Mitochondria as a Conduit for Precision Medicine in Inflammatory Induced Cardiomyopathy

Our cells contain tiny structures called mitochondria, which are primarily responsible for producing energy. However, scientists have recently discovered that their health is crucial to our overall well-being. In addition to providing energy, mitochondria can interact with their surroundings, helping to regulate the function of our cells, tissues, and even our entire body. A recent breakthrough has shown that mitochondria can also communicate directly with the nucleus—the part of the cell that controls genes—through special connections known as nucleus-associated mitochondria (NAM). This communication allows mitochondria and the nucleus to “talk” to each other, helping the cell adapt to stress. But when this communication goes wrong or becomes too active, it can contribute to diseases.

This research aims to explore how these connections play a role in the development of heart disease caused by long-term inflammation. Using advanced medical techniques, we hope to better understand how mitochondria affect the heart and to uncover potential new treatments for this condition.

Aims:

Aim 1: Define molecular and structural properties of NAM in human cardiomyocytes under inflammatory stress.

Aim 2: Identify how stromal and immune cell cross-talk modulates NAM formation and cardiomyocyte vulnerability.

Aim 3: Model pharmacological strategies to ameliorate phenotype by targeting NAM.