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FMD Project Catalogue
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The Role of MRAP2 in Primary Cilia–Mediated Regulation of Energy Homeostasis
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Harnessing immunomodulation to reprogramme macrophage function and restore healing in fracture-related infection
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RESIST: Learning from the best, or how chromaffin cells teach stress resilience to vulnerable cells
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Understanding the effects of bisphosphonates on bone mineral chemistry and atypical femoral fracture in East London
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Investigating a Novel Mechanism Regulating Cell Junctions in Colitis Using Primary Tissues and Patient-Derived Organoids
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Non-coding NRP1 variants: suppressing soluble NRP1 to support vascular health?
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Investigating the role of natriuretic peptides and neutral endopeptidase in abdominal aortic aneurysm: a novel pharmacological approach for therapy
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Understanding the mechanisms through which a novel model of community mental health care influences care trajectories: A mixed methods longitudinal study
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Biological embedding of social adversity and cardiometabolic risk in severe mental illness: a longitudinal multi-omic study in East London
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Using rare disease genetics to understand mechanisms driving neurodegeneration
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Healthy ageing in EAst London (HEAL): Measuring and modelling healthy ageing inequalities to inform action in East London
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qMIDS-V3: A Non-Invasive Oral Cancer Test Validation Study in East London Population
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Decoding epigenetic dysregulation of transposable elements in circulating cell-free DNA of complicated pregnancies
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MICROHEART: Linking Microplastic Exposure to Endothelial Dysfunction and Cardiovascular Disease
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Implementation of NICE-Recommended Chronic Kidney Disease Surveillance in North-East London: Quantifying Gaps, Understanding Barriers, and Estimating the Health and Economic Benefits of Improvement
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Evaluating the long-term impacts of having tuberculosis in childhood and adolescence in Northeast London and nationally.
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Exploring the role of intersectional minoritised identities in assessing and addressing risk factors for cancer and cardiovascular disease
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TRACE: An Integrative Liquid Biopsy Framework for Monitoring PARP Inhibitor Resistance
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Combining MET inhibition with chemotherapy in ovarian cancer to improve patient outcome
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Mechanistic Diversity in Maladaptive Decision-Making Among Parkinson’s Patients in East London
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Targeting XDH mutations to deliver precision medicine therapeutics for hypertension addressing a major unmet need in East London
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Head and Neck Cancer-Specific Mechanisms of Neural Invasion
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Improving the understanding, recognition, and outcomes of linear growth faltering in pre-school children
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Mitochondrial redox metabolism as a therapeutic target in B cell lymphoma
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Understanding and exploiting sterol metabolism in chronic kidney disease and cancer
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Can dietary nitrate supplementation modulate xanthine oxidoreductase activity as a driver of metabolic syndrome complications in high fructose diets?
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Using Host-Pathogen Interaction Dynamics to Identify Novel Drug Targets in Clinically Relevant Mycobacterium tuberculosis Isolates
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Investigating Rare Genetic Drivers of Fatty Liver Disease in British South Asians
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Effect of valproic acid on the gene regulatory landscape of gingival mast cells. A potential role for treatment of dental periodontitis
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Targeting DNA damage repair pathways in YAP/TAZ-driven squamous cell carcinoma as a novel therapeutic strategy
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Simultaneous treatment of infection and fracture healing with a phage cocktail and mesenchymal stem cell composite hydrogel in fracture-related infections
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Long non-coding RNA regulator of Telomere length in short telomere syndrome dyskeratosis congenita
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Enriched Marine Oil Supplement as a Novel Therapeutic Approach for the Management of Inflamatory Arthritis-Associated Cardiomyopathy
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How changing what you eat can fight cancer: focusing on dietary methionine restriction and/or MAT2A inhibition for the treatment of lymphoma
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iPSCs to hepatocytes: modelling cholestatic liver disease in East London
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Addressing Health Inequalities in Access to Device-Assisted Therapies for Parkinson’s Disease in East London
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Senescent endothelial cells promote the accumulation of pathogenic perivascular mast cells in ageing tissues
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Extracellular Vesicles in Atherosclerosis: Decoding Communication and Repair
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CCR7-dependent neutrophil trafficking as a driver of maladaptive T-cell responses developing during acute and chronic sterile pathologies
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Exploring Cellular Dysfunction and Therapeutic Targets in Diabetic Wound Healing: Tackiling a Hidden Disease Burden in East London
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Mitochondria as a Conduit for Precision Medicine in Inflammatory Induced Cardiomyopathy
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Investigating the roles of endogenous retroviruses in the human placenta
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Development of a novel on demand water fluoridation device for prevention of dental decay
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Investigating the immunomodulatory signature of TAGLN+ fibrosis-associated endothelial cells in progressive fibrotic liver disease
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Exploring how host-fungal dynamics in the human gut drive severe forms of inflammatory bowel disease (IBD) in South Asian patients
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Patient-Derived Endothelial Cells to Reveal Ethnic Differences in Coronary Artery Disease
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Haematopoietic Remodelling after Major Trauma
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Investigating the links between cardiometabolic risk factors and dementia in South Asians
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Deciphering the effect of histone acetylation levels on altered placental cell phenotype
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Exploiting fly genetics to prevent clinically-significant prostate cancer
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Does zinc-dependent regulation of sEH contribute to sex differences in diabetes and heart failure?
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Using Non-invasive Sampling Of Tape-Strip Biopsies To Improve Eczema Therapy in the Bangladeshi population in the East-End of London
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Targeting tumour infiltrating B cells to improve treatment outcomes in ovarian cancer
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Delays in type 2 diabetes diagnosis & management in Black and mixed ethnicity people: a population data-driven study to improve NHS care and outcomes
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Understanding the links between gum disease and brain health: Why is periodontitis a risk factor for dementia
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From East London to Global Practice: A Multi-Modal AI Tool for Early Detection of Coronary Artery Disease
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Future risk of cancer after urgent suspected cancer referral
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Mechanisms of HHV-8 (KSHV) pathogenesis in post-renal transplant Kaposi sarcoma: Viral and host factors and the role of immunosuppressive regimens
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AI for Early Diabetes Detection using Oral and Metabolic Signals
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Insulin Resistance Rewires Hepatocyte Antiviral Pathways and Hepatitits B virus HBV Replication Mechanistic Insights Into a Major East London Health Inequality
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Improving chronic kidney disease care in North East London: causal and implementation evaluation of specialist-primary care multidisciplinary teams
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