Blizard Institute - Barts and The London

Dr Mark Scott, PhD


Senior Clinical Scientist; Director, GI Physiology Unit (Colorectal Service)

Centre: Centre for Neuroscience, Surgery and Trauma



Dr Mark Scott, PhD is a Principal Investigator within the Blizard Institute at Queen Mary University of London, and is Director and one of the founders of the internationally-renowned GI (Colorectal) Physiology Unit at Barts and The London School of Medicine and Dentistry / Barts Health NHS Trust. Approximately 1000 patients undergo diagnostic investigations within the Unit each year, which provides the resources for allied research.

Mark has over 25 years’ experience, both clinical and academic, related to the physiological assessment of functional colorectal disorders (primarily constipation and faecal incontinence). He is the most widely published colorectal GI Physiologist in the UK, having authored 158 original articles and 11 book chapters. He has been Guest Editor of 2 journal supplements devoted to the subject of chronic constipation, and is currently one of the European Society of Neurogastroenterology and Motility Working Team members setting guidelines for the management of constipation. Mark is also one of the Leads of an International Anorectal Physiology Working Group into standardisation of diagnostic testing. He has supervised numerous postgraduate students (both clinical and scientific) to successful completion of their higher degrees.


MSc, Gastroenterology


Research Interests:

Research interests are focussed on pathophysiology and treatment, including:

  1. Pioneering work on visceral hyposensitivity
  2. Assessment of colonic motor function
  3. Development of novel investigative technologies (including ingestible telemetric devices, and high-resolution manometry)
  4. Evaluation of novel therapies for both constipation and incontinence


Key Publications

Carrington EV, Heinrich H, Knowles CH, Fox M, Rao S, Altomare DF, Bharucha AE, Burgell R, Chey WD, Chiarioni G, Dinning P, Emmanuel A, Farouk R, Felt-Bersma RJ, Jung KW, Lembo A, Malcolm A, Mittal R, Mion F, Myung SJ, O’Connell PR, Pehl C, Remes-Troche JM, Reveille RM, Vaizey CJ, Vitton V, Whitehead WE, Wong RK, Scott SM, for the International Anorectal Physiology Working Group.
The International Anorectal Physiology Working Group (IAPWG) recommendations: standardized testing protocol and the London classification for disorders of anorectal function.
Neurogastroenterol Motil
2019: in press

Dimidi E, Zdanaviciene A, Christodoulides S, Taheri S, Louis P, Duncan PI, Emami N, Crabbé R, De Castro CA, McLean P, Bergonzelli GE, Whelan K, Scott SM.
Randomised clinical trial: Bifidobacterium lactis NCC2818 probiotic vs placebo, and impact on gut transit time, symptoms and gut microbiology in chronic constipation.
Aliment Pharmacol Ther 2019: 49: 251-64

Dimidi E, Cox C, Grant R, Scott SM, Whelan K.
Perceptions of constipation among the general public and people with constipation differ strikingly from those of general and specialist doctors and the Rome IV criteria.
Am J Gastroenterol 2019: 114: 1116-29

Carrington EV, Scott SM, Bharucha A, Mion F, Remes-Troche JM, Malcolm A, Heinrich H, Fox M, Rao SS. On behalf of the International Anorectal Physiology Working Group and the International Working Group for Disorders of Gastrointestinal Motility and Function.
Expert consensus document. Advances in the evaluation of anorectal function.
Nat Rev Gastroenterol Hepatol 2018: 15: 309-23

Scott SM, Williams AB.
Specialist investigation of anorectal and colonic structure and functions.
In: Keighley MR, Williams NS, Knowles CH, eds. Surgery of the anus, rectum and colon, 2nd Edition.
CRC Press, Taylor Francis Group, Boca Raton, Florida, USA, 2018; 271-304

All Publications


  • Ugo Grossi, PhD
  • Annika Rasijeff, PhD
  • Gursharan Nandhra, PhD (part-time)
  • Phakanant (Pam) Chaichanavichkij, PhD
  • Mary Venn, PhD