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Blizard Institute - Faculty of Medicine and Dentistry

Dr Mark Scott, PhD


Senior Clinical Scientist; Director, GI Physiology Unit (Colorectal Service)

Centre: Centre for Neuroscience, Surgery and Trauma



Dr Mark Scott, PhD is a Principal Investigator within the Blizard Institute at Queen Mary University of London, and is Director and one of the founders of the internationally-renowned GI (Colorectal) Physiology Unit at Barts and The London School of Medicine and Dentistry/Barts Health NHS Trust. Approximately 1,000 patients undergo diagnostic investigations within the Unit each year, which provides the resources for allied research. He also played a central role in the inauguration of the Neurogastroenterology Group at Queen Mary University of London.

Mark has over 30 years’ experience, both clinical and academic, related to the physiological assessment of functional colorectal disorders (primarily constipation and faecal incontinence). He is the most widely published colorectal GI Physiologist in the UK, having authored 176 original articles, 12 book chapters, and been Guest Editor of three journal supplements on chronic constipation. He is one of the Leads of the International Anorectal Physiology Working Group promoting standards for diagnostic testing, and is also a member of a European Society of Neurogastroenterology and Motility Working Team setting guidelines for the management of constipation. Mark has supervised numerous postgraduate students (both clinical and scientific) to successful completion of their higher degrees (PhD, MD[Res], MSc).


MSc, Gastroenterology


Research Interests:

Research interests are focussed on pathophysiology and treatment, including:

  1. Pioneering work on visceral hyposensitivity
  2. Assessment of colonic motor function
  3. Development of novel investigative technologies (including ingestible telemetric devices, and high-resolution manometry)
  4. Evaluation of novel therapies for both constipation and incontinence


Key Publications

Vollebregt PF, Burgell RE, Hooper RL, Knowles CH, Scott SM. Clinical impact of rectal hyposensitivity: a cross-sectional study of 2,876 patients with refractory functional constipation. Am J Gastroenterol 2020: in press

Vollebregt PF, Wiklendt L, Dinning PG, Knowles CH, Scott SM. Coexistent faecal incontinence and constipation: a cross-sectional study of 4,027 adults undergoing specialist assessment. Lancet EClinicalMedicine 2020: in press

Carrington EV, Heinrich H, Knowles CH, Fox M, Rao S, Altomare DF, Bharucha AE, Burgell R, Chey WD, Chiarioni G, Dinning P, Emmanuel A, Farouk R, Felt-Bersma RJ, Jung KW, Lembo A, Malcolm A, Mittal R, Mion F, Myung SJ, O’Connell PR, Pehl C, Remes-Troche JM, Reveille RM, Vaizey CJ, Vitton V, Whitehead WE, Wong RK, Scott SM, for the International Anorectal Physiology Working Group. The International Anorectal Physiology Working Group (IAPWG) recommendations: standardized testing protocol and the London classification for disorders of anorectal function. Neurogastroenterol Motil 2020; 32: e13679

Dimidi E, Zdanaviciene A, Christodoulides S, Taheri S, Louis P, Duncan PI, Emami N, Crabbé R, De Castro CA, McLean P, Bergonzelli GE, Whelan K, Scott SM. Randomised clinical trial: Bifidobacterium lactis NCC2818 probiotic vs placebo, and impact on gut transit time, symptoms and gut microbiology in chronic constipation. Aliment Pharmacol Ther 2019: 49: 251-64

Dimidi E, Cox C, Grant R, Scott SM, Whelan K. Perceptions of constipation among the general public and people with constipation differ strikingly from those of general and specialist doctors and the Rome IV criteria. Am J Gastroenterol 2019: 114: 1116-29


All Publications


  • Annika Rasijeff, PhD
  • Paul Vollebregt, PhD (overseas)
  • Gursharan Nandhra, PhD (part-time)
  • Phakanant (Pam) Chaichanavichkij, PhD
  • Mary Venn, PhD
  • Anisa Choudhary, PhD
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