Blizard Institute Research Seminar: Dr Richard Oram, University of Exeter
When: Friday, November 4, 2022, 3:30 PM - 4:30 PM
Where: Perrin Lecture Theatre, Whitechapel
Speaker: Dr Richard Oram, University of Exeter
Type 1 diabetes genetic risk score (T1D GRS) method to measure genetic risk
Dr Oram developed a type 1 diabetes genetic risk score (T1D GRS) as a method to easily and cheaply measure genetic risk as a single continuous variable that is composed of multiple measures of GWAS SNPs. A key finding of the original paper was that genetic risk can be combined with other factors to better classify diabetes.
This innovative approach of being able to easily and cheaply tag HLA and non-HLA risk has high translational impact as both a research tool to investigate and better understand the biology of T1D and as a future diagnostic test to predict T1D and discriminate T1D from T2D and MODY. Dr Oram will discuss translational potential and limitations of autoimmune genetic risk scores with a focus on type 1 diabetes as an example.