Barts & The London - Institute of Dentistry

Dr Simon Rawlinson, BSc(Hons), PhD, FHEA, MRSB

Senior Lecturer in Oral Biology

Email: s.c.f.rawlinson@qmul.ac.uk
Telephone: +44 20 7882 7139
Room Number: Blizard Building

Profile

Research Technician: Bone Unit, The Royal Veterinary College 1986-2000, during this period the group was at the forefront of loadable bone organ culture model development and use. These had the advantage of maintaining the correct ratio of osteoblasts to osteocytes attached to their natural substrate in appropriate 3D orientation. 1999 PhD Veterinary Anatomy, 'Early loading-related responses of resident cells in mammalian bone organ explants'. In the mid-90s loadable cell culture models allowed for the study of cell monocultures to be investigated. At this time I became interested in the apparent disparity of bone mass and mechanical usage of the skull and limb. Research Associate: Bone Unit, The Royal Veterinary College 2000-2003.

Research Associate: Queen Mary University of London, Barts & The London School of Medicine and Dentistry, Institute of Dentistry 2003-2009. In collaboration with staff at the IOD, investigating the mechanical responsiveness of the mandible and compared the gene profiles of the skull, limb and mandible. This has led us to consider the mechanism by which bone mass is normally maintained at status quo levels. Lecturer: Queen Mary University of London, Barts & The London School of Medicine and Dentistry, Institute of Dentistry 2009 to present. Now lead of 1st Year BDS course and subject convenor for Systems Physiology. Also teach on MSc Oral Biology, MSc Experimental Oral Pathology and intercalated BSc Oral Biology courses.

 

Teaching

BDS Y1 – YEAR LEAD

MSc Oral Biology – MODULE (IOB2) Co-LEAD

MSc Experimental Oral Pathology

Intercalated BSc Oral Biology – Hard Tissue Biology model Co-Convenor

 

Research

Research Interests:

Mechanically adaptive bone remodelling, tissue remodelling, positional identity, bioglass, implants, mechanobiology

At present:

Primary supervisor 1 PhD Student (IoD)

Secondary supervisor 5 PhD students (2 IoD, 3 SEMS)

Publications

Key Publications

Suswillo RF, Javaheri B, Rawlinson SCF, Dowthwaite GP, Lanyon LE, Pitsillides AA. (2017) Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes. Cell Biochem Funct. Jan;35(1):56-65. doi: 10.1002/cbf.3245

Rawlinson SCF (2017). Mechanobiology Exploitation for Medical Benefit. John Wiley & Sons

Rawlinson SCF (2017). Mechanical responsiveness of distinct skeletal elements – possible exploitation of low weight-bearing bone. Mechanobiology: Exploitation for Medical Benefit, Wiley Blackwell (New Jersey),

Huang M, Hill RG, Rawlinson SCF. (2016) Zinc containing bioglasses regulate mineralisation in human dental pulp stem cells Dent. Mater. May;33(5):543-552. doi: 10.1016/j.dental.2017.03.011. Epub 2017 Mar 31.

Liu J, Rawlinson SCF, Hill RG, Fortune F. (2016) Fluoride incorporation in high phosphate containing bioactive glasses and in vitro osteogenic, angiogenic and antibacterial effects. Dent Mater. Jul 22. pii: S0109-5641(16)30119-1. doi: 10.1016/j.dental.2016.07.003. [Epub ahead of print]

Huang M, Hill RG, Rawlinson SCF. (2016) Strontium (Sr) elicits odontogenic differentiation of human dental pulp stem cells (hDPSCs): A therapeutic role for Sr in dentine repair? Acta Biomater. Jul 1;38:201-11. doi: 10.1016/j.actbio.2016.04.037. Epub 2016 Apr 27.

Liu J, Rawlinson SCF, Hill RG, Fortune F. (2016) Strontium-substituted bioactive glasses in vitro osteogenic and antibacterial effects. Dent Mater. Mar;32(3):412-22. doi: 10.1016/j.dental.2015.12.013. Epub 2016 Jan 8.

