.org/10.1016/S2468-1253(18)30318-2 

Study Acronym

IMPART                            

Study Title

IMPlementing IMProved Asthma self-management as Routine Treatment

PCTU Ref

P162

Chief Investigator 

Dr.Hilary Pinnock , Queen Mary University of London

Publications

Study Acronym

ImprovE

Study Title

Exploring shared decision- making practices during involuntary hospital treatment 

PCTU Ref

P191

Chief Investigator

Dr. Domenico Giacco, Queen Mary University of London

Publications

 

Study Acronym

 iWIP                                                      

Study Title

Effects of weight management interventions on maternal and fetal outcomes in pregnancy: Individual patient data (IPD)
meta analysis of randomised trials and model based economic evaluation                                            

PCTU Ref

P105

Chief Investigator

Professor Shakila Thangaratinam, Queen Mary University of London

Publications

Rogozinska E, Marlin N, Betran AP, Astrup A, Bogaerts A, Cecatti JG, Devlieger R, Dodd JM, El Beltagy N, Facchinetti F, Geiker NRW, Guelfi KJ, Haakstad LAH, Harrison CL, Hauner H, Jensen DM, Kinnunen TI, Khoury J, Luoto R, McAuliffe F, Motahari N, Morkved S, Owens J, Perales M, Petrella E, Phelan S, Poston L, Rauh K, Renault KM, Sagedal LR, Salvesen KA, Shen GX, Shub A, Scudeller T, Surita FG, Stafne SN, Teede H, Tonstad S, van Poppel MNM, Vinter CA, Vistad I, Yeo S, Dodds J, Kerry S, Jackson L, Barton P, Molyneaux E, Martin AA, Rayanagoudar G, Ruifrok AE, Roberts T, de Groot CJM, Coomarasamy A, Mol BWJ, Zamora J, Khan KS, Riley RD, Thangaratinam S. Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials The International Weight Management in Pregnancy (i-WIP) Collaborative Group. BMJ 2017;358: https://doi.org/10.1136/bmj.j3119 

Study Acronym

LPE/Homeless

Study Title

Discharge planning for the homeless, examining The London Pathway. Does a GP led discharge team reduce the in-patient burden and improve quality of care?

PCTU Ref

P082

Chief Investigator

Professor Graham Foster, Queen Mary University of London

Publications

Hewett N, Buchman P, Musariri J, Sargeant C, Johnson P, Abeysekera K, Grant L, Oliver EA, Eleftheriades C, McCormick B, Halligan A, Marlin N, Kerry S, Foster GR. Randomised controlled trial of GP-led in-hospital management of homeless people ('Pathway'). Clin Med 2016;16:223-9. 

Study Acronym

MEMPHIS                                                  

Study Title

A smartphone app using psychological approaches for women with chronic pelvic pain: a randomised feasibility trial                                   

PCTU Ref

P156

Chief Investigator

Dr. Elizabeth Ball, Queen Mary University of London

Publications

NEWTON SL, Ball E, Kahan B, Forbes G, Wright N, Cantalapiedra-Calvete C, Gibson H, Rogozinska E et al. ( 2018 ) . Smartphone App Using Mindfulness Meditation for Women With Chronic Pelvic Pain (MEMPHIS): Protocol for a Randomized Feasibility Trial . Journal of Medical Internet Research vol. 7, (1) 

10.2196/resprot.7720 https://qmro.qmul.ac.uk/xmlui/handle/123456789/33343

Study Acronym

NESS 

Study Title

Effectiveness and Cost-Effectiveness of Body Psychotherapy in the Treatment of Negative Symptoms of Schizophrenia – A Multi-Centre Randomised Controlled Trial

                   

PCTU Ref

P013

Chief Investigator

Professor Stefan Priebe, Queen Mary University of London

Publications

Priebe S, Savill M, Wykes T, Bentall R, Lauber C, Reininghaus U, McCrone P, Mosweu I, Bremner S, Eldridge S, Rohricht F. Clinical effectiveness and cost-effectiveness of body psychotherapy in the treatment of negative symptoms of schizophrenia: a multicentre randomised controlled trial. Health Technol Assess 2016;20:vii-xxiii, 1-100.

Priebe S, Savill M, Wykes T, Bentall RP, Reininghaus U, Lauber C, Bremner S, Eldridge S, Rohricht F. Effectiveness of group body psychotherapy for negative symptoms of schizophrenia: multicentre randomised controlled trial. Br J Psychiatry 2016;209:54-61.

Priebe S, Savill M, Reininghaus U, Wykes T, Bentall R, Lauber C, McCrone P, Rohricht F, Eldridge S. Effectiveness and cost-effectiveness of body psychotherapy in the treatment of negative symptoms of schizophrenia--a multi-centre randomised controlled trial. BMC Psychiatry 2013;13:26.

