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Critical Care and Peri-operative Medicine Research Group

Background Papers

Abbott TEF, Minto G, Lee AM, Pearse RM, Ackland GL, Pom-Hr P-O, groups Os: Elevated preoperative heart rate is associated with cardiopulmonary and autonomic impairment in high-risk surgical patients. Br J Anaesth 2017; 119: 87-94
Wijeysundera DN, Pearse RM, Shulman MA, Abbott TEF, Torres E, Ambosta A, Croal BL, Granton JT, Thorpe KE, Grocott MPW, Farrington C, Myles PS, Cuthbertson BH, investigators Ms: Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study. Lancet 2018; 391: 2631-2640
Cramer L, Hildebrandt B, Kung T, Wichmann K, Springer J, Doehner W, Sandek A, Valentova M, Stojakovic T, Scharnagl H, Riess H, Anker SD, von Haehling S: Cardiovascular function and predictors of exercise capacity in patients with colorectal cancer. J Am Coll Cardiol 2014; 64: 1310-9
Ackland GL, Abbott TEF, Cain D, Edwards MR, Sultan P, Karmali SN, Fowler AJ, Whittle JR, MacDonald N, Reyes A, Gallego Paredes L, Stephens RCM, Del Arroyo AG, Woldman S, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E, Pearse RM: Preoperative systemic inflammation and myocardial injury: prospective observational multicentre cohort study of patients undergoing non-cardiac surgery. Br J Anaesth 2018; https://doi.org/10.1016/j.bja.2018.09.002
Abbott TEF, Pearse RM, Cuthbertson BH, Wijeysundera D, Ackland GL: Cardiac vagal dysfunction and myocardial injury after non-cardiac surgery: a planned secondary analysis of the METS study. Br J Anaesth 2018; BJA-2018-01229-MA081; accepted for publication.
Abbott TEF, Pearse RM, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E, Rodseth RN, Devereaux PJ, Ackland GL: Association between preoperative pulse pressure and perioperative myocardial injury: an international observational cohort study of patients undergoing non-cardiac surgery. Br J Anaesth 2017; 119: 78-86
Ackland GL, Abbott TEF, Pearse RM, Karmali SN, Whittle J, Minto G, Investigators P-HS: Arterial pulse pressure and postoperative morbidity in high-risk surgical patients. Br J Anaesth 2018; 120: 94-100
Abbott TEF, Pearse RM, Archbold RA, Ahmad T, Niebrzegowska E, Wragg A, Rodseth RN, Devereaux PJ, Ackland GL: A Prospective International Multicentre Cohort Study of Intraoperative Heart Rate and Systolic Blood Pressure and Myocardial Injury After Noncardiac Surgery: Results of the VISION Study. Anesth Analg 2018; 126: 1936-1945
Abbott TE, Ackland GL, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E, Rodseth RN, Devereaux PJ, Pearse RM: Preoperative heart rate and myocardial injury after non-cardiac surgery: results of a predefined secondary analysis of the VISION study. Br J Anaesth 2016; 117: 172-81
Toner A, Jenkins N, Ackland GL, Investigators P-OS: Baroreflex impairment and morbidity after major surgery. Br J Anaesth 2016; 117: 324-31
Ackland GL, Whittle J, Toner A, Machhada A, Del Arroyo AG, Sciuso A, Jenkins N, Dyson A, Struthers R, Sneyd JR, Minto G, Singer M, Shah AM, Gourine AV: Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness. Crit Care Med 2016; 44: e614-24
Ackland GL, Iqbal S, Paredes LG, Toner A, Lyness C, Jenkins N, Bodger P, Karmali S, Whittle J, Reyes A, Singer M, Hamilton M, Cecconi M, Pearse RM, Mallett SV, Omar RZ: Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial. Lancet Respir Med 2015; 3: 33-41
Ackland GL, Minto G, Clark M, Whittle J, Stephens RCM, Owen T, Prabhu P, Del Arroyo AG: Autonomic regulation of systemic inflammation in humans: A multi-center, blinded observational cohort study. Brain Behav Immun 2018; 67: 47-53
Imai K, Sato H, Hori M, Kusuoka H, Ozaki H, Yokoyama H, Takeda H, Inoue M, Kamada T: Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure. Journal of the American College of Cardiology 1994; 24: 1529-35
Cole CR, Blackstone EH, Pashkow FJ, Snader CE, Lauer MS: Heart-rate recovery immediately after exercise as a predictor of mortality. The New England journal of medicine 1999; 341: 1351-7
Jouven X, Empana JP, Schwartz PJ, Desnos M, Courbon D, Ducimetiere P: Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med 2005; 352: 1951-8
Ackland GL, Gourine AV: Cardiac vagus and exercise. Physiology (Bethesda) 2019; 34: 71-80
Machhada A, Trapp S, Marina N, Stephens RCM, Whittle J, Lythgoe MF, Kasparov S, Ackland GL, Gourine AV: Vagal determinants of exercise capacity. Nat Commun 2017; 8: 15097
Florea VG, Cohn JN: The autonomic nervous system and heart failure. Circ Res 2014; 114: 1815-26
McCrory C, Berkman LF, Nolan H, O'Leary N, Foley M, Kenny RA: Speed of Heart Rate Recovery in Response to Orthostatic Challenge. Circ Res 2016; 119: 666-75