BC-DTP_2027_04
Project Catalogue
Recruited students are able to select their specific topic of study from a wide range of PhD projects offered by our world‑leading academic research staff.
Available projects reflect the full spectrum of biomedical research activity taking place within the Faculty of Medicine and Dentistry, all underpinned by the goal of delivering research that has a real impact on health‑related problems for the benefit of East London and the wider global population. Projects range from laboratory‑based molecular research to population health studies, and from cardiovascular research to cancer. Research projects may also be further developed if selected by a student, depending on individual interests. In addition, all projects undergo ongoing co‑development through patient and public involvement and engagement.
2027 Project Catalogue
The 2027 Project Catalogue is currently a work in progress. The full catalogue will be published on Monday 12 October 2026.
BC-DTP_2027_05
The Role of MRAP2 in Primary Cilia–Mediated Regulation of Energy Homeostasis
BC-DTP_2027_06
Harnessing immunomodulation to reprogramme macrophage function and restore healing in fracture-related infection
BC-DTP_2027_07
RESIST: Learning from the best, or how chromaffin cells teach stress resilience to vulnerable cells
BC-DTP_2027_08
Understanding the effects of bisphosphonates on bone mineral chemistry and atypical femoral fracture in East London
BC-DTP_2027_09
Investigating a Novel Mechanism Regulating Cell Junctions in Colitis Using Primary Tissues and Patient-Derived Organoids
BC-DTP_2027_10
Non-coding NRP1 variants: suppressing soluble NRP1 to support vascular health?
BC-DTP_2027_13
Investigating the role of natriuretic peptides and neutral endopeptidase in abdominal aortic aneurysm: a novel pharmacological approach for therapy
BC-DTP_2027_14
Understanding the mechanisms through which a novel model of community mental health care influences care trajectories: A mixed methods longitudinal study
BC-DTP_2027_16
Biological embedding of social adversity and cardiometabolic risk in severe mental illness: a longitudinal multi-omic study in East London
BC-DTP_2027_17
Using rare disease genetics to understand mechanisms driving neurodegeneration
BC-DTP_2027_18
Healthy ageing in EAst London (HEAL): Measuring and modelling healthy ageing inequalities to inform action in East London
BC-DTP_2027_20
qMIDS-V3: A Non-Invasive Oral Cancer Test Validation Study in East London Population
BC-DTP_2027_21
Decoding epigenetic dysregulation of transposable elements in circulating cell-free DNA of complicated pregnancies
BC-DTP_2027_23
MICROHEART: Linking Microplastic Exposure to Endothelial Dysfunction and Cardiovascular Disease
BC-DTP_2027_28
Implementation of NICE-Recommended Chronic Kidney Disease Surveillance in North-East London: Quantifying Gaps, Understanding Barriers, and Estimating the Health and Economic Benefits of Improvement
BC-DTP_2027_29
Evaluating the long-term impacts of having tuberculosis in childhood and adolescence in Northeast London and nationally.
BC-DTP_2027_30
Exploring the role of intersectional minoritised identities in assessing and addressing risk factors for cancer and cardiovascular disease
BC-DTP_2027_33
TRACE: An Integrative Liquid Biopsy Framework for Monitoring PARP Inhibitor Resistance
BC-DTP_2027_34
Combining MET inhibition with chemotherapy in ovarian cancer to improve patient outcome
BC-DTP_2027_35
Mechanistic Diversity in Maladaptive Decision-Making Among Parkinson’s Patients in East London
BC-DTP_2027_36
Targeting XDH mutations to deliver precision medicine therapeutics for hypertension addressing a major unmet need in East London
BC-DTP_2027_37
Head and Neck Cancer-Specific Mechanisms of Neural Invasion
BC-DTP_2027_38
Improving the understanding, recognition, and outcomes of linear growth faltering in pre-school children
BC-DTP_2027_39
Mitochondrial redox metabolism as a therapeutic target in B cell lymphoma
BC-DTP_2027_40
Understanding and exploiting sterol metabolism in chronic kidney disease and cancer
BC-DTP_2027_41
Can dietary nitrate supplementation modulate xanthine oxidoreductase activity as a driver of metabolic syndrome complications in high fructose diets?