Study Acronym

Oedipus

Study Title

Effect of an Education Programme for South Asians with Asthma and Their Clinicians: A Cluster Randomised Controlled Trial                                                                                        

PCTU Ref

O014

Chief Investigator

Professor Chris Griffiths, Queen Mary University of London 

Publications

Griffiths C, Bremner S, Islam K, Sohanpal R, Vidal DL, Dawson C, Foster G, Ramsay J, Feder G, Taylor S, Barnes N, Choudhury A, Packe G, Bayliss E, Trathen D, Moss P, Cook V, Livingstone AE, Eldridge S. Effect of an Education Programme for South Asians with Asthma and Their Clinicians: A Cluster Randomised Controlled Trial (OEDIPUS). PLoS One 2016;11:e0158783 

Study Acronym

OPERA

Study Title

Older People's Exercise Intervention in Residential and Nursing Accommodation                                                                                      

PCTU Ref

P057

Chief Investigator

Dr. Stephanie Taylor, Queen Mary University of London

Publications

Underwood M, Lamb SE, Eldridge S, Sheehan B, Slowther A, Spencer A, Thorogood M, Atherton N, Bremner SA, Devine A, Diaz-Ordaz K, Ellard DR, Potter R, Spanjers K, Taylor SJ. Exercise for depression in care home residents: a randomised controlled trial with cost-effectiveness analysis (OPERA). Health Technol Assess 2013;17:1-281. 

Underwood M, Eldridge S, Lamb S, Potter R, Sheehan B, Slowther AM, Taylor S, Thorogood M, Weich S. The OPERA trial: protocol for a randomised trial of an exercise intervention for older people in residential and nursing accommodation. Trials 2011;12:27.

Study Acronym

PACE-UP

Study Title

Randomised controlled trial of a pedometer-based walking intervention with and without practice nurse support in primary care patients aged 45-74 years                                                     

PCTU Ref

P059

Chief Investigator

Dr. Tess Harris, St. George's University of London 

Publications

Anokye N, Fox-Rushby J, Sanghera S, Cook DG, Limb E, Furness C, Kerry SM, Victor CR, Iliffe S, Ussher M, Whincup PH, Ekelund U, deWilde S, Harris T. Short-term and long-term cost-effectiveness of a pedometer-based exercise intervention in primary care: a within-trial analysis and beyond-trial modelling. BMJ Open 2018;8:e021978. https://doi.org/10.1136/bmjopen-2018-021978 

Furness C, Howard E, Limb E, Cook DG, Kerry S, Wahlich C, Victor C, Ekelund U, Iliffe S, Ussher M, Whincup P, Fox-Rushby J, Ibison J, DeWilde S, Harris T. Relating process evaluation measures to complex intervention outcomes: findings from the PACE-UP primary care pedometer-based walking trial. Trials 2018;19:58. https://doi.org/10.1186/s13063-017-2428-z 

Harris T, Kerry SM, Limb ES, Furness C, Wahlich C, Victor CR, Iliffe S, Whincup PH, Ussher M, Ekelund U, Fox-Rushby J, Ibison J, DeWilde S, McKay C, Cook DG. Physical activity levels in adults and older adults 3-4 years after pedometer-based walking interventions: Long-term follow-up of participants from two randomised controlled trials in UK primary care. PLoS Med 2018;15:e1002526. https://doi.org/10.1371/journal.pmed.1002526

Kerry SM, Morgan KE, Limb E, Cook DG, Furness C, Carey I, DeWilde S, Victor CR, Iliffe S, Whincup P, Ussher M, Ekelund U, Fox-Rushby J, Ibison J, Harris T. Interpreting population reach of a large, successful physical activity trial delivered through primary care. BMC Public Health 2018;18:170. https://doi.org/10.1186/s12889-018-5034-4

Normansell R, Holmes R, Victor C, Cook DG, Kerry S, Iliffe S, Ussher M, Fox-Rushby J, Whincup P, Harris T. Exploring non-participation in primary care physical activity interventions: PACE-UP trial interview findings.Trials 2016;17:178

Harris T, Kerry SM, Victor CR, Shah SM, Iliffe S, Ussher M, Ekelund U, Fox-Rushby J, Whincup P, David L, Brewin D, Ibison J, DeWilde S, Limb E, Anokye N, Furness C, Howard E, Dale R, Cook DG. PACE-UP (Pedometer and consultation evaluation--UP)--a pedometer-based walking intervention with and without practice nurse support in primary care patients aged 45-75 years: study protocol for a randomised controlled trial. Trials 2013;14:418.

PIMS

Study: Posturing in Macular Hole Surgery. A multicentre interventional comparative randomised controlled clinical trial comparing face-down positioning, with an inactive face-forward position on the outcome of surgery for large macular holes. 