Stachewicz U, Qiao T, Rawlinson SCF, Almeida FV, Li WQ, Cattell M, Barber AH. (2015) 3D imaging of cell interactions with electrospun PLGA nanofiber membranes for bone regeneration. Acta Biomater. 27:88-100. doi: 10.1016/j.actbio.2015.09.003. Epub 2015 Sep 5.

Memarzadeh K, Sharili AS, Huang J, Rawlinson SCF, Allaker RP. (2014) Nanoparticulate zinc oxide as a coating material for orthopedic and dental implants. J Biomed Mater Res A. May 26. doi: 10.1002/jbm.a.35241.

Al-Noaman A, Rawlinson SCF, Hill RG. (2013) Bioactive glass-stoichimetric wollastonite glass alloys to reduce TEC of bioactive glass coatings for dental implants. Materials Letters; 94: 69-71   2013.

Kingsmill VJ, McKay IJ, Ryan P, Ogden MR, Rawlinson SCF. (2013) Gene expression profiles of mandible reveal features of both calvarial and ulnar bones in the adult rat. Journal Of Dentistry; 41:258-264.

Al-Noaman A, Karpukhina N, Rawlinson SCF, Hill RG. (2013) Effect of FA addition on bioactivity of bioactive glass coating for titanium dental implant: Part II- Composite coating. Journal Of Non-Crystalline Solids; 364:99-106. 

Al-Noaman A, Karpukhina N, Rawlinson SCF, Hill RG. (2013) Effect of FA on bioactivity of bioactive glass coating for titanium dental implant. Part I: Composite powder. Journal Of Non-Crystalline Solids; 364:92-98. 

Al-Noaman A, Karpukhina N, Rawlinson SCF, Hill RG. (2013) Behaviour of osteoblast-like cells cultured on titanium coated with FA/glass composite coating. Journal Of Non-Crystalline Solids; 364:85-91.

 

Pitsillides AA and Rawlinson SCF. (2012) Using cell and organ culture models to analyse responses of bone cells to mechanical stimulation. Methods in Molecular Biology, Volume 816, Part 7, 593-619.

Al-Noaman A, Rawlinson SCF, Hill RG. (2012) The influence of CaF2 content on the physical properties and apatite formation of bioactive glass coatings for dental implants. Journal Of Non-Crystalline Solids; 358:1850-1858.

Al-Noaman A, Rawlinson SCF, Hill RG. (2012) The role of MgO on thermal properties, structure and bioactivity of bioactive glass coating for dental implants. Journal Of Non-Crystalline Solids; 358:3019-3027.

Kingsmill VJ, Boyde A, Davis GR, Howell PG, Rawlinson SCF. (2010) Changes in Bone Mineral and Matrix in Response to a Soft Diet. J Dent Res; 89:510-514.

Rawlinson SCF, Boyde A, Davis GR, Howell PG, Hughes FJ, Kingsmill VJ. (2009) Ovariectomy vs. hypofunction: their effects on rat mandibular bone. J Dent Res; 88:615-20.

Rawlinson SCF, McKay IJ, Ghuman M, Wellmann C, Ryan P, Prajaneh S, Zaman G, Hughes FJ, Kingsmill VJ. (2009) Adult Rat Bones Maintain Distinct Regionalized Expression of Markers Associated with Their Development. PLoS ONE; 4:e8358.

Rawlinson SCF, Murray DH, Mosley JR, Wright CD, Bredl JC, Saxon LK, Loveridge N, Leterrier C, Constantin P, Farquharson C, Pitsillides AA. (2009) Genetic selection for fast growth generates bone architecture characterised by enhanced periosteal expansion and limited consolidation of the cortices but a diminution in the early responses to mechanical loading. Bone; 45:357-366.

Simon DW, Clarkin CE, Das-Gupta V, Rawlinson SCF, Emery RJ, Pitsillides AA. (2008) Identifying the cellular basis for reimplantation failure in repair of the rotator cuff. J Bone Joint Surg Br; 90:680-4.

de Souza RL, Matsuura M, Eckstein F, Rawlinson SCF, Lanyon LE, Pitsillides AA. (2005) Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element. Bone; 37:810-8.