BC-DTP_2027_42
Using Host-Pathogen Interaction Dynamics to Identify Novel Drug Targets in Clinically Relevant Mycobacterium tuberculosis Isolates
BC-DTP_2027_43
Investigating Rare Genetic Drivers of Fatty Liver Disease in British South Asians
BC-DTP_2027_44
Effect of valproic acid on the gene regulatory landscape of gingival mast cells. A potential role for treatment of dental periodontitis
BC-DTP_2027_45
Targeting DNA damage repair pathways in YAP/TAZ-driven squamous cell carcinoma as a novel therapeutic strategy
BC-DTP_2027_46
Simultaneous treatment of infection and fracture healing with a phage cocktail and mesenchymal stem cell composite hydrogel in fracture-related infections
BC-DTP_2027_47
Long non-coding RNA regulator of Telomere length in short telomere syndrome dyskeratosis congenita
BC-DTP_2027_48
Enriched Marine Oil Supplement as a Novel Therapeutic Approach for the Management of Inflamatory Arthritis-Associated Cardiomyopathy
BC-DTP_2027_49
How changing what you eat can fight cancer: focusing on dietary methionine restriction and/or MAT2A inhibition for the treatment of lymphoma
BC-DTP_2027_50
iPSCs to hepatocytes: modelling cholestatic liver disease in East London
BC-DTP_2027_51
Addressing Health Inequalities in Access to Device-Assisted Therapies for Parkinson’s Disease in East London
BC-DTP_2027_52
Senescent endothelial cells promote the accumulation of pathogenic perivascular mast cells in ageing tissues
BC-DTP_2027_53
Extracellular Vesicles in Atherosclerosis: Decoding Communication and Repair
BC-DTP_2027_54
CCR7-dependent neutrophil trafficking as a driver of maladaptive T-cell responses developing during acute and chronic sterile pathologies
BC-DTP_2027_55
Exploring Cellular Dysfunction and Therapeutic Targets in Diabetic Wound Healing: Tackiling a Hidden Disease Burden in East London
BC-DTP_2027_56
Mitochondria as a Conduit for Precision Medicine in Inflammatory Induced Cardiomyopathy
BC-DTP_2027_57
Investigating the roles of endogenous retroviruses in the human placenta
BC-DTP_2027_58
Development of a novel on demand water fluoridation device for prevention of dental decay
BC-DTP_2027_59
Investigating the immunomodulatory signature of TAGLN+ fibrosis-associated endothelial cells in progressive fibrotic liver disease
BC-DTP_2027_60
Exploring how host-fungal dynamics in the human gut drive severe forms of inflammatory bowel disease (IBD) in South Asian patients
BC-DTP_2027_61
Patient-Derived Endothelial Cells to Reveal Ethnic Differences in Coronary Artery Disease
BC-DTP_2027_62
Haematopoietic Remodelling after Major Trauma
BC-DTP_2027_63
Investigating the links between cardiometabolic risk factors and dementia in South Asians
BC-DTP_2027_64
Deciphering the effect of histone acetylation levels on altered placental cell phenotype
BC-DTP_2027_65
Exploiting fly genetics to prevent clinically-significant prostate cancer
BC-DTP_2027_66
Does zinc-dependent regulation of sEH contribute to sex differences in diabetes and heart failure?
BC-DTP_2027_67
Using Non-invasive Sampling Of Tape-Strip Biopsies To Improve Eczema Therapy in the Bangladeshi population in the East-End of London
BC-DTP_2027_68
Targeting tumour infiltrating B cells to improve treatment outcomes in ovarian cancer
BC-DTP_2027_69
Delays in type 2 diabetes diagnosis & management in Black and mixed ethnicity people: a population data-driven study to improve NHS care and outcomes
BC-DTP_2027_70
Understanding the links between gum disease and brain health: Why is periodontitis a risk factor for dementia
BC-DTP_2027_71
From East London to Global Practice: A Multi-Modal AI Tool for Early Detection of Coronary Artery Disease
BC-DTP_2027_72
Future risk of cancer after urgent suspected cancer referral
BC-DTP_2027_73
Mechanisms of HHV-8 (KSHV) pathogenesis in post-renal transplant Kaposi sarcoma: Viral and host factors and the role of immunosuppressive regimens
BC-DTP_2027_74
AI for Early Diabetes Detection using Oral and Metabolic Signals
BC-DTP_2027_75
Insulin Resistance Rewires Hepatocyte Antiviral Pathways and Hepatitits B virus HBV Replication Mechanistic Insights Into a Major East London Health Inequality
BC-DTP_2027_02
Improving chronic kidney disease care in North East London: causal and implementation evaluation of specialist-primary care multidisciplinary teams
BC-DTP_2027_76