Chief Investigator: Professor James Bainbridge, University College London

Funder/Funding Stream: NIHR Research for Patient Benefit (27/04/2PB-PG-0213-30085)

Sponsor: Moorfield's Eye Hospital NHS Trust

PCTU Ref: P110 

Study Acronym

PREP

Study Title

Development and validation of a Prediction model for Risk of complications in Early onset Pre-eclampsia                                                             

PCTU Ref

P066

Chief Investigator

Professor Khalid Khan, Queen Mary University of London

Publications

Thangaratinam S, Allotey J, Marlin N, Dodds J, Cheong-See F, von Dadelszen P, Ganzevoort W, Akkermans J, Kerry S, Mol BW, Moons KG, Riley RD, Khan KS. Prediction of complications in early-onset pre-eclampsia (PREP): development and external multinational validation of prognostic models. BMC Med 2017;15:68. https://doi.org/10.1186/s12916-017-0827-3

Thangaratinam S, Allotey J, Marlin N, Mol BW, Von Dadelszen P, Ganzevoort W, Akkermans J, Ahmed A, Daniels J, Deeks J, Ismail K, Barnard AM, Dodds J, Kerry S, Moons C, Riley RD, Khan KS. Development and validation of Prediction models for Risks of complications in Early-onset Pre-eclampsia (PREP): a prospective cohort study. Health Technol Assess 2017;21:1-100. https://doi.org/10.3310/hta21180

PROMISe

Study: Patient Reported Outcome MeasureS using electronic informed consent and data capture – developing methods and infrastructure              

Chief Investigators: Professor Sandra Eldridge, Dr Richard Hooper, Professor Charles Knowles; Queen Mary University of London

Funder/Funding Stream: NIHR CTU Support Funding (NIHR129741)

Sponsor: Barts NHS Trust

PCTU Ref: P265

Study Acronym

PROMISE                                                       

Study Title

Patient Reported Outcome MeasureS using electronic informed consent and data capture – developing methods and infrastructure

PCTU Ref

P265

Chief Investigator

Dr Richard Hooper, Queen Mary University of London

Professor Charles Knowles, Queen Mary University of London

                                                        

Publications

 

Study Acronym

QuEST

Study Title

Quality and Effectiveness of Supported Tenancies for people with mental health problems

PCTU Ref

P080

Chief Investigator

Dr Helen Killaspy, University College London

Publications

 

Study Acronym

RHIVA-2  

Study Title

Effectiveness of HIV screening in Primary Care:

A cluster RCT and economic analysis

PCTU Ref

P007

Chief Investigator

Professor Chris Griffiths, Queen Mary University of London 

Publications

Leber W, McMullen H, Bremner S, Kerry S, Millett D, Mguni S, Awosika D, Creighton S, Figueroa J, Hart G, Sampson M, Anderson J, Griffiths C. Can point of care HIV testing in primary care increase identification of HIV? The RHIVA 2 cluster randomised controlled trial - update. HIV Medicine 2012;13:7-7. 

Study Acronym

SALVO                                                         

Study Title

A Randomised Controlled Trial of Intra-Operative Cell Salvage during Caesarean Section in Women at Risk of Haemorrhage

PCTU Ref

P079

Chief Investigator

Professor Khalid Khan, Queen Mary University of London

Publications

Khan KS, Moore P, Wilson M, Hooper R, Allard S, Wrench I, Roberts T, McLoughlin C, Beresford L, Geoghegan J, Daniels J, Catling S, Clark VA, Ayuk P, Robson S, Gao-Smith F, Hogg M, Jackson L, Lanz D, Dodds J. A randomised controlled trial and economic evaluation of intraoperative cell salvage during caesarean section inwomen at risk of haemorrhage: the SALVO (cell SALVage in Obstetrics) trial. Health Technol Assess 2018;22:1-88. https://doi.org/10.3310/hta22020

Khan KS, Moore PAS, Wilson MJ, Hooper R, Allard S, Wrench I, Beresford L, Roberts TE, McLoughlin C, Geoghegan J, Daniels JP, Catling S, Clark VA, Ayuk P, Robson S, Gao-Smith F, Hogg M, Lanz D, Dodds J, group Ss. Cell salvage and donor blood transfusion during cesarean section: A pragmatic, multicentre randomised controlled trial (SALVO). PLoS Med 2017;14:e1002471. https://doi.org/10.1371/journal.pmed.1002471 

SCENE

Study: Improving quality of life and health outcomes of patients with psychosis through a new structured intervention for expanding social networks

Chief Investigator: Dr. Domenico Giacco, Queen Mary University of London

Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0615-20009)

Sponsor: East London NHS Foundation Trust

PCTU Ref: P206

Study Acronym

SNSvsPTNS     

Study Title

A Randomised pilot and feasability study of sacral and percutaneous tibial nerve stimulation for faecal incontinence.                                                                  