Jessop HL, Suswillo RFL, Rawlinson SCF, Zaman G, Lee K, Das-Gupta V, Pitsillides AA, Lanyon LE.  (2004) Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain. J Bone Miner Res; 19:938-46.

Chambler A, Rawlinson SCF, Emery R, Pitsillides A. (2004) Quantitative cytochemical evidence for local increases in bone turnover at the acromial enthesis of the human coracoacromial ligament. J Rheumatol; 31:2216-25.

Pitsillides AA, Das-Gupta V, Simon D, Rawlinson SCF. (2003) Methods for analysing bone cell responses to mechanical loading using in vitro monolayer and organ culture models. Methods Mol Med; 80:399-422.

Cheng MZ, Rawlinson SCF, Pitsillides AA, Zaman G, Mohan S, Baylink DJ, Lanyon LE. (2002) Human osteoblasts' proliferative responses to strain and 17beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I. J Bone Miner Res; 17:593-602.

Jessop HL, Rawlinson SCF, Pitsillides AA, Lanyon LE. (2002) Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. Bone; 31:186-94.

Rawlinson SCF, Wheeler-Jones CP, Lanyon LE. (2000) Arachidonic acid for loading induced prostacyclin and prostaglandin E(2) release from osteoblasts and osteocytes is derived from the activities of different forms of phospholipase A(2). Bone; 27:241-7.

Cheng M, Zaman G, Rawlinson SCF, Mohan S, Baylink DJ, Lanyon LE. (1999) Mechanical strain stimulates ROS cell proliferation through IGF-II and estrogen through IGF-I. J Bone Miner Res; 14:1742-50.

Zaman G, Pitsillides AA, Rawlinson SCF, Suswillo RFL, Mosley JR, Cheng MZ, Platts LA, Hukkanen M, Polak JM, Lanyon LE. (1999) Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes. J Bone Miner Res; 14:1123-31.

Pitsillides AA, Rawlinson SCF, Mosley JR, Lanyon LE. (1999) Bone's early responses to mechanical loading differ in distinct genetic strains of chick: selection for enhanced growth reduces skeletal adaptability. J Bone Miner Res; 14:980-7.

Rawlinson SCF, Zaman G, Mosley JR, Pitsillides AA, Lanyon LE. (1998) Heme oxygenase isozymes in bone: induction of HO-1 mRNA following physiological levels of mechanical loading in vivo. Bone; 23:433-6.

Cheng MZ, Zaman G, Rawlinson SCF, Pitsillides AA, Suswillo RFL, Lanyon LE. (1997) Enhancement by sex hormones of the osteoregulatory effects of mechanical loading and prostaglandins in explants of rat ulnae. J Bone Miner Res; 12:1424-30.

Cheng MZ, Zaman G, Rawlinson SCF, Suswillo RFL, Lanyon LE. (1996) Mechanical loading and sex hormone interactions in organ cultures of rat ulna. J Bone Miner Res; 11:502-11.

Rawlinson SCF, Pitsillides AA, Lanyon LE. (1996) Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain. Bone; 19:609-14.

Pitsillides AA, Rawlinson SCF, Suswillo RFL, Bourrin S, Zaman G, Lanyon LE. (1995) Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling? FASEB J; 9:1614-22.

Rawlinson SCF, Mosley JR, Suswillo RFL, Pitsillides AA, Lanyon LE. (1995) Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain. J. Bone Miner. Res.; 10:1225-32.

Rawlinson SCF, Mohan S, Baylink DJ, Lanyon LE. (1993) Exogenous prostacyclin, but not prostaglandin E2, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture. Calcif Tissue Int; 53:324-9.

Rawlinson SCF, El-Haj AJ, Minter SL, Tavares IA, Bennett A, Lanyon LE. (1991) Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling? J Bone Miner Res; 6:1345-51.

El-Haj AJ, Minter SL, Rawlinson SCF, Suswillo R, Lanyon LE. (1990) Cellular responses to mechanical loading in vitro. J Bone Miner Res; 5:923-32.