PCTU Ref

P044

Chief Investigator

Professor Charles Knowles, Queen Mary University of London

Publications

McAlees E, Vollebregt PF, Stevens N, Dudding TC, Emmanuel AV, Furlong PL, Hamdy S, Hooper RL, Jones JFX, Norton C, O'Connell PR, Scott SM, Knowles CH. Efficacy and mechanism of sub-sensory sacral (optimised) neuromodulation in adults with faecal incontinence: study protocol for a randomised controlled trial. Trials 2018;19:336. https://doi.org/10.1186/s13063-018-2689-1

Thin NN, Taylor SJ, Bremner SA, Emmanuel AV, Hounsome N, Williams NS, Knowles CH. Randomized clinical trial of sacral versus percutaneous tibial nerve stimulation in patients with faecal incontinence. Br J Surg 2015;102:349-58. 

STOP

Study: Optimising pharmacist-based treatment for smoking cessation

Chief Investigator: Professor Robert Walton, Queen Mary University of London

Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0609-10181)

Sponsor: Barts NHS Trust

PCTU Ref: P027

Study Acronym

 SWAP                          

Study Title

A peer-support weight action programme to supplement brief advice in general practice 

PCTU Ref

P064

Chief Investigator

Dr Hayden McRobbie, Queen Mary University of London

Publications

 

Study Acronym

ViDiAS                                        

Study Title

Randomised, Multi-Centre, Double-Blind, Placebo-
Controlled Trial of Vitamin D Supplementation in Adult and Adolescent Patients with Asthma              

PCTU Ref

P056

Chief Investigator

Dr. Adrian Martineau, Queen Mary University of London

Publications

Jolliffe DA, Greenberg L, Hooper RL, Griffiths CJ, Camargo CA, Jr., Kerley CP, Jensen ME, Mauger D, Stelmach I, Urashima M, Martineau AR. Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data. Lancet Respir Med 2017;5:881-890. https://doi.org/10.1016/S2213-2600(17)30306-5 

Study Acronym

ViDiCO                                           

Study Title

Randomised, Multi-Centre, Double-Blind, Placebo-
Controlled Trial of Vitamin D Supplementation in Patients with Chronic Obstructive Pulmonary Disease                                                                                        

PCTU Ref

P056

Chief Investigator

Dr. Adrian Martineau, Queen Mary University of London

Publications

 

Study Acronym

ViDiFlu                                  

Study Title

Trial Of Vitamin D Supplementation for the Prevention of Influenza and Other Respiratory Infections

PCTU Ref

P056

Chief Investigator

Dr. Adrian Martineau, Queen Mary University of London

Publications

 

VidiKIDS NCD - Substudy

Study: Trial of vitamin D supplementation to prevent acquisition of latent tuberculosis infection in schoolchildren

Chief Investigator: Professor Adrian Martineau, Queen Mary University of London

Funder/Funding Stream: Medical Research Council (MRC)

Sponsor: Barts NHS Trust

PCTU Ref: P274

Study Acronym

Vit D IPD

Study Title

Vitamin D supplementation to prevent acute respiratory infection: individual
patient data meta-analysis of randomised controlled trials

PCTU Ref

P132

Chief Investigator

Dr. Adrian Martineau, Queen Mary University of London

Publications

Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, Goodall EC, Grant CC, Griffiths CJ, Janssens W, Laaksi I, Manaseki-Holland S, Mauger D, Murdoch DR, Neale R, Rees JR, Simpson S, Jr., Stelmach I, Kumar GT, Urashima M, Camargo CA, Jr. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017;356:i6583. https://doi.org/10.1136/bmj.i6583

Study Acronym

VOLUME                                       

Study Title

An Exploratory Randomised Controlled Trial Assessing Volunteering in Mental Health Care for People with Psychosis                       

PCTU Ref

P090

Chief Investigator

Professor Stefan Priebe, Queen Mary University of London

Publications

Priebe S, Pavlickova H, Eldridge S, Golden E, McCrone P, Ockenden N, Pistrang N, King M. Effectiveness of one-to-one volunteer support for patients with psychosis: protocol of a randomised controlled trial. BMJ Open 2016;6:e011582. 

Study Acronym

WAIT                                             

Study Title

Parent-Determined Oral Montelukast Therapy For Preschool Wheeze

PCTU Ref

P003

Chief Investigator

Professor Jonathan Grigg, Queen Mary University of London

Publications

Nwokoro C, Pandya H, Turner S, Eldridge S, Griffiths CJ, Vulliamy T, Price D, Sanak M, Holloway JW, Brugha R, Koh L, Dickson I, Rutterford C, Grigg J. Intermittent montelukast in children aged 10 months to 5 years with wheeze (WAIT trial): a multicentre, randomised, placebo-controlled trial. Lancet Respir Med 2014;2:796-803. 

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